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Journal of Career Development Aug 2023Veterans living with mental health conditions have ambitious career goals and want support to find employment that meets their interests and preferences. Despite calls...
Veterans living with mental health conditions have ambitious career goals and want support to find employment that meets their interests and preferences. Despite calls from researchers to "invest" and "commit" to career development research and practice for individuals living with psychiatric conditions, we still do not have empirically tested models for facilitating career development among individuals with mental health conditions, especially veterans. This qualitative study investigates the career development needs and recommended intervention strategies of veterans living with mental health conditions. Vocational counselors from the Veterans Health Administration (VHA) and veterans receiving vocational rehabilitation services ( = 13) participated in semi-structured focus groups. Findings illuminate the tasks, barriers, interventions, implementation strategies, and transitional work context that hinder and support career development of veterans with mental health conditions. Findings offer theoretical and applied guidance to researchers and counselors regarding career development of veterans living with mental health conditions.
PubMed: 37463233
DOI: 10.1177/08948453221137344 -
RSC Advances Mar 2024Nanoparticle (NP) drug delivery systems have shown promise in tumor therapy. However, limitations such as susceptibility to immune clearance and poor targeting in a... (Review)
Review
Nanoparticle (NP) drug delivery systems have shown promise in tumor therapy. However, limitations such as susceptibility to immune clearance and poor targeting in a complex intercellular environment still exist. Recently, cancer cell membrane-encapsulated nanoparticles (CCM-NPs) constructed using biomimetic nanotechnology have been developed to overcome these problems. Proteins on the membrane surface of cancer cells can provide a wide range of activities for CCM-NPs, including immune escape and homologous cell recognition properties. Meanwhile, the surface of the cancer cell membrane exhibits obvious antigen enrichment, so that CCM-NPs can transmit tumor-specific antigen, activate a downstream immune response, and produce an effective anti-tumor effect. In this review, we first provided an overview of the functions of cancer cell membranes and summarized the preparation techniques and characterization methods of CCM-NPs. Then, we focused on the application of CCM-NPs in tumor therapy. In addition, we summarized the functional modifications of cancer cell membranes and compiled the patent applications related to CCM-NPs in recent years. Finally, we proposed the future challenges and directions of this technology in order to provide guidance for researchers in this field.
PubMed: 38567339
DOI: 10.1039/d4ra01026d -
PloS One 2021Located in the Eurasian continent's hinterland, Xinjiang is a typical arid and resource-developing region in China's northwest. Problems such as excessive resource...
Located in the Eurasian continent's hinterland, Xinjiang is a typical arid and resource-developing region in China's northwest. Problems such as excessive resource consumption, environmental pollution, and ecological imbalance are becoming severe, which have become the bottleneck that further restricts Xinjiang's sustainable development. Due to its outstanding quantitative advantages, ecological efficiency has become a significant indicator and analytical tool for measuring the green economy and sustainable development. In this study, we analyzed ecological efficiency variation for Xinjiang's 14 prefectures between 2001 and 2015 using a super-efficient data envelopment model (DEA), Malmquist Index, and Tobit model. These analyses indicated that: (1) The overall ecological efficiency level of Xinjiang is low, and development among regions is unbalanced, out of sync, lacks sustainability. (2) From 2001 to 2015, Xinjiang's ecological efficiency showed a W-shaped rising trend and finally increased by 5.7%. It is due to the substantial improvement in environmental efficiency. (3) By analyzing the environmental efficiency and resource efficiency, 14 prefectures in Xinjiang consist of four development modes: low energy consumption and low emission, high energy consumption and low emission, low energy consumption and high emission, and high energy consumption and high emission. (4) Water resources are restricting factors of arid regions. In most prefectures, there exist excessive water resource investment, excessive COD, and NH3-N emissions. (5) By analyzing the Malmquist index, it shows that the technical progress index(TC) restricted ecological efficiency. In contrast, the technical efficiency index (EC) promoted ecological efficiency.(6)The ecological efficiency was positively correlated with the utilization of foreign capital, urbanization rate, and average education degree but negatively correlated with the marketization degree. The study has guidance and reference function for the sustainable development of Xinjiang-a vital corridor of the Silk Road Economic Belt, and also provides a reference to the research work of other arid resource-based regions.
Topics: China; Conservation of Natural Resources; Desert Climate; Economic Development; Efficiency; Environmental Pollution; Industry; Investments; Socioeconomic Factors; Sustainable Development; Urbanization; Water Resources
PubMed: 33945573
DOI: 10.1371/journal.pone.0251088 -
Journal of Environmental and Public... 2022The development of information technology has a profound impact on the development of education. The integration of information technology into the teaching of...
The development of information technology has a profound impact on the development of education. The integration of information technology into the teaching of professional courses has changed not only teaching methods and means, but more importantly, the teaching philosophy, teaching organization, and teaching evaluation are supported by information technology. Changes and progress have also been made. Piano improvisational accompaniment is an indispensable and important course in the teaching of music majors in colleges and universities. Relying on the information-based teaching environment and means, systematically designing piano impromptu accompaniment teaching for music performance majors to improve the effectiveness of teaching is a new exploration in the education and teaching reform of the current higher vocational music performance talent training courses. This study analyzes and studies the problems existing in the current teaching of piano improvisation accompaniment in colleges and universities and proposes the feasible strategies of piano improvisation accompaniment teaching in a targeted manner, to provide reference and guidance for the majority of educators.
Topics: Educational Status; Humans; Music; Universities
PubMed: 35844941
DOI: 10.1155/2022/5245256 -
BMC Psychology May 2024During emerging adulthood, vocational indecision (i.e., the inability to make coherent career choices) develops in a heterogeneous fashion, with three distinct patterns:...
BACKGROUND, OBJECTIVE AND HYPOTHESES
During emerging adulthood, vocational indecision (i.e., the inability to make coherent career choices) develops in a heterogeneous fashion, with three distinct patterns: low; decreasing (i.e., developmental or adaptative); high and stable or increasing (i.e., chronic or maladaptive). Among the determinants of vocational indecision that have been identified in past research, academic motivation is a crucial an excellent choice, since it is at school that students' vocational choices are validated or not. According to SDT, this motivation can vary both in quantity and quality, and students tend to experience more positive academic outcomes when their motivational profile is optimal (high quantity, high quality) as opposed to suboptimal (e.g., low quantity, low quality). Thus, the purpose of this longitudinal study was to verify if the patterns found with emerging adulthood students characterized vocational indecision in adolescent students, and if supported, to predict the belonging to the most problematic trajectory by using students' academic motivational profiles. We expected several distinct trajectories of vocational indecision that would differ in shape and magnitude, and several motivational profiles that vary in quality as well as in quantity. We also expected students in high-quality or quantity motivational profiles to be less likely to follow a chronic indecision trajectory.
METHOD AND RESULTS
Using data from 384 students (56% female; Mage = 13.52 years; SD = .52 at Secondary 2) surveyed annually from Secondary 2 to 5, person-centered analyses enabled estimation of motivational profile in Secondary 2 and vocational indecision trajectories during the 4-year period. Results revealed four distinct patterns of vocational indecision during adolescence labelled Low and Stable, Moderate and Stable, Developmental and Chronic Intermittent. Four motivational profiles were also identified in Secondary 2, ranging from poor (Highly Amotivated) to moderate (Autonomous-Introjected) quality of self-determination level. Also, in reference to the most self-determined profile, students in the Mixed profile were at greatest risk of following Chronically-Intermittently Undecided trajectory. Finally, the most self-determined students were at greatest probability of following the Developmentally Undecided trajectory.
CONCLUSION
Overall, the findings suggest that the student motivational functioning in early secondary school years could be used to identify students at risk of experiencing the negative indecision patterns across secondary school. Several theoretical and practical implications are suggested.
Topics: Humans; Motivation; Adolescent; Female; Male; Career Choice; Longitudinal Studies; Students; Young Adult; Adolescent Behavior
PubMed: 38702790
DOI: 10.1186/s40359-024-01747-0 -
Journal of Thrombosis and Haemostasis :... Jul 2016Early career researchers and clinicians face unique challenges in comparison with more senior colleagues, for instance connecting with expert leaders outside of their...
Early career researchers and clinicians face unique challenges in comparison with more senior colleagues, for instance connecting with expert leaders outside of their own institution to enhance their expertise. As the largest international thrombosis and hemostasis professional society, the ISTH can play a central role in supporting the development of early career professionals. The ISTH Early Career Task Force was formed to improve support for, and encourage collaboration between early career thrombosis and hemostasis researchers and clinicians. These activities include (1) maintaining an online forum for early career ISTH members to connect, promote clinical, research, funding and educational activities, and to generate a sense of community; (2) broaden ISTH's reach with early career professionals in the developing world through promotion of the Reach-the-World fellowships and translating ISTH websites into six languages; (3) encourage early career engagement with ISTH activities, such as guidelines and guidance document processing and online webinar series; and (4) establishing this early career forum series in this journal. The JTH Forum series will highlight the early career perspective on a wide range of issues relevant to this group, and all ISTH early career members are encouraged to contribute.
Topics: Biomedical Research; Cardiology; Career Choice; Hematology; Hemostasis; Humans; International Cooperation; Internet; Leadership; Societies, Medical; Thrombosis; Vocational Guidance
PubMed: 27173129
DOI: 10.1111/jth.13363 -
Nature May 2016
Topics: Academic Dissertations as Topic; Career Mobility; Education, Graduate; Mentors; Research Personnel; Vocational Guidance
PubMed: 27200448
DOI: 10.1038/nj7603-429a -
Nature Jan 2016
Topics: Adaptation, Psychological; Anxiety Disorders; Career Mobility; Deception; Job Satisfaction; Neuroticism; Personality Disorders; Research Personnel; Self Concept; Syndrome; Vocational Guidance
PubMed: 26824109
DOI: 10.1038/nj7587-555a -
Medicina Intensiva May 2023SEMICYUC's first Mentoring Programme aims to support the research careers of the Society's youngest members. Added benefits include acquiring new research and/or...
SEMICYUC's first Mentoring Programme aims to support the research careers of the Society's youngest members. Added benefits include acquiring new research and/or clinical skills, increasing the ability of critical thought, and fostering the development of the next generation of research leaders. This project would not be possible without the exceptional team of mentors or research experts willing to embark on the journey with the young trainees. This article sets out the foundations of such a programme and proposes future changes for continuous improvement.
Topics: Humans; Mentors; Mentoring
PubMed: 36948924
DOI: 10.1016/j.medine.2023.03.006 -
Pharmaceutics Nov 2022Carbon dots (CDs), a new member of carbon nanostructures, rely on surface modification and functionalization for their good fluorescence phosphorescence and excellent... (Review)
Review
Carbon dots (CDs), a new member of carbon nanostructures, rely on surface modification and functionalization for their good fluorescence phosphorescence and excellent physical and chemical properties, including small size (<10 nm), high chemical stability, biocompatibility, non-toxicity, low cost, and easy synthesis. In the field of medical research on cancer (IARC), CDs, a new material with unique optical properties as a photosensitizer, are being applied to heating local apoptosis induction of cancer cells. In addition, imaging tools can also be combined with a drug to form the nanometer complex compound, the imaging guidance for multi-function dosage, so as to improve the efficiency of drug delivery, which also plays a big role in genetic diagnosis. This paper mainly includes three parts: The first part briefly introduces the synthesis and preparation of carbon dots, and summarizes the advantages and disadvantages of different preparation methods; The second part introduces the preparation methods of carbon dot composites. Finally, the application status of carbon dot composites in biomedicine, cancer theranostics, drug delivery, electrochemistry, and photocatalysis is summarized.
PubMed: 36432673
DOI: 10.3390/pharmaceutics14112482