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NeoReviews Feb 2023
Topics: Infant, Newborn; Infant; Humans; Infant, Premature; Purpura
PubMed: 36720692
DOI: 10.1542/neo.24-2-e125 -
BMJ (Clinical Research Ed.) Jun 2023
Topics: Humans; Leg; Purpura; Lower Extremity; Exanthema
PubMed: 37348904
DOI: 10.1136/bmj-2023-075249.r1 -
Cutis Apr 2023
Topics: Humans; Leg; Purpura; Skin Diseases, Vascular
PubMed: 37289690
DOI: 10.12788/cutis.0756 -
BMJ Case Reports Jan 2021
Topics: Female; Humans; Middle Aged; Pigmentation Disorders; Pruritus; Purpura
PubMed: 33462064
DOI: 10.1136/bcr-2020-240052 -
Transfusion and Apheresis Science :... Aug 2014Thrombotic thrombocytopenic purpura diagnosis and therapy has transformed with improved understanding of the disorder and availability of therapies. Plasma exchange... (Review)
Review
Thrombotic thrombocytopenic purpura diagnosis and therapy has transformed with improved understanding of the disorder and availability of therapies. Plasma exchange remains the cornerstone of treatment. Prompt therapy can improves morbidity and mortality. However, given the plasma volumes used, those offering protection against transfer of microbes are preferable. Reviewed is a brief history of TTP and current plasmas available, their use and safety profiles, concentrating on the current UK recommendations.
Topics: Humans; Plasma Exchange; Purpura, Thrombotic Thrombocytopenic; United Kingdom
PubMed: 25305101
DOI: 10.1016/j.transci.2014.08.001 -
Journal of Cosmetic Dermatology Dec 2019
Topics: Drug Therapy, Combination; Humans; Purpura
PubMed: 30809925
DOI: 10.1111/jocd.12880 -
Clinical Rheumatology Apr 2021
Topics: Humans; IgA Vasculitis; Immunoglobulin A; Lip; Male; Purpura; Vasculitis
PubMed: 33151478
DOI: 10.1007/s10067-020-05486-6 -
Arthritis & Rheumatology (Hoboken, N.J.) Oct 2020Cutaneous manifestations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic...
OBJECTIVE
Cutaneous manifestations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), are poorly characterized. This report describes the dermatologic features of AAV and their association with systemic manifestations of vasculitis.
METHODS
A cross-sectional study identifying and comparing the cutaneous manifestations of AAV was performed using data from a large, international, collaborative effort in order to collect comprehensive clinical data on patients with vasculitis.
RESULTS
Data from 1,184 patients with AAV from 130 centers worldwide were available. Cutaneous manifestations were common in all AAV subtypes: GPA (223 of 656, or 34%), MPA (85 of 302, or 28%), and EGPA (106 of 226, or 47%). The most frequent cutaneous manifestation in AAV (all types) was petechiae/purpura, which was observed in 181 patients (15%). Allergic and nonspecific manifestations, such as pruritus, urticaria, and maculopapular rash, were more common in EGPA than in other disease subtypes (all P < 0.01). Skin biopsy, while underutilized (performed in 22-44% of patients), was frequently found to be an effective test suitable for diagnosis of AAV (diagnostic in 68-94% of patients). Compared to patients without cutaneous manifestations, those with skin lesions more frequently had severe systemic manifestations of vasculitis (such as alveolar hemorrhage and glomerulonephritis), specifically patients with GPA or EGPA and cytoplasmic/anti-proteinase 3 (anti-PR3) ANCA-positive or ANCA-negative patients (hazard ratio >1.9 for all), but not those with MPA or perinuclear/antimyeloperoxidase ANCAs.
CONCLUSION
Cutaneous manifestations are common and varied in AAV and are associated with disease severity in patients with GPA, EGPA, cytoplasmic/anti-PR3 ANCA, or ANCA-negative disease. These findings underscore the potential diagnostic and prognostic importance of the cutaneous examination in the evaluation and management of AAV.
Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Pruritus; Purpura; Skin; Urticaria
PubMed: 32419292
DOI: 10.1002/art.41310 -
Nursing Jan 2019Acquired autoimmune thrombotic thrombocytopenic purpura (TTP)-the most common form of TTP-is a life-threatening hematologic disease characterized by hemolytic anemia and...
Acquired autoimmune thrombotic thrombocytopenic purpura (TTP)-the most common form of TTP-is a life-threatening hematologic disease characterized by hemolytic anemia and thrombocytopenia. Acquired autoimmune TTP can cause signs and symptoms of neurologic and other organ involvement, with mortality approaching 90% if the disease is not promptly recognized and treated. Since the introduction of plasma exchange in 1991, the acquired autoimmune TTP survival rate has increased to 78%.
Topics: Humans; Nursing Diagnosis; Purpura, Thrombotic Thrombocytopenic; Survival Rate; Treatment Outcome
PubMed: 30531363
DOI: 10.1097/01.NURSE.0000549721.69197.4d -
Cleveland Clinic Journal of Medicine Jan 2024
Topics: Humans; Endocarditis, Bacterial; Endocarditis; Purpura
PubMed: 38167396
DOI: 10.3949/ccjm.91a.23041