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Sports Medicine - Open Jun 2021Wearable tracking devices are commonly utilised to quantify the external acceleration load of team sport athletes during training and competition. The ability to...
BACKGROUND
Wearable tracking devices are commonly utilised to quantify the external acceleration load of team sport athletes during training and competition. The ability to accelerate is an important attribute for athletes in many team sports. However, there are many different acceleration metrics that exist in team sport research. This review aimed to provide researchers and practitioners with a clear reporting framework on acceleration variables by outlining the different metrics and calculation processes that have been adopted to quantify acceleration loads in team sport research.
METHODS
A systematic review of three electronic databases (CINAHL, MEDLINE, SPORTDiscus), was performed to identify peer-reviewed studies that published external acceleration load in elite team sports during training and/or competition. Articles published between January 2010 and April 2020 were identified using Boolean search phrases in relation to team sports (population), acceleration/deceleration (comparators), and competition and/or training (outcome). The included studies were required to present external acceleration and/or deceleration load (of any magnitude) from able-bodied athletes (mean age ≥ 18 years) via wearable technologies.
RESULTS
A total of 124 research articles qualified for inclusion. In total, 113/124 studies utilised GPS/GNSS technology to outline the external acceleration load of athletes. Count-based metrics of acceleration were predominant of all metrics in this review (72%). There was a lack of information surrounding the calculation process of acceleration with 13% of studies specifying the filter used in the processing of athlete data, whilst 32% outlined the minimum effort duration (MED). Markers of GPS/GNSS data quality, including horizontal dilution of precision (HDOP) and the average number of satellites connected, were outlined in 24% and 27% of studies respectively.
CONCLUSIONS
Team sport research has predominantly quantified external acceleration load in training and competition with count-based metrics. Despite the influence of data filtering processes and MEDs upon acceleration, this information is largely omitted from team sport research. Future research that outlines acceleration load should present filtering processes, MEDs, HDOP, and the number of connected satellites. For GPS/GNSS systems, satellite planning tools should document evidence of available satellites for data collection to analyse tracking device performance. The development of a consistent acceleration filtering method should be established to promote consistency in the research of external athlete acceleration loads.
PubMed: 34191142
DOI: 10.1186/s40798-021-00332-8 -
PloS One 2020Accelerometry is a recent method used to quantify workload in team sports. A rapidly increasing number of studies supports the practical implementation of accelerometry...
Accelerometry is a recent method used to quantify workload in team sports. A rapidly increasing number of studies supports the practical implementation of accelerometry monitoring to regulate and optimize training schemes. Therefore, the purposes of this study were: (1) to reflect the current state of knowledge about accelerometry as a method of workload monitoring in invasion team sports according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, and (2) to conclude recommendations for application and scientific investigations. The Web of Science, PubMed and Scopus databases were searched for relevant published studies according to the following keywords: "accelerometry" or "accelerometer" or "microtechnology" or "inertial devices", and "load" or "workload", and "sport". Of the 1383 studies initially identified, 118 were selected for a full review. The main results indicate that the most frequent findings were (i) devices' body location: scapulae; (b) devices brand: Catapult Sports; (iii) variables: PlayerLoadTM and its variations; (iv) sports: rugby, Australian football, soccer and basketball; (v) sex: male; (vi) competition level: professional and elite; and (vii) context: separate training or competition. A great number of variables and devices from various companies make the comparability between findings difficult; unification is required. Although the most common location is at scapulae because of its optimal signal reception for time-motion analysis, new methods for multi-location skills and locomotion assessment without losing tracking accuracy should be developed.
Topics: Female; Humans; Male; Accelerometry; Athletic Performance; Basketball; Geographic Information Systems; Microtechnology; Soccer; Workload; Sports
PubMed: 32841239
DOI: 10.1371/journal.pone.0236643 -
PloS One 2023The microfluidic sperm selection (MFSS) device has emerged as a promising adjunct in assisted reproduction treatments (ART). It employs mechanisms of biomimicry based on... (Meta-Analysis)
Meta-Analysis
BACKGROUND
The microfluidic sperm selection (MFSS) device has emerged as a promising adjunct in assisted reproduction treatments (ART). It employs mechanisms of biomimicry based on the microanatomy of the female reproductive tract through strategies like chemotaxis and rheotaxis. Numerous studies assert improvements in ART outcomes with the use of MFSS, often attributed to the theoretical reduction in sperm DNA damage compared to other techniques. However, these attributed benefits lack validation through large-scale clinical trials, and there is no significant evidence of enhanced assisted reproductive treatments (ART) outcomes.
OBJECTIVE
To evaluate whether the utilization of MFSS enhances clinical pregnancy results and abortion outcomes in couples undergoing ART compared to standard sperm selection techniques for Intracytoplasmic Sperm Injection (ICSI). We also assessed laboratory outcomes as a supplementary analysis.
SEARCH METHODS
We conducted searches across databases including PubMed, NIH, LILACS, CENTRAL, Crossref, Scopus, and OpenAlex. A total of 1,255 records were identified. From these, 284 duplicate records were eliminated, and an additional 895 records were excluded due to their association with patent applications, diagnostic tests, forensic analyses, or irrelevance to the research focus. Among the initially eligible 76 studies, 63 were excluded, encompassing abstracts, studies lacking adequate control groups, and ongoing clinical trials. Ultimately, 13 studies were selected for inclusion in the ensuing meta-analysis.
RESULTS
Regarding clinical pregnancy, we assessed a total of 868 instances of clinical pregnancies out of 1,646 embryo transfers. Regarding miscarriage, we examined 95 cases of pregnancy loss among the 598 confirmed clinical pregnancies in these studies.
CONCLUSION
The utilization of MFSS demonstrates marginal positive outcomes compared to standard sperm selection techniques, without statistical significance in any of the analyses.
BROADER IMPLICATIONS
This study conducted the first meta-analysis to evaluate clinical pregnancy rates, miscarriage rates, and laboratory results associated with the use of MFSS compared to standard sperm selection techniques. We have also listed potentially eligible studies for future inclusion. It's important to emphasize the need for multicenter studies with standardized parameters to attain a more robust clarification of this issue.
Topics: Pregnancy; Male; Female; Humans; Abortion, Spontaneous; Microfluidics; Semen; Sperm Injections, Intracytoplasmic; Pregnancy Rate; Spermatozoa; Live Birth
PubMed: 37983267
DOI: 10.1371/journal.pone.0292891 -
Frontiers in Endocrinology 2020The current gold standard for the diagnosis of osteoporosis and the prediction of fracture risk is the measurement of bone mineral density (BMD) using dual energy x-ray...
The current gold standard for the diagnosis of osteoporosis and the prediction of fracture risk is the measurement of bone mineral density (BMD) using dual energy x-ray absorptiometry (DXA). A low BMD is clearly associated with increased fracture risk, but BMD is not the only determinant of bone strength, particularly in secondary osteoporosis and metabolic bone disorders in which components other than BMD are affected and DXA often underestimates true fracture risk. Material properties of bone which significantly contribute to bone strength have become evaluable with the impact microindentation (IMI) technique using the OsteoProbe® device. The question arises whether this new tool is of added value in the evaluation of bone fragility. To this effect, we conducted a systematic review of all clinical studies using IMI in humans also addressing practical aspects of the technique and differences in study design, which may impact outcome. Search data generated 38 studies showing that IMI can identify patients with primary osteoporosis and fractures, patients with secondary osteoporosis due to various underlying systemic disorders, and scarce longitudinal data also show that this tool can detect changes in bone material strength index (BMSi), following bone-modifying therapy including use of corticosteroids. However, this main outcome parameter was not always concordant between studies. This systematic review also identified a number of factors that impact on BMSi outcome. These include subject- and disease-related factors such as the relationship between BMSi and age, geographical region and the presence of fractures, and technique- and operator-related factors. Taken together, findings from this systematic review confirm the added value of IMI for the evaluation and follow-up of elements of bone fragility, particularly in secondary osteoporosis. Notwithstanding, the high variability of BMSi outcome between studies calls for age-dependent reference values, and for the harmonization of study protocols. Prospective multicenter trials using standard operating procedures are required to establish the value of IMI in the prediction of future fracture risk, before this technique is introduced in routine clinical practice.
Topics: Absorptiometry, Photon; Biopsy, Needle; Bone Density; Bone Diseases, Metabolic; Bone and Bones; Equipment and Supplies; Fractures, Bone; Humans; Microtechnology; Osteoporosis; Osteoporotic Fractures; Predictive Value of Tests; Risk Factors; Specimen Handling
PubMed: 32117052
DOI: 10.3389/fendo.2020.00015 -
Journal of Pharmaceutical Sciences Jul 2024The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure... (Review)
Review
The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure therapeutic efficacy, safety, and tolerability in paediatric patients, who have specific physiological needs and characteristics. In recent years, there has been a significant increase in attention towards this area, driven by the need to improve drug administration to children and ensure optimal and specific treatments. Technological innovation has played a crucial role in meeting these requirements, opening new frontiers in the design and production of paediatric pharmaceutical forms. In particular, three emerging technologies have garnered considerable interest and attention within the scientific and industrial community: 3D printing, prilling/vibration, and microfluidics. These technologies offer advanced approaches for the design, production, and customization of paediatric pharmaceutical forms, allowing for more precise dosage modulation, improved solubility, and greater drug acceptability. In this review, we delve into these cutting-edge technologies and their impact on the production of paediatric pharmaceutical forms. We analyse their potential, associated challenges, and recent developments, providing a comprehensive overview of the opportunities that these innovative methodologies offer to the pharmaceutical sector. We examine different pharmaceutical forms generated using these techniques, evaluating their advantages and disadvantages.
Topics: Printing, Three-Dimensional; Humans; Child; Microfluidics; Dosage Forms; Technology, Pharmaceutical; Pediatrics; Pharmaceutical Preparations; Drug Compounding; Chemistry, Pharmaceutical; Solubility
PubMed: 38582283
DOI: 10.1016/j.xphs.2024.04.001 -
Biomedicine & Pharmacotherapy =... Dec 2020The human blood-brain barrier (BBB) is a complex multi-dimensional reticular barrier system composed of cerebral microvascular endothelial cells, pericytes, astrocytes...
The human blood-brain barrier (BBB) is a complex multi-dimensional reticular barrier system composed of cerebral microvascular endothelial cells, pericytes, astrocytes and a variety of neurons. The conventional in vitro cell culture model fails to truly present the dynamic hemodynamics of BBB and the interaction between neurons. And it is even more impossible to explore brain-related multi-organ diseases, which brings huge obstacles to explore diseases of the central nervous system and the interaction between brain-related multi-organs, and evaluate drug efficacy. Miniaturized microfluidics based BBB chips are being commonly used to co-culture a variety of cells on a small-sized chip to construct a three-dimensional (3D) BBB or BBB-related organ disease models. By combining with other electrophysiological, biochemical sensors or equipment and imaging systems, it can in real time and quickly screen disease-related markers and evaluate drug efficacy. This review systematically summarized the research progress of in vitro BBB and BBB-related organ chips, and analyzed the obstacles of BBB models in depth. Parallelly combined with the current research trends and hot spots, we give the further improvement measures of microfluidic BBB chips.
Topics: Animals; Blood-Brain Barrier; Cell Culture Techniques; Coculture Techniques; Drug Development; Humans; Microfluidics; Neurons
PubMed: 33059264
DOI: 10.1016/j.biopha.2020.110822 -
Molecules (Basel, Switzerland) Sep 2019Use of sonication for designing and fabricating reactors, especially the deposition of catalysts inside a microreactor, is a modern approach. There are many reports that...
Use of sonication for designing and fabricating reactors, especially the deposition of catalysts inside a microreactor, is a modern approach. There are many reports that prove that a microreactor is a better setup compared with batch reactors for carrying out catalytic reactions. Microreactors have better energy efficiency, reaction rate, safety, a much finer degree of process control, better molecular diffusion, and heat-transfer properties compared with the conventional batch reactor. The use of microreactors for photocatalytic reactions is also being considered to be the appropriate reactor configuration because of its improved irradiation profile, better light penetration through the entire reactor depth, and higher spatial illumination homogeneity. Ultrasound has been used efficiently for the synthesis of materials, degradation of organic compounds, and fuel production, among other applications. The recent increase in energy demands, as well as the stringent environmental stress due to pollution, have resulted in the need to develop green chemistry-based processes to generate and remove contaminants in a more environmentally friendly and cost-effective manner. It is possible to carry out the synthesis and deposition of catalysts inside the reactor using the ultrasound-promoted method in the microfluidic system. In addition, the synergistic effect generated by photocatalysis and sonochemistry in a microreactor can be used for the production of different chemicals, which have high value in the pharmaceutical and chemical industries. The current review highlights the use of both photocatalysis and sonochemistry for developing microreactors and their applications.
Topics: Catalysis; Equipment Design; Microfluidics; Nanoparticles; Photochemistry; Sonication; Ultrasonics
PubMed: 31547232
DOI: 10.3390/molecules24183315 -
International Journal of Molecular... Aug 2021Today there are many devices that can be used to study blood clotting disorders by identifying abnormalities in blood platelets. The Total Thrombus Formation Analysis...
BACKGROUND
Today there are many devices that can be used to study blood clotting disorders by identifying abnormalities in blood platelets. The Total Thrombus Formation Analysis System is an automated microchip flow chamber system that is used for the quantitative analysis of clot formation under blood flow conditions. For several years, researchers have been using a tool to analyse various clinical situations of patients to identify the properties and biochemical processes occurring within platelets and their microenvironment.
METHODS
An investigation of recent published literature was conducted based on PRISMA. This review includes 52 science papers directly related to the use of the Total Clot Formation Analysis System in relation to bleeding, surgery, platelet function assessment, anticoagulation monitoring, von Willebrand factor and others.
CONCLUSION
Most available studies indicate that The Total Thrombus Formation Analysis System may be useful in diagnostic issues, with devices used to monitor therapy or as a significant tool for predicting bleeding events. However, T-TAS not that has the potential for diagnostic indications, but allows the direct observation of the flow and the interactions between blood cells, including the intensity and dynamics of clot formation. The device is expected to be of significant value for basic research to observe the interactions and changes within platelets and their microenvironment.
Topics: Blood Coagulation; Blood Platelets; Humans; Lab-On-A-Chip Devices; Microfluidics; Thrombosis
PubMed: 34445311
DOI: 10.3390/ijms22168605