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The Science of the Total Environment May 2023Short-chain chlorinated paraffins (SCCPs) are ubiquitously distributed in various environmental matrics due to their wide production and consumption globally in the past... (Review)
Review
Short-chain chlorinated paraffins (SCCPs) are ubiquitously distributed in various environmental matrics due to their wide production and consumption globally in the past and ongoing production and use in some developing countries. SCCPs have been detected in various human samples including serum, milk, placenta, nail, and hair, and internal SCCP levels were found to be positively correlated with biomarkers of some diseases. While the environmental occurrence has been reported in a lot of studies, the toxicity and underlying molecular mechanisms of SCCPs remain largely unknown. The current tolerable daily intakes (TDIs) recommended by the world health organization/international programme on chemical safety (WHO/IPCS, 100 μg/kg bw/d) and the UK Committee on Toxicity (COT, 30 μg/kg bw/d) were obtained based on a no observed adverse effect level (NOAEL) of SCCP from the repeated-dose study (90 d exposure) in rodents performed nearly 40 years ago. Importantly, the health risks assessment of SCCPs in a variety of studies has shown that the estimated daily intakes (EDIs) may approach and even over the established TDI by UK COT. Furthermore, recent studies revealed that lower doses of SCCPs could also result in damage to multiple organs including the liver, kidney, and thyroid. Long-term effects of SCCPs at environmental-related doses are warranted.
Topics: Animals; Humans; China; Hair; Hydrocarbons, Chlorinated; Milk; Paraffin
PubMed: 36781137
DOI: 10.1016/j.scitotenv.2023.162187 -
Environmental Science & Technology Sep 2017Accurate quantification of short-chain chlorinated paraffins (SCCPs) poses an exceptional challenge to analytical chemists. SCCPs are complex mixtures of chlorinated...
Accurate quantification of short-chain chlorinated paraffins (SCCPs) poses an exceptional challenge to analytical chemists. SCCPs are complex mixtures of chlorinated alkanes with variable chain length and chlorination level; congeners with a fixed chain length (n) and number of chlorines (m) are referred to as a "congener group" CCl. Recently, we resolved individual CCl by mathematically deconvolving soft ionization high-resolution mass spectra of SCCP mixtures. Here we extend the method to quantifying CCl by introducing CCl specific response factors (RFs) that are calculated from 17 SCCP chain-length standards with a single carbon chain length and variable chlorination level. The signal pattern of each standard is measured on APCI-QTOF-MS. RFs of each CCl are obtained by pairwise optimization of the normal distribution's fit to the signal patterns of the 17 chain-length standards. The method was verified by quantifying SCCP technical mixtures and spiked environmental samples with accuracies of 82-123% and 76-109%, respectively. The absolute differences between calculated and manufacturer-reported chlorination degrees were -0.9 to 1.0%Cl for SCCP mixtures of 49-71%Cl. The quantification method has been replicated with ECNI magnetic sector MS and ECNI-Q-Orbitrap-MS. CCl concentrations determined with the three instruments were highly correlated (R > 0.90) with each other.
Topics: Environment; Environmental Monitoring; Halogenation; Hydrocarbons, Chlorinated; Paraffin
PubMed: 28813149
DOI: 10.1021/acs.est.7b02269 -
Environmental Pollution (Barking, Essex... Sep 2023In this study, very short-, short-, medium-, and long-chain chlorinated paraffins (vSCCPs, SCCPs, MCCPs and LCCPs, respectively) were measured in 40 indoor dust samples...
In this study, very short-, short-, medium-, and long-chain chlorinated paraffins (vSCCPs, SCCPs, MCCPs and LCCPs, respectively) were measured in 40 indoor dust samples from four countries including Japan (n = 10), Australia (n = 10), Colombia (n = 10) and Thailand (n = 10). Homologues of the chemical formula CHCl ranging C and Cl were analysed using liquid chromatography coupled to Orbitrap high resolution mass spectrometry (LC-Orbitrap-HRMS) and integrated using novel custom-built CP-Seeker software. CPs were detected in all dust samples with MCCPs the dominant homologue group in all countries. Overall median ∑SCCP, ∑MCCP and ∑LCCP (C) concentrations determined in dust samples were 30 μg/g (range; 4.0-290 μg/g), 65 μg/g (range; 6.9-540 μg/g) and 8.6 μg/g (range; <1.0-230 μg/g), respectively. Of the quantified CP classes, overall concentrations were generally highest in the samples from Thailand and Colombia, followed by Australia and Japan. vSCCPs with C were detected in dust from each country with an overall frequency of 48%, while LCCPs (C) were present in 100% of samples. Estimated daily intakes (EDIs) calculated for SCCPs and MCCPs relating to ingestion of contaminated indoor dust were considered not to represent health risks based on currently available toxicological data using the margin of exposure (MOE) approach. To the authors' knowledge, this study provides the first data on CPs in indoor dust from Japan, Colombia and Thailand, and is among the first reports of vSCCPs in indoor dust, globally. These findings indicate that further toxicological data and the availability of appropriate analytical standards are needed to evaluate the potential for negative health outcomes deriving from exposure to vSCCPs and LCCPs.
Topics: Environmental Monitoring; Hydrocarbons, Chlorinated; Paraffin; Dust; Mass Spectrometry; China
PubMed: 37302785
DOI: 10.1016/j.envpol.2023.121994 -
Environmental Science and Pollution... Jan 2023Paraffin (petroleum) oils have been used for many years for their insecticidal properties, but relatively little research had been conducted towards their introduction... (Review)
Review
Paraffin (petroleum) oils have been used for many years for their insecticidal properties, but relatively little research had been conducted towards their introduction into the agricultural praxis, due to their potential phytotoxic effects. In the recent years, however, there has been an increased interest in petroleum-based pesticides due to their compatibility with integrated pest management (IPM) programs. Various improvements in the refinement methods have enhanced the manufacture of commercial products with many advantageous features over the original oil formulas. However, literature is still lacking of a general overview about the applicability of newly introduced commercial petroleum oils in agriculture and their compatibility with modern pest management practices. Therefore, the present work aims to depict the current status of petroleum oils in arboriculture and beyond, providing an in-depth analysis of their insecticidal properties with respect to the knowledge gained over the years about the factors responsible for the pesticidal efficacy and the phytotoxic activity of petroleum-derived oil insecticides. Moreover, commercial aspects of petroleum oil formulations and their toxicological profile to non-target organisms have also been addressed through the current legislation in EU and the USA.
Topics: Paraffin; Agriculture; Oils; Pesticides; Insecticides; Petroleum
PubMed: 36396765
DOI: 10.1007/s11356-022-24059-5 -
Environmental Pollution (Barking, Essex... Feb 2023Chlorinated paraffins (CPs) are released into natural environment during processes of production and utilization with diet being the most important exposure route of CPs... (Review)
Review
Chlorinated paraffins (CPs) are released into natural environment during processes of production and utilization with diet being the most important exposure route of CPs for human beings. Short-chain chlorinated paraffins (SCCPs) have lower molecular weights, higher vapor pressures, and higher water solubilities than medium-chain chlorinated paraffins (MCCPs) and long-chain chlorinated paraffins (LCCPs), making SCCPs more likely to be readily released into the environment. Thus, SCCPs were enlisted as persistent organic pollutants being included in the Stockholm Convention in 2017. This review article summarized sample preparation and instrumental analysis methods of CPs for food types such as oil, meat, and aquatic foods. In addition, reported concentrations and profiles, dietary intake and risk assessment of CPs in food samples from various regions, such as China, Japan, and Germany are discussed for studies published between 2005 and 2022. This review is timely given the lack of a recent literature summary of the concentration and distribution of CPs in food. All these studies warranted the necessity to maintain continuous monitoring of CPs concentrations and their potential health risks given the concentrations of CPs in food are increasing worldwide.
Topics: Humans; Environmental Monitoring; Paraffin; Hydrocarbons, Chlorinated; China; Meat
PubMed: 36526055
DOI: 10.1016/j.envpol.2022.120875 -
Environment International Aug 2023Chlorinated paraffins (CPs), a group of chlorinated alkane mixtures, are frequently detected in various environmental matrices and human bodies. Recently, CPs have... (Review)
Review
Chlorinated paraffins (CPs), a group of chlorinated alkane mixtures, are frequently detected in various environmental matrices and human bodies. Recently, CPs have garnered considerable attention owing to their potential to induce health hazards in wildlife and human. Several reviews have discussed short-chain CPs (SCCPs) induced ecological risk; however, a comprehensive understanding of the underlying toxic mechanisms and a comparison among SCCPs, medium-, and long-chain CPs (MCCPs and LCCPs, respectively) are yet to be established. This review summarizes the latest research progress on the toxic effects and the underlying molecular mechanisms of CPs. The main toxicity mechanisms of CPs include activation of several receptors, oxidative stress, disturbance of energy metabolism, and inhibition of gap junction-mediated communication. The sensitivity of different species to CP-mediated toxicities varies markedly, with aquatic organisms exhibiting the highest sensitivity to CP-induced toxicity. The toxicity comparison analysis indicated that MCCPs may be unsafe as potential substitutes for SCCPs.
Topics: Humans; Paraffin; Hydrocarbons, Chlorinated; Environmental Monitoring; China
PubMed: 37354881
DOI: 10.1016/j.envint.2023.108020 -
Chemosphere Jul 2016This review provides an update on information regarding the production volumes, regulations, as well as the environmental levels, trends, fate and human exposure to... (Review)
Review
This review provides an update on information regarding the production volumes, regulations, as well as the environmental levels, trends, fate and human exposure to chlorinated paraffin mixtures (CPs). CPs encompas thousands congeners with varying properties and environmental fate. Based on their carbon chain lengths, CPs are divided into short- (SCCPs; C10-13), medium- (MCCPs; C14-17) and long- (LCCPs; C ≥ 18) chained groups. They are high production volume and persistent chemicals, and their cumulative global production already surpasses that of other persistent anthropogenic chemicals (e.g. PCBs). However, international regulations are still curbed by insufficient information on their levels and fate, including bioaccumulation and toxicity potential. An increasing number of studies since 2010 demonstrate that CPs are detected in almost every compartment in the environment, including remote areas. Consensus on the long range transport and high bioaccumulation potential (BCF > 5000 & TMF > 1) has recently been reached for SCCPs, fulfilling criteria under the Stockholm Convention for designation as a persistent organic pollutant; information on their levels is, however, still sparse for many countries. M/LCCPs have received comparatively little attention in the past, but as replacement chemicals for SCCPs, MCCPs are now considered in an increasing number of studies. The limited data to date suggests MCCPs are widely used. Although data on their bioaccumulation and toxicity are still inconclusive, MCCPs and LCCPs with C<20 may also have a bioaccumulation potential. Considering this and their high production volumes, use, and ubiquitous occurrence in the environment, a better understanding on the levels and fate of all CPs is needed.
Topics: Environmental Monitoring; Environmental Pollutants; Humans; Hydrocarbons, Chlorinated; Paraffin
PubMed: 27135701
DOI: 10.1016/j.chemosphere.2016.04.037 -
Chemosphere Jun 2024Short-chain and medium-chain chlorinated paraffins (SCCPs and MCCPs) have garnered significant attention because they have persistence and potential toxicity, and can...
Short-chain and medium-chain chlorinated paraffins (SCCPs and MCCPs) have garnered significant attention because they have persistence and potential toxicity, and can undergo long-distance transport. Chlorinated paraffins (CPs) inhaled in the size-fractionated particulate phase and gas phase can carry different risks to human health due to their ability to accumulate in different regions of the respiratory tract and exhibit varying deposition efficiencies. In our study, large-volume ambient air samples in both the size-fractionated particulate phase (Dp < 1.0 μm, 1.0-2.5 μm, 2.5-10 μm, and Dp ≥ 10 μm) and gas phase were collected simultaneously in Beijing using an active sampler. The overall levels of SCCPs and MCCPs were relatively high, the ranges being 57-881 and 30-385 ng/m, respectively. SCCPs tended to be partitioned in the gas phase (on average 75% of the ΣSCCP concentration), while MCCPs tended to be partitioned in the particulate phase (on average 62% of the ΣMCCP concentration). Significant correlations were discovered between the logarithm-transformed gas-particle partition coefficients (K) and predicted subcooled vapor pressures (P) (p < 0.01 for SCCPs and MCCPs) and between the logarithm-transformed K values and octanol-air partition coefficients (K) (p < 0.01 for SCCPs and MCCPs). Thus, the slopes indicated that organic matter absorption was the dominant process involved in gas-particle partitioning. We used the ICRP model to calculate deposition concentrations for particulate-associated CPs in head airways region (15.6-71.4 ng/m³), tracheobronchial region (0.8-4.8 ng/m³), and alveolar region (5.1-21.9 ng/m³), then combined these concentrations with the CP concentrations in the gas phase to calculate estimated daily intakes (EDIs) for inhalation. The EDIs for SCCPs and MCCPs through inhalation of ambient air for the all-ages group were 67.5-184.2 ng/kg/day and 19.7-53.7 ng/kg/day, respectively. The results indicated that SCCPs and MCCPs in ambient air do not currently pose strong risks to human health in the study area.
Topics: Paraffin; Air Pollutants; Humans; Particulate Matter; Hydrocarbons, Chlorinated; Environmental Monitoring; Particle Size; Risk Assessment; Inhalation Exposure; Beijing; Halogenation; Gases
PubMed: 38705415
DOI: 10.1016/j.chemosphere.2024.142225 -
Environmental Science & Technology Jun 2021Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs, respectively) have raised environmental concern due to their potential for persistence, long-range...
Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs, respectively) have raised environmental concern due to their potential for persistence, long-range transport, bioaccumulation, and toxicity. However, little is known about the production, use, and environmental emissions of SCCPs and MCCPs in China, the world's largest producer and consumer. In this study, we estimated the amounts of SCCPs and MCCPs produced and used in China in 2018-2019 based on a nationwide survey and measurements of concentrations in products, from which we estimated the environmental emissions of SCCPs and MCCPs in China. Our results show that 225.2 and 236.4 metric kilotons (kt) of SCCPs and 428.5 and 450.2 kt of MCCPs were used in China in 2018 and 2019, respectively, with poly(vinyl chloride) (PVC) products dominating SCCP and MCCP usage. Moreover, a total of 3.9 and 4.2 kt SCCPs and 3.8 and 4.1 kt MCCPs were emitted into China's environment in 2018 and 2019, respectively. Although less MCCPs are released into the air relative to SCCPs, their level exceeds the emission of SCCPs into soil. Finally, detailed mass balance calculation indicates that, although emissions from the use of PVC products dominate SCCP and MCCP inputs into the air, emissions from the use of polyurethane foam adhesives are more closely related to input into surface waters for SCCPs and MCCPs. For input into soil, the main emission sources are the use of polyurethane foam adhesives (for SCCPs) and rubber products (for MCCPs). This study provides a preliminary overview of the distributions of SCCPs and MCCPs in products and insight into the mass balance of SCCPs and MCCPs from their production and use to emission in China. This assessment also provides an important foundation for better understanding the environmental risks and fates associated with SCCPs and MCCPs in China and around the world.
Topics: China; Environmental Monitoring; Hydrocarbons, Chlorinated; Paraffin; Soil
PubMed: 33988974
DOI: 10.1021/acs.est.0c07058 -
Environmental Pollution (Barking, Essex... Dec 2021This study reports on concentrations of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs, respectively) in a wide range of food samples (n = 211)...
This study reports on concentrations of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs, respectively) in a wide range of food samples (n = 211) purchased in Belgium during 2020. Samples were analysed by gas chromatography-mass spectrometry (GC-MS) and quantified using chlorine content calibration. ∑SCCPs were present above LOQ in 25% of samples with an overall range of
Topics: Animals; Belgium; China; Environmental Monitoring; Hydrocarbons, Chlorinated; Paraffin; Vegetables
PubMed: 34582924
DOI: 10.1016/j.envpol.2021.118236