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Internal and Emergency Medicine Dec 2014
Topics: Citrobacter koseri; Enterococcus; Female; Humans; Middle Aged; Pyelonephritis; Tomography, X-Ray Computed
PubMed: 24615280
DOI: 10.1007/s11739-014-1068-5 -
Immunotherapy 2016Acute pyelonephritis is an infection of the renal parenchyma and renal pelvis. When it is caused by a typical pathogen in an immunocompetent female patient with normal... (Review)
Review
Acute pyelonephritis is an infection of the renal parenchyma and renal pelvis. When it is caused by a typical pathogen in an immunocompetent female patient with normal urinary tract, it is considered uncomplicated. In all other cases, sepsis is the most worrisome complication. In the event of sepsis, patients should be hospitalized and treated aggressively with antibiotics, intravenous fluids and agents that enhance the immune response of the host. In this review, we summarize findings from immunomodulatory interventions in experimental studies of acute pyelonephritis and the application of these interventions into clinical practice. Vaccine against bacterial virulence factors and agents aiming to modulate the immune response of the host belong to these interventions and they are discussed.
Topics: Acute Disease; Female; Humans; Immunomodulation; Immunotherapy; Pyelonephritis; Sepsis; Urinary Tract Infections; Virulence Factors
PubMed: 26641200
DOI: 10.2217/imt.15.98 -
Medicina 2021
Topics: Diabetes Complications; Emphysema; Humans; Pyelonephritis
PubMed: 34137715
DOI: No ID Found -
Urologiia (Moscow, Russia : 1999) Aug 2016
Topics: Chronic Disease; Humans; Practice Guidelines as Topic; Pyelonephritis
PubMed: 28247614
DOI: No ID Found -
BMJ Case Reports Jun 2016
Topics: Ceftriaxone; Diagnosis, Differential; Female; Humans; Middle Aged; Nephrectomy; Pyelonephritis, Xanthogranulomatous; Weight Loss
PubMed: 27307431
DOI: 10.1136/bcr-2016-216025 -
Aktuelle Urologie Dec 2021
Topics: Acute Disease; Humans; Procalcitonin; Prognosis; Pyelonephritis
PubMed: 34847597
DOI: 10.1055/a-1530-0587 -
Journal of the American Society of... Jun 2019
Review
Topics: Acute Disease; Bacteriuria; Biomarkers; Disease Progression; Forecasting; History, 19th Century; History, 20th Century; Humans; Nephrology; Prognosis; Pyelonephritis; Renal Insufficiency, Chronic; Uromodulin
PubMed: 31028101
DOI: 10.1681/ASN.2019010017 -
Revista Do Instituto de Medicina... 2015
Topics: Emphysema; Female; Humans; Middle Aged; Pyelonephritis
PubMed: 26422167
DOI: 10.1590/S0036-46652015000400019 -
Current Opinion in Pediatrics Apr 2021The aim of this review is to highlight the most recent developments in the understanding of kidney damage associated with vesico ureteral reflux. The severe damage, with... (Review)
Review
PURPOSE OF REVIEW
The aim of this review is to highlight the most recent developments in the understanding of kidney damage associated with vesico ureteral reflux. The severe damage, with major adverse long-term sequelae, was thought to be, for the most part, the result of pyelonephritis, predisposed to by vesico ureteral reflux.
RECENT FINDINGS
It is now recognized that there are two distinct forms of kidney damage (congenital and acquired), in association with reflux. We examined the most recent research regarding these two conditions.
SUMMARY
The most recent articles focus on an understanding and the possible interventions for the congenital and acquired abnormalities of the kidney, associated with reflux. Of particular interest in congenital disorders, is the importance of urothelium and gene mutations in normal and aberrant development of the urinary tract. As regards the predisposition to urinary tract infections and kidney scarring, the importance of uromodulin in the defence mechanism preventing infection, and the role of interventions aimed at reducing scarring, such as vitamin A and steroids during the acute phase of the infection, are discussed. A recent article of particular value demonstrated the absence of long-term adverse outcomes during pregnancy, in women investigated for urinary tract infections in childhood.
Topics: Female; Humans; Kidney; Kidney Diseases; Pregnancy; Pyelonephritis; Urinary Tract Infections; Vesico-Ureteral Reflux
PubMed: 33534423
DOI: 10.1097/MOP.0000000000000996 -
BMJ Clinical Evidence Nov 2014Pyelonephritis is usually caused by ascent of bacteria (most often Escherichia coli) from the bladder, and is more likely in people with structural or functional urinary... (Review)
Review
INTRODUCTION
Pyelonephritis is usually caused by ascent of bacteria (most often Escherichia coli) from the bladder, and is more likely in people with structural or functional urinary tract abnormalities. The prognosis is good if pyelonephritis is treated appropriately, but complications include renal abscess, renal impairment, and septic shock.
METHODS AND OUTCOMES
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of antibiotic treatments for acute pyelonephritis in non-pregnant women with uncomplicated infection? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS
We found four studies that met our inclusion criteria.
CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: antibiotics (intravenous), antibiotics (oral), and antibiotics (switch therapy).
Topics: Anti-Bacterial Agents; Female; Humans; Pyelonephritis
PubMed: 25373019
DOI: No ID Found