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Dermatologic Clinics Jul 2021Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies... (Review)
Review
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction and grafting that it is possible to offer to patient's excellent clinical results. Adjuvant modalities such as platelet-rich plasma injections, lasers, and stem cells can further enhance the durability, health, and appearance of hair transplants.
Topics: Alopecia; Female; Hair; Humans; Skin Transplantation
PubMed: 34053590
DOI: 10.1016/j.det.2021.03.002 -
Expert Opinion on Emerging Drugs Dec 2014Alopecia is a common concern encountered in the medical practice. Treatment approach varies according to the type and severity of alopecia. However, available treatment... (Review)
Review
INTRODUCTION
Alopecia is a common concern encountered in the medical practice. Treatment approach varies according to the type and severity of alopecia. However, available treatment options have limited efficacy and several adverse effects. Presently, there are different treatment options being studied to overcome these limitations. Additionally, cellular pathways involved in the pathophysiology of alopecia are further being clarified to potentially target pathogenic molecules.
AREAS COVERED
We searched the literature for recently published articles discussing new treatment options as well as mechanisms involved in alopecia. We discuss the use of stem cells, growth factors, cellular pathways and robotic hair transplant, among other emerging therapies used for alopecia.
EXPERT OPINION
Future looks very promising and new effective treatments such as janus kinase inhibitors could possibly be available for alopecia areata. The stem-cell technology is advancing and companies involved in hair follicle neogenesis are starting clinical trials on patients with androgenetic alopecia.
Topics: Alopecia; Alopecia Areata; Animals; Hair; Hair Follicle; Humans; Janus Kinases; Stem Cell Transplantation
PubMed: 25330928
DOI: 10.1517/14728214.2014.974550 -
Annals of Medicine Sep 2016Hair loss is both a common chief complaint by patients and a clinical challenge for physicians, especially general practitioners, yet few dermatological problems yield... (Review)
Review
Hair loss is both a common chief complaint by patients and a clinical challenge for physicians, especially general practitioners, yet few dermatological problems yield as much patient satisfaction when resolved as hair loss. The diagnosis is often attributed to androgen-related hair loss, while other causes, some of which are life-threatening but treatable, are overlooked. We searched for relevant literature on hair loss and supported these findings with our clinical experience to identify seven major systemic etiologies of hair loss, ranging from infectious agents to consumption of unsafe supplements. Many causes are only described in the literature through case studies, though some original articles and meta-analyses are available. Careful history taking, proper examination techniques, and judicious use of laboratory tests are essential to reach at the correct diagnosis in a cost-effective manner when performing patient work-up. Such methodical evaluation of hair loss can result in the appropriate treatment plan and provide significant patient satisfaction. Key messages Hair loss is a common chief complaint and a difficult challenge for both general practitioners and dermatology consultants. We identified seven major categories of systemic hair loss etiology and present a framework for their clinical evaluation. A methodical approach to hair loss can result in the appropriate treatment plan and provide significant patient satisfaction.
Topics: Alopecia; Androgens; Communicable Diseases; Dietary Supplements; Disease Management; Early Diagnosis; Humans; Patient Satisfaction
PubMed: 27145919
DOI: 10.1080/07853890.2016.1180426 -
Alternative Therapies in Health and... Jul 2020Androgenic alopecia is a common and unpleasant problem that directly influences the self-confidence and individual life quality. There are various treatment choices that... (Review)
Review
BACKGROUNDS
Androgenic alopecia is a common and unpleasant problem that directly influences the self-confidence and individual life quality. There are various treatment choices that currently are used by people suffering from androgenic alopecia. Drug therapies (e. g. minoxidil, finasteride, dutasteride, prostaglandin analogues, ketoconazole, Cyproterone acetate and spironolactone), Laser-light treatment, surgical treatment, cell mediated treatment and alternative treatments (vitamin, mineral and herbal components) are common therapeutic methods suggested for management of androgenic alopecia. Herbal medicines are now commonly used all over the world and this has increased global demand. Quality, safety and efficacy of these drugs have become a serious concern.
OBJECTIVES
The aim of this review is evaluating the herbal or fungal medicines were used in androgenic alopecia and introducing the phytochemicals, biological effects, responsible constituents and the mechanism of this action.
RESULTS
The 23 medicinal fungi or plants with their possible mechanisms and active phytoconstituents, which were used in androgenic alopecia are described.
METHODS/DESIGN
In this review, most of the natural sources that used in the treatment of androgenic alopecia were collected from electronic databases including Web of Science, PubMed, Scopus and Google Scholar were searched for these plants. Data were gathered from 1970 to 2016.
CONCLUSION
The summarized findings in this article could be inspiration to product new formulations for treatment of androgenic alopecia with more effective properties and fewer side effect.
Topics: Alopecia; Finasteride; Herbal Medicine; Humans; Minoxidil; Phytotherapy; Plants, Medicinal; Scalp
PubMed: 31221945
DOI: No ID Found -
ACS Biomaterials Science & Engineering May 2023Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation of... (Review)
Review
Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation of mechanisms in tissue engineering, the proliferation of HFs in vitro has achieved more promising trust for the treatments of alopecia and other skin impairments. Theoretically, HF organoids have great potential to develop into native HFs and attachments such as sweat glands after transplantation. However, since the rich extracellular matrix (ECM) deficiency, the induction characteristics of skin-derived cells gradually fade away along with their trichogenic capacity after continuous cell passaging in vitro. Therefore, ECM-mimicking support is an essential prelude before HF transplantation is implemented. This review summarizes the status of providing various epidermal and dermal cells with a three-dimensional (3D) scaffold to support the cell homeostasis and better mimic in vivo environments for the sake of HF regeneration. HF-relevant cells including dermal papilla cells (DPCs), hair follicle stem cells (HFSCs), and mesenchymal stem cells (MSCs) are able to be induced to form HF organoids in the vitro culture system. The niche microenvironment simulated by different forms of biomaterial scaffold can offer the cells a network of ordered growth environment to alleviate inductivity loss and promote the expression of functional proteins. The scaffolds often play the role of ECM substrates and bring about epithelial-mesenchymal interaction (EMI) through coculture to ensure the functional preservation of HF cells during in vitro passage. Functional HF organoids can be formed either before or after transplantation into the dermis layer. Here, we review and emphasize the importance of 3D culture in HF regeneration in vitro. Finally, the latest progress in treatment trials and critical analysis of the properties and benefits of different emerging biomaterials for HF regeneration along with the main challenges and prospects of HF regenerative approaches are discussed.
Topics: Humans; Hair Follicle; Dermis; Regeneration; Alopecia; Tissue Engineering
PubMed: 37036820
DOI: 10.1021/acsbiomaterials.3c00028 -
JAMA Dermatology Jan 2020
Topics: Adult; Alopecia; Dermatologic Agents; Eyebrows; Female; Fibrosis; Humans; Pruritus; Treatment Outcome
PubMed: 31664430
DOI: 10.1001/jamadermatol.2019.3110 -
The British Journal of General Practice... Oct 2014
Topics: Alopecia; Decision Making; General Practice; Humans; Ointments; Physician-Patient Relations; Self Concept
PubMed: 25267042
DOI: 10.3399/bjgp14X681985 -
Klinicka Onkologie : Casopis Ceske a... 2019Damage and loss of hair (alopecia) is a predictable adverse event of oncological therapy. It can be caused by chemotherapy, radiotherapy, or targeted and hormonal... (Review)
Review
Damage and loss of hair (alopecia) is a predictable adverse event of oncological therapy. It can be caused by chemotherapy, radiotherapy, or targeted and hormonal therapy. From the point of view of patients with malignant disease, hair loss is one of the most feared side effects and adversely affects their mental health. Hair loss can be diffuse, complete, partial, or regional. Worsening of hair quality, cutaneous inflammation, and scarring can also occur. Eyelashes, eyebrows, and body hair can also be lost. Alopecia is mostly reversible, but permanent damage can occur depending on the type, overall length, and dose of oncological treatment and other factors. The risk of alopecia is high with high-dose docetaxel, doxorubicin, and cyclophosphamide, but low with platinum chemotherapy, melphalan, and capecitabin. Targeted therapy and immunotherapy can cause immune-mediated alopecia such as alopecia areata and scarring alopecia as well as paradoxically hypertrichosis and trichomegaly. Physical and pharmacological approaches can be used to prevent and treat alopecia; however, their effectiveness and availability are limited. Modern radiotherapy scalp-sparing methods minimize hair loss. Good results have been obtained with scalp cooling, which reduces the toxic effects of cytostatic agents on hair follicles during short infusion regimens. Several systems cool the scalp to less than 22°C. Minoxidil accelerates hair regrowth and is used as a topical therapy. Psychological support and provision of cosmetically acceptable head coverings are also very important.
Topics: Alopecia; Antineoplastic Agents; Humans; Minoxidil; Neoplasms; Radiotherapy
PubMed: 31610668
DOI: 10.14735/amko2019353 -
Journal of the American Veterinary... Jun 2018
Topics: Alopecia; Animals; Cat Diseases; Cats; Female; Hyperpigmentation; Sebaceous Gland Diseases
PubMed: 29772977
DOI: 10.2460/javma.252.11.1359 -
Journal of the American Academy of... Jun 2021
Topics: Alopecia; Alopecia Areata; Humans; Treatment Outcome
PubMed: 32763325
DOI: 10.1016/j.jaad.2020.08.001