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Neurosciences (Riyadh, Saudi Arabia) Oct 2015Multiple sclerosis (MS) is a common neurological disease, and its etiology remains unknown. In recent years, increasing attention has been paid to the possible... (Review)
Review
Multiple sclerosis (MS) is a common neurological disease, and its etiology remains unknown. In recent years, increasing attention has been paid to the possible association between MS and vitamin D deficiency. Here, we review the current literature between MS and vitamin D, showing clear evidence that vitamin D deficiency is a risk factor for MS despite the lack of direct evidence for the effects of vitamin D in MS progression.
Topics: Humans; Multiple Sclerosis; Risk Factors; Vitamin D Deficiency
PubMed: 26492110
DOI: 10.17712/nsj.2015.4.20150357 -
Critical Pathways in Cardiology Sep 2017Vitamin D has been traditionally recognized as a vitamin quintessential for bone-mineral health. In the past 2 decades, numerous experimental and observational studies... (Review)
Review
Vitamin D has been traditionally recognized as a vitamin quintessential for bone-mineral health. In the past 2 decades, numerous experimental and observational studies have highlighted the role of vitamin D in immunity, metabolic syndrome (obesity and diabetes), cancers, renal disease, memory, and neurological dysfunction. In this article, we review important studies that focused on the impact of vitamin D on blood pressure, myocardial infarction, peripheral arterial disease, heart failure, and statin intolerance. Amidst the current pool of ambiguous evidence, we intend to discuss the role of vitamin D in "high-value cardiovascular health care".
Topics: Cardiovascular Diseases; Dietary Supplements; Humans; Vitamin D Deficiency
PubMed: 28742648
DOI: 10.1097/HPC.0000000000000122 -
Endocrinology and Metabolism Clinics of... Dec 2023Nutritional rickets is a global health problem reflecting both historical and contemporary health disparities arising from racial, ethnic, environmental, and... (Review)
Review
Nutritional rickets is a global health problem reflecting both historical and contemporary health disparities arising from racial, ethnic, environmental, and geopolitical circumstances. It primarily affects marginalized populations and can contribute to long-term morbidity. Deficits in bone health in childhood may also contribute to osteomalacia/osteoporosis. Solutions require a global public health approach.
Topics: Humans; Vitamin D; Global Health; Rickets; Osteomalacia; Osteoporosis; Vitamin D Deficiency
PubMed: 37865479
DOI: 10.1016/j.ecl.2023.05.011 -
Nutrients May 2023This study aimed to evaluate the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. This was a...
This study aimed to evaluate the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. This was a population-based record-linkage study which used data from the French National Health Database System. Maternal Vitamin D3 supplementation consisted of a single high oral dose of cholecalciferol, (100,000 IU) from the seventh month of pregnancy, according to national guidelines. In total, 125,756 term-born singleton children were included, of which 37% had respiratory illness defined as hospital admission due to respiratory causes or inhalation treatment up to 24 months of age. Infants prenatally exposed to maternal Vitamin D3 supplementation (n = 54,596) were more likely to have a longer gestational age (GA) at birth (GA 36-38 weeks, 22% vs. 20%, < 0.001 in exposed vs. non-exposed infants, respectively). After adjusting for the main risk factors (maternal age, socioeconomic level, mode of delivery, obstetrical and neonatal pathology, birth weight appropriateness, sex, and birth season), the risk of RD was found to be 3% lower than their counterparts (aOR [IC 95%], 0.97 [0.95-0.99], = 0.01). In conclusion, this study provides evidence for the association between maternal gestational Vitamin D3 supplementation and improved early respiratory outcomes in young children.
Topics: Infant, Newborn; Infant; Pregnancy; Female; Humans; Child; Child, Preschool; Vitamin D; Dietary Supplements; Vitamins; Cholecalciferol; Birth Weight; Vitamin D Deficiency
PubMed: 37242263
DOI: 10.3390/nu15102380 -
Spinal Cord Dec 2016Narrative review. (Review)
Review
STUDY DESIGN
Narrative review.
OBJECTIVES
This review provides an overview of the etiological factors and consequences of vitamin D insufficiency in relation to spinal cord injury (SCI) as well as important considerations for vitamin D supplementation.
SETTING
Montreal, Canada.
METHODS
Literature search.
RESULTS
Vitamin D insufficiency is common in SCI individuals owing to the presence of many contributing factors including limited sun exposure and intake, use of medication and endocrine perturbations. Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI. In the absence of guidelines for the management of vitamin D insufficiency in this high-risk population and in an attempt to provide clinical guidance, considerations for vitamin D supplementation such as the type of vitamin D, dosing regimens and toxicity are discussed and tentative recommendations suggested with particular reference to issues faced by SCI patients.
CONCLUSION
Although high rates of vitamin D insufficiency are encountered in SCI individuals, its consequences and the amount of vitamin D required to prevent insufficiency are still unknown, indicating a need for more intervention studies with well-defined outcome measures. Routine screening and monitoring of vitamin D as well as treatment of suboptimal status should be instituted in both acute and chronic setting. The close interactions between vitamin D and related bone minerals should be kept in mind when supplementing SCI individuals, and practices should be individualized with clinical conditions.
Topics: Animals; Humans; Spinal Cord Injuries; Vitamin D Deficiency
PubMed: 27645263
DOI: 10.1038/sc.2016.131 -
Endocrinology and Metabolism Clinics of... Dec 2017Vitamin D deficiency occurs all over the world, mainly in the Middle East, China, Mongolia, and India. This article focuses on the vitamin D status in adults. Risk... (Review)
Review
Vitamin D deficiency occurs all over the world, mainly in the Middle East, China, Mongolia, and India. This article focuses on the vitamin D status in adults. Risk groups include older persons, pregnant women, and non-Western immigrants. Adequate vitamin D status, defined as serum 25-hydroxyvitamin D greater than 50 nmol/L, is present in less than 50% of the world population, at least in winter. Preventative strategies, such as increasing fish consumption, fortification of foods, use of vitamin D supplements, and advice for moderate sunlight exposure, are warranted.
Topics: Cholecalciferol; Dietary Supplements; Food, Fortified; Global Health; Humans; Risk Factors; Seasons; Vitamin D Deficiency
PubMed: 29080639
DOI: 10.1016/j.ecl.2017.07.002 -
The Korean Journal of Gastroenterology... Dec 2020Vitamin D contributes to bone metabolism and acts as an immune modulator for both innate and adaptive immunity. The serum level of vitamin D has been associated with... (Review)
Review
Vitamin D contributes to bone metabolism and acts as an immune modulator for both innate and adaptive immunity. The serum level of vitamin D has been associated with inflammatory diseases, such as inflammatory bowel disease (IBD). In epidemiologic studies, IBD patients have been shown to have low levels of vitamin D. The suboptimal circulating levels of vitamin D in IBD patients may be caused by low exposure to sunlight, dietary malabsorption, and the impaired conversion of active metabolites (1,25[OH]D). Recent studies have demonstrated that vitamin D deficiency in IBD can increase the chance of disease recurrence, IBD-related hospitalization or surgery, and deterioration of quality of life. Supplementation with vitamin D is therefore thought to reduce the risk of flare-ups and the improvement of the quality of life in IBD patients. This review aims to summarize the latest knowledge on the effects of vitamin D deficiency on IBD and the possible benefits of vitamin D supplementation in IBD patients.
Topics: Colitis; Humans; Inflammatory Bowel Diseases; Quality of Life; Vitamin D; Vitamin D Deficiency
PubMed: 33361704
DOI: 10.4166/kjg.2020.160 -
JBJS Reviews Aug 2017
Review
Topics: Aged; Athletes; Bone Density; Bone Diseases; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Orthopedic Procedures; Prevalence; Treatment Outcome; Vitamin D; Vitamin D Deficiency
PubMed: 28763352
DOI: 10.2106/JBJS.RVW.16.00084 -
Vascular Pharmacology Apr 2022
Review
Topics: Cardiovascular Diseases; Humans; Vitamin D; Vitamin D Deficiency
PubMed: 35065298
DOI: 10.1016/j.vph.2022.106956 -
Fertility and Sterility Jul 2022
Topics: Dietary Supplements; Female; Humans; Pregnancy; Vitamin D; Vitamin D Deficiency; Vitamins
PubMed: 35725113
DOI: 10.1016/j.fertnstert.2022.04.031