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Endocrinology and Metabolism Clinics of... Jun 2024
Topics: Humans; Puberty, Precocious; Puberty; Female; Puberty, Delayed
PubMed: 38677874
DOI: 10.1016/j.ecl.2024.03.002 -
Journal of Medical Ethics Nov 2020
Topics: Humans; Puberty
PubMed: 33033114
DOI: 10.1136/medethics-2020-106822 -
Journal of Research on Adolescence :... Mar 2019This special section is the product of a small-group meeting of those who study puberty and its relevance. Our aim was to gather information and write manuscripts to...
This special section is the product of a small-group meeting of those who study puberty and its relevance. Our aim was to gather information and write manuscripts to inform scientists of advances and continuing obstacles, as well as to stimulate interdisciplinary research on puberty relevant across the lifespan. The themes of the nine position or review papers (and commentary), range from cell to society. We hope this introduction will entice you to read all the papers and consider how they apply or expand your next steps in research or help you synthesize the literature on puberty. We anticipate the papers can embellish your adolescent courses, and, for junior scientists, we hope the many intriguing possibilities for future research on puberty will be apparent.
Topics: Adolescent; Adolescent Health; Biobehavioral Sciences; Congresses as Topic; Guidelines as Topic; Humans; Manuscripts as Topic; Puberty; Research; Sexual Maturation
PubMed: 30869840
DOI: 10.1111/jora.12449 -
Endocrine Practice : Official Journal... Apr 2024This study aims to explore the significant impact of environmental chemicals on disease development, focusing on their role in developing metabolic and endocrine... (Review)
Review
OBJECTIVE
This study aims to explore the significant impact of environmental chemicals on disease development, focusing on their role in developing metabolic and endocrine diseases. The objective is to understand how these chemicals contribute to the increasing prevalence of precocious puberty, considering various factors, including epigenetic changes, lifestyle, and emotional disturbances.
METHODS
The study employs a comprehensive review of descriptive observational studies in both human and animal models to identify a degree of causality between exposure to environmental chemicals and disease development, specifically focusing on endocrine disruption. Due to ethical constraints, direct causation studies in human subjects are not feasible; therefore, the research relies on accumulated observational data.
RESULTS
Puberty is a crucial life period with marked physiological and psychological changes. The age at which sexual characteristics develop is changing in many regions. The findings indicate a correlation between exposure to endocrine-disrupting chemicals and the early onset of puberty. These chemicals have been shown to interfere with normal hormonal processes, particularly during critical developmental stages such as adolescence. The research also highlights the interaction of these chemical exposures with other factors, including nutritional history, social and lifestyle changes, and emotional stress, which together contribute to the prevalence of precocious puberty.
CONCLUSION
Environmental chemicals significantly contribute to the development of certain metabolic and endocrine diseases, particularly in the rising incidence of precocious puberty. Although the evidence is mainly observational, it adequately justifies regulatory actions to reduce exposure risks. Furthermore, these findings highlight the urgent need for more research on the epigenetic effects of these chemicals and their wider impact on human health, especially during vital developmental periods.
Topics: Adolescent; Animals; Humans; Endocrine Disruptors; Endocrine System; Endocrine System Diseases; Puberty; Puberty, Precocious; Observational Studies as Topic
PubMed: 38185329
DOI: 10.1016/j.eprac.2024.01.006 -
Journal of Research on Adolescence :... Mar 2019The measurement of puberty is an intricate and precise task, requiring a match between participants' developmental age and appropriate techniques to identify and capture... (Review)
Review
The measurement of puberty is an intricate and precise task, requiring a match between participants' developmental age and appropriate techniques to identify and capture variations in maturation. Much of the foundational work on puberty and its psychosocial correlates was conducted several decades ago. In this article, we review the biological foundation of puberty; the operationalization of puberty in statistical analyses; and strategies for considering diversity and social context in research to help researchers align measurement with meaningful conceptual questions. These three areas are particularly important, given new statistical techniques, greater awareness of individual variations in development, and key differences between past cohorts and youth coming of age today.
Topics: Adolescent; Adolescent Development; Adolescent Health; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Gene-Environment Interaction; Humans; Male; Models, Biological; Puberty; Research Design; Sexual Maturation; Social Environment
PubMed: 30869839
DOI: 10.1111/jora.12371 -
Pediatrics in Review Jul 2016
Review
Topics: Adolescent; Child; Female; Humans; Male; Puberty; Sexual Maturation
PubMed: 27368360
DOI: 10.1542/pir.2015-0065 -
Social Science & Medicine (1982) May 2015This scoping review synthesizes existing research on two major transitions in females' lives: puberty and perimenopause. These two periods of vast physiological change... (Review)
Review
This scoping review synthesizes existing research on two major transitions in females' lives: puberty and perimenopause. These two periods of vast physiological change demarcate the beginning and the end of the reproductive life cycle and are associated with major neuroendocrine reorganization across two key systems, the hypothalamic-pituitary-gonadal (HPG) axis the hypothalamus-pituitary-adrenal (HPA) axis. Despite growing evidence suggesting that the timing and experience of puberty and perimenopause are related to various physical and mental health outcomes (e.g., mood disorders, metabolism, cardiovascular health, autoimmune conditions, and cancer), these two processes are rarely examined together. In this paper, we bridge these disparate literatures to highlight similarities, isolate inconsistencies, and identify important areas for future research in women's health.
Topics: Age Factors; Autoimmune Diseases; Cardiovascular Diseases; Female; Health Status; Hormones; Humans; Hypothalamo-Hypophyseal System; Mental Health; Mortality; Neoplasms; Perimenopause; Pituitary-Adrenal System; Puberty; Sexual Maturation; Women's Health
PubMed: 25797100
DOI: 10.1016/j.socscimed.2015.03.031 -
Endocrinology and Metabolism Clinics of... Jun 2019For children and adolescents with gender dysphoria, an interdisciplinary care team is essential for proper diagnosis and appropriate treatment. For children who present... (Review)
Review
For children and adolescents with gender dysphoria, an interdisciplinary care team is essential for proper diagnosis and appropriate treatment. For children who present with gender dysphoria, once puberty begins, they can be treated with gonadotropin-releasing hormone analogs to stop pubertal progression. This allows for further gender exploration, relief of dysphoria, and better cosmetic outcomes by avoiding the physical changes associated with puberty of the gender assigned at birth. After pubertal suppression, the individual may opt to proceed with puberty or start treatment with gender-affirming hormones.
Topics: Adolescent; Child; Female; Gender Dysphoria; Hormone Replacement Therapy; Humans; Male; Puberty; Transsexualism
PubMed: 31027543
DOI: 10.1016/j.ecl.2019.01.003 -
Trends in Endocrinology and Metabolism:... May 2022Normal growth pattern variations [i.e., constitutional advancement and constitutional delay of growth and puberty (CAGP and CDGP)] are the mirror image of each other and... (Review)
Review
Normal growth pattern variations [i.e., constitutional advancement and constitutional delay of growth and puberty (CAGP and CDGP)] are the mirror image of each other and are associated with early puberty (EP) and delayed puberty (DP), respectively. Differences between CAGP and CDGP relate not only to auxological characteristics (height, weight) but also to insulin-like growth factor-1 (IGF-1). IGF-1 levels in CAGP are above average whereas in CDGP they are below average, suggesting a role for IGF-1 in the induction of these growth patterns. Herein, we provide data suggesting that early activation of the growth hormone (GH)/IGF-1 axis induces the growth pattern of CAGP. Moreover, we suggest that IGF-1 is a decisive factor for the release of the gonadotropin-releasing hormone (GnRH) inhibition brake that occurs in prepuberty. It is therefore crucial for puberty onset.
Topics: Growth Hormone; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Puberty
PubMed: 35331614
DOI: 10.1016/j.tem.2022.02.004 -
Tidsskrift For Den Norske Laegeforening... May 2021
Topics: Humans; Puberty
PubMed: 33950643
DOI: 10.4045/tidsskr.21.0210