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The Canadian Journal of Cardiology Jul 2021
Topics: Heart Ventricles; Humans; Tricuspid Valve; Tricuspid Valve Insufficiency; Ventricular Function, Right
PubMed: 33845137
DOI: 10.1016/j.cjca.2021.04.001 -
JACC. Clinical Electrophysiology Jan 2023
Topics: Humans; Tachycardia, Ventricular; Heart Ventricles; Arrhythmias, Cardiac
PubMed: 36697198
DOI: 10.1016/j.jacep.2022.10.020 -
Romanian Journal of Morphology and... 2022Isolated right ventricle hypoplasia (IRVH) is a disease characterized by an underdeveloped right ventricle. It is a congenital heart disease than can associate...
Isolated right ventricle hypoplasia (IRVH) is a disease characterized by an underdeveloped right ventricle. It is a congenital heart disease than can associate heterogeneous structural defects and nonspecific clinical features, which can often present a challenging therapeutic management. In this article, there are presented diagnostic methods and treatment options for right ventricle hypoplasia (RVH) according to clinical features, patients age and associated structural heart defects. RVH has a different prognosis in accordance with the severity of the heart defects and the patient's age at which the diagnosis is established. Thus, isolated forms of RVH generally present mild structural and functional defects that can be associated with the onset of symptoms in adolescence or even in adulthood. In these cases, atrial septal defect closure with or without superior cavo-pulmonary anastomosis can be the only procedures needed to correct the hemodynamic abnormalities and relief the symptomatology. Patients with severe form of RVH associated with complex cardiac malformations and onset of the symptoms in the neonatal period require prompt intervention and necessitate palliative procedures. In the long term, these patients could need multiple reinterventions. The family physician should be aware of the cardiac origin of isolated symptoms or clinical signs, such as exertional dyspnea or clubbing fingers, and send the patient for pediatric cardiological evaluation.
Topics: Adolescent; Adult; Anastomosis, Surgical; Child; Heart Defects, Congenital; Heart Septal Defects, Atrial; Heart Ventricles; Humans; Infant, Newborn
PubMed: 36074667
DOI: 10.47162/RJME.63.1.04 -
Physiological Reports Jan 2020Chronic hypoxia from diseases in the lung, such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, can increase pulmonary vascular...
Chronic hypoxia from diseases in the lung, such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, can increase pulmonary vascular resistance, resulting in hypertrophy and dysfunction of the right ventricle (RV). In order to obtain insight into RV biology and perhaps uncover potentially novel therapeutic approaches for RV dysfunction, we performed RNA-sequencing (RNA-seq) of RV and LV tissue from rats in normal ambient conditions or subjected to hypoxia (10% O ) for 2 weeks. Gene ontology and pathway analysis of the RV and LV revealed multiple transcriptomic differences, in particular increased expression in the RV of genes related to immune function in both normoxia and hypoxia. Immune cell profiling by flow cytometry of cardiac digests revealed that in both conditions, the RV had a larger percentage than the LV of double-positive CD45 /CD11b/c cells (which are predominantly macrophages and dendritic cells). Analysis of gene expression changes under hypoxic conditions identified multiple pathways that may contribute to hypoxia-induced changes in the RV, including increased expression of genes related to cell mitosis/proliferation and decreased expression of genes related to metabolic processes. Together, the findings indicate that the RV differs from the LV with respect to content of immune cells and expression of certain genes, thus suggesting the two ventricles differ in aspects of pathophysiology and in potential therapeutic targets for RV dysfunction.
Topics: Animals; Dendritic Cells; Heart Ventricles; Hypoxia; Macrophages; Male; Rats; Transcriptome
PubMed: 31960631
DOI: 10.14814/phy2.14344 -
Hellenic Journal of Cardiology : HJC =... 2021
Topics: Biomarkers; Cardiac Pacing, Artificial; Cardiomyopathies; Heart Ventricles; Humans
PubMed: 33188887
DOI: 10.1016/j.hjc.2020.11.004 -
European Journal of Cardio-thoracic... Aug 2022
Topics: Cardiac Surgical Procedures; Heart Ventricles; Heart-Assist Devices; Humans; Transposition of Great Vessels; Tricuspid Valve
PubMed: 35396989
DOI: 10.1093/ejcts/ezac240 -
Cardiology Journal 2016Pulmonary valve insufficiency may develop after surgical treatment of tetralogy of Fallot (ToF). Severe pulmonary valve insufficiency may result in right ventricular...
BACKGROUND
Pulmonary valve insufficiency may develop after surgical treatment of tetralogy of Fallot (ToF). Severe pulmonary valve insufficiency may result in right ventricular dysfunction. We aimed to compare cardiac magnetic resonance (CMR), with echocardiography.
METHODS
Patients who developed severe pulmonary valve insufficiency after total correction for ToF, were included in the study. CMR was used to measure end-diastolic, end-systolic volumes and ejection fraction of the right ventricle before and 6 months after replacement, and echocar-diographic strain imaging was obtained before, and 1, 3, and 6 months after replacement.
RESULTS
There were significant differences between pre- and post-replacement QRS durations, and right ventricle end-diastolic and end-systolic volumes measured with CMR (p < 0.05). However, right ventricular ejection fraction (RVEF) did not change. Therefore, CMR determined that right ventricle size and volume increased, and right ventricular function deteriorated before replacement. After replacement, no significant improvement was seen in RVEF. Lower-than-normal right ventricle strain and strain rate before replacement indicated that healthy and dysfunctional myocardium could be differentiated by this method. Pre-replacement strain and strain rate of asymptomatic and symptomatic patients were similar. Strain and strain rate values increased 6 months after replacement (p < 0.05).
CONCLUSIONS
We suppose that increased experience with strain imaging, and further studies on a larger patient group with a longer follow-up period would show that this method is quite advantageous, and it will take its place in the literature as a non-invasive technique that may be used instead of magnetic resonance.
Topics: Adolescent; Child; Echocardiography; Female; Heart Valve Prosthesis Implantation; Heart Ventricles; Humans; Magnetic Resonance Imaging, Cine; Male; Prognosis; Pulmonary Valve; Pulmonary Valve Insufficiency; Ventricular Dysfunction, Right; Ventricular Function, Right; Young Adult
PubMed: 26779972
DOI: 10.5603/CJ.a2016.0007 -
JACC. Heart Failure Nov 2018In the last decade, there has been renewed interest in the study of the right ventricle. It is now well established that right ventricular function is a strong predictor... (Review)
Review
In the last decade, there has been renewed interest in the study of the right ventricle. It is now well established that right ventricular function is a strong predictor of mortality, not only in heart failure but also in pulmonary hypertension, congenital heart disease, and cardiothoracic surgery. The right ventricle is part of a cardiopulmonary unit with connections to the pulmonary circulation, venous return, atria, and left ventricle. In this context, ventriculoarterial coupling, interventricular interactions, and pericardial constraint become important to understand right ventricular adaptation to injury or abnormal loading conditions. This state-of-the-art review summarizes major advances that occurred in the field of right ventricular research over the last decade. The first section focuses on right ventricular physiology and pulmonary circulation. The second section discusses the emerging data on right ventricular phenotyping, highlighting the importance of myocardial deformation (strain) imaging and assessment of end-systolic dimensions. The third section reviews recent clinical trials involving patients at risk for or with established right ventricular failure, focusing on beta blockade, phosphodiesterase inhibition, and mechanical support of the failing right heart. The final section presents a perspective on active areas of research that are most likely to translate in clinical practice in the next decade.
Topics: Cardiovascular Diseases; Heart Ventricles; Humans; Ventricular Function, Right
PubMed: 30316939
DOI: 10.1016/j.jchf.2018.05.022 -
Annals of Cardiac Anaesthesia Oct 2016The left ventricle, with its thickened myocardial walls, unlike the right ventricle has no measurable geometric shape. It has a conical apex and its function... (Review)
Review
The left ventricle, with its thickened myocardial walls, unlike the right ventricle has no measurable geometric shape. It has a conical apex and its function quantification, needs intensive, 2D, 3D and M mode transesophageal echocardiography, which is described in this review.
Topics: Echocardiography, Transesophageal; Heart Ventricles; Humans; Ventricular Dysfunction, Left; Ventricular Function, Left
PubMed: 27762246
DOI: 10.4103/0971-9784.192617 -
JACC. Cardiovascular Imaging Oct 2023Right ventricular perforation is a catastrophic complication of catheter-based intracardiac interventions. In this context, appreciation of 5 attachments of the right...
Right ventricular perforation is a catastrophic complication of catheter-based intracardiac interventions. In this context, appreciation of 5 attachments of the right ventricle to the aortoventricular unit is essential to recognize extent of right ventricular free wall. We herein present progressive dissection and virtual and photographic endoscopic images of the hearts without distortion. Real dissection images show us how and where to avoid this complication by indicating the true muscular component of the ventricular septum. Both virtual and photographic endoscopic images, when combined with transillumination, beautifully shows the thin wall regions and trabeculations with unprecedented clarity. We believe recognition of these anatomical nuances can reduce the likelihood of right ventricular perforation.
Topics: Humans; Heart Ventricles; Predictive Value of Tests; Ventricular Septum; Diagnostic Imaging; Heart Injuries
PubMed: 37656118
DOI: 10.1016/j.jcmg.2023.06.026