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The Journal of Neuroscience : the... Jan 2018We examine whether peripheral information at a planned saccade target affects immediate postsaccadic processing at the fovea on saccade landing. Current neuroimaging...
We examine whether peripheral information at a planned saccade target affects immediate postsaccadic processing at the fovea on saccade landing. Current neuroimaging research suggests that presaccadic stimulation has a late effect on postsaccadic processing, in contrast to the early effect seen in behavioral studies. Human participants (both male and female) were instructed to saccade toward a face or a house that, on different trials, remained the same, changed, or disappeared during the saccade. We used a multivariate pattern analysis of electroencephalography data to decode face versus house processing directly after the saccade. The classifier was trained on separate trials without a saccade, where a house or face was presented at the fovea. When the saccade target remained the same across the saccade, we could reliably decode the target 123 ms after saccade offset. In contrast, when the target was changed during the saccade, the new target was decoded at a later time-point, 151 ms after saccade offset. The "same" condition advantage suggests that congruent presaccadic information facilitates processing of the postsaccadic stimulus compared with incongruent information. Finally, the saccade target could be decoded above chance even when it had been removed during the saccade, albeit with a slower time course (162 ms) and poorer signal strength. These findings indicate that information about the (peripheral) presaccadic stimulus is transferred across the saccade so that it becomes quickly available and influences processing at its expected new retinal position (the fovea). Here we provide neural evidence for early information transfer across saccades. Specifically, we examined the effect of presaccadic sensory information on the initial neuronal processing of a postsaccadic stimuli. Using electroencephalography and multivariate pattern analysis, we found the following: (1) that the identity of the presaccadic stimulus modulated the postsaccadic latency of stimulus relevant information; and (2) that a saccadic neural marker for a saccade target stimulus could be detected even when the stimulus had been removed during saccade. These results demonstrate that information about the peripheral presaccadic stimulus was transferred across the saccade and influenced processing at a new retinal position (the fovea) directly after the saccade landed.
Topics: Adult; Electroencephalography; Face; Female; Fixation, Ocular; Humans; Male; Memory; Neuroimaging; Photic Stimulation; Retina; Saccades; Visual Perception; Young Adult
PubMed: 29263239
DOI: 10.1523/JNEUROSCI.0854-17.2017 -
Progress in Brain Research 2022This chapter describes the metrics and kinematics of saccades and quick phases of nystagmus, including microsaccades and large eye-head saccades. Small saccades often...
This chapter describes the metrics and kinematics of saccades and quick phases of nystagmus, including microsaccades and large eye-head saccades. Small saccades often display dynamic overshoot, predominantly in the abducting eye. Although the function of these overshoots is unclear, the return movement is saccadic in nature. The saccade kinematics can be quantified by stereotyped relations between amplitude, duration, peak eye velocity, and peak acceleration, which vary somewhat with the initial eye position and saccade direction (centripetal vs centrifugal), possibly due to ocular plant characteristics. Saccades in a structured light environment are considerably faster than when executed in total darkness, although the origin for this facilitation is not known. The horizontal and vertical components of slant saccades are coupled, approximately matching their durations, for which possible underlying neural mechanisms are discussed. The chapter closes with a cross-species comparison of saccade characteristics.
Topics: Biomechanical Phenomena; Humans; Movement; Nystagmus, Pathologic; Saccades; Sleep, REM
PubMed: 35074058
DOI: 10.1016/bs.pbr.2021.10.013 -
Experimental Brain Research Apr 2019Saccadic eye movements move the high-resolution fovea to point at regions of interest. Saccades can only be generated serially (i.e., one at a time). However, what... (Review)
Review
Saccadic eye movements move the high-resolution fovea to point at regions of interest. Saccades can only be generated serially (i.e., one at a time). However, what remains unclear is the extent to which saccades are programmed in parallel (i.e., a series of such moments can be planned together) and how far ahead such planning occurs. In the current experiment, we investigate this issue with a saccade contingent preview paradigm. Participants were asked to execute saccadic eye movements in response to seven small circles presented on a screen. The extent to which participants were given prior information about target locations was varied on a trial-by-trial basis: participants were aware of the location of the next target only, the next three, five, or all seven targets. The addition of new targets to the display was made during the saccade to the next target in the sequence. The overall time taken to complete the sequence was decreased as more targets were available up to all seven targets. This was a result of a reduction in the number of saccades being executed and a reduction in their saccade latencies. Surprisingly, these results suggest that, when faced with a demand to saccade to a large number of target locations, saccade preparation about all target locations is carried out in parallel.
Topics: Adolescent; Adult; Eye Movement Measurements; Female; Humans; Male; Pattern Recognition, Visual; Saccades; Space Perception; Young Adult
PubMed: 30725153
DOI: 10.1007/s00221-019-05481-7 -
Journal of Vision Aug 2016Static visual stimuli are smeared across the retina during saccades, but in normal conditions this smear is not perceived. Instead, we perceive the visual scene as... (Review)
Review
Static visual stimuli are smeared across the retina during saccades, but in normal conditions this smear is not perceived. Instead, we perceive the visual scene as static and sharp. However, retinal smear is perceived if stimuli are shown only intrasaccadically, but not if the stimulus is additionally shown before a saccade begins, or after the saccade ends (Campbell & Wurtz, 1978). This inhibition has been compared to forward and backward metacontrast masking, but with spatial relations between stimulus and mask that are different from ordinary metacontrast during fixation. Previous studies of smear masking have used subjective measures of smear perception. Here we develop a new, objective technique for measuring smear masking, based on the spatial localization of a gap in the smear created by very quickly blanking the stimulus at various points during the saccade. We apply this technique to show that smear masking survives dichoptic presentation (suggesting that it is therefore cortical in origin), as well as separations of as much as 6° between smear and mask.
Topics: Humans; Perceptual Masking; Retina; Saccades; Visual Perception
PubMed: 27479918
DOI: 10.1167/16.10.1 -
Journal of Neurophysiology Mar 2021The planning and execution of sequential saccades can overlap in time, and abrupt changes in neural activity in the oculomotor system can alter the normal trajectory of...
The planning and execution of sequential saccades can overlap in time, and abrupt changes in neural activity in the oculomotor system can alter the normal trajectory of saccades. In this study, we analyzed saccade trajectories to assess the combined programming of sequential saccades. In two separate psychophysical experiments, subjects were instructed to make a sequence of two saccades. The results showed modulation of saccade curvature by the direction and amplitude of both the preceding and following saccade: saccade curvature is modulated in the direction of preceding saccades and away from the direction of following saccades. Moreover, larger preceding and following saccades have stronger effects on curvature. These results support the idea that sequential saccades are programmed concurrently. Finally, the amount of saccade curvature is correlated with the deviation of saccade start and end points, and the time of maximum deviation of saccade trajectories is highly consistent in both experiments. Based on this, we propose a novel benefit for the modulation of saccade trajectories by the oculomotor system: minimizing the saccadic error in sequential saccades. We show that in saccade sequences, saccade trajectory is modulated in the direction of the preceding saccade and away from the following saccade. The magnitude of this effect is correlated with preceding and following saccade amplitude. This confirms that programming of sequential saccades overlaps. Curvature is also correlated with the deviation of saccade start and end points. Thus, we propose a novel benefit for the modulation of saccade trajectories: minimizing end point error in sequential saccades.
Topics: Adult; Female; Humans; Male; Orientation; Photic Stimulation; Reaction Time; Saccades
PubMed: 33471606
DOI: 10.1152/jn.00106.2020 -
Clinical Neurophysiology : Official... Oct 2021We clarified the clinical and mechanistic significance of physiological modulations of high-frequency broadband cortical activity associated with spontaneous saccadic...
OBJECTIVE
We clarified the clinical and mechanistic significance of physiological modulations of high-frequency broadband cortical activity associated with spontaneous saccadic eye movements during a resting state.
METHODS
We studied 30 patients who underwent epilepsy surgery following extraoperative electrocorticography and electrooculography recordings. We determined whether high-gamma activity at 70-110 Hz preceding saccade onset would predict upcoming ocular behaviors. We assessed how accurately the model incorporating saccade-related high-gamma modulations would localize the primary visual cortex defined by electrical stimulation.
RESULTS
The dynamic atlas demonstrated transient high-gamma suppression in the striatal cortex before saccade onset and high-gamma augmentation subsequently involving the widespread posterior brain regions. More intense striatal high-gamma suppression predicted the upcoming saccade directed to the ipsilateral side and lasting longer in duration. The bagged-tree-ensemble model demonstrated that intense saccade-related high-gamma modulations localized the visual cortex with an accuracy of 95%.
CONCLUSIONS
We successfully animated the neural dynamics supporting saccadic suppression, a principal mechanism minimizing the perception of blurred vision during rapid eye movements. The primary visual cortex per se may prepare actively in advance for massive image motion expected during upcoming prolonged saccades.
SIGNIFICANCE
Measuring saccade-related electrocorticographic signals may help localize the visual cortex and avoid misperceiving physiological high-frequency activity as epileptogenic.
Topics: Adolescent; Child; Child, Preschool; Drug Resistant Epilepsy; Electrocorticography; Female; Gamma Rhythm; Humans; Male; Saccades; Visual Cortex; Young Adult
PubMed: 34454266
DOI: 10.1016/j.clinph.2021.06.020 -
Journal of Neurophysiology Jun 2019The neuronal substrate underlying the learning of a sophisticated task has been difficult to study. However, the advent of a behavioral paradigm that deceives the... (Review)
Review
The neuronal substrate underlying the learning of a sophisticated task has been difficult to study. However, the advent of a behavioral paradigm that deceives the saccadic system into thinking it is making an error has allowed the mechanisms of the adaptation that corrects this error to be revealed in a primate. The neural elements that fashion the command signal for the generation of accurate saccades involve subcortical structures in the brain stem and cerebellum. In this review we show that sites in both those structures also are involved with the gradual adaptation of saccade size, a form of motor learning. Pharmacological manipulation of the oculomotor vermis (lobules VIc and VII) impairs mechanisms that either increase or decrease saccade size during adaptation. The net saccade-related simple spike (SS) activity of its Purkinje cells is correlated with the changes in saccade characteristics that occur during adaptation. These changes in SS activity are driven by an error signal delivered over climbing fibers, which create complex spikes whose probability of occurrence reflects the motor error between the actual and desired saccade size. These climbing fibers originate in the part of the inferior olive that receives projections from the superior colliculus (SC). Disabling the SC prevents adaptation and stimulation of the SC just after a normal saccade produces a surrogate error signal that drives adaptation without an actual visual error. Therefore, the SC provides not only the initial command that generates a saccade, as shown by others, but also the error signal that ensures that saccades remain accurate.
Topics: Adaptation, Physiological; Animals; Cerebellum; Humans; Learning; Motor Activity; Saccades; Superior Colliculi
PubMed: 30995136
DOI: 10.1152/jn.00781.2018 -
Vision Research Jan 2018With every saccade, humans must reconcile the low resolution peripheral information available before a saccade, with the high resolution foveal information acquired...
With every saccade, humans must reconcile the low resolution peripheral information available before a saccade, with the high resolution foveal information acquired after the saccade. While research has shown that we are able to integrate peripheral and foveal vision in a near-optimal manner, it is still unclear which mechanisms may underpin this important perceptual process. One potential mechanism that may moderate this integration process is visual attention. Pre-saccadic attention is a well documented phenomenon, whereby visual attention shifts to the location of an upcoming saccade before the saccade is executed. While it plays an important role in other peri-saccadic processes such as predictive remapping, the role of attention in the integration process is as yet unknown. This study aimed to determine whether the presentation of an attentional distractor during a saccade impaired trans-saccadic integration, and to measure the time-course of this impairment. Results showed that presenting an attentional distractor impaired integration performance both before saccade onset, and during the saccade, in selected subjects who showed integration in the absence of a distractor. This suggests that visual attention may be a mechanism that facilitates trans-saccadic integration.
Topics: Adult; Attention; Discrimination, Psychological; Female; Humans; Male; Photic Stimulation; Saccades; Visual Perception; Young Adult
PubMed: 29183779
DOI: 10.1016/j.visres.2017.11.006 -
Current Topics in Behavioral... 2019Several times per second, humans make rapid eye movements called saccades which redirect their gaze to sample new regions of external space. Saccades present unique... (Review)
Review
Several times per second, humans make rapid eye movements called saccades which redirect their gaze to sample new regions of external space. Saccades present unique challenges to both perceptual and motor systems. During the movement, the visual input is smeared across the retina and severely degraded. Once completed, the projection of the world onto the retina has undergone a large-scale spatial transformation. The vector of this transformation, and the new orientation of the eye in the external world, is uncertain. Memory for the pre-saccadic visual input is thought to play a central role in compensating for the disruption caused by saccades. Here, we review evidence that memory contributes to (1) detecting and identifying changes in the world that occur during a saccade, (2) bridging the gap in input so that visual processing does not have to start anew, and (3) correcting saccade errors and recalibrating the oculomotor system to ensure accuracy of future saccades. We argue that visual working memory (VWM) is the most likely candidate system to underlie these behaviours and assess the consequences of VWM's strict resource limitations for transsaccadic processing. We conclude that a full understanding of these processes will require progress on broader unsolved problems in psychology and neuroscience, in particular how the brain solves the object correspondence problem, to what extent prior beliefs influence visual perception, and how disparate signals arriving with different delays are integrated.
Topics: Brain; Humans; Memory, Short-Term; Saccades; Visual Perception
PubMed: 30523616
DOI: 10.1007/7854_2018_66 -
Journal of Neurophysiology Jul 2024Temporal intervals appear compressed at the time of saccades. Here, I asked if saccadic compression of time is related to motor planning or to saccade execution. To...
Temporal intervals appear compressed at the time of saccades. Here, I asked if saccadic compression of time is related to motor planning or to saccade execution. To dissociate saccade motor planning from its execution, I used the double-step paradigm, in which subjects have to perform two horizontal saccades successively. At various times around the saccade sequence, I presented two large horizontal bars, which marked an interval lasting 100 ms. After 700 ms, a second temporal interval was presented, varying in duration across trials. Subjects were required to judge which interval appeared shorter. I found that during the first saccades in the double-step paradigm, temporal intervals were compressed. Maximum temporal compression coincided with saccade onset. Around the time of the second saccade, I found temporal compression as well, however, the time of maximum compression preceded saccade onset by about 70 ms. I compared the magnitude and time of temporal compression between double-step saccades and amplitude-matched single saccades, which I measured separately. Although I found no difference in time compression magnitude, the time when maximum compression occurred differed significantly. I conclude that the temporal shift of time compression in double-step saccades demonstrates the influence of saccade motor planning on time perception. Visually defined temporal intervals appear compressed at the time of saccades. Here, I tested time perception during double-step saccades dissociating saccade planning from execution. Although around the time of the first saccade, peak compression was found at saccade onset, compression around the time of the second saccade peaked 70 ms before saccade onset. The results suggest that saccade motor planning influences time perception.
Topics: Saccades; Humans; Male; Adult; Female; Time Perception; Young Adult; Psychomotor Performance
PubMed: 38810256
DOI: 10.1152/jn.00117.2024