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Ginekologia Polska 2021To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.
OBJECTIVES
To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.
MATERIAL AND METHODS
This retrospective case- control study included 257 preeclampsia patients and 264 healthy pregnant women as the control group. The groups were compared in terms of platelet count (PC), mean platelet volume (MPV), platelet distribution range (PDW), plateletcrit (Pct), Pct / MPV ratio and PC / MPV ratio.
RESULTS
Between the preeclampsia group and the control group; mean platelet count (227.22 ± 78.58 vs 236.69 ± 64.30), plateletcrit (PCT) (0.21 ± 0.06 vs 0.24 ± 0.27), and platelet distribution width (PDW) (17.11 ± 0.80 vs 17.29 ± 0.82) were not significantly different (p> 0.05). However, MPV values were significantly higher in the preclampsia group compared to the control group (9.66 ± 1.62 and 8.92 ± 1.33, respectively) (p < 0.001). In our study, the optimum cut-off value of MPV was 9.15 with 58.7% sensitivity and 61.7% specificity for the prediction of preeclampsia. Pct/MPV ratio (0.02 ± 0.007 vs 0.027 ± 0.029) ( p = 0.01) and PC/MPV ratio ( 24.63 ± 10.90 vs 27.63 ± 10.24) (p = 0.001) were significantly lower in the preeclampsia group than in the control group.
CONSLUSIONS
In preeclampsia, changes in platelet functions, destruction and production lead to changes in platelet indices. Compared with normal healthy pregnant women, preeclamptic pregnant women have higher MPV values. In preeclampsia prediction, MPV and PC/MPV ratio are promising as a diagnostic parameter.
Topics: Blood Platelets; Female; Humans; Mean Platelet Volume; Platelet Count; Pre-Eclampsia; Pregnancy; Retrospective Studies
PubMed: 34105753
DOI: 10.5603/GP.a2021.0056 -
Diabetes Research and Clinical Practice Sep 2018The aim of this study is to investigate the effect of platelet count on the incidence of type 2 diabetes mellitus (DM) in the overall Korean adults and in participants...
AIMS
The aim of this study is to investigate the effect of platelet count on the incidence of type 2 diabetes mellitus (DM) in the overall Korean adults and in participants with impaired glucose tolerance (IGT) at baseline.
METHODS
A total of 7502 participants (3528 men and 3974 women) aged 40-69 years were enrolled in this study. The study population was divided into tertiles (T) of serum platelet counts. We used Cox regression to analyse the relationship between baseline platelet count and new-onset type 2 DM.
RESULTS
A total of 602 (8.0%) subjects developed type 2 DM during a mean follow-up of 8.4 years. Compared to the lowest tertile, the hazard ratio (95% confidence interval [CI]) for the incidence of type 2 DM was 1.28 (1.04-1.57) for T3 after adjusting for possible confounding factors. In subjects with IGT at baseline, the hazard ratio (95% CI) for the incidence of type 2 DM in T3 compared with T1 was 1.45 (1.05-2.00) after adjusting for the same confounders.
CONCLUSION
This prospective longitudinal study demonstrated that the incidence of type 2 DM increased as the serum platelet count at baseline increased within the normal range. This positive association was more prominent in subjects with IGT.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Incidence; Male; Middle Aged; Platelet Count; Prospective Studies; Republic of Korea
PubMed: 30075179
DOI: 10.1016/j.diabres.2018.07.033 -
Anesthesiology Feb 2016
Topics: Acute Kidney Injury; Coronary Artery Bypass; Hospital Mortality; Humans; Platelet Count; Postoperative Complications
PubMed: 26594914
DOI: 10.1097/ALN.0000000000000960 -
BMC Pediatrics Aug 2020Sepsis is still one of the main causes of infants and children mortality especially in developing, economically challenged countries with limited resources. Our...
BACKGROUND
Sepsis is still one of the main causes of infants and children mortality especially in developing, economically challenged countries with limited resources. Our objective in this study was to determine, the prognostic value of platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) in critically ill infants and children with severe sepsis, as they are readily available biomarkers, that can guide clinicians during managing of severe sepsis.
METHODS
Sixty children were included; they were diagnosed with severe sepsis according to the international pediatric sepsis consensus conference criteria. At admission to Pediatric intensive care unit, complete blood count with platelet count and parameters (MPV, PDW and PCT) and C-reactive protein (CRP) level were determined for all children. Also, assessment of the Pediatric Risk of Mortality (PRISM III) score was done to all. These children were followed up till discharge from hospital or death. Accordingly, they were grouped into: (1) Survivor group: included 41 children. (2) Non-survivor group: included 19 children.
RESULTS
Platelet count and PCT were significantly lower (p < 0.001) and MPV was significantly higher in non-survivor than survivors (p = 0.004). MPV/PLT, MPV/PCT, PDW/PLT, PDW/PCT ratios were found to be significantly higher in the non-survivors than survivor (p < 0.001 in all). PCT with sensitivity = 94.74%, was the most sensitive platelet parameter for prediction of death, while MPV/PCT was the most sensitive ratio (sensitivity = 94.7%).
CONCLUSION
Thrombocytopenia, platelet indices and their ratios, especially plateletcrit and MPV/PCT, are readily available, sensitive, prognostic markers, that can identify the severe sepsis patients with poorest outcome.
Topics: Blood Platelets; Child; Hospitals; Humans; Infant; Platelet Count; Prospective Studies; Sepsis
PubMed: 32814554
DOI: 10.1186/s12887-020-02278-4 -
Journal of Clinical Apheresis Feb 2021Algorithms have been developed to predict the platelet yield after apheresis from the donor's data, as well as the effect on the blood cell count, to extract an...
INTRODUCTION
Algorithms have been developed to predict the platelet yield after apheresis from the donor's data, as well as the effect on the blood cell count, to extract an acceptable platelet number without affecting the donor. However, the evaluation of these algorithms has not been widely reported. This study aimed to assess the accuracy of the predictive algorithms of the Trima Accel v. 6 blood collection system.
METHODS
Platelet concentrates (PCs) obtained by apheresis were analyzed. Platelet count and hematocrit were compared pre- and post-apheresis. Calculated post-apheresis platelet count (CPAPC), hematocrit (CPAH), and platelet yield (CPY), and their actual values were correlated. The bias of the algorithms was assessed with Bland-Altman plots, and the prediction of the extraction of single or double platelet products was evaluated.
RESULTS
Two hundred and seventy-nine PCs were analyzed. Post-apheresis platelet count (PAPC) and hematocrit were decreased. A moderate correlation was observed between CPY and the actual yield, with a negative bias, and a trend to increase alongside the magnitude of the measurements. CPAPC and CPAH were strongly correlated with their actual values without bias. Prediction of single or double platelet product extraction showed a significant agreement with the actual outcomes.
CONCLUSIONS
The predictive algorithm for the platelet yield showed bias, and a trend to underestimate the actual platelet yields when they are higher. The algorithms for the prediction of the PAPC and hematocrit did not show bias, proving their accuracy. Prediction of a single or double platelet product extraction has a strong agreement with the APY.
Topics: Adult; Algorithms; Female; Humans; Male; Platelet Count; Plateletpheresis; Software
PubMed: 33016510
DOI: 10.1002/jca.21846 -
Veterinary Clinical Pathology Jun 2022Thrombocytopenia has been associated with some neoplastic processes, including hematologic neoplasia. There is no information regarding specific changes in platelet...
INTRODUCTION
Thrombocytopenia has been associated with some neoplastic processes, including hematologic neoplasia. There is no information regarding specific changes in platelet measurands in dogs with hematologic neoplasia compared with healthy dogs. The objectives of our study were to establish RIs, evaluate platelet measurands in dogs with hematologic neoplasia, and compare these measurands in patients with hematologic malignancies with or without thrombocytopenia.
METHODS
This was a retrospective study. Platelet measurands were determined using the ADVIA 120 Hematology analyzer when a CBC was performed and included the platelet count, MPV, platelet distribution width (PDW), plateletcrit (PCT), mean platelet component (MPC), platelet component distribution width (PCDW), mean platelet mass (MPM), platelet mass distribution width (PMDW), and number of large platelets. Reference intervals were determined retrospectively using data from 129 healthy dogs. Patients with hematologic neoplasia (n = 50) were identified through retrospective evaluation of medical records from the Auburn University Veterinary Teaching Hospital and separated into thrombocytopenic (n = 20) and nonthrombocytopenic groups (n = 30).
RESULTS
Platelet count and PCT were significantly higher in older healthy dogs compared with younger dogs. Significant differences were identified when comparing healthy dogs with those with hematologic neoplasia without thrombocytopenia for PDW, PCDW, PMDW, and the number of large platelets, indicating the presence of more heterogeneous platelets. Thrombocytopenic dogs with hematologic neoplasia had significantly decreased MPCs and increased MPVs, MPMs, and PCDWs compared with nonthrombocytopenic dogs with neoplasia.
CONCLUSIONS
Dogs with hematologic neoplasia had more heterogeneous platelets, whereas thrombocytopenic patients with neoplasia had more activated platelets.
Topics: Animals; Blood Platelets; Dog Diseases; Dogs; Hematologic Neoplasms; Hospitals, Animal; Hospitals, Teaching; Humans; Mean Platelet Volume; Platelet Count; Retrospective Studies; Thrombocytopenia
PubMed: 35274337
DOI: 10.1111/vcp.13089 -
The Journal of Maternal-fetal &... Jul 2017The current study objective was to compare blood platelet indices in late preterm newborns (LPN) and full term newborns (FTN).
BACKGROUND
The current study objective was to compare blood platelet indices in late preterm newborns (LPN) and full term newborns (FTN).
MATERIALS AND METHODS
We recruited 58 LPN and 71 FTN. Platelet indices were estimated in blood samples collected from the umbilical artery.
RESULTS
LPN demonstrated a decreased count of blood platelets (249 × 10³/μL) as compared to FTN (295 × 10³/μL), p < 0.001. Platelet hematocrit (PCT) also showed substantial differences in both groups (LPN = 0.2% vs. FTN = 0.23%; p < 0.001). Mean platelet volume (MPV) was found to be nearly the same (LPN = 7.98fl, FTN = 7.9fl). Platelet distribution width (PDW) was higher in LPN (52.8%) than in FTN (50.6%), p = 0.02. Large platelet count (LP) was lower in LPN (4.0%) in comparison with FTN (6.0%), (p = 0.01).
CONCLUSIONS
The obtained results may indicate immaturity of thrombopoiesis in newborns born late preterm. Decrease in platelet count, platelet hematocrit and large platelets can cause disturbances in the hemostatic system and lead to bleeding complications and can increase the risk of infections. Morphological parameters of blood platelets in infants born late preterm differ from those of term neonates as in other preterm infants. This reflects the immaturity of this newborn and shows the need to pay special diagnostic and therapeutic care to them.
Topics: Female; Humans; Infant, Newborn; Infant, Premature; Male; Mean Platelet Volume; Platelet Count
PubMed: 27628188
DOI: 10.1080/14767058.2016.1222519 -
Medicina (Kaunas, Lithuania) Nov 2019The mean platelet volume (MPV) represents a possible marker of platelet activation. There is an association between the platelet count (PC) and inflammation and...
The mean platelet volume (MPV) represents a possible marker of platelet activation. There is an association between the platelet count (PC) and inflammation and platelet reactivity. We assessed the association between the MPV/PC ratio and circadian alterations in blood pressure (BP). One hundred and twenty subjects in total, 80 hypertensive subjects and 40 healthy subjects (controls), were enrolled in the study group. Twenty four hour ambulatory BP monitoring (ABPM) was applied to all subjects. According to ABPM results, the hypertensive subjects were separated into two groups, such as dippers ( = 40) and non-dippers ( = 40). In all subjects, the collection of venous peripheral blood samples was performed on admission for PC and MPV measurements. : The two groups exhibited similar clinical baseline characteristics. A significantly higher MPV/PC ratio was determined in non-dippers compared to that in dippers and normotensives. The higher MPV/PC ratio was observed in non-dippers in comparison with that in dippers and normotensives (0.046 ± 0.007 to 0.032 ± 0.004 fL/[10/L]; 0.046 ± 0.007 to 0.026 ± 0.004 fL/[10/L], < 0.001, respectively). A receiver operating characteristic (ROC) curve analysis showed that the optimum cut-off value of the MPV/PC ratio for predicting non-dipping patterns in hypertensive patients was 0.036 (area under the curve [AUC]: 0.98, < 0.001). According to the cut-off value, sensitivity and specificity were found to be 95% and 95%, respectively. The higher MPV/PC ratio was determined in non-dipper hypertensive subjects in comparison with that in dipper hypertensive subjects. An elevation of platelet activity and an increase in thrombus burden are reflected by an increase in the MPV/PC ratio. The MPV/PC ratio may underlie the increase in cardiovascular risk in non-dippers compared to that in dippers.
Topics: Adult; Blood Platelets; Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory; Chi-Square Distribution; Correlation of Data; Female; Humans; Male; Middle Aged; Platelet Count
PubMed: 31744048
DOI: 10.3390/medicina55110742 -
Platelets Apr 2022Reticulated platelets (RP) are young, functionally active platelet forms which are detected by RNA staining. Their content in the circulation reflects the intensity of...
Reticulated platelets (RP) are young, functionally active platelet forms which are detected by RNA staining. Their content in the circulation reflects the intensity of bone marrow thrombocytopoesis. The aim of this study was to assess in healthy volunteers the relationship between RP percentage and platelet size and activity. RP were quantitated by thiazole orange staining using flow cytometry. Platelet size indexes included mean platelet volume (MPV), platelet large cell ratio (-LCR) measured in a Coulter type hematological analyzer and forward scattering (FSC) measured in a flow cytometer. Platelet functional activity was evaluated by expression of activated glycoprotein (GP) IIb-IIIa (PAC-1 antibody binding) and -selectin with the use of flow cytometry. Platelets were activated by thrombin receptor activating peptide (TRAP) (10 and 1 µM) and ADP (20 and 2.5 µM). The percentage of RP in healthy volunteers varied from 2.9% to 23.8% (mean ± SD ‒ 11.7 ± 4.7%, n = 99) and correlated with all platelet size indexes: MPV, -LCR and FCS (r from 0.452 to 0.529, < .001, n = 87-99). On average, RP were distributed at a ratio of 9:1 between 50% subpopulations of large and small platelets according to their FSC index. Expression of GP IIb-IIIa activated form correlated with RP percentage and platelet size indexes when platelets were activated by TRAP and ADP at both applied concentrations (r from 0.309 to 0.560, p from 0.014 to < 0.001, n = 50-62). -selectin expression correlated with RP percentage and platelet size indexes when platelets were activated by 10 µM TRAP inducing maximum expression of this activation marker (r from 0.332 to 0.556, p from 0.008 to < 0.001, n = 65), but not by weaker agonists: 1 µM TRAP, 20 and 2.5 µM ADP (r < 0.3, n = 54-66). Thus, high RP content in healthy volunteers is associated with increased platelet size and activity in the whole platelet population.
Topics: Adolescent; Adult; Blood Platelets; Case-Control Studies; Healthy Volunteers; Humans; Middle Aged; Platelet Count; Platelet Function Tests; Young Adult
PubMed: 34029503
DOI: 10.1080/09537104.2021.1922659 -
Medicine Sep 2023Platelet count is a key component of sepsis severity score. However, the predictive value of the platelet count at admission for mortality in sepsis remains unclear. We... (Observational Study)
Observational Study
Platelet count is a key component of sepsis severity score. However, the predictive value of the platelet count at admission for mortality in sepsis remains unclear. We designed a retrospective observational study of patients with sepsis admitted to our hospital from January 2017 to September 2021 to explore the predictive value of platelet count at admission for mortality. A total of 290 patients with sepsis were included in this study. Multivariate logistic regression analysis was used to evaluate the risk factors for mortality and construct a predictive model with statistically significant factors. Compared with survivors, nonsurvivors tended to be much older and had significantly higher acute physiology and chronic health evaluation II and sequential organ failure assessment scores (P < .001). The platelet count was significantly lower in the nonsurvivor group than in the survivor group (P < .001). Multivariate logistic regression analysis indicated that age (P = .003), platelet count (P < .001) and lactate level (P = .018) were independent risk factors for mortality in patients with sepsis. Finally, the area under the receiver operating characteristic curve of platelet count predicting mortality in sepsis was 0.763 (95% confidence interval, 0.709-0.817, P < .001), with a sensitivity of 55.6% and a specificity of 91.8%. In our study, platelet count at admission as a single biomarker showed good predictability for mortality in patients with sepsis.
Topics: Humans; Platelet Count; Sepsis; APACHE; Hospitalization; Hospitals
PubMed: 37746944
DOI: 10.1097/MD.0000000000035335