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International Journal of Molecular... Apr 2019Arthritis has a high prevalence globally and includes over 100 types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis and...
Arthritis has a high prevalence globally and includes over 100 types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis, but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for these patients. In this editorial, the twenty articles published in the Special Issue Research of Pathogenesis and Novel Therapeutics in Arthritis 2019 are summarized and discussed as part of the global picture of the current understanding of arthritis.
Topics: Arthritis; Biomarkers; Biomedical Research; Humans
PubMed: 30987068
DOI: 10.3390/ijms20071646 -
Journal of Clinical Rheumatology :... Aug 2020
Topics: Arthritis; Humans; Pancreatitis; Panniculitis
PubMed: 30273266
DOI: 10.1097/RHU.0000000000000914 -
Nature Reviews. Rheumatology Nov 2014For patients that present with musculoskeletal symptoms, diagnostic procedures carried out by physicians and rheumatologists are primarily aimed at confirming or... (Review)
Review
For patients that present with musculoskeletal symptoms, diagnostic procedures carried out by physicians and rheumatologists are primarily aimed at confirming or excluding the occurrence of primary rheumatic diseases. Another important trigger for musculoskeletal disease, however, is the presence of a tumour. Careful clinical investigation and knowledge of the gestalt of musculoskeletal syndromes related to respective tumour entities is of utmost importance for the diagnosis of paraneoplastic rheumatic diseases such as hypertrophic osteoarthropathy, paraneoplastic polyarthritis, RS3PE syndrome, palmar fasciitis and polyarthritis, cancer-associated myositis and tumour-induced osteomalacia. This places great responsibility on rheumatologists in diagnosing malignancies and referring the patient for effective treatment. The selective influence of tumours on musculoskeletal tissue is surprising and indicates that tumours alter tissues such as the periosteum, synovial membrane, subcutaneous connective tissue, fascia, muscles and bones by specific molecular processes. Some of the underlying mechanisms have been unravelled, providing valuable information on the physiologic and pathophysiologic roles of mediators such as vascular endothelial growth factor and fibroblast growth factor 23.
Topics: Arthritis; Edema; Fasciitis; Humans; Musculoskeletal Diseases; Myositis; Neoplasms; Osteoarthropathy, Secondary Hypertrophic; Osteomalacia; Paraneoplastic Syndromes; Rheumatic Diseases; Syndrome; Synovitis
PubMed: 25136782
DOI: 10.1038/nrrheum.2014.138 -
The Lancet. Rheumatology Jul 2023
Topics: Humans; Overtreatment; Arthritis
PubMed: 38251543
DOI: 10.1016/S2665-9913(23)00166-2 -
Current Rheumatology Reports Dec 2019Arthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical... (Review)
Review
PURPOSE OF REVIEW
Arthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM.
RECENT FINDINGS
Arthritis is reported in 18-55% of patients with IIM. It is particularly frequent (20-70%) in those with antisynthetase syndrome (ASS); highest prevalence is associated with anti-Jo-1 positivity. Most common manifestation is non-erosive polyarthritis. X-ray erosions may be found occasionally in ASS, particularly in patients with overlap with rheumatoid arthritis (RA). Arthritis is often present at the time of IIM diagnosis and it may even precede the onset of muscle weakness. Arthritis may in some cases be the main disease manifestation responsible for the disease burden in patients with IIM. Arthritis is a frequent symptom of IIM. Polyarthritis of small joints of the hands is the most frequent clinical manifestation. Arthritis may be the first or dominant symptom in IIM and therefore patients may be initially misdiagnosed as having RA. Particularly in seronegative RA patients with interstitial lung disease or Raynaud's phenomenon, the possibility of IIM should be considered.
Topics: Arthritis; Humans; Myositis
PubMed: 31813070
DOI: 10.1007/s11926-019-0878-x -
Seminars in Arthritis and Rheumatism Aug 2023Polyarthritis is commonly reported in idiopathic inflammatory myositis patients, but few studies have focused on the overlap of myositis with rheumatoid arthritis which... (Review)
Review
OBJECTIVES
Polyarthritis is commonly reported in idiopathic inflammatory myositis patients, but few studies have focused on the overlap of myositis with rheumatoid arthritis which is a difficult diagnosis in the absence of well-defined diagnostic criteria. The primary objective of this scoping review was to map the field of research to explore the potential diagnoses in patients presenting with both myositis and polyarthritis.
METHODS
Two electronic databases (MEDLINE/PubMed® and Web of Science®) were systematically searched using the terms (myositis OR 'inflammatory idiopathic myopathies') AND (polyarthritis OR 'rheumatoid arthritis') without any publication date limit.
RESULTS
Among individual records, 280 reports met inclusion criteria after full-text review. There was heterogeneity in the definition of overlap myositis as well as the characteristics of rheumatoid arthritis. In many studies, key data were lacking; rheumatoid factor status was reported in 56.8% (n=151), anti-citrullinated proteins antibodies status in 18.8% (n=50), and presence or absence of bone erosions in 45.1% (n=120) of the studies. Thirteen different diagnoses were found to associate myositis with polyarthritis: antisynthetase syndrome (29.6%, n=83), overlap myositis with rheumatoid arthritis (16.1%, n=45), drug-induced myositis (20.0%, n=56), rheumatoid myositis (7.5%, n=21), inclusion body myositis (1.8%, n=5), overlap with connective tissue disease (20.0%, n=56), and others (5.0%, n=14).
CONCLUSION
The spectrum of joint and muscle inflammatory diseases encompasses many diagnoses including primitive and secondary myositis associated with RA or arthritis mimicking RA. This review highlights the need for a consensual definition of OM with RA to better individualise this entity from the numerous differential diagnoses.
Topics: Humans; Arthritis, Rheumatoid; Autoantibodies; Muscles; Myositis; Myositis, Inclusion Body
PubMed: 37210805
DOI: 10.1016/j.semarthrit.2023.152227 -
Clinical Rheumatology Jun 2021
Topics: Arthritis; Fasciitis; Hand; Humans; Paraneoplastic Syndromes
PubMed: 33502626
DOI: 10.1007/s10067-020-05552-z -
Current Opinion in Rheumatology Jul 2017Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. Fever, rash and severe arthralgia are the hallmarks of chikungunya fever (CHIKF), the disease caused by this... (Review)
Review
PURPOSE OF REVIEW
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. Fever, rash and severe arthralgia are the hallmarks of chikungunya fever (CHIKF), the disease caused by this virus. The acute course of the disease usually lasts few weeks to months. Chronic, relapsing or persistent arthralgia and arthritis have been described mimicking rheumatoid arthritis (RA), requiring immunosuppressive drugs.The purpose of this review is to characterize both the chronic clinical course of CHIKF-associated arthritis and the immunological pathogenic mechanisms involved.
RECENT FINDINGS
The effect of postepidemic chronic persistent rheumatic course on the functional status of affected individuals, affecting large populations, has been studied. One-third of affected individuals had persistent pain months to years postepidemic and the identified risk factors for functional disability were identified.Inflammatory biomarkers associated with disease severity of RA such as interleukin 6 (IL6), and relevant chemokines have been found to correlate with the severity of postepidemic chronic disease. There are conflicting reports on antinuclear antibodies (ANAs) as well as rheumatoid factor and anti-citrullinated peptide antibody (ACPA) sero-positivity during infections.According to a recent study, eight out of 10 infected individuals developed chronic persistent rheumatic course and met classification criteria for seronegative RA.In a flow cytology analyses, these eight patients, similar to a group of RA patients, had a greater percentage of activated and effector CD4 and CD8 T cells than healthy controls.
SUMMARY
Patients with CHKV infections may have a chronic persistent course of musculoskeletal disease, overlapping clinical and immunologic features with RA patients. In the appropriate setting and awareness, CHIKV infection should be considered when a patient is evaluated with a new symmetric polyarthritis.The question to be raised: Is it possible that in genetic prone individuals and in a particular environmental and infectious setting, such as CHIKF outbreak, an autoimmune disease will emerge?
Topics: Antibodies, Antinuclear; Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; CD8-Positive T-Lymphocytes; Chikungunya Fever; Chikungunya virus; Humans; Interleukin-6; Peptides, Cyclic; Rheumatoid Factor
PubMed: 28376065
DOI: 10.1097/BOR.0000000000000396 -
Best Practice & Research. Clinical... Jun 2018Peripheral spondyloarthritis refers to spondyloarthritis with predominant peripheral (arthritis, enthesitis or dactylitis) involvement. Diagnosis can be challenging,... (Review)
Review
Peripheral spondyloarthritis refers to spondyloarthritis with predominant peripheral (arthritis, enthesitis or dactylitis) involvement. Diagnosis can be challenging, particularly in the absence of SpA extra-articular manifestations such as uveitis, psoriasis or inflammatory bowel disease. Evaluation of disease activity should always include assessment of objective signs of inflammation, particularly in the presence of enthesitis as the sole peripheral manifestation, mainly due to the potential misdiagnosis with fibromyalgia tender points. Several recommendations for management/treatment of psoriatic arthritis have been published by EULAR and GRAPPA but none for peripheral SpA in general. NSAIDs and glucocorticoids are recommended as the first step of treatment in all peripheral manifestations, while conventional synthetic (cs) DMARDs seem only efficacious in arthritis. Several biologics and targeted synthetic (ts) DMARDs (TNFi, anti-IL17 and JAK-inhibitors) have been proven to be efficacious in peripheral involvement in PsA (arthritis and enthesitis), but studies on peripheral SpA are lacking.
Topics: Antirheumatic Agents; Arthritis; Humans; Spondylarthritis
PubMed: 31171308
DOI: 10.1016/j.berh.2019.02.010 -
Deutsche Medizinische Wochenschrift... Apr 2021Polyarthritis is defined by the palpable synovitic swelling of more than 4 joints. Polyarthritis is always due to a systemic disease and not a local process. Causes... (Review)
Review
Polyarthritis is defined by the palpable synovitic swelling of more than 4 joints. Polyarthritis is always due to a systemic disease and not a local process. Causes include a broad spectrum of rheumatic and infectious diseases with clearly different therapeutic options. It is also important to differentiate arthritis from osteoarthrosis. The objective of this paper is to give an overview on patient history, clinical presentation, diagnostic investigations and the differential diagnosis of the most common diseases that present as polyarthritis.
Topics: Arthritis; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Physical Examination
PubMed: 33931836
DOI: 10.1055/a-1294-1205