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Cutis May 2020
Topics: Aged; Arm; Blood Pressure Determination; Capillaries; Ecchymosis; Humans; Male; Purpura; Skin; Tourniquets; Vascular Diseases
PubMed: 32603394
DOI: No ID Found -
Advances in Pediatrics Aug 2024Pediatric immune thrombocytopenia (ITP) is a fairly common bleeding disorder PRESENTING with a decreased number of platelets. The typical clinical presentation involves... (Review)
Review
Pediatric immune thrombocytopenia (ITP) is a fairly common bleeding disorder PRESENTING with a decreased number of platelets. The typical clinical presentation involves mild bleeding symptoms with bruising and petechiae and occasional mucosal bleeding. ITP is thought to be an autoimmune disorder and more recently other mechanisms have been described. Most cases resolve spontaneously and can undergo watchful waiting as the platelet count improves. Initially, steroids or intravenous immunoglobulin G (IVIg) can be used to increase platelets. For those cases that do not resolve and become persistent or chronic, there are multiple treatment options, with new agents being studied in adults that will hopefully make it to clinical trials in pediatrics in the future.
Topics: Humans; Child; Purpura, Thrombocytopenic, Idiopathic; Immunoglobulins, Intravenous; Platelet Count
PubMed: 38944486
DOI: 10.1016/j.yapd.2024.02.007 -
Cutis Nov 2021
Topics: Humans; Purpura Fulminans; Vibrio vulnificus
PubMed: 35100541
DOI: 10.12788/cutis.0395 -
Rheumatology (Oxford, England) Mar 2021
Topics: Aged; Ecchymosis; Female; Humans; Immunoglobulin Light-chain Amyloidosis; Orbital Diseases; Purpura
PubMed: 32944781
DOI: 10.1093/rheumatology/keaa545 -
Clinical Pediatrics Jul 2024
Topics: Humans; Infant, Newborn; Purpura; Diagnosis, Differential; Male; Female
PubMed: 37646241
DOI: 10.1177/00099228231196744 -
QJM : Monthly Journal of the... Mar 2024
Topics: Humans; Purpura Fulminans; Infections; Splenic Diseases; Purpura
PubMed: 37831903
DOI: 10.1093/qjmed/hcad233 -
International Journal of Dermatology Oct 2022
Topics: Aged, 80 and over; Female; Humans; Levamisole; Purpura
PubMed: 35106756
DOI: 10.1111/ijd.16120 -
La Revue de Medecine Interne Jan 2021Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an immune peripheral destruction of platelets and an inappropriate platelet production. The...
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an immune peripheral destruction of platelets and an inappropriate platelet production. The pathogenesis of ITP is now better understood: it involves a humoral immune response which dependents on the stimulation of B cells by specific T cells called T follicular helper cells, leading to their differentiation into plasma cells that produce antiplatelet antibodies thus promoting the phagocytosis of platelets mainly by splenic macrophages. The deciphering of ITP pathogenesis has led to a better understanding of the inefficiency of treatments such as rituximab, although it has not provided yet the determination of biological predictive factor of response to treatments. Moreover, new therapeutic perspectives have been opened in the last few years with the development of molecules targeting Fcγ receptor signalling such as Syk inhibitor, or molecules increasing the clearance of pathogenic autoantibodies such as inhibitors of the neonatal Fc receptor (FcRn).
Topics: Autoimmunity; B-Lymphocytes; Blood Platelets; Humans; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia
PubMed: 32741715
DOI: 10.1016/j.revmed.2020.06.020 -
Frontiers in Immunology 2022Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially life-threatening hematologic disease, presenting a myriad of diagnostic and management challenges in... (Review)
Review
Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially life-threatening hematologic disease, presenting a myriad of diagnostic and management challenges in children. Here, we provide a review of this disorder and discuss 2 exemplary cases of TTP occurring in adolescents, emphasizing the need for consideration of late-onset congenital TTP (cTTP). We demonstrate the importance of early confirmation of ADAMTS13 enzyme deficiency and the presence or absence of ADAMTS13 inhibitor in order to rapidly initiate the appropriate life-saving therapies. Ultimately, molecular testing is paramount to distinguishing between congenital and acquired immune-mediated TTP.
Topics: Adolescent; Child; Humans; Purpura, Thrombotic Thrombocytopenic
PubMed: 35479064
DOI: 10.3389/fimmu.2022.836960 -
Forensic Science, Medicine, and... Sep 2020Ligature strangulation causes death due to neck compression without suspension. However, suicidal ligature strangulation is rare. The suicide of a 32-year-old man is...
Ligature strangulation causes death due to neck compression without suspension. However, suicidal ligature strangulation is rare. The suicide of a 32-year-old man is presented. After a dispute, the man was found outdoors with a lashing belt around his neck which had been pulled tight with a ratchet. Conjunctival petechiae were found, but hemorrhages in the soft tissues were not observed. The hyoid bone and larynx did not show fractures or hemorrhage. Other injuries as well as signs of defence were not observed. The differentiation between homicidal and suicidal ligature strangulation can be difficult and requires careful investigation and collaboration by police and forensic pathologists.
Topics: Adult; Asphyxia; Conjunctiva; Humans; Male; Neck Injuries; Pulmonary Emphysema; Purpura; Suicide, Completed
PubMed: 32146575
DOI: 10.1007/s12024-020-00223-6