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Progress in Neuro-psychopharmacology &... Mar 2021In the present study we conducted a genome-wide association study (GWAS) in a cohort of 505 patients with paranoid schizophrenia (SCZ), of which 95 had tardive...
In the present study we conducted a genome-wide association study (GWAS) in a cohort of 505 patients with paranoid schizophrenia (SCZ), of which 95 had tardive dyskinesia (TD), and 503 healthy controls. Using data generated by the PsychENCODE Consortium (PEC) and other bioinformatic databases, we revealed a gene network, implicated in neurodevelopment and brain function, associated with both these disorders. Almost all these genes are in gene or isoform co-expression PEC network modules important for the functioning of the brain; the activity of these networks is also altered in SCZ, bipolar disorder and autism spectrum disorders. The associated PEC network modules are enriched for gene ontology terms relevant to the brain development and function (CNS development, neuron development, axon ensheathment, synapse, synaptic vesicle cycle, and signaling receptor activity) and to the immune system (inflammatory response). Results of the present study suggest that orofacial and limbtruncal types of TD seem to share the molecular network with SCZ. Paranoid SCZ and abnormal involuntary movements that indicate the orofacial type of TD are associated with the same genomic loci on chromosomes 3p22.2, 8q21.13, and 13q14.2. The limbtruncal type of TD is associated with a locus on chromosome 3p13 where the best functional candidate is FOXP1, a high-confidence SCZ gene. The results of this study shed light on common pathogenic mechanisms for SCZ and TD, and indicate that the pathogenesis of the orofacial and limbtruncal types of TD might be driven by interacting genes implicated in neurodevelopment.
Topics: Alleles; Antipsychotic Agents; Forkhead Transcription Factors; Gene Regulatory Networks; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Repressor Proteins; Schizophrenia, Paranoid; Tardive Dyskinesia
PubMed: 33065217
DOI: 10.1016/j.pnpbp.2020.110134 -
La Revue Du Praticien Jan 2019The "syndrome de glissement" The "syndrome de glissement » is a controversial notion that is still used by some French geriatricians, although it does not belong to any... (Review)
Review
The "syndrome de glissement" The "syndrome de glissement » is a controversial notion that is still used by some French geriatricians, although it does not belong to any international disease classification and has very few evidence-based data. Some authors found clinical relevance to this notion, whereas others believe its use is potentially associated with certain risks. The clinical practice and the few available evidence related to syndrome de glissement" tend to suggest that this syndrome usually belong to other disorders including apathy, depression and delusional disorder. "Risks associated with the use of the "syndrome de glissement" include the risk of blocking discussion on diagnosis, clinic and therapy. In general, it seems possible to avoid the use of the notion of "syndrome de glissement" in clinical practice, which does not necessarily prevent to question the desire of death of the older adults.
Topics: Aged; Aging; Depression; Depressive Disorder; Humans; Psychophysiologic Disorders; Schizophrenia, Paranoid; Suicide; Syndrome
PubMed: 30983294
DOI: No ID Found -
Schizophrenia Bulletin Sep 2017Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the...
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013. Diagnoses of schizophrenia made by psychiatrists were ascertained between January 1, 1996 and December 31, 2013. Having an affected co-twin, first-degree relative, second-degree relative, or spouse was associated with an adjusted RR (95% CI) of 37.86 (30.55-46.92), 6.30 (6.09-6.53), 2.44 (1.91-3.12), and 1.88 (1.64-2.15), respectively. Compared with the general population, individuals with one affected first-degree relative had a RR (95% CI) of 6.00 (5.79-6.22) and those with 2 or more had a RR (95% CI) of 14.66 (13.00-16.53) for schizophrenia. The accountability for the phenotypic variance of schizophrenia was 47.3% for genetic factors, 15.5% for shared environmental factors, and 37.2% for non-shared environmental factors. The RR (95% CI) in individuals with a first-degree relative with schizophrenia was 3.49 (3.34-3.64) for mood disorders and 3.91 (3.35-4.57) for delusional disorders. A family history of schizophrenia is therefore associated with a higher risk of developing schizophrenia, mood disorders, and delusional disorders. Heritability and environmental factors each account for half of the phenotypic variance of schizophrenia.
Topics: Adult; Family; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mood Disorders; Registries; Risk; Schizophrenia; Schizophrenia, Paranoid; Taiwan; Young Adult
PubMed: 27872260
DOI: 10.1093/schbul/sbw159 -
Reumatologia Clinica 2017
Topics: Adult; Animals; Ascorbic Acid; Feeding Behavior; Gingivitis; Hemarthrosis; Humans; Knee Joint; Magnetic Resonance Imaging; Male; Malnutrition; Milk; Schizophrenia, Paranoid; Scurvy; Yogurt
PubMed: 28433625
DOI: 10.1016/j.reuma.2017.03.001 -
Journal of Clinical Pharmacy and... Dec 2015There is no consensus regarding treatment of catatonia and the main recent therapeutic progress has been the development of the zolpidem diagnostic and therapeutic test....
WHAT IS KNOWN AND OBJECTIVE
There is no consensus regarding treatment of catatonia and the main recent therapeutic progress has been the development of the zolpidem diagnostic and therapeutic test. We report on the use of this test in one of our patients.
CASES SUMMARY
Mr. S. suffered from a paranoid schizophrenia. Three episodes of catatonia are described to illustrate the effect of zolpidem in a patient for whom lorazepam was ineffective or inadequate.
WHAT IS NEW AND CONCLUSION
Zolpidem with appropriate testing appears to be a credible alternative to electroconvulsive therapy or increased lorazepam dosing and allows continuation of antipsychotic administration.
Topics: Adult; Antipsychotic Agents; Catatonia; Humans; Male; Pyridines; Schizophrenia, Paranoid; Zolpidem
PubMed: 26547135
DOI: 10.1111/jcpt.12330 -
International Journal of Environmental... Jan 2023The study aimed to assess the impact of clinical symptoms and cognitive impairment on disability in patients with paranoid schizophrenia (PS).
UNLABELLED
The study aimed to assess the impact of clinical symptoms and cognitive impairment on disability in patients with paranoid schizophrenia (PS).
METHODS
108 patients with schizophrenia were included (66 male and 42 female). Their average age was 38.86 ± 10.02 years and the disease duration was 12.80 ± 8.20 years, with mean disease onset of 24 years. Clinical symptoms were assessed with the PANSS, and cognitive performance was measured using a seven-item neurocognitive battery. The disability level of the subjects was assessed using the World Health Organization-Disability Assessment Schedule 2.0 (WHO-DAS 2.0). The relation between the variables studied was assessed using Spearman's rank correlation coefficient () at a probability level of < 0.05.
RESULTS
An increase in symptom severity resulted in worsening of the "participation in society" ( = 0.56, < 0.01), "life activities-household" ( = 0.55, < 0.01), and "getting along with people" ( = 0.59, < 0.01) WHO-DAS 2.0 domains. Positive symptoms (13.89 ± 3.48) correlated strongly with "getting along with people" ( = 0.55, < 0.01), "life activities-household" ( = 0.58, < 0.01), and "participation in society" ( = 0.62, < 0.01), and negative symptoms (14.25 ± 4.16) with "participation in society" ( = 0.53, < 0.01) and "life activities-household" ( = 0.48, < 0.01). Symptoms of disorganization (15.67 ± 4.16) had the highest impact on "life activities-household" ( = 0.81, < 0.01), "getting along with people" ( = 0.56, < 0.05), and "participation in society" ( = 0.65, < 0.01). Episodic memory ( = -0.28, < 0.01) was remotely related to comprehension and communication. The information processing speed ( = 0.38, < 0.01), visual memory ( = -0.30, < 0.01), and focused executive functions showed moderate correlations with all domains on the WHO-DAS 2.0 scale ( = 0.38, < 0.01). Attention ( = -0.33, < 0.01) was moderately related to community activities. Semantic ( = -0.29, < 0.01) and literal ( = -0.27, < 0.01) verbal fluency demonstrated weak correlations with "cognition-understanding", "getting along with people", and "participation in society".
CONCLUSION
Symptoms of disorganization and disturbed executive functions contribute most to disability in patients with schizophrenia through impairment of real-world functioning, especially in social interactions and communication. Severe clinical symptoms (negative and disorganization-related ones) as well as deficits in executive function, verbal memory, and verbal fluency cause the biggest problems in the functional domains of interaction with other people and participation in society.
Topics: Humans; Male; Female; Adult; Middle Aged; Schizophrenia, Paranoid; Bulgaria; Cognition Disorders; Neuropsychological Tests; Cognitive Dysfunction; Cognition
PubMed: 36767826
DOI: 10.3390/ijerph20032459 -
Psychiatry Research Nov 2021Clozapine is a second-generation antipsychotic often used for treatment-refractory schizophrenia and has many adverse effects. Cardiac adverse events potentiated by...
Clozapine is a second-generation antipsychotic often used for treatment-refractory schizophrenia and has many adverse effects. Cardiac adverse events potentiated by clozapine include myocarditis which is a black box warning. Even more rarely, there are multiple cases of pericarditis reported in the literature. This is a case report of a 32-year old male with paranoid schizophrenia who developed pericarditis after initiation and titration of clozapine in the inpatient psychiatry unit. Patient presented with chest pain, persistent tachycardia, and orthostatic hypotension two weeks after titration of clozapine. The diagnosis of pericarditis was supported by the repeat electrocardiogram which revealed PR depressions, the audible friction rub, and the pleuritic/episodic nature of the chest pain. All other possible causes of pericarditis were ruled out and clozapine was suspected as the most likely explanation. The pericarditis resolved with treatment of colchine and ibuprofen on evidence from a repeat echocardiogram. This case report demonstrates and supports few cases of clozapine induced pericarditis in the literature. Cardiac events of clozapine can be life-threatening; therefore, greater baseline and subsequent cardiac monitoring may be implicated in the future.
Topics: Adult; Antipsychotic Agents; Clozapine; Humans; Male; Myocarditis; Pericarditis; Schizophrenia, Paranoid
PubMed: 34749222
DOI: 10.1016/j.psychres.2021.114250 -
Zhurnal Nevrologii I Psikhiatrii Imeni... 2020To evaluate the radical-producing function of neutrophils in paranoid schizophrenia and Alzheimer's disease.
OBJECTIVE
To evaluate the radical-producing function of neutrophils in paranoid schizophrenia and Alzheimer's disease.
MATERIAL AND METHODS
The study included 40 patients with paranoid schizophrenia and 22 with Alzheimer's disease. To assess the functional activity of neutrophils, whole blood samples were analyzed using the chemiluminescent method with two-step cell stimulation. Indicators of radical-producing activity of neutrophils in patients were compared to those in age-matched healthy people.
RESULTS
The quantitative indicators of radical-producing activity of neutrophils in the paranoid schizophrenia group and in the Alzheimer's disease group correspond to reference intervals of healthy donors, however almost one third of patients with paranoid schizophrenia had an altered shape of the chemiluminescent curve.
CONCLUSION
The neutrophil immune response might be involved in the pathogenesis of paranoid schizophrenia only in some cases.
Topics: Alzheimer Disease; Humans; Neutrophils; Schizophrenia, Paranoid
PubMed: 32490625
DOI: 10.17116/jnevro202012004197 -
PeerJ 2022This article describes the most likely classes of proteins and molecular processes that specifically characterize schizophrenic spectrum disorders such as simple and...
This article describes the most likely classes of proteins and molecular processes that specifically characterize schizophrenic spectrum disorders such as simple and paranoid schizophrenia, schizotypal disorder, and acute polymorphic psychotic disorder (APPD). The identification of patients' serum proteins was carried out using mass spectrometry. For patients with paranoid schizophrenia, the proteins responsible for translation and transcription are characteristic. A significant part of the proteins of patients with simple schizophrenia regulate the cell's main metabolic and transport processes. These are proteins of the receptor system, vesicular transport, and extracellular matrix, which mainly carry out catabolic processes. The proteins of patients with schizotypal disorder mostly coincided with the classes of other patients, apart from chaperone proteins, which were not found in other studied groups. These proteins are mainly involved in anabolic processes. The main classes of proteins found in patients with APPD are responsible for the metabolism of nucleic acids. Active apoptosis processes were also revealed in these patients. These results from our basic knowledge about the molecular mechanisms of the pathogenesis of these disorders.
Topics: Humans; Proteomics; Schizophrenic Psychology; Psychotic Disorders; Schizotypal Personality Disorder; Schizophrenia, Paranoid
PubMed: 36061748
DOI: 10.7717/peerj.13907 -
Neuromolecular Medicine Mar 2020This study aimed to find the potential association between HSPA1B polymorphisms and risk of paranoid schizophrenia, clinical variables of the disease, and suicidal...
This study aimed to find the potential association between HSPA1B polymorphisms and risk of paranoid schizophrenia, clinical variables of the disease, and suicidal behavior. A total of 901 unrelated Polish subjects of Caucasian origin (377 schizophrenia patients and 524 controls) were recruited. Four single-nucleotide polymorphisms (SNP) were genotyped using PCR-RFLP (rs539689, rs9281590) and TaqMan assays (rs263979, rs6547452). A strong tendency towards statistical significance (p = 0.051) was observed in rs539689 allele distribution between patients and controls in overall study subjects. After stratification according to gender, we found that rs539689 was significantly associated with schizophrenia in males, but not in females. The minor allele C had a protective effect in males [OR 0.73 (95% CI 0.61-0.88, p < 0.05)]. In addition, two SNPs (rs539689, rs9281590) were significantly associated with PANSS scores. Another important finding was a strong significant association between the HSPA1B rs539689 polymorphism and attempted suicide in schizophrenic patients. The C/C genotype and C allele were protective against suicidal behavior in entire sample (p < 0.001), in males (p < 001), and in females (p < 0.05), although associations were weaker than in males. Our findings support that HSPA1B gene may be involved in susceptibility to schizophrenia and clinical presentation of the disease in a sex-dependent manner, and may play a role in suicidal behavior in the Polish population of schizophrenic patients. Further independent analyses in different populations should be performed to clarify the role of HSPA1B in the pathogenesis of schizophrenia.
Topics: Adolescent; Adult; Aged; Alleles; Case-Control Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; HSP70 Heat-Shock Proteins; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Poland; Polymorphism, Single Nucleotide; Schizophrenia, Paranoid; Sex Distribution; Suicide, Attempted; White People; Young Adult
PubMed: 31642026
DOI: 10.1007/s12017-019-08575-1