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American Journal of Clinical Dermatology Mar 2022Pruritus in pregnancy is a common and burdensome symptom that may be a first sign of a pregnancy-specific pruritic disease (atopic eruption of pregnancy, polymorphic... (Review)
Review
Pruritus in pregnancy is a common and burdensome symptom that may be a first sign of a pregnancy-specific pruritic disease (atopic eruption of pregnancy, polymorphic eruption of pregnancy, pemphigoid gestationis, and intrahepatic cholestasis in pregnancy) or a dermatosis coinciding with pregnancy by chance. Despite its high prevalence, pruritus is often underrated by physicians, and data regarding the safety profiles of drugs for pruritus are very limited. In this review, we illustrate the epidemiology, possible pathophysiology, clinical characteristics, and diagnostic workup of various pregnancy-related diseases and discuss antipruritic treatments. The prevalence of pruritus in pregnancy demonstrates the importance of symptom recognition and the need for an holistic approach, taking into account both the potential benefits for the patient and the potential risks to the fetus.
Topics: Cholestasis, Intrahepatic; Exanthema; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications; Pruritus
PubMed: 35191007
DOI: 10.1007/s40257-021-00668-7 -
Clinical Case Reports Jul 2018Pemphigoid gestationis is a rare autoimmune skin disorder emerging exclusively during pregnancy. Topical and oral glucocorticoids as well as oral antihistamines are the...
Pemphigoid gestationis is a rare autoimmune skin disorder emerging exclusively during pregnancy. Topical and oral glucocorticoids as well as oral antihistamines are the standard medications administered during pregnancy, aiming to relieve pruritus and to suppress extensive blister formation. Obstetricians should be able to recognize and treat this rare clinical condition accordingly.
PubMed: 29988643
DOI: 10.1002/ccr3.1545 -
Clinics in Dermatology 2022Annular bullous dermatoses represent an etiologically diverse group of cutaneous phenomena that present with a figurate morphology in association with vesicles and... (Review)
Review
Annular bullous dermatoses represent an etiologically diverse group of cutaneous phenomena that present with a figurate morphology in association with vesicles and bullae. This group of diverse conditions consists of bullous pemphigoid; pemphigoid gestationis; epidermolysis bullosa simplex, Dowling-Meara type; linear immunoglobulin A bullous dermatosis; chronic bullous disease of childhood; anti-p200 pemphigoid; subcorneal pustular dermatosis; and immunoglobulin A pemphigus. Astute examination of clinical, histopathologic, and serologic features is crucial in distinguishing these bullous dermatoses. We review the clinical presentation, pathophysiology, histopathology, and treatments for each bullous annular disease to aid physicians in their recognition, diagnosis, and management.
Topics: Humans; Skin Diseases, Vesiculobullous; Pemphigoid, Bullous; Pemphigus; Linear IgA Bullous Dermatosis; Blister; Immunoglobulin A; Autoimmune Diseases
PubMed: 34979265
DOI: 10.1016/j.clindermatol.2021.12.012 -
Medicina Clinica Apr 2020
Topics: Female; Humans; Pemphigoid Gestationis; Pemphigoid, Bullous; Pregnancy; Pregnancy Complications
PubMed: 31506200
DOI: 10.1016/j.medcli.2019.05.037 -
Clinical Practice and Cases in... Feb 2019
PubMed: 30775676
DOI: 10.5811/cpcem.2018.11.39258 -
The New England Journal of Medicine Aug 2020
Topics: Adult; Biopsy; Complement C3; Female; Humans; Immunoglobulin Isotypes; Pemphigoid Gestationis; Pregnancy; Skin
PubMed: 32846065
DOI: 10.1056/NEJMicm2000922 -
The British Journal of Dermatology Jan 2015
Topics: Female; Humans; Pemphigoid Gestationis; Pregnancy
PubMed: 25581583
DOI: 10.1111/bjd.13457 -
Orphanet Journal of Rare Diseases Sep 2014Gestational pemphigoid (pemphigoid gestationis, PG) is a rare autoimmune skin disorder occurring characteristically during pregnancy. Autoantibodies against placental... (Review)
Review
Gestational pemphigoid (pemphigoid gestationis, PG) is a rare autoimmune skin disorder occurring characteristically during pregnancy. Autoantibodies against placental BP180 (also known as BPAG2 or collagen XVII) cause damage to the skin basement membrane, resulting in severe itching and blistering rash over the body and the extremities. The diagnosis of PG is confirmed by immunofluorescence analysis of a skin biopsy, while serum levels of pemphigoid antigen BP180 antibody can be used to assess disease activity. PG with mild symptoms can be treated with topical corticosteroids, while oral corticosteroids are the mainstay in treatment of severe PG. PG usually flares up at the time of delivery, and resolves spontaneously shortly after. However, relapses in subsequent pregnancies are common. As PG has been linked to the risk of prematurity and fetal growth restriction, prenatal monitoring jointly by a dermatologist and an obstetrician is recommended. Mothers should also be informed of the potential risk of re-activation of the disease in subsequent pregnancies and during hormonal contraception.
Topics: Autoantigens; Biopsy; Diagnosis, Differential; Female; Fluorescent Antibody Technique, Direct; Humans; Infant, Newborn; Non-Fibrillar Collagens; Pemphigoid, Bullous; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prognosis; Collagen Type XVII
PubMed: 25178359
DOI: 10.1186/s13023-014-0136-2