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Nature Reviews. Disease Primers Jul 2018Vibrio is a genus of ubiquitous bacteria found in a wide variety of aquatic and marine habitats; of the >100 described Vibrio spp., ~12 cause infections in humans.... (Review)
Review
Vibrio is a genus of ubiquitous bacteria found in a wide variety of aquatic and marine habitats; of the >100 described Vibrio spp., ~12 cause infections in humans. Vibrio cholerae can cause cholera, a severe diarrhoeal disease that can be quickly fatal if untreated and is typically transmitted via contaminated water and person-to-person contact. Non-cholera Vibrio spp. (for example, Vibrio parahaemolyticus, Vibrio alginolyticus and Vibrio vulnificus) cause vibriosis - infections normally acquired through exposure to sea water or through consumption of raw or undercooked contaminated seafood. Non-cholera bacteria can lead to several clinical manifestations, most commonly mild, self-limiting gastroenteritis, with the exception of V. vulnificus, an opportunistic pathogen with a high mortality that causes wound infections that can rapidly lead to septicaemia. Treatment for Vibrio spp. infection largely depends on the causative pathogen: for example, rehydration therapy for V. cholerae infection and debridement of infected tissues for V. vulnificus-associated wound infections, with antibiotic therapy for severe cholera and systemic infections. Although cholera is preventable and effective oral cholera vaccines are available, outbreaks can be triggered by natural or man-made events that contaminate drinking water or compromise access to safe water and sanitation. The incidence of vibriosis is rising, perhaps owing in part to the spread of Vibrio spp. favoured by climate change and rising sea water temperature.
Topics: Anti-Bacterial Agents; Cholera; Cholera Vaccines; Fluid Therapy; Humans; Quality of Life; Trace Elements; Vibrio; Vibrio Infections; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; Zinc
PubMed: 30002421
DOI: 10.1038/s41572-018-0005-8 -
Food Microbiology Aug 2016Vibrio parahaemolyticus and Vibrio vulnificus are the leading causes of seafood associated infections and mortality in the United States. The main syndromes caused by... (Review)
Review
Vibrio parahaemolyticus and Vibrio vulnificus are the leading causes of seafood associated infections and mortality in the United States. The main syndromes caused by these pathogens are gastroenteritis, wound infections, and septicemia. This article reviewed the antibiotic resistance profile of V. parahaemolyticus and V. vulnificus in the United States and other countries including Italy, Brazil, Philippines, Malaysia, Thailand, China, India, Iran, South Africa and Australia. The awareness of antimicrobial resistance of these two pathogens is not as well documented as other foodborne bacterial pathogens. Vibrio spp. are usually susceptible to most antimicrobials of veterinary and human significance. However, many studies reported that V. vulnificus and V. parahaemolyticus showed multiple-antibiotic resistance due to misuse of antibiotics to control infections in aquaculture production. In addition, both environmental and clinical isolates showed similar antibiotic resistance profiles. Most frequently observed antibiotic resistance profiles involved ampicillin, penicillin and tetracycline regardless of the countries. The presence of multiple-antibiotic resistant bacteria in seafood and aquatic environments is a major concern in fish and shellfish farming and human health.
Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Food Contamination; Humans; Seafood; Vibrio Infections; Vibrio parahaemolyticus; Vibrio vulnificus
PubMed: 27052711
DOI: 10.1016/j.fm.2016.02.008 -
The New England Journal of Medicine Jul 2018
Topics: Aged; Amputation, Surgical; Humans; Male; Vibrio Infections; Vibrio vulnificus
PubMed: 30044934
DOI: 10.1056/NEJMicm1716464 -
Critical Reviews in Food Science and... 2019Seafood products are widely consumed all around the world and play a significant role on the economic market. Bacteria of the Vibrio genus can contaminate seafood and... (Review)
Review
Vibrio species involved in seafood-borne outbreaks (Vibrio cholerae, V. parahaemolyticus and V. vulnificus): Review of microbiological versus recent molecular detection methods in seafood products.
Seafood products are widely consumed all around the world and play a significant role on the economic market. Bacteria of the Vibrio genus can contaminate seafood and thus pose a risk to human health. Three main Vibrio species, V. cholerae, V. parahaemolyticus and V. vulnificus, are potentially pathogenic to humans. These species are responsible for a dramatic increase of seafood-borne infections worldwide. Hence, early detection of total and pathogenic Vibrio is needed and should rely on quick and effective methods. This review aims to present the standard methods FDA-BAM, ISO/TS 21872-1:2007 and TS 21872-2:2007 and compare them to recent molecular biology methods including endpoint PCR, quantitative real-time PCR (qPCR) and PCR-derived methods with a focus on LAMP (loop-mediated isothermal amplification). The available methods presented here are dedicated to the detection and identification of the Vibrio species of interest in seafood.
Topics: DNA, Bacterial; Disease Outbreaks; Food Microbiology; Foodborne Diseases; Humans; Polymerase Chain Reaction; Real-Time Polymerase Chain Reaction; Seafood; Vibrio; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus
PubMed: 28956623
DOI: 10.1080/10408398.2017.1384715 -
Trends in Microbiology Jan 2020
Topics: Foodborne Diseases; Gene Transfer, Horizontal; Genome, Bacterial; Hemorrhagic Septicemia; Humans; Phylogeny; Vibrio Infections; Vibrio vulnificus; Wound Infection
PubMed: 31519331
DOI: 10.1016/j.tim.2019.08.006 -
Advances in Experimental Medicine and... 2023V. vulnificus, continues being an underestimated yet lethal zoonotic pathogen. In this chapter, we provide a comprehensive review of numerous aspects of the biology,... (Review)
Review
V. vulnificus, continues being an underestimated yet lethal zoonotic pathogen. In this chapter, we provide a comprehensive review of numerous aspects of the biology, epidemiology, and virulence mechanisms of this poorly understood pathogen. We will emphasize the widespread role of horizontal gene transfer in V. vulnificus specifically virulence plasmids and draw parallels from aquaculture farms to human health. By placing current findings in the context of climate change, we will also contend that fish farms act as evolutionary drivers that accelerate species evolution and the emergence of new virulent groups. Overall, we suggest that on-farm control measures should be adopted both to protect animals from Vibriosis, and also as a public health measure to prevent the emergence of new zoonotic groups.
Topics: Humans; Animals; Vibrio vulnificus; Vibrio Infections; Aquaculture; Gene Transfer, Horizontal; Virulence
PubMed: 36792876
DOI: 10.1007/978-3-031-22997-8_9 -
Future Microbiology Apr 2023is a fatal, opportunistic human pathogen transmitted through the consumption of raw/undercooked seafood or direct contact. infection progresses rapidly and has severe... (Review)
Review
is a fatal, opportunistic human pathogen transmitted through the consumption of raw/undercooked seafood or direct contact. infection progresses rapidly and has severe consequences; some cases may require amputation or result in death. Growing evidence suggests that virulence factors and regulators play a large role in disease progression, involving host resistance, cellular damage, iron acquisition, virulence regulation and host immune responses. Its disease mechanism remains largely undefined. Further evaluation of pathogenic mechanisms is important for selecting appropriate measures to prevent and treat infection. In this review, the possible pathogenesis of infection is described to provide a reference for treatment and prevention.
Topics: Humans; Vibrio Infections; Vibrio vulnificus; Virulence; Virulence Factors
PubMed: 37158065
DOI: 10.2217/fmb-2022-0243 -
Marine Drugs Dec 2021is a Gram-negative pathogenic bacterium that causes serious infections in humans and requires iron for growth. A clinical isolate, . M2799, secretes a catecholate... (Review)
Review
is a Gram-negative pathogenic bacterium that causes serious infections in humans and requires iron for growth. A clinical isolate, . M2799, secretes a catecholate siderophore, vulnibactin, that captures ferric ions from the environment. In the ferric-utilization system in . M2799, an isochorismate synthase (ICS) and an outer membrane receptor, VuuA, are required under low-iron conditions, but alternative proteins FatB and VuuB can function as a periplasmic-binding protein and a ferric-chelate reductase, respectively. The vulnibactin-export system is assembled from TolCV1 and several RND proteins, including VV1_1681. In heme acquisition, HupA and HvtA serve as specific outer membrane receptors and HupB is a sole periplasmic-binding protein, unlike FatB in the ferric-vulnibactin utilization system. We propose that ferric-siderophore periplasmic-binding proteins and ferric-chelate reductases are potential targets for drug discovery in infectious diseases.
Topics: Animals; Aquatic Organisms; Ions; Iron; Periplasmic Binding Proteins; Vibrio vulnificus
PubMed: 34940709
DOI: 10.3390/md19120710 -
Advances in Experimental Medicine and... 2023The Vibrionaceae is a highly diverse family of aquatic bacteria. Some members of this ubiquitous group can cause a variety of diseases in humans ranging from cholera...
The Vibrionaceae is a highly diverse family of aquatic bacteria. Some members of this ubiquitous group can cause a variety of diseases in humans ranging from cholera caused by Vibrio cholerae, severe septicemia caused by Vibrio vulnificus, to acute gastroenteritis by Vibrio parahaemolyticus. Planet Earth is experiencing unprecedented changes of planetary scale associated with climate change. These environmental perturbations paired with overpopulation and pollution are increasing the distribution of pathogenic Vibrios and exacerbating the risk of causing infections. In this chapter, we discuss various aspects of Vibrio infections within the context of the twenty-first century with a major emphasis on the aforementioned pathogenic species. Overall, we believe that the twenty-first century is posed to be both one full of challenges due to the rise of these pathogens, and also a catalyst for innovative and groundbreaking discoveries.
Topics: Humans; Vibrio Infections; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; Cholera
PubMed: 36792868
DOI: 10.1007/978-3-031-22997-8_1