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Sensors (Basel, Switzerland) Jun 2024Internet of Things (IoT) technology has become an inevitable part of our daily lives. With the increase in usage of IoT Devices, manufacturers continuously develop IoT... (Review)
Review
Internet of Things (IoT) technology has become an inevitable part of our daily lives. With the increase in usage of IoT Devices, manufacturers continuously develop IoT technology. However, the security of IoT devices is left behind in those developments due to cost, size, and computational power limitations. Since these IoT devices are connected to the Internet and have low security levels, one of the main risks of these devices is being compromised by malicious malware and becoming part of IoT botnets. IoT botnets are used for launching different types of large-scale attacks including Distributed Denial-of-Service (DDoS) attacks. These attacks are continuously evolving, and researchers have conducted numerous analyses and studies in this area to narrow security vulnerabilities. This paper systematically reviews the prominent literature on IoT botnet DDoS attacks and detection techniques. Architecture IoT botnet DDoS attacks, evaluations of those attacks, and systematically categorized detection techniques are discussed in detail. The paper presents current threats and detection techniques, and some open research questions are recommended for future studies in this field.
PubMed: 38894365
DOI: 10.3390/s24113571 -
Chinese Clinical Oncology May 2024Patients with surgically resectable BRAF-mutated colorectal liver metastases (CRLM) or limited extrahepatic disease constitute a highly selective subgroup among...
BACKGROUND
Patients with surgically resectable BRAF-mutated colorectal liver metastases (CRLM) or limited extrahepatic disease constitute a highly selective subgroup among BRAF-mutated patients, characterized by a more indolent disease biology. This is evident in their suitability for surgical resection. However, initial studies from a decade ago presented a discouraging outlook for these patients, citing early, frequent, multifocal recurrences and a very limited median overall survival (OS) of less than two years. Our objective was to provide an updated, comprehensive, and critically assessed review of the current literature on the prognostic impact of BRAF variants in CRLM, as well as to explore optimal treatment strategies for these patients through a systematic search.
METHODS
A systematic literature search of the Medline, Scopus, and CENTRAL databases for studies reporting long-term outcomes of patients with a known BRAF status was performed.
RESULTS
A total of 386 unique studies were screened during the study selection process. After applying the exclusion criteria, a total of 18 studies published between 2012 and 2023 were deemed eligible for inclusion.
CONCLUSIONS
In contrast to older studies, more recent studies, with larger sample sizes, have revealed that the rate of extrahepatic recurrence is comparable between BRAF-mutated and wild-type patients. Furthermore, they have reported significantly improved survival outcomes, with OS extending up to 52 months. Notably, patients with non-V600E BRAF mutations may even achieve outcomes comparable to those with wild-type BRAF CRLM. Additionally, a few recent studies have compared surgery and systemic therapies, indicating that surgery is associated with improved survival rates, even for patients with the V600E mutation. This challenges the previous belief that BRAF mutations are absolute contraindications to surgical treatment. Surgical denial for technically resectable patients may now be reserved for specific clinical scenarios, such as the presence of a BRAF V600E mutation and concurrent extrahepatic disease.
PubMed: 38859602
DOI: 10.21037/cco-23-128