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Chemical Society Reviews Jul 2022The purpose of this Tutorial Review is to outline the fundamental photochemistry of metal carbonyls, and to show how the advances in technology have increased our... (Review)
Review
The purpose of this Tutorial Review is to outline the fundamental photochemistry of metal carbonyls, and to show how the advances in technology have increased our understanding of the detailed mechanisms, particularly how relatively simple experiments can provide deep understanding of complex problems. We recall some important early experiments that demonstrate the key principles underlying current research, concentrating on the binary carbonyls and selected substituted metal carbonyls. At each stage, we illustrate with examples from recent applications. This review first considers the detection of photochemical intermediates in three environments: glasses and matrices; gas phase; solution. It is followed by an examination of the theory underpinning these observations. In the final two sections, we briefly address applications to the characterization and behaviour of complexes with very labile ligands such as N, H and alkanes, concentrating on key mechanistic points, and also describe some principles and examples of photocatalysis.
Topics: Ligands; Metals; Photochemistry; Transition Elements
PubMed: 35708003
DOI: 10.1039/d1cs00826a -
Analytical Chemistry Jan 2018
Review
Topics: Electrochemical Techniques; Immunoassay; Photochemistry
PubMed: 29135236
DOI: 10.1021/acs.analchem.7b04672 -
Cannabis and Cannabinoid Research Dec 2022Photochemistry is a powerful synthetic tool resulting in the construction of unique substances. Remarkably, photochemistry has been relatively underexplored in the...
Photochemistry is a powerful synthetic tool resulting in the construction of unique substances. Remarkably, photochemistry has been relatively underexplored in the cannabinoid area and represents a valuable opportunity for further discovery.
Topics: Photochemistry
PubMed: 36251456
DOI: 10.1089/can.2022.0113 -
Chemistry (Weinheim An Der Bergstrasse,... May 2022The ability of light to remotely control the properties of soft matter materials in a dynamic fashion has fascinated material scientists and photochemists for decades....
The ability of light to remotely control the properties of soft matter materials in a dynamic fashion has fascinated material scientists and photochemists for decades. However, only recently has our ability to map photochemical reactivity in a finely wavelength resolved fashion allowed for different colors of light to independently control the material properties of polymer networks with high precision, driven by monochromatic irradiation enabling orthogonal reaction control. The current concept article highlights the progress in visible light-induced photochemistry and explores how it has enabled the design of polymer networks with dynamically adjustable properties. We will explore current applications ranging from dynamic hydrogel design to the light-driven adaptation of 3D printed structures on the macro- and micro-scale. While the alternation of mechanical properties via remote control is largely reality for soft matter materials, we herein propose the next frontiers for adaptive properties, including remote switching between conductive and non-conductive properties, hydrophobic and hydrophilic surfaces, fluorescent or non-fluorescent, and cell adhesive vs. cell repellent properties.
Topics: Adhesives; Electric Conductivity; Hydrogels; Photochemistry; Polymers
PubMed: 35213069
DOI: 10.1002/chem.202104466 -
Nature Methods Aug 2018
Topics: Luminescent Proteins; Nanotechnology; Photochemistry; Red Fluorescent Protein
PubMed: 30065372
DOI: 10.1038/s41592-018-0078-z -
Journal of Medicinal Chemistry Mar 2024Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced... (Review)
Review
Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced reactions enable the efficient synthesis of intricate organic structures and have found applications throughout the different stages of the drug discovery and development processes. Moreover, photochemical techniques provide innovative solutions in chemical biology, allowing precise spatiotemporal drug activation and targeted delivery. In this Perspective, we highlight the already numerous remarkable applications and the even more promising future of photochemistry in medicinal chemistry and chemical biology.
Topics: Photochemistry; Chemistry, Pharmaceutical; Drug Discovery; Biology
PubMed: 38457829
DOI: 10.1021/acs.jmedchem.3c02109 -
Nanoscale Jul 2016As clinical nanomedicine has emerged over the past two decades, phototherapeutic advancements using nanotechnology have also evolved and impacted disease management.... (Review)
Review
As clinical nanomedicine has emerged over the past two decades, phototherapeutic advancements using nanotechnology have also evolved and impacted disease management. Because of unique features attributable to the light activation process of molecules, photonanomedicine (PNM) holds significant promise as a personalized, image-guided therapeutic approach for cancer and non-cancer pathologies. The convergence of advanced photochemical therapies such as photodynamic therapy (PDT) and imaging modalities with sophisticated nanotechnologies is enabling the ongoing evolution of fundamental PNM formulations, such as Visudyne®, into progressive forward-looking platforms that integrate theranostics (therapeutics and diagnostics), molecular selectivity, the spatiotemporally controlled release of synergistic therapeutics, along with regulated, sustained drug dosing. Considering that the envisioned goal of these integrated platforms is proving to be realistic, this review will discuss how PNM has evolved over the years as a preclinical and clinical amalgamation of nanotechnology with PDT. The encouraging investigations that emphasize the potent synergy between photochemistry and nanotherapeutics, in addition to the growing realization of the value of these multi-faceted theranostic nanoplatforms, will assist in driving PNM formulations into mainstream oncological clinical practice as a necessary tool in the medical armamentarium.
Topics: Nanomedicine; Neoplasms; Photochemistry; Photochemotherapy; Theranostic Nanomedicine
PubMed: 27328309
DOI: 10.1039/c5nr08691d -
Methods in Molecular Biology (Clifton,... 2017The discovery of the protein targets of small molecule probes is a crucial aspect of activity-based protein profiling and chemical biology. Mass spectrometry is the... (Review)
Review
The discovery of the protein targets of small molecule probes is a crucial aspect of activity-based protein profiling and chemical biology. Mass spectrometry is the primary method for target identification, and in the last decade, cleavable linkers have become a popular strategy to facilitate protein enrichment and identification. In this chapter, we provide an overview of cleavable linkers used in chemical proteomics approaches, discuss their different chemistries, and describe how they aid in protein identification.
Topics: Molecular Probes; Photochemistry; Proteins; Proteolysis; Proteomics
PubMed: 27778290
DOI: 10.1007/978-1-4939-6439-0_14 -
Macromolecular Rapid Communications Aug 2023Poly(vinyl ketones) (PVKs) have received considerable attention over the past few decades due to their unique photochemistry and photodegradation properties under... (Review)
Review
Poly(vinyl ketones) (PVKs) have received considerable attention over the past few decades due to their unique photochemistry and photodegradation properties under ultraviolet (UV) light. Many PVKs rapidly undergo photodegradation under UV light. The side-chain carbonyl moieties of PVKs permit photolysis through Norrish type I or Norrish type II reaction mechanisms and can also be readily modified by nucleophilic addition reactions. These unique properties lead to this class of polymers serving as versatile scaffolds for generating functional materials. This review captures the evolution of synthetic routes to access well-defined PVKs, along with their photochemistry and photo-degradation pathways, and discusses recent and potential applications of these photodegradable materials.
Topics: Polymers; Ketones; Ultraviolet Rays; Photolysis; Photochemistry
PubMed: 37163690
DOI: 10.1002/marc.202300126 -
Journal of Materials Chemistry. B Dec 2019The scientific analysis of food safety issues and the establishment of rapid and efficient food safety detection methods are of great significance for safeguarding the... (Review)
Review
The scientific analysis of food safety issues and the establishment of rapid and efficient food safety detection methods are of great significance for safeguarding the health of consumers, ensuring the healthy development of food safety systems and realizing food safety strategies. As an emerging electrochemical analysis technology, photoelectrochemical (PEC) biosensors, which combine the advantages of biological analysis and optical analysis, have attracted extensive attention. Due to the complete separation of the excitation source (light) and the detection signal (current), the background signal of PEC biosensors is greatly decreased, and their sensitivity is high. The detection principle is that under illumination, the biological recognition effect between the bio-specific recognition element and the corresponding target causes a change in the signal generated by the photoactive nanomaterial. This review aims to cover the most recent advances of PEC biosensing in the field of food analysis, including mycotoxins, heavy metals, antibiotics, and pesticide residues. The future prospects in this field are also discussed.
Topics: Biosensing Techniques; Catalysis; Electrochemistry; Electrodes; Equipment Design; Food Analysis; Food Safety; Graphite; Light; Metals, Heavy; Nanostructures; Photochemistry; Polymers; Semiconductors
PubMed: 31720680
DOI: 10.1039/c9tb01644a