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Applied Neuropsychology. Adult 2023Bilingualism may affect the profile of cognitive disturbances associated with stroke. Its impact on aphasia severity, however, is in need of substantiation. (Observational Study)
Observational Study
BACKGROUND
Bilingualism may affect the profile of cognitive disturbances associated with stroke. Its impact on aphasia severity, however, is in need of substantiation.
AIMS
To determine the relationship between bilingualism and vascular aphasia severity.
METHODS
This is an observational cross-sectional study conducted on people with post-stroke aphasia. Our sample included 155 monolingual and 53 bilingual vascular aphasia patients. They were selected in a neurological hospital in Kolkata (West Bengal, India).
RESULTS
The Bengali version of Western Aphasia Battery (BWAB) was used in this study. Aphasia severity was compared between monolingual and bilingual participants. The overall difference in the mean aphasia quotient (AQ) between bilingual and monolingual participants was statistically significant ( = 0.009). It was also found that in bilingual participants, aphasia was less severe in certain subgroups, namely: higher lesion volume, male gender, and sub-cortical stroke, while in none of the subgroups a monolingual advantage was documented.
CONCLUSION
Current results suggest that bilingualism represents a protective factor in vascular aphasia; this effect is observed particularly in some aphasia subgroups.
Topics: Humans; Male; Multilingualism; Protective Factors; Cross-Sectional Studies; Aphasia; Stroke
PubMed: 34392763
DOI: 10.1080/23279095.2021.1960837 -
Alcoholism, Clinical and Experimental... Dec 2022Although alcohol-related liver disease (ALD) is a global health threat, there are no specific effective treatments for it. Thus, efforts at preventing ALD are important... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Although alcohol-related liver disease (ALD) is a global health threat, there are no specific effective treatments for it. Thus, efforts at preventing ALD are important and could be enhanced by using strategies based on validated risk and protective factors for the disease.
METHODS
The literature on factors influencing the risk for ALD was systematically searched from PubMed, Embase, and the Cochrane library databases from inception to June 2022. Factors suitable for quantitative analysis were submitted to meta-analysis using fixed-effects and random-effects models to calculate each factor's risk ratio (RR) and 95% confidence interval (CI).
RESULTS
Ten cohort studies (covering 1,005,339 subjects) that reported a clear causal relationship were included in the analysis, involving 11 potential risk factors (sex, race, education level, body mass index, alcohol consumption, types of alcoholic beverage, duration of drinking, drinking frequency, smoking, coffee consumption, and tea consumption). Three of these factors (sex, alcohol consumption, and smoking) were subjected to meta-analysis, and the results showed that male sex (RR = 2.84, 95% CI = 1.86-4.36), alcohol consumption ≥280 g/week (RR = 4.96, 95% CI = 2.71-9.07), and smoking (RR = 2.39, 95% CI = 1.97-2.89) were risk factors for ALD.
CONCLUSIONS
Many factors are likely to influence the incidence of ALD, and male sex, heavy alcohol consumption, and smoking increase the risk of ALD. The relationship between other factors and ALD risk needs further evaluation.
Topics: Male; Humans; Alcohol Drinking; Protective Factors; Risk Factors; Alcoholic Beverages; Liver Diseases
PubMed: 36203342
DOI: 10.1111/acer.14951 -
Infant Mental Health Journal Nov 2019Since disturbances in the mother-child bond increase the risk of negative consequences for child development, it is important to identify risk and protective factors for...
Since disturbances in the mother-child bond increase the risk of negative consequences for child development, it is important to identify risk and protective factors for bonding as well as longitudinal associations. Previous research has used different bonding instruments during pregnancy and the postnatal phase, leading to inconsistent results. In the current study, the same instrument was used during the various phases. In a large, community-based sample (N = 793), general information, feelings of pre- and postnatal bonding (Pre- and Postnatal Bonding Scale), depressive symptoms (Edinburgh Postnatal Depression Scale), and partner support (subscale Tilburg Pregnancy/Postnatal Distress Scale) were measured at both 32 weeks of pregnancy and 8 months postnatally. Partner support was found to be a protective factor for suboptimal pre- and postnatal bonding, as was the engagement with fetal movements for prenatal bonding. High maternal educational level was a risk factor for suboptimal prenatal bonding, as were depressive symptoms for suboptimal postnatal bonding. The associations between most prenatal determinants and postnatal bonding were mediated by prenatal bonding, which underlines the importance of promoting prenatal bonding. Professionals in clinical practice should be aware of partner support, engagement with fetal movements, and postnatal depressive symptoms: All these factors offer opportunities for improving the bonding processes.
Topics: Adult; Depression; Depression, Postpartum; Emotions; Epidemiologic Methods; Female; Humans; Mother-Child Relations; Object Attachment; Pregnancy; Protective Factors; Psychiatric Status Rating Scales; Risk Factors
PubMed: 31430393
DOI: 10.1002/imhj.21811 -
Neurology Mar 2019
Topics: Biological Specimen Banks; Delirium; Humans; Mendelian Randomization Analysis; Protective Factors; United Kingdom; Vitamin D
PubMed: 30770428
DOI: 10.1212/WNL.0000000000007121 -
International Journal of Circumpolar... Dec 2023Since the 1970s, suicide has been a major public health issue in Greenland. The World Health Organization has emphasised the importance of the identification of both... (Review)
Review
Since the 1970s, suicide has been a major public health issue in Greenland. The World Health Organization has emphasised the importance of the identification of both risk and protective factors in relation to suicide. The aim of this paper was to identify scientific literature on risk and protective factors for suicide and suicidal behaviour among Greenland Inuit. Searches in PubMed and PsycInfo resulted in 420 studies that were screened by three of the authors. After screening, the authors included 15 studies that were subject to quality assessment and data extraction. All 15 studies reported on risk factors, and only three mentioned protective factors. Most reported risk factors were on an individual level and were related to socioeconomic status, mental health, alcohol and substance use, and life stress. Risk factors related to the family mainly related to adverse childhood experiences, while the community level concerned access to education, work, and conflicts. The results indicate a large knowledge gap about protective factors for suicide and suicidal behaviour. The few protective factors reported were related to men having a family, high socioeconomic status, and being born between 1901 and 1950.
Topics: Male; Humans; Suicidal Ideation; Greenland; Inuit; Protective Factors; Suicide; Risk Factors
PubMed: 37343597
DOI: 10.1080/22423982.2023.2226284 -
Cell Communication and Signaling : CCS May 2023Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell...
BACKGROUND
Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) acts as a protective factor of vascular homeostasis and is known to be repressed by massive and persistent inflammation, associated to the development of vascular pathologies. Bacterial extracellular vesicles (bEVs) are released upon infection and may interact with ECs to mediate EC barrier dysfunction. Here, we investigated the impact of bEVs of sepsis-related pathogens on human EC RNase1 regulation.
METHODS
bEVs from sepsis-associated bacteria were isolated via ultrafiltration and size exclusion chromatography and used for stimulation of human lung microvascular ECs combined with and without signaling pathway inhibitor treatments.
RESULTS
bEVs from Escherichia coli, Klebsiella pneumoniae and Salmonella enterica serovar Typhimurium significantly reduced RNase1 mRNA and protein expression and activated ECs, while TLR2-inducing bEVs from Streptococcus pneumoniae did not. These effects were mediated via LPS-dependent TLR4 signaling cascades as they could be blocked by Polymyxin B. Additionally, LPS-free ClearColi™ had no impact on RNase1. Further characterization of TLR4 downstream pathways involving NF-кB and p38, as well as JAK1/STAT1 signaling, revealed that RNase1 mRNA regulation is mediated via a p38-dependent mechanism.
CONCLUSION
Blood stream bEVs from gram-negative, sepsis-associated bacteria reduce the vascular protective factor RNase1, opening new avenues for therapeutical intervention of EC dysfunction via promotion of RNase1 integrity. Video Abstract.
Topics: Humans; Endothelial Cells; Ribonucleases; Toll-Like Receptor 4; Protective Factors; Lung; Extracellular Vesicles; RNA, Messenger; Bacteria; Sepsis
PubMed: 37189117
DOI: 10.1186/s12964-023-01131-2 -
Clinical Psychology Review Feb 2017This systematic review aimed to identify early risk and protective factors (in childhood, adolescence or young adulthood) longitudinally associated with the subsequent... (Meta-Analysis)
Meta-Analysis Review
This systematic review aimed to identify early risk and protective factors (in childhood, adolescence or young adulthood) longitudinally associated with the subsequent development of gambling problems. A systematic search of peer-reviewed and grey literature from 1990 to 2015 identified 15 studies published in 23 articles. Meta-analyses quantified the effect size of 13 individual risk factors (alcohol use frequency, antisocial behaviours, depression, male gender, cannabis use, illicit drug use, impulsivity, number of gambling activities, problem gambling severity, sensation seeking, tobacco use, violence, undercontrolled temperament), one relationship risk factor (peer antisocial behaviours), one community risk factor (poor academic performance), one individual protective factor (socio-economic status) and two relationship protective factors (parent supervision, social problems). Effect sizes were on average small to medium and sensitivity analyses revealed that the results were generally robust to the quality of methodological approaches of the included articles. These findings highlight the need for global prevention efforts that reduce risk factors and screen young people with high-risk profiles. There is insufficient investigation of protective factors to adequately guide prevention initiatives. Future longitudinal research is required to identify additional risk and protective factors associated with problem gambling, particularly within the relationship, community, and societal levels of the socio-ecological model.
Topics: Alcohol Drinking; Depression; Female; Gambling; Humans; Impulsive Behavior; Male; Protective Factors; Risk Factors; Sex Factors
PubMed: 27855334
DOI: 10.1016/j.cpr.2016.10.008 -
Cyberpsychology, Behavior and Social... May 2018Cyberbullying perpetration continues to be a prevalent and harmful phenomenon. Despite the recent wealth of studies that examine cyberbullying frequency, further...
Cyberbullying perpetration continues to be a prevalent and harmful phenomenon. Despite the recent wealth of studies that examine cyberbullying frequency, further research is needed to investigate protective factors or variables that decrease the likelihood of engaging in cyberbullying perpetration. Past work has identified certain types of parenting as a potential protective factor against adolescent cyberbullying perpetration; however, there is a paucity of research testing these relations over time. This study explores parenting during early adolescence as predicting attitudes and behaviors associated with cyberbullying in late adolescence. Data were derived from the Flourishing Families Project (FFP) at Wave 2 (M age = 12) and Wave 9 (M age = 19). Results suggest that the authoritative parenting style-specifically the warmth and support dimension-was associated with less supportive attitudes toward cyberbullying and lower levels of cyberbullying in emerging adulthood. Moreover, particularly for boys, authoritarian parenting behaviors served as a risk factor for cyberbullying engagement. Suggestions are offered to advocate for greater positive parenting education during early adolescence as a potential protective factor against cyberbullying.
Topics: Adolescent; Adolescent Behavior; Attitude; Bullying; Female; Humans; Male; Parent-Child Relations; Parenting; Prevalence; Protective Factors; Risk Factors
PubMed: 29762067
DOI: 10.1089/cyber.2017.0586 -
Archives de Pediatrie : Organe Officiel... Nov 2023Suicidal behaviors present a public health challenge in children and adolescents. Although the risk factors have long been well documented, protective factors have only... (Review)
Review
BACKGROUND
Suicidal behaviors present a public health challenge in children and adolescents. Although the risk factors have long been well documented, protective factors have only been documented for a few years, and there has not been a literature review concerning the suicidal behaviors of children and adolescents since 2006.
METHODS
Relevant articles were collected using the Medline/PubMed, Web of Science, and ScienceDirect databases. Studies meeting the following inclusion criteria were included: age of participants from 6 to 19 years, qualitative and quantitative cohort or case-control studies, multivariate analysis studies, and studies with significant results for at least one protective factor. The methodology used in this review is based on the PRISMA criteria.
RESULTS
A total of 26 studies were included in this review, which highlights various individual and environmental protective factors. The results were too heterogeneous to perform a meta-analysis, and therefore the discussion is in the form of a narrative summary. High-quality relationships with family and in the school environment were the most frequently found protective factors. The presence of positive links with peers, with other adults, and with the culture of origin was also noted. On an individual level, self-esteem, emotional intelligence, and particular coping abilities were found to be the most important protective factors.
CONCLUSION
There are numerous important protective factors for suicidal behaviors in children and adolescents and also for adapting care to their needs. A future challenge will be to determine the best protective factors to be consolidated or strengthened using self-assessment tools that are already in use or being developed.
Topics: Adolescent; Adult; Child; Humans; Young Adult; Adaptation, Psychological; Protective Factors; Risk Factors; Self Concept; Suicidal Ideation
PubMed: 37777349
DOI: 10.1016/j.arcped.2023.07.006 -
Paediatric Respiratory Reviews Mar 2015Childhood asthma prevalence worldwide has been increasing markedly over several decades. Various theories have been proposed to account for this alarming trend. The... (Review)
Review
Childhood asthma prevalence worldwide has been increasing markedly over several decades. Various theories have been proposed to account for this alarming trend. The disease has a broad spectrum of potential determinants ranging from genetics to lifestyle and environmental factors. Epidemiological observations have demonstrated that several important lifestyle and environmental factors including obesity, urban living, dietary patterns such as food low in antioxidants and fast food, non-breastfeeding, gut flora imbalance, cigarette smoking, air pollution, and viral infection are associated with asthma exacerbations in children. However, only environmental tobacco smoke has been associated with the development of asthma. Despite epidemiological studies indicating that many other factors are probably associated with the development of asthma, the relationships are not considered causal due to the inadequate evidence and inconsistent results from recent studies. This may highlight that sufficient data and exact mechanisms of causality are still in need of further study.
Topics: Adolescent; Asthma; Child; Female; Humans; Infant; Male; Prevalence; Protective Factors; Risk Factors
PubMed: 25155282
DOI: 10.1016/j.prrv.2014.07.004