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Heliyon Apr 2019Cobalt (Co(II)) and copper (Cu(II)) complexes of sulfamerazine-salicylaldehyde (SS) ligand intercalated Mg/Al-layered double hydroxide [Co-SS-LDH/Cu-SS-LDH] were...
Cobalt (Co(II)) and copper (Cu(II)) complexes of sulfamerazine-salicylaldehyde (SS) ligand intercalated Mg/Al-layered double hydroxide [Co-SS-LDH/Cu-SS-LDH] were prepared for the antimicrobial application. Sulfamerazine and salicylaldehyde were mixed together and dissolved in methanol for the synthesis of SS ligand and modified further by the complexation with Co(II) and Cu(II) metal ions [Co-SS/Cu-SS]. The delaminating/restacking method was used to intercalate the Mg/Al-NO-LDH with the metal complexed ligands (Co-SS/Cu-SS). The obtained materials were analyzed using different characterization techniques to prove their successful synthesis and preparation. The antibacterial activity of the synthesized Co-SS-LDH/Cu-SS-LDH were checked by the inhibition zone method. The prepared hybrid materials showed good antimicrobial activity against both gram negative () and gram positive () bacteria.
PubMed: 31049432
DOI: 10.1016/j.heliyon.2019.e01521 -
Environmental Technology Jul 2024Natural organic matter (NOM) can impede the removal of organic micro-pollutants (OMPs) through several mechanisms, including inner filter effect, competition with the...
Natural organic matter (NOM) can impede the removal of organic micro-pollutants (OMPs) through several mechanisms, including inner filter effect, competition with the target OMP, and radical scavenging, during synchronous adsorption/photocatalysis of multi-functional composites. In this study, the fate and inhibitory mechanisms of sulfamerazine (SMZ, a model OMP) that occurred in presence of seven different NOM samples (i.e. three standard NOM surrogates, a river water sample, a carbon filter effluent and two different sand filter effluents) during the adsorption/photocatalysis by a composite of BiO-TiO supported on powdered activated carbon (BiO-TiO/PAC, abbreviated as BTP) when exposed to visible light irradiation were revealed. The results indicated that adsorption played a greater attribution than photocatalysis on SMZ removal. The primary impediment to the adsorption and photocatalytic degradation of SMZ was attributed to the presence of terrestrial-derived, humic-like NOM fractions with high aromaticity. The adsorption efficacy of SMZ was weakened by the absorption of NOM and its degradation products onto the BTP surface. The inner filter effect, competition between NOM and SMZ, and radical scavenging were responsible for the reduced photocatalysis of SMZ. In the cases of real water matrices, the presence of inorganic anion and co-existed NOM reduced the removal of SMZ. In summary, the findings of this work offer a comprehensive comprehension of the impact of NOM fractions on photocatalysis, emphasizing the necessity to examine the interplay between NOM and background inorganic constituents in the degradation of OMP via adsorption/photocatalysis.
Topics: Adsorption; Water Pollutants, Chemical; Sulfamerazine; Humic Substances; Titanium; Bismuth; Catalysis; Water Purification; Light; Charcoal
PubMed: 37337954
DOI: 10.1080/09593330.2023.2224065 -
Environmental Pollution (Barking, Essex... Jan 2023Various hydrogen bonds, especially charge-assisted hydrogen bond (CAHB), is considered as one of vital mechanisms affecting the environmental behavior and risk of...
Various hydrogen bonds, especially charge-assisted hydrogen bond (CAHB), is considered as one of vital mechanisms affecting the environmental behavior and risk of pharmaceutical contaminants (PCs). Herein the sorption/desorption of three PCs including clofibric acid (CA), acetaminophen (ACT), and sulfamerazine (SMZ) on three Oxygen-rich (O-rich) nanoparticles (nano-silica: Nano-SiO, nano-alumina: Nano-AlO, and oxidized carbon nanotubes: O-CNTs) were investigated to explore the effect of various hydrogen bonds with different strengths on environmental behaviors of PCs. The results indicated that although solvent-assisted CAHB, solvent-uninvolved CAHB, and ordinary hydrogen bond (OHB) all played a crucial role in sorption of PCs on three O-rich nanomaterials, they showed significantly different effects on the desorption behaviors of PCs from three sorbents. Compared with OHB (hysteresis index ≤0.0766), the stronger CAHB (hysteresis index ≥0.1981) between PCs and O-rich nanoparticles having comparable pK with PCs, caused obvious desorption hysteresis of PCs, resulting in their better immobilization on O-rich nanomaterials. The FTIR characterization found that both solvent-assisted and solvent-uninvolved CAHB formation resulted in a new characteristic peak appeared in the high frequency (3660 cm for Nano-SiO, 3730 cm for Nano-AlO, and 3780 cm for O-CNTs). Also, density functional theory (DFT) calculation verified that the smaller |ΔpK| between PCs and O-rich sorbents, the shorter bond length, and the larger bond angle resulted in the stronger hydrogen bond formed, thereby leading to the greater immobilization of PCs. These results provide in-depth understanding of the environmental behavior and risk of PCs, and light new idea for designed materials to control PCs pollution in the environment.
Topics: Hydrogen Bonding; Adsorption; Nanotubes, Carbon; Oxygen; Silicon Dioxide; Solvents; Pharmaceutical Preparations
PubMed: 36335784
DOI: 10.1016/j.envpol.2022.120572 -
Journal of Enzyme Inhibition and... Dec 2020Carbonic anhydrases (CAs) are metalloenzymes responsible for the reversible hydration of carbon dioxide to bicarbonate, a fundamental reaction involved in various...
Carbonic anhydrases (CAs) are metalloenzymes responsible for the reversible hydration of carbon dioxide to bicarbonate, a fundamental reaction involved in various physiological and pathological processes. In the last decades, CAs have been considered as important drug targets for different pathologies such as glaucoma, epilepsy and cancer. The design of potent and selective inhibitors has been an outstanding goal leading to the discovery of new drugs. Among the different strategies developed to date, the design of carbohydrate-based CA inhibitors (CAIs) has emerged as a versatile tool in order to selectively target CAs. The insertion of a glycosyl moiety as a hydrophilic tail in sulfonamide, sulfenamide, sulfamate or coumarin scaffolds allowed the discovery of many different series of sugar-based CAIs, with relevant inhibitory results. This review will focus on carbohydrate-based CAIs developed so far, classifying them in glycosidic and glycoconjugated inhibitors based on the conjugation chemistry adopted.
Topics: Binding Sites; Carbohydrates; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Coumarins; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Protein Binding; Structure-Activity Relationship; Sulfamerazine; Sulfonamides; Sulfonic Acids; Triazoles
PubMed: 33078634
DOI: 10.1080/14756366.2020.1825409 -
Water Science and Technology : a... Sep 2021Ozone, UV/ozone, ozone/persulfate (PS) and UV/ozone/PS systems were used to mineralize sulfonamides. Sulfadiazine (SDZ), sulfamerazine (SMR) and sulfamethazine (SMZ)...
Ozone, UV/ozone, ozone/persulfate (PS) and UV/ozone/PS systems were used to mineralize sulfonamides. Sulfadiazine (SDZ), sulfamerazine (SMR) and sulfamethazine (SMZ) were the target compounds. The novel contribution of this study is its determination of the effects of PS addition, sulfonamide structure, pH and salinity on sulfonamide mineralization in ozone-based systems. The mineralization rate of sulfonamides satisfied pseudo-first-order kinetics. The SMZ mineralization rate constant in ozone, UV/ozone, ozone/PS and UV/ozone/PS systems at pH 5 were 0.0058; 0.0101; 0.0069 and 0.0802 min, respectively, and those at pH 7 were 0.0075; 0.0116; 0.0083 and 0.0873 min, respectively. The increase in the number of methyl substituents in the heterocyclic group of SMZ and the corresponding increase in the steric hindrance of radical addition, reduced mineralization rates below those of SMR and SDZ. The addition of PS promoted sulfonamide mineralization in the ozone-based systems; conversely, salinity inhibited sulfonamide mineralization.
Topics: Ozone; Sulfadiazine; Sulfonamides; Wastewater; Water Pollutants, Chemical
PubMed: 34559073
DOI: 10.2166/wst.2021.325 -
Journal of Pharmaceutical and... Nov 2014This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin... (Comparative Study)
Comparative Study
This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. The combination of MEG with MβCD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MβCD or HPβCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallography, X-Ray; Delayed-Action Preparations; Freeze Drying; Kinetics; Magnetic Resonance Spectroscopy; Meglumine; Powder Diffraction; Solubility; Spectroscopy, Fourier Transform Infrared; Sulfamerazine; Technology, Pharmaceutical; Thermogravimetry; beta-Cyclodextrins
PubMed: 25129645
DOI: 10.1016/j.jpba.2014.07.008 -
Environmental Research Sep 2022Heteroatom-doped carbon materials can effectively activate HO into •OH during the metal-free electro-Fenton (EF) process. However, information on bifunctional...
Heteroatom-doped carbon materials can effectively activate HO into •OH during the metal-free electro-Fenton (EF) process. However, information on bifunctional catalysts for the simultaneous generation and activation of HO is scarce. In this study, O- and F-doped porous carbon cathode materials (PPCs) were prepared by the direct carbonization of polyvinylidene fluoride (PVDF) for sulfamerazine (SMR) removal in a metal-free EF process. The porous structure and chemical composition of the PPCs were regulated by the carbonization temperature. PPC-6 (carbonized at 600 °C) exhibited optimal electrocatalytic performance in terms of electrochemical HO generation and activation owing to its high specific surface area, mesoporous structure, and optimum fractions of doped O and F. Excellent performance of the 2e oxygen reduction reaction was found with an HO selectivity of 93.5% and an average electron transfer number of 2.13. An HO accumulative concentration of 103.9 mg/L and an SMR removal efficiency of 90.1% were achieved during the metal-free EF process. PPC-6 was able to stably remove SMR over five consecutive cycles, retaining 92.6% of its original performance. Quantitative structure-activity relationship analysis revealed that doped oxygen functional groups contributed substantially to HO generation, and semi-ionic C-F bonds with high electronegativity were the cause of the activation of HO to •OH. These findings suggest that the PVDF-derived carbonaceous catalysts are feasible and desirable for metal-free EF processes.
Topics: Carbon; Fluorocarbon Polymers; Hydrogen Peroxide; Metals; Oxidation-Reduction; Oxygen; Polyvinyls; Porosity; Sulfamerazine; Water Pollutants, Chemical
PubMed: 35613635
DOI: 10.1016/j.envres.2022.113508 -
Molecules (Basel, Switzerland) Jun 2021Rapid chromatographic procedure for quantification of five sulfonamides in medicated feeds are proposed. Satisfactory separation of sulfonamides from medicated feeds was...
Rapid chromatographic procedure for quantification of five sulfonamides in medicated feeds are proposed. Satisfactory separation of sulfonamides from medicated feeds was achieved using a Zorbax Eclipse XDB C18 column (4.6 × 150 mm, 5 µm particle size) with a micellar mobile phase consisting of 0.05 M sodium dodecyl sulphate, 0.02 M phosphate buffer, and 6% propan--ol (pH 3). UV quantitation was set at 260 nm. The proposed procedure allows the determination of sulfaguanidine, sulfadiazine, sulfamerazine, sulfamethazine, and sulfamethoxazole in medicated feeds for pigs and poultry. Application of the proposed method to the analysis of five pharmaceuticals gave recoveries between 72.7% to 94.7% and coefficients of variations for repeatability and reproducibility between 2.9% to 9.8% respectively, in the range of 200 to 2000 mg/kg sulfonamides in feeds. Limit of detection and limit of quantification were 32.7-56.3 and 54.8-98.4 mg/kg, respectively, depending on the analyte. The proposed procedure for the quantification of sulfonamides is simple, rapid, sensitive, free from interferences and suitable for the routine control of feeds. In the world literature, we did not find the described method of quantitative determination of sulfonamides in medicated feeds with the use of micellar liquid chromatography.
Topics: Animal Feed; Animals; Micelles; Sulfonamides; Swine
PubMed: 34206391
DOI: 10.3390/molecules26133791 -
Ecotoxicology and Environmental Safety Jul 2019To evaluate the occurrence and ecological risk of organic contaminants in aquatic environment in China, a method for simultaneously detecting 130 pharmaceuticals and...
To evaluate the occurrence and ecological risk of organic contaminants in aquatic environment in China, a method for simultaneously detecting 130 pharmaceuticals and personal care products (PPCPs) and 35 pesticides has been established using solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry (SPE-UPLC-MS/MS) method. In the present survey, a total of 122 target compounds (103 PPCPs and 19 pesticides) were detected in seven major watersheds in China, with average concentrations ranged from 0.02 ng/L (sulfamerazine) to 332.75 ng/L (bisphenol A), revealing that PPCPs and pesticides were widely distributed in surface water of China. Antibiotics and organophosphorus were the most ubiquitously PPCPs and pesticides, respectively; quinolones were the predominant antibiotics, most of which were detected in more than 96% sampling sites, with average concentrations ranged from 2.14 to 309.67 ng/L; six pesticides including isoprocarb, fenobucarb, acetamiprid, imidacloprid, acetochlor and bentazone were detected in more than 80% sampling sites, with average concentrations ranged from 5.62 to 225.93 ng/L; more than half of the non-antibiotic pharmaceuticals were hormones; and diethyltoluamide (DEET) was predominant personal care products; The risk assessment showed that each watershed was at potential medium ecological risk based on their mean concentration (RQ > 1), and pesticides were the main compounds arising risks.
Topics: China; Chromatography, Liquid; Cosmetics; Environmental Monitoring; Fresh Water; Pesticides; Pharmaceutical Preparations; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical
PubMed: 30898333
DOI: 10.1016/j.ecoenv.2019.01.131 -
Pharmaceutics May 2022Several literature publications have described the potential application of active pharmaceutical ingredient (API)-polymer phase diagrams to identify appropriate...
Several literature publications have described the potential application of active pharmaceutical ingredient (API)-polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot-melt extrusion (HME) technique. However, systematic investigations and reliable applications of the phase diagram as a risk assessment tool for HME are non-existent. Accordingly, within AbbVie, an HME risk classification system (HCS) based on API-polymer phase diagrams has been developed as a material-sparing tool for the early risk assessment of especially high melting temperature APIs, which are typically considered unsuitable for HME. The essence of the HCS is to provide an API risk categorization framework for the development of ASDs via the HME process. The proposed classification system is based on the recognition that the manufacture of crystal-free ASD using the HME process fundamentally depends on the ability of the melt temperature to reach the API's thermodynamic solubility temperature or above. Furthermore, we explored the API-polymer phase diagram as a simple tool for process design space selection pertaining to API or polymer thermal degradation regions and glass transition temperature-related dissolution kinetics limitations. Application of the HCS was demonstrated via HME experiments with two high melting temperature APIs, sulfamerazine and telmisartan, with the polymers Copovidone and Soluplus. Analysis of the resulting ASDs in terms of the residual crystallinity and degradation showed excellent agreement with the preassigned HCS class. Within AbbVie, the HCS concept has been successfully applied to more than 60 different APIs over the last 8 years as a robust validated risk assessment and quality-by-design (QD) tool for the development of HME ASDs.
PubMed: 35631630
DOI: 10.3390/pharmaceutics14051044