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Ear, Nose, & Throat Journal May 2021The aim is to analyze the clinical outcomes of patients with extramedullary plasmacytoma (EMP) and review the characteristics of this disease. We retrospectively... (Review)
Review
The aim is to analyze the clinical outcomes of patients with extramedullary plasmacytoma (EMP) and review the characteristics of this disease. We retrospectively reviewed the clinical data of a cohort of 22 patients diagnosed with EMP between 1983 and 2017. Baseline characteristics and progression data were collected to calculate the incidence of progression to multiple myeloma (MM) and to analyze survival rates and outcomes. Previous major cohort studies were reviewed and compared with this study. Extramedullary plasmacytomas were located in the head and neck in 17 (77%) of the 22 patients. The median time between onset and diagnosis was 7 months, and the median age at diagnosis was 52.5 years (range 15-72 years). Extramedullary plasmacytoma occurred more frequently in men with an approximate ratio of 2.1:1. The majority of patients underwent surgery (13/22, 59.1%) and half received radiation (11/22, 50%). A small proportion of patients received chemotherapy (2/22, 9.1%). There was a median follow-up time of 98.5 months. The 5-year overall survival, progression-free survival, and MM-free survival rates were 84.2%, 67.3% and 75.9%, respectively. Complete resection without major functional damage is a promising option that can favorably improve prognosis in patients with resectable disease. Patients with regional lymph node metastasis or positive immunoelectrophoresis results require more aggressive treatment and may have poorer prognosis.
Topics: Adolescent; Adult; Aged; China; Female; Head and Neck Neoplasms; Humans; Incidence; Male; Middle Aged; Plasmacytoma; Prognosis; Retrospective Studies; Survival Rate; Young Adult
PubMed: 32941076
DOI: 10.1177/0145561320950587 -
The Canadian Veterinary Journal = La... Oct 2021A 10-year-old, intact male Siberian husky dog was presented for a suspected left renal cyst. Computed tomography (CT) identified a large, left kidney mass with...
A 10-year-old, intact male Siberian husky dog was presented for a suspected left renal cyst. Computed tomography (CT) identified a large, left kidney mass with retroperitoneal hemorrhage. A left-sided nephrectomy was performed, and histopathology confirmed a renal plasmacytoma. Perioperative screening for multiple myeloma was negative. The dog was lost to follow-up and was euthanized 11 months after surgery. A necropsy was not performed. To the authors' knowledge, this is the first case of renal extramedullary plasmacytoma in a dog. Key clinical message: This report describes the clinical presentation, and laboratory, diagnostic imaging, and surgery findings of a case of renal extramedullary plasmacytoma in a dog.
Topics: Animals; Dog Diseases; Dogs; Euthanasia, Animal; Kidney; Kidney Neoplasms; Male; Plasmacytoma; Tomography, X-Ray Computed
PubMed: 34602635
DOI: No ID Found -
Brazilian Journal of Otorhinolaryngology 2018Solitary plasmacytoma is a rare malignant tumor of plasma cells with no evidence of systemic proliferation. There are two known subtypes: extramedullary solitary... (Review)
Review
INTRODUCTION
Solitary plasmacytoma is a rare malignant tumor of plasma cells with no evidence of systemic proliferation. There are two known subtypes: extramedullary solitary plasmacytoma and solitary bone plasmacytoma. The etiology is still unknown. Both lesions present a risk of progression to multiple myeloma. A number of approaches have been used for treatment of solitary plasmacytoma.
OBJECTIVE
To carry out a systematic review of the case reports described in the literature, focusing on therapeutic and prognostic aspects.
METHODS
A search of clinical case reports was performed in the PubMed database using Mesh Terms related to "plasmacytoma" under the following criteria: type of study (case report), articles in English language, conducted in humans, with no publication date limits.
RESULTS
Of the 216 articles found, only 21 articles met the pre-established inclusion criteria.
CONCLUSION
The occurrence of solitary bone plasmacytoma in the bones of the face is a rare condition prevalent between the 4th and 6th decades of life, located in the posterior region of the mandible in most cases. Histopathological examination and systemic investigation are mandatory for confirmation of diagnosis.
Topics: Disease Progression; Humans; Jaw Neoplasms; Mandibular Neoplasms; Paraproteins; Plasmacytoma; Prognosis; Radiotherapy
PubMed: 29941386
DOI: 10.1016/j.bjorl.2018.05.002 -
Indian Journal of Pathology &... 2016
Review
Topics: Amyloidosis; Humans; Plasmacytoma; Soft Tissue Neoplasms
PubMed: 27721272
DOI: 10.4103/0377-4929.191752 -
Clinical Nuclear Medicine Jun 2024A 56-year-old man with thoracal mass suspected of solitary plasmacytoma was referred for 18 F-FDG PET-CT scan. His PET-CT revealed FDG-avid rib mass and cervical lesion...
A 56-year-old man with thoracal mass suspected of solitary plasmacytoma was referred for 18 F-FDG PET-CT scan. His PET-CT revealed FDG-avid rib mass and cervical lesion at level 2. He also underwent 18 F-fluorocholine (FCH) PET-CT to evaluate possible metastatic spread of the disease. FCH PET-CT showed increased uptake at the rib mass, while the cervical lesion was not FCH-avid. Biopsies confirmed rib lesion was a solitary plasmacytoma; however, the cervical lesion was an amyloid deposited lymph node. This case showed FCH PET-CT is a valuable companion of FDG scan for the evaluation of plasma cell dyscrasias with a better specificity.
Topics: Humans; Male; Middle Aged; Plasmacytoma; Fluorodeoxyglucose F18; Positron Emission Tomography Computed Tomography; Choline; Lymphadenopathy; Amyloid
PubMed: 38557413
DOI: 10.1097/RLU.0000000000005210 -
Zhonghua Xue Ye Xue Za Zhi = Zhonghua... Jan 2024Extramedullary plasmacytoma (EMP) is a special type of malignant plasmacytosis, which is complex and heterogeneous. Most EMP patients have poor prognosis and lack a...
Extramedullary plasmacytoma (EMP) is a special type of malignant plasmacytosis, which is complex and heterogeneous. Most EMP patients have poor prognosis and lack a stratified prognostic system or ideal treatment strategy supported by evidence-based medical evidence, which cannot meet clinical needs. In order to improve the understanding of this disease entity, Plasma Cell Disease Group, Chinese Society of Hematology, Chinese Medical Association and Chinese Myeloma Committee-Chinese Hematology Association developed the "Chinese Expert Consensus on the diagnosis and treatment of extramedullary plasmacytoma", which aims to standardize the clinical diagnosis and treatment of EMP and ultimately improve the overall survival of patients with plasmacytoma.
Topics: Humans; Plasmacytoma; Consensus; Multiple Myeloma; Prognosis; Paraproteinemias
PubMed: 38527832
DOI: 10.3760/cma.j.cn121090-20231107-00253 -
World Journal of Surgical Oncology Aug 2016Extramedullary plasmacytoma is a rare plasma cell neoplasm within soft tissue and without bone marrow involvement or other systemic characteristics of multiple myeloma.... (Review)
Review
BACKGROUND
Extramedullary plasmacytoma is a rare plasma cell neoplasm within soft tissue and without bone marrow involvement or other systemic characteristics of multiple myeloma. Primary pulmonary plasmacytoma is a rare type of extramedullary plasmacytoma.
CASE PRESENTATION
A 48-year-old male with a tumor in the right middle ear was referred to our hospital. A routine chest X-ray was arranged and showed enlargement of the left lung hilum. His bilateral breathing sounded clear. A chest CT scan revealed a well-circumscribed mass. Pathological biopsy yielded a diagnosis of isolated pulmonary plasmacytoma.
CONCLUSIONS
This is the first presentation of primary pulmonary plasmacytoma with a solitary pulmonary nodule and no lymph node involvement.
Topics: Antineoplastic Agents; Biopsy, Needle; Bone Marrow Examination; Bronchoscopy; Disease-Free Survival; Ear Neoplasms; Ear, Middle; Follow-Up Studies; Humans; Image-Guided Biopsy; Lung Neoplasms; Male; Middle Aged; Plasmacytoma; Solitary Pulmonary Nodule; Tomography, X-Ray Computed
PubMed: 27487779
DOI: 10.1186/s12957-016-0948-8 -
Journal of Medical Imaging and... Feb 2020Extramedullary plasmacytomas are rare and can occur at any site. The imaging results are often nonspecific. This report highlights the radiographic, sonographic and...
Extramedullary plasmacytomas are rare and can occur at any site. The imaging results are often nonspecific. This report highlights the radiographic, sonographic and cross-sectional imaging features of extramedullary plasmacytomas.
Topics: Adult; Aged; Aged, 80 and over; Diagnostic Imaging; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plasmacytoma; Radiography; Retrospective Studies; Tomography, X-Ray Computed; Ultrasonography
PubMed: 31785037
DOI: 10.1111/1754-9485.12975 -
Internal Medicine (Tokyo, Japan) Sep 2023
Topics: Humans; Plasmacytoma; Gallbladder Neoplasms; Multiple Myeloma
PubMed: 36517034
DOI: 10.2169/internalmedicine.1079-22 -
Nihon Rinsho. Japanese Journal of... Jul 2016
Topics: Humans; Plasmacytoma
PubMed: 30707825
DOI: No ID Found