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Journal Francais D'ophtalmologie Jan 2022
Topics: Conjunctiva; Granuloma, Pyogenic; Humans; Pterygium
PubMed: 34281761
DOI: 10.1016/j.jfo.2021.02.009 -
Burns : Journal of the International... May 2015Patients with pygenic granuloma following burns (PGB) presents dramatic clinical features which are different from those with classic pyogenic granuloma. This review... (Review)
Review
BACKGROUND
Patients with pygenic granuloma following burns (PGB) presents dramatic clinical features which are different from those with classic pyogenic granuloma. This review aims to discuss whether pyogenic granuloma following burns (PGB) need excision or not.
METHODS
Using the PubMed, EMBASE, Cochrane Library and web of science databases. All articles which discussed diagnosis and treatment of pyogenic granuloma following burns with histological results were included from 1978 to 2013. Reports from meetings were not included. Only articles published in English were included.
RESULTS
Twenty one articles excluded from a total of 32 studies. One study was excluded from the 11 descriptive studies because of typical histological results. The rest, 10 studies were case reports. Only one article was published in French, whose abstract was published in French and English. Patients with PGB presented six distinctive clinical features. First, all the patients had burns initially. The second, PGB acutely erupted between 1 and 4 weeks in patients' burned area, which may be infected by bacteria, fungus and virus. The fourth, PGB can be classified into proliferative and shrivelling stages. The fifth, three hisiological characteristics including hyperkeratosis or acanthosis, numerous newly formed proliferative vascular, edematous stroma with infiltration by plasma cells and lymphocytes. Finally, recurrence, 6 out of 16 patients with PGB involuted spontaneously with no recurrence. Three out of 16 patients were conservatively managed with no recurrence, neither patients (5) who had surgery and 2 patients treated with electro coagulation had recurrence.
CONCLUSIONS
PGB lesions are benign based on clinical features and histological examinations. The clinical process of PGB could be divided into proliferative and shrivelling stages. Conservative treatment including wound management and antibiotic could be chosen firstly, especially when large PGBs are on the face or other important area of one's body. When conservative treatment is ineffective, a surgery could be chosen.
Topics: Anti-Bacterial Agents; Bandages; Burns; Dermatologic Surgical Procedures; Granuloma, Pyogenic; Humans
PubMed: 25440850
DOI: 10.1016/j.burns.2014.07.010 -
Dermatology (Basel, Switzerland) 2022Burn hemangioma, also known as scalded pyogenic granuloma, is considered a variant of pyogenic granuloma, but unlike the classic type it presents with rapid progression....
BACKGROUND
Burn hemangioma, also known as scalded pyogenic granuloma, is considered a variant of pyogenic granuloma, but unlike the classic type it presents with rapid progression. Most patients are infants and young children with a history of burns caused by liquids.
OBJECTIVE
The present study aims to present all patients with burn hemangiomas treated at our institutions with a full clinical and histopathological assessment.
PATIENTS AND METHODS
This case series includes 34 cases that were treated during the period from 2016 to 2021.
RESULTS
A total of 34 patients (16 female/18 male, mean age of 17.6 years) were included. Two age groups presented: infants and children (n = 22, age range 0.5-8 years, 10 female/12 male), and adults (n = 11, age range 25-44 years, 6 female/6 male). Lesions appeared 1-2 weeks following predominantly second-degree burns, and multiple lesions predominated in infants and children. The lesions evolved to large lesions within weeks, and these appeared to be either static or involute. The histopathology was compatible with hemangioma, rather than pyogenic granuloma.
CONCLUSION
Burn hemangioma should be considered a new variant of hemangioma rather than a type of pyogenic granuloma that follows second-degree burns. They have many similarities with infantile hemangioma, both clinically and histopathologically.
Topics: Adolescent; Adult; Burns; Child; Child, Preschool; Female; Granuloma, Pyogenic; Hemangioma; Hemangioma, Capillary; Humans; Infant; Male; Skin Diseases
PubMed: 34847566
DOI: 10.1159/000520616 -
The Journal of Emergency Medicine Sep 2022Pyogenic granulomas are acquired, benign growths of capillary blood vessels that are commonly seen in the pediatric population. Patients with these lesions often present... (Review)
Review
BACKGROUND
Pyogenic granulomas are acquired, benign growths of capillary blood vessels that are commonly seen in the pediatric population. Patients with these lesions often present to emergency departments and urgent care centers with persistent bleeding after minor trauma. Much of the published literature describing the management of pyogenic granulomas, however, is focused on outpatient or definitive therapies, and there is limited information on the management of acute bleeding.
OBJECTIVE
We conducted a narrative review to present and evaluate strategies and therapies available to emergency physicians for managing actively bleeding pyogenic granulomas in acute care settings.
DISCUSSION
Multiple options are available to emergency physicians to achieve hemostasis. Direct pressure with a nonadherent dressing remains first-line treatment. Additional therapeutic options, such as dressings impregnated with topical vasoconstrictors or hemostatic dressings or agents, can be used if bleeding persists. Certain approaches-silver nitrate, suture ligation, or electrocautery-may be available to some emergency physicians. These therapies, however, can compromise future histologic analysis of tissue for definitive diagnosis and have potential risks.
CONCLUSION
Although there are multiple options to achieve hemostasis in cases of bleeding, some treatments may lead to suboptimal cosmesis or interfere with future management. Many bleeding pyogenic granulomas will become hemostatic with treatments available to emergency physicians. Surgical consultation may be warranted for pyogenic granulomas that are unresponsive to the therapies described in this review.
Topics: Child; Humans; Granuloma, Pyogenic; Hemorrhage; Vasoconstrictor Agents; Hemostatics; Critical Care
PubMed: 36210284
DOI: 10.1016/j.jemermed.2022.04.031 -
Arquivos Brasileiros de Oftalmologia 2021Pyogenic granuloma is a common benign, vascular lesion of the skin and mucosa. Our case was a 34-year-old woman at 28 weeks of gestation. She presented with a complaint...
Pyogenic granuloma is a common benign, vascular lesion of the skin and mucosa. Our case was a 34-year-old woman at 28 weeks of gestation. She presented with a complaint of a growing and occasionally bleeding mass on the left lower eyelid conjunctiva for approximately 3 months. On examination, a red, pedunculated fragile lesion on the medial lower eyelid conjunctiva was observed. Ophthalmologic examination revealed that visual acuity was 20/20 in both eyes. Anterior and posterior segment examination was normal bilaterally. The lesion was excised completely under local anesthesia and sent for pathological examination. Histopathological examination revealed multiple vascular structures with small-diameters in the fibrous stroma. Vessels showed strong CD31 expression in immunohistochemical staining. Kaposi sarcoma was excluded due to negative HHV-8 staining. These findings were diagnostic of pyogenic granuloma. The frequency of pyogenic granuloma increases during pregnancy and surgical excision is important in diagnosis and treatment of these patients. This is the first reported case of conjunctival pyogenic granuloma during pregnancy.
Topics: Adult; Conjunctiva; Conjunctivitis; Female; Granuloma, Pyogenic; Humans; Pregnancy; Sarcoma, Kaposi
PubMed: 34550219
DOI: 10.5935/0004-2749.20210072 -
Dermatologic Surgery : Official... Jan 2022Polidocanol is a safe sclerosing agent with anesthetic properties and minimal skin toxicity. (Clinical Trial)
Clinical Trial
BACKGROUND
Polidocanol is a safe sclerosing agent with anesthetic properties and minimal skin toxicity.
OBJECTIVE
To evaluate the efficacy, safety, and recurrence rates with polidocanol sclerotherapy in the treatment of pyogenic granulomas (PGs).
METHODS AND METHODS
Thirty-nine patients with PG were injected with polidocanol 1% solution. Repeat injections were given weekly in case of incomplete clinical/dermoscopic resolution, until a maximum of 3 sittings. A higher strength (3%) was used for subsequent sessions in those with a minimal response to 1% solution. A final assessment for relapses was performed at 3, 6, and 12 months.
RESULTS
All 39 patients achieved complete resolution (100% clearance rate), with most (n = 26) lesions resolving after the first sitting. Side effects noted were postprocedure pain (22), erythema (2), superficial ulceration (2), paresthesias (1), prominent edema (4), thrombophlebitis (1), cyanotic discoloration (1), purpuric staining around injection site (4), and mild local pruritus (1). The procedure was well tolerated across the age spectrum (4-63 years) included.
CONCLUSION
We report polidocanol to be a highly effective, safe, and cost-effective sclerosant for treatment of PGs with no recurrences or need for special postprocedure care.
Topics: Adolescent; Adult; Child; Child, Preschool; Cost-Benefit Analysis; Drug Costs; Female; Granuloma, Pyogenic; Humans; Injections, Intralesional; Male; Middle Aged; Polidocanol; Recurrence; Sclerosing Solutions; Sclerotherapy; Secondary Prevention; Young Adult
PubMed: 34816819
DOI: 10.1097/DSS.0000000000003308 -
JAAD Case Reports Jun 2019
PubMed: 31194014
DOI: 10.1016/j.jdcr.2019.04.008 -
Ugeskrift For Laeger Oct 2017
Topics: Accidental Falls; Adolescent; Granuloma, Pyogenic; Humans; Male; Nose Diseases
PubMed: 29429472
DOI: No ID Found -
Graefe's Archive For Clinical and... Apr 2024To evaluate immunophenotypic profiles of infiltrating cells in surgically excised tissues of chalazion and pyogenic granuloma associated with chalazion.
PURPOSE
To evaluate immunophenotypic profiles of infiltrating cells in surgically excised tissues of chalazion and pyogenic granuloma associated with chalazion.
METHODS
Eighty-two surgical specimens from 74 consecutive patients newly diagnosed with chalazion or chalazion-associated pyogenic granuloma at Tokyo Medical University Hospital between 2016 and 2022 were studied. Sixty specimens were chalazion lesions and 22 specimens were pyogenic granuloma lesions (from 15 men and 7 women, mean age 36.6 ± 14.4 years). All patients were immunocompetent Asian Japanese adults. Specimens were analyzed by immunohistochemistry and flow cytometry. Flow cytometry was performed using the following antibodies: CD3, CD4, CD8, CD11b, CD11c, CD16, CD19, CD20, CD23, CD25, CD34, CD44, CD56, CD69, and CD138.
RESULTS
In flow cytometric analysis, the proportion of cells expressing the T cell marker CD3 was significantly higher compared with other immune cells expressing specific markers (p < 0.0001), and the proportion of CD4-positive T cells was significantly higher than that of CD8-positive T cells (p < 0.0001), in both chalazion and pyogenic granuloma specimens. The chalazion and pyogenic granuloma lesions shared similar immunophenotypic profile characterized by predominant T cell infiltration, and CD4 T cells dominating over CD8 cells. The pattern of expression of CD4 and CD8 in the specimens was confirmed by immunohistochemistry.
CONCLUSION
The present study demonstrates immunophenotypic features of chalazion and chalazion-associated pyogenic granuloma. Although various inflammatory cells are involved in the pathology of chalazion and pyogenic granuloma, a significantly higher proportion of CD4-positive T cells may be closely related to the pathological mechanisms of both lesions.
Topics: Male; Adult; Humans; Female; Young Adult; Middle Aged; Chalazion; Granuloma, Pyogenic; Immunophenotyping; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry
PubMed: 37934292
DOI: 10.1007/s00417-023-06304-w -
The Journal of Craniofacial Surgery Mar 2017Pyogenic granuloma is a common cause of growth of soft tissue in the oral cavity, especially in the gingiva. It is mainly associated with local and chronic irritants...
Pyogenic granuloma is a common cause of growth of soft tissue in the oral cavity, especially in the gingiva. It is mainly associated with local and chronic irritants besides hormonal changes during pregnancy. Here, the authors present an unusual patient of an extra-gingival pyogenic granuloma with large dimensions and displacing teeth arising in a male patient. This is an interesting patient to be reported due to its exacerbated and atypical clinical features.
Topics: Granuloma, Pyogenic; Humans; Lip Diseases; Male; Middle Aged; Tooth Migration
PubMed: 27755424
DOI: 10.1097/SCS.0000000000003122