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The Journal of General Physiology Mar 2022JGP study reveals that lower troponin expression in the right ventricle underlies interventricular differences in excitation-contraction coupling.
JGP study reveals that lower troponin expression in the right ventricle underlies interventricular differences in excitation-contraction coupling.
Topics: Excitation Contraction Coupling; Heart Ventricles; Myocardial Contraction; Troponin
PubMed: 35179560
DOI: 10.1085/jgp.202213119 -
Journal of Cardiothoracic and Vascular... Jun 2021
Topics: Heart Ventricles; Humans
PubMed: 33478881
DOI: 10.1053/j.jvca.2021.01.002 -
Journal of the College of Physicians... Dec 2019A double-chambered right ventricle (DCRV) is a rare congenital heart defect. The clinical features of DCRV, especially in the pediatric population, have not been...
A double-chambered right ventricle (DCRV) is a rare congenital heart defect. The clinical features of DCRV, especially in the pediatric population, have not been sufficiently elaborated. There are many unanswered questions regarding the surgical indications, surgical timing, natural history, and patient outcomes. This article will discuss the definition, pathophysiology, clinical features and treatment of DCRV. This systematic review showed a higher prevalence of symptomatic patients among children with DCRV with signs of right ventricular pressure overload and associated congenital heart defects. The spatial relation between ventricular septal defect and the anomalous muscle bundle might be a determinant of right ventricular obstruction. Symptomatic patients with an intra-right ventricular pressure gradient of >20 mmHg are indicated for a surgical repair. DCRV has a favourable postoperative course as no postoperative death was reported. Mechanisms of right ventricular obstruction warrant further elucidations based on larger patient population in the near future.
Topics: Child; Echocardiography; Global Health; Heart Defects, Congenital; Heart Ventricles; Humans; Prevalence; Ventricular Pressure
PubMed: 31839094
DOI: 10.29271/jcpsp.2019.12.1193 -
Cardiovascular Research Oct 2017Congenital heart disease is a major health issue, accounting for a third of all congenital defects. Improved early surgical management has led to a growing population of... (Review)
Review
Congenital heart disease is a major health issue, accounting for a third of all congenital defects. Improved early surgical management has led to a growing population of adults with congenital heart disease, including patients with defects affecting the right ventricle, which are often classified as severe. Defects affecting the right ventricle often cause right ventricular volume or pressure overload and affected patients are at high risk for complications such as heart failure and sudden death. Recent insights into the developmental mechanisms and distinct developmental origins of the left ventricle, right ventricle, and the outflow tract have shed light on the common features and distinct problems arising in specific defects. Here, we provide a comprehensive overview of the current knowledge on the development into the normal and congenitally malformed right heart and the clinical consequences of several congenital heart defects affecting the right ventricle.
Topics: Animals; Gene Expression Regulation, Developmental; Heart Defects, Congenital; Heart Ventricles; Humans; Hypertrophy, Right Ventricular; Morphogenesis; Risk Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling
PubMed: 28957538
DOI: 10.1093/cvr/cvx155 -
Clinical Cardiology Aug 2017Interest in evaluation of the right ventricle (RV) has increased recently. With the growth of new echocardiographic techniques and technology, there has been a... (Review)
Review
Interest in evaluation of the right ventricle (RV) has increased recently. With the growth of new echocardiographic techniques and technology, there has been a corresponding increase in the ability to evaluate the RV, both qualitatively and quantitatively. Older echocardiographic techniques, such as right ventricular fractional area of change, tricuspid annular plane systolic excursion, and tissue S', and newer echocardiographic techniques including 3-dimensional evaluation and global longitudinal strain, can improve our evaluation of RV function. These techniques provide both diagnostic and prognostic data on a large variety of clinical diseases including pulmonary hypertension and congestive heart failure. With the continuing and exponential advances in technology, echocardiography is well poised to become the primary modality to evaluate the RV.
Topics: Biomechanical Phenomena; Echocardiography, Doppler; Echocardiography, Three-Dimensional; Heart Ventricles; Humans; Predictive Value of Tests; Prognosis; Risk Factors; Stress, Mechanical; Ventricular Dysfunction, Right; Ventricular Function, Right
PubMed: 28295398
DOI: 10.1002/clc.22694 -
Heart Failure Clinics Jul 2018The right ventricle plays a major role in congenital heart disease. This article describes the right ventricular mechanics in some selected congenital heart diseases... (Review)
Review
The right ventricle plays a major role in congenital heart disease. This article describes the right ventricular mechanics in some selected congenital heart diseases affecting the right ventricle in different ways: tetralogy of Fallot, Ebstein anomaly, and the systemic right ventricle.
Topics: Echocardiography; Heart Defects, Congenital; Heart Ventricles; Humans; Magnetic Resonance Imaging, Cine; Pulmonary Circulation; Ventricular Dysfunction, Right
PubMed: 29966627
DOI: 10.1016/j.hfc.2018.02.005 -
American Journal of Physiology. Heart... Dec 2018The Fontan procedure, which creates a total cavopulmonary anastomosis and represents the final stage of palliation for hypoplastic left heart syndrome, generates a... (Review)
Review
The Fontan procedure, which creates a total cavopulmonary anastomosis and represents the final stage of palliation for hypoplastic left heart syndrome, generates a unique circulation relying on a functionally single right ventricle (RV). The RV pumps blood in series around the systemic and pulmonary circulation, which requires adaptations to the abnormal volume and pressure loads. Here, we provide a complete review of RV adaptations as the RV assumes the role of the systemic ventricle, the progression of RV dysfunction to a distinct pattern of heart failure unique to this disease process, and the assessment and management strategies used to protect and rehabilitate the failing RV of Fontan circulation.
Topics: Adaptation, Physiological; Fontan Procedure; Heart Ventricles; Hemodynamics; Humans; Postoperative Complications
PubMed: 30239235
DOI: 10.1152/ajpheart.00336.2018 -
Postgraduate Medical Journal Aug 2020Anatomical complexities coupled with a protracted subclinical disease course, particularly in the early stages, makes the right ventricle (RV) the less studied entity... (Review)
Review
Anatomical complexities coupled with a protracted subclinical disease course, particularly in the early stages, makes the right ventricle (RV) the less studied entity when compared with the left. RV failure is an important predictor of survival in patients with cardiovascular disease. Technological advances have made it possible to visualise and characterise a variety of diseases that affect the RV. This review article will give a broad overview of the main RV pathology to general radiologists in particular those that manifest in adulthood. Congenital heart disease is a vast topic that is beyond the scope of this paper.
Topics: Adult; Heart Ventricles; Humans; Magnetic Resonance Imaging; Tomography, X-Ray Computed; Ventricular Dysfunction, Right; Ventricular Function, Right
PubMed: 32184259
DOI: 10.1136/postgradmedj-2019-137220 -
Cardiovascular Research Oct 2017
Topics: Animals; Cardiovascular Diseases; Heart Ventricles; Hemodynamics; Humans; Ventricular Function, Right; Ventricular Remodeling
PubMed: 28957539
DOI: 10.1093/cvr/cvx168 -
Trends in Cardiovascular Medicine Nov 2021
Topics: Cardiomyopathies; Echocardiography; Heart Ventricles; Humans
PubMed: 33129974
DOI: 10.1016/j.tcm.2020.10.009