-
Orbit (Amsterdam, Netherlands) Jun 2022A 69-year-old man with myelofibrosis presented with a two-day history of left periorbital swelling, blurred vision, and non-radiating dull orbital pain. On examination,... (Review)
Review
A 69-year-old man with myelofibrosis presented with a two-day history of left periorbital swelling, blurred vision, and non-radiating dull orbital pain. On examination, there was restricted left-sided extraocular motility with conjunctival injection, chemosis, and periorbital edema. Magnetic resonance imaging demonstrated left-sided pre- and post-septal fat stranding concerning for orbital cellulitis. Two weeks before symptom onset, the patient began fedratinib therapy for myelofibrosis but discontinued this medication upon hospital admission. After restarting fedratinib, he presented with similar right-sided ophthalmic signs. A review of his medication history revealed a temporal relationship between symptom onset and fedratinib use. After medication discontinuation, his symptoms improved rapidly.
Topics: Aged; Humans; Inflammation; Male; Orbital Cellulitis; Primary Myelofibrosis; Pyrrolidines; Sulfonamides
PubMed: 33243070
DOI: 10.1080/01676830.2020.1852263 -
Current Opinion in Ophthalmology Sep 2019This study is a review of recent literature in the diagnosis and management of preseptal cellulitis, orbital cellulitis and dacryocystitis, including causative... (Review)
Review
PURPOSE OF REVIEW
This study is a review of recent literature in the diagnosis and management of preseptal cellulitis, orbital cellulitis and dacryocystitis, including causative organisms, diagnosis and medical or surgical therapy and potential complications.
RECENT FINDINGS
Advances in vaccination against Haemophilus influenzae B have resulted in a shift in the most common causative organisms of preseptal and orbital cellulitis. Management of orbital cellulitis has been advanced by adjuvant corticosteroids, and subperiosteal abscess volumes of more than 1250 ml has been shown as predictive for requiring potential surgical intervention.
SUMMARY
Periorbital infections require prompt evaluation and management. Although the infectious organisms in both preseptal and orbital cellulitis include Staphylococcus/Streptococcus species, management may differ significantly on the basis of the nidus of infection, presenting signs and symptoms, and response to initial medical management.
Topics: Abscess; Anti-Bacterial Agents; Bacteria; Child; Child, Preschool; Dacryocystitis; Eye Infections, Bacterial; Female; Humans; Male; Orbital Cellulitis
PubMed: 31261188
DOI: 10.1097/ICU.0000000000000589 -
Neurologic Clinics Aug 2022Cross-sectional imaging with computed tomography (CT) and MRI are diagnostic examinations useful in the diagnosis of painful ophthalmologic disorders and their potential... (Review)
Review
Cross-sectional imaging with computed tomography (CT) and MRI are diagnostic examinations useful in the diagnosis of painful ophthalmologic disorders and their potential complications. CT is a first-line imaging study for suspected orbital infections, particularly useful in differentiating preseptal cellulitis and orbital cellulitis and detecting complications such as orbital abscess. When compared with CT, MRI is better for orbital soft tissue evaluation, particularly useful for optic neuritis, ocular diseases such as endophthalmitis, and invasive fungal rhinosinusitis with orbital involvement. CT angiography is the preferred noninvasive imaging modality for the detection and classification of carotid cavernous fistula.
Topics: Anti-Bacterial Agents; Humans; Magnetic Resonance Imaging; Orbital Cellulitis; Orbital Diseases; Sinusitis; Tomography, X-Ray Computed
PubMed: 35871789
DOI: 10.1016/j.ncl.2022.03.002 -
International Medical Case Reports... 2019Proptosis in children with acute-onset accompanied by signs of inflammation is commonly caused by orbital cellulitis, however, the possibility of rhabdomyosarcoma should... (Review)
Review
INTRODUCTION
Proptosis in children with acute-onset accompanied by signs of inflammation is commonly caused by orbital cellulitis, however, the possibility of rhabdomyosarcoma should always be considered by the clinician. This is a case report of a five-year-old boy presenting with an acute-onset of proptosis without a history of trauma and systemic infection. Our clinical differential diagnosis included orbital cellulitis and orbital rhabdomyosarcoma.
PURPOSE
To report a case of orbital cellulitis that clinically and radiologically mimics rhabdomyosarcoma.
CASE PRESENTATION
A five-year-old boy presented with rapid-onset proptosis, periorbital edema, pain and visual loss in the left eye for two weeks without a history of trauma, upper respiratory tract infection, sinusitis or immunosuppression. Our clinical differential diagnosis includes rhabdomyosarcoma and orbital cellulitis. Complete blood count reveals a leukocytosis. Multislice computed tomography (MSCT) scan shows lesions involving the lateral orbit and the retro bulbar space. Antibiotics combination and adjunct anti-inflammatory intravenously shows excellent clinical resolution.
CONCLUSIONS
The study demonstrates difficulty in differentiating acute orbital cellulitis from rhabdomyosarcoma based on clinical findings. In addition, the case highlights that antibiotic combination of cephalosporin and aminoglycosides together with an adjuvant corticosteroid as an anti-inflammatory was effective in the case of acute orbital cellulitis.
PubMed: 31692563
DOI: 10.2147/IMCRJ.S201678 -
Facial Plastic Surgery : FPS Feb 2018Postoperative periorbital edema and ecchymosis are most bothersome to rhinoplasty patients. The degree of swelling and bruising is influenced by several factors, and... (Review)
Review
Postoperative periorbital edema and ecchymosis are most bothersome to rhinoplasty patients. The degree of swelling and bruising is influenced by several factors, and numerous prophylactic and therapeutic measures have been described in the literature. This article reviews the current literature and concludes with the author's suggestions on how to best minimize postoperative periorbital edema and ecchymosis.
Topics: Adrenal Cortex Hormones; Anticoagulants; Ecchymosis; Edema; Eye Pain; Female; Humans; Hypothermia, Induced; Lidocaine; Male; Perioperative Care; Postoperative Complications; Prognosis; Rhinoplasty; Risk Assessment; Treatment Outcome
PubMed: 29409099
DOI: 10.1055/s-0037-1617444 -
Deutsches Arzteblatt International Jan 2020
Topics: Adolescent; Humans; Male; Orbital Cellulitis
PubMed: 32036856
DOI: 10.3238/arztebl.2020.060b -
Indian Journal of Psychiatry 2020Clozapine is an atypical antipsychotic which is generally used as a second line antipsychotic drug in clinical practice due to its side effects. It is known that...
Clozapine is an atypical antipsychotic which is generally used as a second line antipsychotic drug in clinical practice due to its side effects. It is known that Clozapine may induce hypersensitivity reaction, angioedema at the beginning of the treatment, late onset angioedema related to clozapine treatment is very rare in the literature. In this case report, we present a 19 years old man who was admitted to psychiatry with clozapine induced periorbital edema. He was receiving clozapine 200 mg per day for last two years when he applied to psychiatry. After reducing daily dose of clozapine to 150 mg, his periorbital edema regressed. It should be known that clozapine induced angioedema may develop not only at the beginning of the treatment but also during the treatment and may regress with dose reduction.
PubMed: 32001938
DOI: 10.4103/psychiatry.IndianJPsychiatry_379_18 -
Ear, Nose, & Throat Journal Feb 2021Open rhinoplasty has been performed for over 50 years. Rhinoplasty procedures have a risk of complications and it is important to follow each step diligently in order to...
BACKGROUND
Open rhinoplasty has been performed for over 50 years. Rhinoplasty procedures have a risk of complications and it is important to follow each step diligently in order to avoid complications. Periorbital edema is the most common complication of septorhinoplasty. As far as we are aware, there are no studies in the available literature examining the impact of the septorhinoplasty on intraocular pressure and the retina.
OBJECTIVES
The aim of this study was to evaluate the effects of septorhinoplasty-related periorbital edema on intraocular pressure and the retina by means of objective tests.
METHODS
Ten patients with phase 4 periorbital edema (5 males and 5 females) who underwent open rhinoplasty with bilateral lateral osteotomies were enrolled in the study. All the patients were examined by an eye specialist for visual acuity, intraocular pressure, retinal nerve fiber layer, and ganglion cell complex pathologies with optical coherence tomography preoperatively and postoperatively on the seventh day.
RESULTS
Preoperative and postoperative best-corrected visual acuity; intraocular pressure; average, superior, and inferior retinal nerve fiber layer thickness; and total, superior, and inferior ganglion cell complex thickness in both eyes for all patients were within normal limits. There was no statistical difference between preoperative and postoperative values ( > .05).
CONCLUSION
We concluded that periorbital edema after septorhinoplasty causes no significant complications affecting intraocular pressure and visual acuity. We believe that when osteotomies and local anesthetic injections are undertaken correctly, periorbital complications do not affect vision.
Topics: Adult; Edema; Female; Humans; Intraocular Pressure; Male; Nasal Septum; Orbital Diseases; Osteotomy; Postoperative Complications; Retina; Rhinoplasty; Tomography, Optical Coherence; Treatment Outcome; Visual Acuity
PubMed: 31547702
DOI: 10.1177/0145561319875734 -
Ocular Immunology and Inflammation 2016
Topics: Adrenergic alpha-2 Receptor Agonists; Antibodies, Monoclonal; Brimonidine Tartrate; Diphosphonates; Glaucoma; Humans; Ipilimumab; Orbital Cellulitis; Pharmaceutical Preparations; Uveitis, Anterior
PubMed: 27074544
DOI: 10.3109/09273948.2016.1160683