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American Journal of Clinical Pathology Feb 2022Small-volume biopsy-fine-needle aspiration biopsy (FNAB) with or without core biopsy-is in increasing use in diagnosis and management of lymphoma patients. Our objective...
OBJECTIVES
Small-volume biopsy-fine-needle aspiration biopsy (FNAB) with or without core biopsy-is in increasing use in diagnosis and management of lymphoma patients. Our objective was to survey the current practice in small-volume biopsy diagnosis of lymphoma, focusing on the interaction among hematopathologists and cytopathologists and the integration of FNAB, core biopsy, and flow cytometry studies at sign-out.
METHODS
This study used a cross-sectional survey design employing the RedCap database distributed via nine pathology professional society email listservs. The survey consisted of 25 multiple-choice questions and several free text fields. In total, 128 pathologists participated.
RESULTS
Most respondents indicated that FNAB specimens in which lymphoma is a diagnostic consideration (FNAB-L) are seen daily or weekly (68/116; 58.6%). However, most institutions have separate hematopathology and cytopathology services (72/116; 62.1%) with inconsistent communication. When communication occurred, respondents were frequently inclined to reconsider their original diagnoses. Barriers identified included lack of communication, inadequate access to diagnostic studies, no formal subspecialty training, and various opinions regarding FNAB in diagnosing lymphoma.
CONCLUSIONS
This survey showed that FNAB-L specimens are common, with a lack of uniformity in how complementary fine-needle aspiration and core biopsy specimens or flow immunophenotyping results are shared across hematopathology and cytopathology services.
Topics: Biopsy, Fine-Needle; Biopsy, Large-Core Needle; Cross-Sectional Studies; Humans; Immunophenotyping; Pathologists
PubMed: 34508545
DOI: 10.1093/ajcp/aqab111 -
Journal of Clinical Oncology : Official... Mar 2022
Topics: Adult; Biopsy, Needle; Female; Humans; Lymphoma; Mental Health; Physicians
PubMed: 34874754
DOI: 10.1200/JCO.21.01523 -
The Veterinary Clinics of North... Jan 2017Cytology of bone is a useful diagnostic tool. Aspiration of lytic or proliferative lesions can assist with the diagnosis of inflammatory or neoplastic processes.... (Review)
Review
Cytology of bone is a useful diagnostic tool. Aspiration of lytic or proliferative lesions can assist with the diagnosis of inflammatory or neoplastic processes. Bacterial, fungal, and protozoal organisms can result in significant osteomyelitis, and these organisms can be identified on cytology. Neoplasms of bone including primary bone tumors such as osteosarcoma, chondrosarcoma, fibrosarcoma, synovial cell sarcoma, and histiocytic sarcoma and tumors of bone marrow including plasma cell neoplasia and lymphoma and metastatic neoplasia can result in significant bone lysis or proliferation and can be diagnosed effectively with cytology.
Topics: Animals; Biopsy, Needle; Bone Diseases; Bone and Bones; Cytological Techniques; Specimen Handling
PubMed: 27531040
DOI: 10.1016/j.cvsm.2016.07.005 -
Gastrointestinal Endoscopy Clinics of... Apr 2019There remains an important role for liver biopsy in the management of liver disorders. Image-guided liver biopsy can be obtained with percutaneous or transjugular... (Review)
Review
There remains an important role for liver biopsy in the management of liver disorders. Image-guided liver biopsy can be obtained with percutaneous or transjugular approaches. Real-time image-guided liver biopsy can be accomplished with endoscopic ultrasound (EUS). EUS-guided liver biopsy (EUS-LB) has emerged as a safe means of obtaining liver biopsy. EUS-LB confers several advantages over other methods, including the ability to target both lobes of the liver, increased patient comfort and decreased apprehension during the procedure, and shorter recovery time after the biopsy. Future development of technology that allows for EUS-guided portal pressure measurement could further drive EUS-LB use.
Topics: Biopsy, Needle; Endosonography; Humans; Liver; Liver Diseases; Postoperative Care; Tissue Fixation; Ultrasonography, Interventional
PubMed: 30846147
DOI: 10.1016/j.giec.2018.11.002 -
Neuroimaging Clinics of North America Nov 2019Fine-needle aspiration (FNA) and core needle biopsy are the primary diagnostic modalities for assessing mass lesions. Any superficial or deep-seated lesion occurring... (Review)
Review
Fine-needle aspiration (FNA) and core needle biopsy are the primary diagnostic modalities for assessing mass lesions. Any superficial or deep-seated lesion occurring anywhere in the body, including bone and soft tissue, can undergo this procedure to pathologically characterize it. The outcomes of FNA, performed either alone or in combination with core biopsy, are best when performed and interpreted by skilled individuals. The roles of interventional radiologists and cytologists are pivotal in ensuring adequacy of the specimen and leading the clinical team in making the diagnosis and avoiding repeat diagnostic procedures or a more invasive open surgical biopsy.
Topics: Biopsy, Fine-Needle; Biopsy, Large-Core Needle; Humans; Spinal Neoplasms; Spine
PubMed: 31677735
DOI: 10.1016/j.nic.2019.07.009 -
Diagnostic and Interventional Imaging 2014Imaging-guided percutaneous biopsies in patients in oncology provide an accurate diagnosis of malignant tumors. Percutaneous biopsy results are improved by correct use...
Imaging-guided percutaneous biopsies in patients in oncology provide an accurate diagnosis of malignant tumors. Percutaneous biopsy results are improved by correct use of sampling procedures. The risks of percutaneous biopsy are low and its complications are generally moderate. These risks can be reduced using aids such as blund tip introducers, hydrodissection and correct patient positioning. The multidisciplinary team meetings dialogue between oncologist, surgeon and radiologist correctly defines the indications in order to improve the treatment strategies.
Topics: Biopsy, Needle; Equipment Design; Humans; Neoplasms
PubMed: 25043316
DOI: 10.1016/j.diii.2014.04.016 -
Hematology (Amsterdam, Netherlands) Dec 2021Bone marrow (BM) biopsy is the most common diagnostic procedure in hematology. Bleeding is an expected complication, and its risk is assumed to be increased in patients... (Review)
Review
BACKGROUND
Bone marrow (BM) biopsy is the most common diagnostic procedure in hematology. Bleeding is an expected complication, and its risk is assumed to be increased in patients on anticoagulants. However, the effect of anticoagulation on BM biopsy safety is unclear and guidelines are lacking robust data in this regard. As such, physicians use their clinical judgement to guide periprocedural management of anticoagulation.
OBJECTIVE
To provide the best available evidence regarding management of anticoagulation in patients who need BM biopsy.
METHODS
We reviewed and summarized available guidelines directing management of periprocedural anticoagulation for BM biopsy, and share our experience and practices with BM biopsy at our institution.
RESULTS
The incidence of significant hemorrhage after BM biopsy is very low (0.007-1.1%). BM biopsy is classified as having a low to moderate bleeding risk. Interrupting anticoagulation is not consistently recommended. Strategies exist to minimize bleeding risk for anticoagulated patients. Patients with myeloproliferative neoplasms can develop an acquired von Willebrand syndrome which increases their risk for bleeding and therefore require extra vigilance to ensure appropriate hemostasis.
CONCLUSION
Withholding anticoagulation prior to BM biopsy is not routinely recommended. Instead, assessment and optimization of bleeding risk factors should be done on a patient by patient basis.
Topics: Anticoagulants; Biopsy, Needle; Bone Marrow; Clinical Decision-Making; Disease Management; Female; Hemorrhage; Humans; Male; Practice Guidelines as Topic; Practice Patterns, Physicians'; Risk Assessment; Risk Factors
PubMed: 33594950
DOI: 10.1080/16078454.2021.1880762 -
World Journal of Gastroenterology Mar 2023Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030, a high mortality rate considering the number of... (Review)
Review
Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030, a high mortality rate considering the number of cases. Surgery and chemotherapy are the main treatment options, but they are burdensome for patients. A clear histological diagnosis is needed to determine a treatment plan, and endoscopic ultrasound (EUS)-guided tissue acquisition (TA) is a suitable technique that does not worsen the cancer-specific prognosis even for lesions at risk of needle tract seeding. With the development of personalized medicine and precision treatment, there has been an increasing demand to increase cell counts and collect specimens while preserving tissue structure, leading to the development of the fine-needle biopsy (FNB) needle. EUS-FNB is rapidly replacing EUS-guided fine-needle aspiration (FNA) as the procedure of choice for EUS-TA of pancreatic cancer. However, EUS-FNA is sometimes necessary where the FNB needle cannot penetrate small hard lesions, so it is important clinicians are familiar with both. Given these recent dev-elopments, we present an up-to-date review of the role of EUS-TA in pancreatic cancer. Particularly, technical aspects, such as needle caliber, negative pressure, and puncture methods, for obtaining an adequate specimen in EUS-TA are discussed.
Topics: Humans; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Pancreatic Neoplasms; Pancreas; Endosonography
PubMed: 37032729
DOI: 10.3748/wjg.v29.i12.1863 -
Seminars in Cutaneous Medicine and... Jun 2015The diagnosis of alopecia is an area of dermatology that frequently relies on the close correlation of clinical and pathological features. Therefore,careful selection of... (Review)
Review
The diagnosis of alopecia is an area of dermatology that frequently relies on the close correlation of clinical and pathological features. Therefore,careful selection of the scalp biopsy site, optimal biopsy technique, and proper specimen processing followed by informed histological interpretation are essential steps in the successful evaluation of both cicatricial and noncicatricial alopecias. This review will serve as a primer for clinicians and pathologists alike wishing to optimize their approach to the scalp biopsy and interpretation of key noncicatricial and cicatricial alopecias.
Topics: Alopecia; Biopsy, Needle; Humans; Scalp
PubMed: 26176281
DOI: 10.12788/j.sder.2015.0144 -
Cancer Cytopathology Oct 2017
Topics: Biopsy, Fine-Needle; Biopsy, Large-Core Needle; Breast Neoplasms; Humans
PubMed: 28837269
DOI: 10.1002/cncy.21908