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Australian Family Physician Apr 2016Male baldness is very common. Its effect on individuals is extremely variable, and in some people it will have a significant adverse effect on their quality of life.
BACKGROUND
Male baldness is very common. Its effect on individuals is extremely variable, and in some people it will have a significant adverse effect on their quality of life.
OBJECTIVE
The objectives of this article are to help general practitioners (GPs) be aware of potential health problems related to male baldness, to have an approach to assessing hair loss and to be aware of treatment options.
DISCUSSION
Male baldness is, most often, a normal occurrence, but it may have significant effects on a man's health. It may also be a pointer to other potential health issues. The GP is in the ideal position to conduct an initial evaluation, consider other health issues and advise on treatment options.
Topics: Alopecia; General Practice; Health Status; Humans; Male
PubMed: 27052131
DOI: No ID Found -
Journal of Cosmetic Dermatology Mar 2024Topical minoxidil is the recommended first-line pharmacologic treatment for male and female pattern hair loss. However, low-dose oral minoxidil has been used off-label... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Topical minoxidil is the recommended first-line pharmacologic treatment for male and female pattern hair loss. However, low-dose oral minoxidil has been used off-label with good clinical efficacy and safety.
AIM
To compare the effectiveness and safety of topical minoxidil as a first-choice treatment of androgenetic alopecia versus 1 mg daily oral minoxidil.
METHOD
Sixty-five AGA patients were randomly allocated to receive either 5% topical solution or 1 mg/day oral minoxidil for 6 months. Treatment efficacy was evaluated by measuring hair diameter, photographic assessment, and patient self-assessment questionnaires. The safety of treatment was checked through history taking and physical examination.
RESULTS
Both topical and oral minoxidil groups showed significant improvement in hair diameter after 6 months of treatment (p < 0.001). However, there was no significant difference between the two groups. The photographic assessment demonstrated a significant improvement in hair density in the topical minoxidil group in all marked points located at 12 cm (p = 0.025), 16 cm (p = 0.034), and 24 cm (p = 0.014) distance from the glabella but not in the oral minoxidil group. Nevertheless, the difference between the two groups was not significant. In each group, over 60% of patients expressed satisfaction with their treatments, and no significant difference was detected between the two groups.
CONCLUSION
Although topical minoxidil has a better overall therapeutic effect than 1 mg oral minoxidil, the difference between the two groups was not significant. Therefore, 1 mg oral minoxidil may be as effective and safe as standard topical minoxidil in female and male pattern hair loss.
Topics: Humans; Female; Male; Minoxidil; Alopecia; Treatment Outcome; Hair; Photography
PubMed: 38031516
DOI: 10.1111/jocd.16086 -
Der Hautarzt; Zeitschrift Fur... Nov 2016Within the group of cicatricial alopecias, Kossard first described frontal fibrosing alopecia (FFA) in 1994 as a variant of lichen planopilaris (LPP). This... (Review)
Review
Within the group of cicatricial alopecias, Kossard first described frontal fibrosing alopecia (FFA) in 1994 as a variant of lichen planopilaris (LPP). This classification is based on the histopathological findings of FFA and LPP, which are identical and therefore not separable. The clinical picture of FFA, however, is very characteristic and marked by regionally distinct structures of the skin. Typically, postmenopausal women present with a band-shaped atrophy that is several centimeters wide located in the frontotemporal area. Adjacent to the hairline, perifollicular erythema and papules can be found. In the majority of patients there is a loss of the eyebrows. Circumscribed alopecia and perifollicular papules occur only rarely on the extremities or the trunk. Etiology and pathogenesis of FFA are unclear. Hormone-related involutionary phenomena of the follicle, genetic factors, disruption of lipid homeostasis, and in accordance with the lichen planus associated T‑cell cytotoxic autoimmune response are discussed. Treatment of FFA is difficult. Atrophy cannot be influenced by the currently available treatment options. With regard to the follicular inflammation, topical steroids and systemic hydroxychloroquine, antiandrogens, and tetracyclines are mainly used on a topical basis.
Topics: Alopecia; Diagnosis, Differential; Evidence-Based Medicine; Fibrosis; Forehead; Humans; Lichen Planus; Skin
PubMed: 27538878
DOI: 10.1007/s00105-016-3855-6 -
Skinmed 2018A wide range of conditions can present with congenital hypotrichoses/atrichia. Awareness of these conditions can help in the proper and timely diagnosis and counseling... (Review)
Review
A wide range of conditions can present with congenital hypotrichoses/atrichia. Awareness of these conditions can help in the proper and timely diagnosis and counseling of affected families, and in some cases avoid unnecessary investigations. The rapid growth in genetic analysis of diseases has also led to an increased knowledge of the genetic and molecular basis of many of these conditions. This contribution briefly reviews updates on some of the most common conditions associated with congenital hypotrichosis/atrichia.
Topics: Alopecia; Humans; Hypotrichosis
PubMed: 29551108
DOI: No ID Found -
Dermatologic Surgery : Official... Nov 2021
Topics: Alopecia; Humans; Male
PubMed: 34608090
DOI: 10.1097/DSS.0000000000003201 -
JAMA Dermatology Apr 2021
Topics: Alopecia; Dermatologists; Humans
PubMed: 33688909
DOI: 10.1001/jamadermatol.2020.5731 -
Skin Therapy Letter Jul 2016Frontal fibrosing alopecia, described just over 20 years ago, has become one of the most frequently seen causes of scarring alopecia at many specialist hair clinics....
Frontal fibrosing alopecia, described just over 20 years ago, has become one of the most frequently seen causes of scarring alopecia at many specialist hair clinics. Considered a clinical variant of lichen planopilaris (LPP), it has distinctive features and associations which distinguish it from LPP. Although largely affecting postmenopausal women, a small but increasing number of men and premenopausal women are affected. The spectrum of the disease has expanded from involvement of the frontal hairline and eyebrows, to potentially affecting the entire hairline, facial and body hair. Genetic and environmental factors have been implicated but the aetiology remains uncertain. A range of treatments have been used in management of the condition, but clinical trials are required to establish effectiveness.
Topics: Alopecia; Environment; Female; Fibrosis; Humans; Lichen Planus; Male
PubMed: 27388531
DOI: No ID Found -
Facial Plastic Surgery Clinics of North... May 2020Hair restoration in women involves mastering both the medical and the surgical treatment. Preoperatively, women should be thoroughly evaluated for biochemical causes of... (Review)
Review
Hair restoration in women involves mastering both the medical and the surgical treatment. Preoperatively, women should be thoroughly evaluated for biochemical causes of hair loss along with a complete history and physical examination taken. The physician must recognize the clinical presentation of scarring alopecias and maintain a low threshold for biopsy to rule out this condition. Postoperative hair shock loss is a common feature following hair transplant in women, and the surgeon should understand the preoperative counseling and preventative measures needed, the intraoperative methods to reduce the incidence, and the postoperative strategies to handle the situation.
Topics: Alopecia; Biopsy; Combined Modality Therapy; Eyebrows; Female; Hair; Humans; Preoperative Care; Skin; Skin Transplantation; Tissue and Organ Harvesting
PubMed: 32312508
DOI: 10.1016/j.fsc.2020.01.007 -
Journal of Cosmetic Dermatology Nov 2022There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is... (Review)
Review
BACKGROUND
There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is important in reaping results in alopecia. Minoxidil has come a long-way finding its use from topical formulations to systemic at lower dose in different alopecia.
OBJECTIVE
The objective of this article is to discuss various conditions in alopecia where oral minoxidil has found its role.
METHODS
A comprehensive literature search was performed relating to oral minoxidil role in various alopecia. Various clinical trials, case series, and case reports were searched on PubMed and Google Scholar. The references of available studies were also reviewed to collect the additional resources. Available data from various studies and case reports were collected and consolidated to provide a concise overview of oral minoxidil indications in various alopecia.
RESULTS
Oral minoxidil has been used in various non-scarring and scarring alopecia at a lower dosage with less side effects and with promising results. Androgenetic alopecia and female pattern hair loss were the two conditions where it has been used more commonly than other alopecia, providing a ray of hope along with overcoming the issues related to topical formulations and compliance.
Topics: Humans; Female; Minoxidil; Treatment Outcome; Alopecia; Administration, Topical
PubMed: 36065675
DOI: 10.1111/jocd.15324 -
Facial Plastic Surgery Clinics of North... May 2023Hair loss is a common problem among men and women. Hair replacement surgery (HRS) has become increasingly popular as technological advancements have been made producing... (Review)
Review
Hair loss is a common problem among men and women. Hair replacement surgery (HRS) has become increasingly popular as technological advancements have been made producing remarkably natural results when performed by a skilled surgeon. Although complications from HRS are low compared with other esthetic surgeries, they can still occur even with the best-trained and qualified surgeon or staff. The process of hair restoration can be a long road for some patients and active patient participation and education is key for successful results. In this article, we seek to discuss the surgical risks of HRS and discuss methods to prevent them in your practice.
Topics: Male; Humans; Female; Hair Follicle; Hair; Alopecia; Surgery, Plastic
PubMed: 37001929
DOI: 10.1016/j.fsc.2023.01.009