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Molecular and Clinical Oncology Nov 2018Invasive Paget's disease of the vulva (IP) is rare among patients with vulvar cancer. Radiation therapy and chemotherapy are not considered as radical, whereas surgical...
Invasive Paget's disease of the vulva (IP) is rare among patients with vulvar cancer. Radiation therapy and chemotherapy are not considered as radical, whereas surgical resection of the tumor with abdominal lymphadenectomy is highly invasive. Thus, more effective and less invasive treatments for IP are required. The present study reports a case of a 64-year-old woman with IP, who was treated with a combination of surgery and concurrent chemoradiotherapy (CCRT). The patient was diagnosed with IP with suspected lymph node metastases to the inguinal and pelvic lymph nodes, after having suffered from pruritus vulvae for 7 years. Following mapping biopsy, wide local excision, bilateral inguinal lymph node resection and laparoscopic pelvic lymphadenectomy were successfully performed. The vulva was reconstructed with a local fat flap. Postoperative pathological examination revealed metastases to the bilateral superficial inguinal and the left obturator and lateral suprainguinal lymph nodes. Adjuvant CCRT (whole pelvic irradiation, 50.4 Gy with weekly cisplatin, 40 mg/m) was completed without notable complications. Therefore, laparoscopic pelvic lymphadenectomy may be useful in determining the irradiation field for adjuvant CCRT in patients with advanced IP.
PubMed: 30402231
DOI: 10.3892/mco.2018.1719 -
Level of use and safety of botanical products for itching vulvar dermatoses. Are patch tests useful?Contact Dermatitis May 2016Topical remedies based on botanical ingredients are popular. (Observational Study)
Observational Study
BACKGROUND
Topical remedies based on botanical ingredients are popular.
OBJECTIVES
To assess: (i) the usage of botanical substances in subjects affected with itching and chronic vulvar complaints; (ii) the incidence of side-effects associated with their use and the frequency of contact allergy; (iii) the diagnostic usefulness of patch testing.
METHODS
Sixty-six patients were provided with a questionnaire to assess the prevalence and type of topical botanical preparations used and the occurrence of adverse reactions. Patients were patch tested with (i) the Italian baseline series, (ii) a topical medicament series, and (iii) a botanical series.
RESULTS
Forty-two patients (63.6%) reported the use of natural topical products on the vulva. Seven (16.7%) noted adverse reactions; 27 showed positive reactions with the baseline series; 14 (21.2%) had at least one relevant reaction, mainly to allergens in topical products and cosmetics; and 2 (3%) showed positive reactions to the botanical series. Of the 7 patients complaining of adverse effects of botanical products, 3 (42.8%) showed relevant sensitization.
CONCLUSIONS
The use of natural topical products is widespread among women affected with itching vulvar diseases. Contact dermatitis is a possible adverse effect. Botanical series are of questionable usefulness, owing to the wide variety of botanical ingredients.
Topics: Adult; Aged; Allergens; Cosmetics; Dermatitis, Allergic Contact; Female; Humans; Italy; Lichen Planus; Middle Aged; Neurodermatitis; Patch Tests; Phytotherapy; Plant Preparations; Pruritus Vulvae; Psoriasis; Surveys and Questionnaires; Vulvar Diseases; Vulvar Lichen Sclerosus; Vulvitis
PubMed: 26928795
DOI: 10.1111/cod.12559 -
Zhongguo Zhen Jiu = Chinese Acupuncture... Jan 2015
Topics: Acupuncture Therapy; Female; Humans; Middle Aged; Pruritus Vulvae
PubMed: 25906578
DOI: No ID Found -
Zhongguo Zhong Yao Za Zhi = Zhongguo... Mar 2015Mycotic vaginitis is a common and frequently-occurring gynaecopathia and easy to attack repeatedly, so painful to patients. In this study, the authors observed the... (Randomized Controlled Trial)
Randomized Controlled Trial
Mycotic vaginitis is a common and frequently-occurring gynaecopathia and easy to attack repeatedly, so painful to patients. In this study, the authors observed the clinical efficacy of Sophora gel combined with Fluconazole capsules in treating mycotic vaginitis, in order to seek an effective method for treating mycotic vaginitis. Totally 85 patients with mycotic vaginitis treated in our hospital between December 2012 and July 2014 were randomly divided into the treatment group (43 patients) and the control group (42 patients). The treatment group was given vaginally Sophora gel (one piece every night for 14 days) and orally Fluconazole capsules (150 mg, once every three days, four times in total); The control group was only administered with Fluconazole capsules. The total efficacy, cure rate, recurrence rate and clinical symptom improvements of the two groups were observed. The results show that the total efficacy, the cure rate and the recurrence rate of the treatment group vs. the control group were respectively 97.7%, 90.7% and 2.6% vs. 83.3%, 71.4% and 20.0%, with statistical significance in their differences (P < 0.05). The treatment group showed reduced leucorrhea, pruritus vulvae disappearance and earlier mucosal hyperemia disappearance than the control group, with statistical significance in their differences (P < 0.05). In conclusion Sophora gel combined with Fluconazole capsules can improve antifungal activity of drugs, relieve clinical symptoms, shorten the course of disease, enhance the cure rate and reduce the recurrence rate; So this therapy can be widely applied in clinic.
Topics: Adult; Antifungal Agents; Capsules; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Fluconazole; Humans; Mycoses; Sophora; Treatment Outcome; Vaginitis; Young Adult
PubMed: 26087566
DOI: No ID Found -
The Journal of Dermatology Jun 2020
Topics: Adult; Cervix Uteri; Eosinophilia; Female; Folliculitis; Humans; Indomethacin; Pruritus Vulvae; Skin Diseases, Vesiculobullous; Tomography, X-Ray Computed; Treatment Outcome; Uterine Cervical Neoplasms; Vulva
PubMed: 32173885
DOI: 10.1111/1346-8138.15319 -
Journal Der Deutschen Dermatologischen... Sep 2021
Topics: Atmospheric Pressure; Female; Humans; Plasma Gases; Pruritus; Pruritus Vulvae; Vulvar Diseases
PubMed: 34390188
DOI: 10.1111/ddg.14541 -
Taiwanese Journal of Obstetrics &... Feb 2018
Topics: Child; Female; Foreign Bodies; Humans; Magnetic Resonance Imaging; Pruritus Vulvae; Tissue Adhesions; Vagina; Vaginal Discharge
PubMed: 29458893
DOI: 10.1016/j.tjog.2017.12.030 -
Acta Dermato-venereologica Sep 2015
Randomized Controlled Trial
Topics: Administration, Cutaneous; Antipruritics; Biopsy; Cell Extracts; Double-Blind Method; Female; Fibroblasts; Humans; Pilot Projects; Pruritus Vulvae; Remission Induction; Skin Cream; Time Factors; Treatment Outcome; Vulva; Vulvar Lichen Sclerosus
PubMed: 25634582
DOI: 10.2340/00015555-2052 -
Dermatology (Basel, Switzerland) 2015Studies assessing symptoms of plasma cell vulvitis (PCV) are lacking. (Observational Study)
Observational Study
BACKGROUND
Studies assessing symptoms of plasma cell vulvitis (PCV) are lacking.
OBJECTIVES
To assess the prevalence and severity of PCV-related symptoms and identify possible associations between patient characteristics, clinical features of PCV and treatments administered before a definitive diagnosis.
METHODS
Thirty-six patients affected with PCV were included. Data were collected by direct interview and clinical examination.
RESULTS
Thirty patients (83.3%) complained of symptoms: burning was the most frequent (80.6%) while dyspareunia was the severest. Of the symptomatic patients, 73.3% experienced severe symptoms. Severity of symptoms was not associated with age at onset and duration of PCV. Almost 70% of the patients had previously undergone treatments.
CONCLUSIONS
Symptoms in PCV are frequent and more than often severe. Neither age at onset nor duration of the disease nor the extent of vulvar involvement were associated with symptom severity. Both the delay in diagnosis and the inappropriate previous treatments seem to indicate frequent misdiagnosis.
Topics: Adult; Age of Onset; Aged; Dyspareunia; Female; Humans; Middle Aged; Pain; Pain Measurement; Plasma Cells; Pruritus Vulvae; Retrospective Studies; Severity of Illness Index; Vulvitis; Young Adult
PubMed: 25633048
DOI: 10.1159/000367786 -
Journal of Obstetrics and Gynaecology :... 2016
Topics: Biopsy; Gynecology; Humans; Pruritus Vulvae
PubMed: 26467628
DOI: 10.3109/01443615.2015.1049991