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Zhongguo Xue Xi Chong Bing Fang Zhi Za... Apr 2019To analyze the clinical manifestations and imaging characteristics of pulmonary and extra pulmonary paragonimiasis westermani.
OBJECTIVE
To analyze the clinical manifestations and imaging characteristics of pulmonary and extra pulmonary paragonimiasis westermani.
METHODS
A retrospective analysis was performed of 30 patients diagnosed by clinical features, laboratory serological tests and surgical pathology.
RESULTS
The symptoms of the lung included mainly chest distress, fever, chest pain, cough and expectoration, and dyspnea. The extra pulmonary symptoms included abdominal pain, vomiting, diarrhea, poor appetite, emaciation, both lower extremities asthenia, headache, dizziness, epileptic seizures, and subcutaneous migratory masses. The laboratory examination showed that the eosinophil numbers of serum and pleural effusion of all the thirty patients were increased, and the eggs of were found by the stool tests in four cases. The chest CT tests found abnormal nodules, ground glass changes, insect damages, pleural effusion, "tunnel" signs, and "halo" signs. Cranial CT and MRI showed intracranial hemorrhage foci, and extensive "finger-like" edema. Abdominal CT showed serpentine deformation and "tunnel" signs in the hepatic and spleen capsules.
CONCLUSIONS
Paragonimiasis westermani is a multiple organ system involved infection, and it has complex and varied clinical manifestations. The "tunnel" sign and serpentine deformations in the intracranial part, lung, liver and spleen are important imaging manifestations of the disease.
Topics: Animals; Feces; Humans; Paragonimiasis; Paragonimus westermani; Pleural Effusion; Retrospective Studies; Tomography, X-Ray Computed
PubMed: 31184058
DOI: 10.16250/j.32.1374.2017244 -
Le Infezioni in Medicina Jun 2017Paragonimiasis is highly prevalent endemic food-borne disease in Southeast Asia and Latin America, and constitutes a major public health concern. A bibliometric analysis...
Paragonimiasis is highly prevalent endemic food-borne disease in Southeast Asia and Latin America, and constitutes a major public health concern. A bibliometric analysis was performed about the worldwide scientific production of paragonimiasis. We browsed in the Science Citation Index-Expanded (SCI-E) (1957-2015), Scopus (1976-2015), Medline/PubMed/GoPubMed® (1970-2015), ScIELO (1981-2014) and LILACS (1985-2011). All types of articles were included and categorized by year of publication, number, type of scientific article, city and institution of origin, international cooperation, scientific journal, impact factor, language of publication, authors and H index. In SCI-E, 1,028 manuscripts were recovered, while Japan (21.9%) and the USA (17.7%) were the countries with highest scientific production. In this database, Asian region studies received 5,454 citations (H index=32). In Scopus 2161 items were recovered, corresponding to 45.8% of Asian countries. Japan (18.2%) was the first with the University of Miyazaki (11.7% of the country); South Korea (9.5%) was second with the Seoul National University (11.2% of the country). In SciELO 29 items were found, with no contributions from the Asian region. In LILACS 1487 articles were found (22.9% covering Asia). Among the databases, the Journal of Parasitology (Impact factor=1.227) showed the highest number of manuscripts and "Agatsuma T", from Japan, was the author with most records. Japan and South Korea lead global scientific production on paragonimiasis. By contrast, in Latin America, production has been extremely low especially in the last five years.
Topics: Asia; Australia; Bibliometrics; Databases, Bibliographic; Europe; Humans; Latin America; Paragonimiasis; Parasitology; Publishing; Research; United States
PubMed: 28603233
DOI: No ID Found -
Infectious Diseases of Poverty Apr 2018Snail-borne parasitic diseases, such as angiostrongyliasis, clonorchiasis, fascioliasis, fasciolopsiasis, opisthorchiasis, paragonimiasis and schistosomiasis, pose risks... (Review)
Review
BACKGROUND
Snail-borne parasitic diseases, such as angiostrongyliasis, clonorchiasis, fascioliasis, fasciolopsiasis, opisthorchiasis, paragonimiasis and schistosomiasis, pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical countries. In this review we summarize the core roles of snails in the life cycles of the parasites they host, their clinical manifestations and disease distributions, as well as snail control methods.
MAIN BODY
Snails have four roles in the life cycles of the parasites they host: as an intermediate host infected by the first-stage larvae, as the only intermediate host infected by miracidia, as the first intermediate host that ingests the parasite eggs are ingested, and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic animal. Snail-borne parasitic diseases target many organs, such as the lungs, liver, biliary tract, intestines, brain and kidneys, leading to overactive immune responses, cancers, organ failure, infertility and even death. Developing countries in Africa, Asia and Latin America have the highest incidences of these diseases, while some endemic parasites have developed into worldwide epidemics through the global spread of snails. Physical, chemical and biological methods have been introduced to control the host snail populations to prevent disease.
CONCLUSIONS
In this review, we summarize the roles of snails in the life cycles of the parasites they host, the worldwide distribution of parasite-transmitting snails, the epidemiology and pathogenesis of snail-transmitted parasitic diseases, and the existing snail control measures, which will contribute to further understanding the snail-parasite relationship and new strategies for controlling snail-borne parasitic diseases.
Topics: Animals; Disease Vectors; Host-Parasite Interactions; Humans; Parasitic Diseases; Snails
PubMed: 29628017
DOI: 10.1186/s40249-018-0414-7 -
Journal of Neuroradiology = Journal de... Jun 2016The early diagnosis of cerebral paragonimiasis (CP) is essential for a good prognosis. We seek to provide references for early diagnosis by analyzing the imaging...
BACKGROUND AND PURPOSE
The early diagnosis of cerebral paragonimiasis (CP) is essential for a good prognosis. We seek to provide references for early diagnosis by analyzing the imaging characteristics of cerebral paragonimiasis.
MATERIALS AND METHODS
Images of 27 patients with CP (22 males and 5 females; median age 20.3 years; range: 4 to 47 years) were retrospectively evaluated. All patients underwent head computed tomography (CT) scans; 22 patients underwent conventional magnetic resonance imaging (MRI) sequences, including contrast-enhanced MRI for 20 patients and diffusion-weighted-imaging (DWI) for 1 patient. The diagnosis was confirmed based on a positive antibody test using enzyme-linked immunosorbent assay (ELISA) for paragonimiasis in the serum.
RESULTS
The most common imaging findings of CP were isodense or hypodense lesions combined with extensive hypodense areas of perilesional edema on CT scans and a large mass composed of multiple ring-shaped lesions with surrounding edema on MRI images. The conglomeration of multiple ring-shaped lesions (n=11 patients), "tunnel signs" (n=12 patients) and worm-eaten signs (n=5 patients) were characteristic of most CP images. In 14 patients, contrast-enhanced MRI showed varying degrees of contrast enhancement combined with adjacent meningeal enhancement (n=10).
CONCLUSIONS
A large mass comprising multiple ring-shaped lesions of different sizes, "tunnel signs" and worm-eaten signs with surrounding edema are the most characteristic features of CP. Extensive invasions of the adjacent meninges and ventricular wall (19 patients), multiple intracerebral lesions, bilateral hemispheric involvement, and lesion migration are other noteworthy imaging characteristics.
Topics: Adolescent; Adult; Cerebral Cortex; Child; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Paragonimiasis; Tomography, X-Ray Computed; Young Adult
PubMed: 27261801
DOI: 10.1016/j.neurad.2014.10.006 -
Medical Journal, Armed Forces India 2023A pulmonary nodule is a common radiological finding encountered in routine medical practice. It needs to be extensively evaluated as the differential diagnosis can range...
A pulmonary nodule is a common radiological finding encountered in routine medical practice. It needs to be extensively evaluated as the differential diagnosis can range from sinister malignancies to fully treatable infectious causes. Here, we present a rare case of pulmonary paragonimiasis presenting as pulmonary nodule. This case report aims to sensitise the medical practitioner regarding pulmonary paragonimiasis which is completely treatable but carries a high risk of being under diagnosed.
PubMed: 37719913
DOI: 10.1016/j.mjafi.2021.02.009 -
Paediatrics and International Child... Nov 2018An 11-year-old boy collapsed during morning assembly at his junior high school. The automated external defibrillator detected ventricular fibrillation and provided shock...
An 11-year-old boy collapsed during morning assembly at his junior high school. The automated external defibrillator detected ventricular fibrillation and provided shock delivery. He was successfully resuscitated and reverted to sinus rhythm. Electrocardiography showed ST-T elevation in the precordial leads. Echocardiography and angiography demonstrated akinesia of the apex and mid-wall of the left ventricle with preserved contraction of the basal segments, which suggested Takotsubo cardiomyopathy. The patient and his family had often eaten uncooked crab, and his father had a past history of infection with Paragonimiasis westermani. The patient had had a persistent cough and chest pain for several weeks. Chest radiograph showed cystic cavities in the left upper lung. Microbiological examination of the sputum demonstrated an egg of P. westermani and immunological assay showed a raised antibody titre to P. westermani. On the12th day of admission, he developed seizures, and magnetic resonance imaging demonstrated cerebral involvement. After the administration of praziquantel for 3 days, the clinical manifestations improved immediately, and echocardiography normalised within 3 weeks. The patient was discharged on the 32nd day + and follow-up was normal. Takotsubo cardiomyopathy following a potentially fatal arrhythmia is a rare cardiac complication associated with pulmonary and central nervous system infection by P. westermani.
Topics: Angiography; Animals; Antiparasitic Agents; Central Nervous System Parasitic Infections; Child; Echocardiography; Electrocardiography; Humans; Magnetic Resonance Imaging; Male; Microbiological Techniques; Paragonimiasis; Paragonimus westermani; Praziquantel; Radiography, Thoracic; Takotsubo Cardiomyopathy; Treatment Outcome
PubMed: 28884631
DOI: 10.1080/20469047.2017.1371482 -
Chinese Medical Journal Mar 2018
Topics: Clonorchiasis; Humans; Paragonimiasis
PubMed: 29483405
DOI: 10.4103/0366-6999.226079 -
QJM : Monthly Journal of the... Jun 2023
Topics: Humans; Paragonimiasis
PubMed: 36633295
DOI: 10.1093/qjmed/hcad006 -
Journal of Neurosurgery. Pediatrics Jan 2015The authors retrospectively analyzed the clinical characteristics, existing problems, and treatment experiences in recently diagnosed cerebral paragonimiasis (CP) cases...
OBJECT
The authors retrospectively analyzed the clinical characteristics, existing problems, and treatment experiences in recently diagnosed cerebral paragonimiasis (CP) cases and sought to raise awareness of CP and to supply reference data for early diagnosis and treatment.
METHODS
Twenty-seven patients (22 male and 5 female; median age 20.3 years, range 4-47 years) with CP were diagnosed between September 2008 and September 2013. These diagnoses were confirmed by IgG enzyme-linked immunosorbent assays. Follow-up was performed in 24 cases for a period of 6-56 months.
RESULTS
Cerebral paragonimiasis accounted for 21.6% of paragonimiasis cases (27 of 125). The average duration from onset to praziquantel treatment was 69 days. All patients resided in rural areas. Twenty patients had positive lung results, which included visible lung lesions in 14 cases. The lesions were surgically removed in 8 of these cases. Twenty-four patients had high eosinophil counts (≥ 0.08 × 10(9)/L), and eosinophilic meningitis was noted in 17 cases. The rate of misdiagnosis and missed diagnosis was 30.4%. Most symptoms were markedly improved after treatment, but mild movement disorders combined with impaired memory and personality changes remained in a small number of patients.
CONCLUSIONS
Clinicians should be alert to the possibility of CP in young patients (4-16 years) with the primary symptoms of epilepsy and hemorrhage. Early diagnosis and timely treatment can reduce the need for surgery and further impairments to brain function. Liquid-based cytological examination of CSF and peripheral blood eosinophil counts can aid in differentiating CP from similar lesions.
Topics: Adolescent; Adult; Anthelmintics; Central Nervous System Parasitic Infections; Child; Child, Preschool; China; Diagnosis, Differential; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Epilepsy; Female; Humans; Lung Diseases, Parasitic; Male; Middle Aged; Paragonimiasis; Photomicrography; Praziquantel; Retrospective Studies; Rural Population; Tomography, X-Ray Computed; Treatment Outcome; Young Adult
PubMed: 25380173
DOI: 10.3171/2014.10.PEDS14208 -
Zhonghua Bing Li Xue Za Zhi = Chinese... Feb 2017To analyze the clinical, pathological and radiological characteristics of paragonimiasis in children for accurate diagnosis and therapy. A total of 31 patients with...
To analyze the clinical, pathological and radiological characteristics of paragonimiasis in children for accurate diagnosis and therapy. A total of 31 patients with paragonimiasis treated from 2002 to 2016 were selected, including 17 cases from migrant areas and 14 cases from Wenzhou area. In migrant children group, the serum IgE was significantly higher than that in Wenzhou area group [(2 379±944) IU/mL∶(1 552±1 121) IU/mL, =-2.23, <0.05], and the duration of therapy was remarkable longer [(13.8±6.5) days∶(9.9±3.4) days, =-2.15, <0.05]. Among all cases, 10 showed polyserositis including pleural effusion, ascites and pericardial effusion at different degrees on chest CT scans. Five cases with cerebral paragonimiasis were confirmed by MR imaging. Most of the lesions were located in the parietal lobe with slight low signal on T1WI but high signal on T2WI surrounded by disproportionate edema. Annular enhancement was prominent by Gd-DTPA. Paragonimiasis serum antibody was positive in all cases by ELISA. Pathologic features included formation of irregular lacunae or sinus tracts, presence of paragonimus bodies, and eosinophilic infiltration in the adjacent tissues. Clinical manifestations of paragonimiasis are complex and non-specific in children.In migrant children group, clinical manifestations are diverse, more serious with more complications and difficulties in treatment, while patients in Wenzhou area group have favorable prognosis and less complicated treatment. The early diagnosis and timely treatment should be determined by patient's detailed history, eosinophilic count, radiologic findings and immunological test to avoid serious complications.
Topics: Ascites; Brain Diseases; Child; China; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin E; Male; Paragonimiasis; Parietal Lobe; Pleural Effusion; Tomography, X-Ray Computed; Transients and Migrants
PubMed: 28173670
DOI: 10.3760/cma.j.issn.0529-5807.2017.02.009