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Environmental Research Jan 2024Pesticides are extensively used agrochemicals across the world to control pest populations. However, irrational application of pesticides leads to contamination of... (Review)
Review
Pesticides are extensively used agrochemicals across the world to control pest populations. However, irrational application of pesticides leads to contamination of various components of the environment, like air, soil, water, and vegetation, all of which build up significant levels of pesticide residues. Further, these environmental contaminants fuel objectionable human toxicity and impose a greater risk to the ecosystem. Therefore, search of methodologies having potential to detect and degrade pesticides in different environmental media is currently receiving profound global attention. Beyond the conventional approaches, Artificial Intelligence (AI) coupled with machine learning and artificial neural networks are rapidly growing branches of science that enable quick data analysis and precise detection of pesticides in various environmental components. Interestingly, nanoparticle (NP)-mediated detection and degradation of pesticides could be linked to AI algorithms to achieve superior performance. NP-based sensors stand out for their operational simplicity as well as their high sensitivity and low detection limits when compared to conventional, time-consuming spectrophotometric assays. NPs coated with fluorophores or conjugated with antibody or enzyme-anchored sensors can be used through Surface-Enhanced Raman Spectrometry, fluorescence, or chemiluminescence methodologies for selective and more precise detection of pesticides. Moreover, NPs assist in the photocatalytic breakdown of various organic and inorganic pesticides. Here, AI models are ideal means to identify, classify, characterize, and even predict the data of pesticides obtained through NP sensors. The present study aims to discuss the environmental contamination and negative impacts of pesticides on the ecosystem. The article also elaborates the AI and NP-assisted approaches for detecting and degrading a wide range of pesticide residues in various environmental and agrecultural sources including fruits and vegetables. Finally, the prevailing limitations and future goals of AI-NP-assisted techniques have also been dissected.
Topics: Humans; Pesticides; Pesticide Residues; Artificial Intelligence; Ecosystem; Nanoparticles
PubMed: 37977271
DOI: 10.1016/j.envres.2023.117601 -
Zhongguo Zhong Yao Za Zhi = Zhongguo... Mar 2022The present study counted the frequency of detection technologies and monitoring frequency of pesticide species by frequency analysis based on the 28 258 pieces of data...
The present study counted the frequency of detection technologies and monitoring frequency of pesticide species by frequency analysis based on the 28 258 pieces of data on pesticide content of Chinese medicinal materials in CNKI, calculated the detection rate and exceeding rate of different types of pesticides, and systematically analyzed the pesticide residue pollution of Chinese medicinal materials. The results showed that there were 40 types of pesticides with detection rates higher than 10%, where new pesticides such as organochlorines and nicotine accounted for 55%, and organic phosphorus, pyrethroids, and carbamates accounted for 17.5%, 15.0%, and 12.5%, respectively. Seventeen types of pesticides exceeded the standard to varying degrees, including 12 types(70.59%) with exceeding rates not higher than 5%, four types(23.53%) with exceeding rates in the range of 5%-10%, and one type(5.88%) with an exceeding rate higher than 10%. As revealed by the analysis results of the past five years, the pesticide residue pollution of Chinese medicinal materials showed a downward trend. Compared with the conditions at worst, organochlorines decreased by about 2/3 in detection rate and 47.23% in exceeding rate, carbamates by about 1/2 in detection rate and 10.78% in exceeding rate, organic phosphorus by 3/4 in detection rate and 7.22% in exceeding rate, pyrethroids by 1/2 in detection rate and 11.05% in exceeding rate, and other types by about 1/2 in detection rate but not exceeded the standard. In general, pesticide residues in Chinese medicinal materials and safety have been significantly improved. However, pesticide residues are still important factors affecting the quality and safety of Chinese medicinal materials. It is suggested to further improve the control standards of pesticide residues in Chinese medicinal materials, strengthen the monitoring of pesticides used in practical production, and promote the ecological planting mode to facilitate the high-quality development of the Chinese medicinal material industry.
Topics: China; Hydrocarbons, Chlorinated; Pesticide Residues; Pesticides; Pyrethrins
PubMed: 35347938
DOI: 10.19540/j.cnki.cjcmm.20211220.101 -
Journal of Agricultural and Food... Jun 2024Finding highly active molecular scaffold structures is always the key research content of new pesticide discovery. In the research and development of new pesticides, the... (Review)
Review
Finding highly active molecular scaffold structures is always the key research content of new pesticide discovery. In the research and development of new pesticides, the discovery of new agricultural molecular scaffold structures and new targets still faces great challenges. In recent years, quinoline derivatives have developed rapidly in the discovery of new agriculturally active molecules, especially in the discovery of fungicides. The unique quinoline scaffold has many advantages in the discovery of new pesticides and can provide innovative and feasible solutions for the discovery of new pesticides. Therefore, we reviewed the use of quinoline derivatives and their analogues as molecular scaffolds in the discovery of new pesticides since 2000. We systematically summarized the agricultural biological activity of quinoline compounds and discussed the structure-activity relationship (SAR), physiological and biochemical properties, and mechanism of action of the active compounds, hoping to provide ideas and inspiration for the discovery of new pesticides.
Topics: Quinolines; Pesticides; Structure-Activity Relationship; Drug Discovery; Molecular Structure; Animals; Fungicides, Industrial; Humans
PubMed: 38775264
DOI: 10.1021/acs.jafc.4c01582 -
Environmental Research Nov 2022Organophosphate (OP) and pyrethroid pesticides (PYR) are extensively used in agriculture, resulting in higher exposures among farmworkers. The present study reports the...
Organophosphate (OP) and pyrethroid pesticides (PYR) are extensively used in agriculture, resulting in higher exposures among farmworkers. The present study reports the occurrence of 8 urinary OP and PYR metabolites in a sample of farmworkers and residents from Sucs (n = 87), a rural township in North West Catalonia (Spain). The aim of the present study was to examine differences in urinary pesticide metabolite concentrations between occupationally-exposed (farmworkers; n = 45) and environmentally-exposed subjects (n = 42) and to assess the relationship between pesticide's exposures and occupational activities in a real-case scenario. Six OP and two PYR metabolites have been investigated, urine samples were extracted using SPE extraction and analyzed by UPLC-MS/MS. Three OP metabolites were commonly detectable in urine, namely TCPY (metabolite of chlorpyrifos), PNP (parathion) and DEAMPY (pirimiphos). Regarding pyrethroids, the two analyzed metabolites, 3-PBA and 4F-3-PBA, were detected in a high proportion of urine samples. Differences in concentrations between both groups were statistically significant for TCPY and 4F-3-PBA (Mann-Whitney U Test for independent groups, p < 0.05). In the case of TCPY, the concentrations were higher among the farmworkers, which is consistent with their occupational activity. The small differences found in DEAMPY, PNP, 3-PBA or even the significant higher concentrations of 4F-3-PBA among rural population suggest a general exposure to these compounds, even in those who do not carry an occupational activity. Specific personal protective equipment (PPE) among farmworkers, such as the use of gloves and mask during mixing, showed a decrease in the exposure levels, although the differences were not statistically significant. However, a positive association was found between the use of a cap during mixing (for PNP and 3-PBA) and during application (only for 3-PBA). However, this piece of cloth is mainly used for sun protection, and when not cleaned after the handling of pesticides, it might represent a continuous source of exposure through dermal contact. Farmworkers using tractors with cabin had statistically significant lower concentrations of DEAMPY than those using a tractor without cabin. The previous results suggest that occupational protections should be encouraged among farmworkers and other potential workers handling with pesticides.
Topics: Agriculture; Chlorpyrifos; Chromatography, Liquid; Humans; Occupational Exposure; Pesticides; Pyrethrins; Rural Population; Tandem Mass Spectrometry
PubMed: 36030920
DOI: 10.1016/j.envres.2022.114186 -
International Journal of Molecular... Jul 2022Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, with endocrine-disrupting properties is considered to be involved in...
Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, with endocrine-disrupting properties is considered to be involved in this reproductive disorder, especially when it occurs during early life. Pesticides are present in various facets of the environment, and consumers are exposed to a combination of multiple pesticide residues through food intake. The consequences of such exposure with respect to female fertility are not well known. Therefore, we aimed to assess the impact of pre- and postnatal dietary exposure to a pesticide mixture on folliculogenesis, a crucial process in female reproduction. Mice were exposed to the acceptable daily intake levels of six pesticides in a mixture (boscalid, captan, chlorpyrifos, thiacloprid, thiophanate and ziram) from foetal development until 8 weeks old. Female offspring presented with decreased body weight at weaning, which was maintained at 8 weeks old. This was accompanied by an abnormal ovarian ultrastructure, a drastic decrease in the number of corpora lutea and progesterone levels and an increase in ovary cell proliferation. In conclusion, this study shows that this pesticide mixture that can be commonly found in fruits in Europe, causing endocrine disruption in female mice with pre- and postnatal exposure by disturbing folliculogenesis, mainly in the luteinisation process.
Topics: Animals; Chlorpyrifos; Dietary Exposure; Female; Fruit; Mice; Pesticide Residues; Pesticides
PubMed: 35886873
DOI: 10.3390/ijms23147525 -
Chemico-biological Interactions Jul 2016This review aims to provide an update on our current knowledge of the various effects of pesticide cocktails. We have collected data from studies conducted in mammalian... (Review)
Review
This review aims to provide an update on our current knowledge of the various effects of pesticide cocktails. We have collected data from studies conducted in mammalian models in vitro and in vivo that was published between 2000 and 2014. All ecotoxicological studies were voluntarily excluded. Cocktail effects were classified according to how they had been classified by each author. The frequency of the various cocktail effects and the classes and chemical families of pesticides involved in the observed effects were assessed. When focusing on the function of pesticides (i.e. herbicide, insecticide or fungicide), 46% of the mixtures contained insecticides alone, 15% fungicides alone, and 4.5% herbicides alone. Mixtures with effects associated with neurotoxicity were mainly composed of insecticides, and most studies on the effects of fungicide mixtures (90%) were associated with effects on endocrine regulation and/or reproduction. Dose addition was observed with each kind of mixture except herbicide combinations. In contrast, synergic interactions or greater-than-additive effects were mainly reported for insecticide mixtures. There were few examples of potentiating and antagonistic interactions. We have identified chemical families of compounds specifically involved in synergy, addition, potentiation and antagonism, and those that do not interact when combined. The chemical families identified as being involved in synergy are in agreement with data from another recently published compilation of ecotoxicological studies. For most mixtures investigated, further validation data is still needed from experiments using other compounds and other experimental models but this update provides useful information to help in human health risk assessments.
Topics: Animals; Apoptosis; Drug Synergism; Humans; Models, Animal; Models, Biological; Pesticides
PubMed: 27312199
DOI: 10.1016/j.cbi.2016.06.003 -
The Science of the Total Environment Mar 2024Bees carry out vital ecosystem services by pollinating both wild and economically important crop plants. However, while performing this function, bee pollinators may... (Review)
Review
Bees carry out vital ecosystem services by pollinating both wild and economically important crop plants. However, while performing this function, bee pollinators may encounter potentially harmful xenobiotics in the environment such as pesticides (fungicides, herbicides and insecticides). Understanding the key factors that influence the toxicological outcomes of bee exposure to these chemicals, in isolation or combination, is essential to safeguard their health and the ecosystem services they provide. In this regard, recent work using toxicogenomic and phylogenetic approaches has begun to identify, at the molecular level, key determinants of pesticide sensitivity in bee pollinators. These include detoxification systems that convert pesticides to less toxic forms and key residues in insecticide target-sites that underlie species-specific insecticide selectivity. Here we review this emerging body of research and summarise the state of knowledge of the molecular determinants of pesticide sensitivity in bee pollinators. We identify gaps in our knowledge for future research and examine how an understanding of the genetic basis of bee sensitivity to pesticides can be leveraged to, a) predict and avoid negative bee-pesticide interactions and facilitate the future development of pest-selective bee-safe insecticides, and b) inform traditional effect assessment approaches in bee pesticide risk assessment and address issues of ecotoxicological concern.
Topics: Bees; Animals; Pesticides; Insecticides; Phylogeny; Ecosystem; Fungicides, Industrial
PubMed: 38246392
DOI: 10.1016/j.scitotenv.2024.170174 -
The Science of the Total Environment Nov 2022To guarantee an adequate food supply for the world's growing population, intensive agriculture is necessary to ensure efficient food production. The use of pesticides... (Review)
Review
To guarantee an adequate food supply for the world's growing population, intensive agriculture is necessary to ensure efficient food production. The use of pesticides helps maintain maximum productivity in intensive agriculture by minimizing crop losses due to pests. However, pesticide contamination of surface waters constitutes a major problem as they are resistant to degradation and soluble enough to be transported in water. In recent years, all groups of pesticides defined by the World Health Organization have increased their use and, therefore, their prevalence in the different environmental compartments that can have harmful effects. Despite this effort, there is no rigorous monitoring program that quantifies and controls the toxic effects of each pesticide. However, multiple scientific studies have been published by specialized research groups in which this information is disseminated. Therefore, any attempt to systematize this information is relevant. This review offers a current overview of the presence and distribution of the most widely-used pesticides (insecticides, herbicides, and fungicides) by crop type and an evaluation of the relationships between their uses and environmental implications in Spain. The data demonstrated that there are correlations between the presence of specific pesticides used in the main crops and their presence in the environmental compartments. We have found preliminary data pointing to existing associations between specific pesticides used in the main crops and their presence in environmental compartments within different geographical areas of Spain; this should be the subject of further investigation.
Topics: Agriculture; Crops, Agricultural; Environment; Environmental Monitoring; Fungicides, Industrial; Herbicides; Pesticides
PubMed: 35835192
DOI: 10.1016/j.scitotenv.2022.157291 -
Ecotoxicology and Environmental Safety Aug 2022Due to the frequent pesticide applications, bees are suffered from pesticide exposure risks via consumption and direct contact with sprayed drifts. However, if...
Due to the frequent pesticide applications, bees are suffered from pesticide exposure risks via consumption and direct contact with sprayed drifts. However, if pesticides are misused and the potential exposure risk to bees based on realistic pesticide application data are still little reported. In this study, pesticide application patterns in wheat-maize rotation system, vegetable and apple producing areas, was studied by interviewing farmers in Quzhou County, the North China Plain. The pesticide use status was evaluated by the recommended and actual applied dose and risk quotient (RQ) based Bee-REX model was used to assess the exposure risks of pesticide to bees based on the collected pesticide application data. The results showed that over half (52 %) of farmers in selected sites misused pesticides and orchard owners were frequently misused pesticides. Positive correlations were found between pesticide usage performance and farmers' specialized training experience. Pesticides applied in orchards have caused higher exposure risks to bees with the mean of RQs exceed 120 and 1880 via acute contact and dietary routes, respectively. Pesticide misuse significantly elevates the exposure risk to bees that the mean RQ under misuse scenarios was 5.8 times than that of correct use. Abamectin, fipronil and neonicotinoids contributed most to the pesticide exposure risk to bees. The main findings of this study imply that more sustainable pest and pollinator management strategies, including the moratorium high-risk insecticides and providing diverse flower resources and habitats, are highly needed. Additionally, measures such as implementing farmer educating and training programs should also be put on the agenda.
Topics: Animals; Bees; China; Farmers; Humans; Insecticides; Neonicotinoids; Pesticides
PubMed: 35667311
DOI: 10.1016/j.ecoenv.2022.113713 -
Journal of Environmental Management Dec 2021The application of pesticides in agricultural and public health sectors has resulted in substantially contaminated water resources with residues in many countries.... (Review)
Review
The application of pesticides in agricultural and public health sectors has resulted in substantially contaminated water resources with residues in many countries. Almost no reviews have addressed pesticide residues in drinking water globally; calculated hazard indices for adults, children, and infants; or discussed the potential health risk of pesticides to the human population. The objectives of this article were to summarize advances in research related to pesticide residues in drinking water; conduct health risk assessments by estimating the daily intake of pesticide residues consumed only from drinking water by adults, children, and infants; and summarize options for pesticide removal from water systems. Approximately 113 pesticide residues were found in drinking water samples from 31 countries worldwide. There were 61, 31, and 21 insecticide, herbicide, and fungicide residues, respectively. Four residues were in toxicity class IA, 14 residues were in toxicity class IB, 55 residues were in toxicity class II, 17 residues were in toxicity class III, and 23 residues were in toxicity class IV. The calculated hazard indices (HIs) exceeded the value of one in many cases. The lowest HI value (0.0001) for children was found in Canada, and the highest HI value (30.97) was found in Egypt, suggesting a high potential health risk to adults, children, and infants. The application of advanced oxidation processes (AOPs) showed efficient removal of many pesticide classes. The combination of adsorption followed by biodegradation was shown to be an effective and efficient purification option. In conclusion, the consumption of water contaminated with pesticide residues may pose risks to human health in exposed populations.
Topics: Adult; Child; Drinking Water; Humans; Insecticides; Pesticide Residues; Pesticides; Water Pollutants, Chemical
PubMed: 34526283
DOI: 10.1016/j.jenvman.2021.113611