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Cell Communication and Signaling : CCS Mar 2023Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or in combination in a variety of cancers, while it has been found to cause serious... (Review)
Review
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or in combination in a variety of cancers, while it has been found to cause serious cardiac side effects in clinical application. More and more researchers are trying to explore the molecular mechanisms of DOX-induced cardiomyopathy (DIC), in which oxidative stress and inflammation are considered to play a significant role. This review summarizes signaling pathways related to oxidative stress and inflammation in DIC and compounds that exert cardioprotective effects by acting on relevant signaling pathways, including the role of Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α signaling pathways and NOS, NOX, Fe signaling in oxidative stress, as well as the role of NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB pathways in DOX-induced inflammation. Hence, we attempt to explain the mechanisms of DIC in terms of oxidative stress and inflammation, and to provide a theoretical basis or new idea for further drug research on reducing DIC. Video Abstract.
Topics: Humans; Src Homology 2 Domain-Containing, Transforming Protein 1; NF-kappa B; Sirtuin 1; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Cardiomyopathies; Doxorubicin; Inflammation
PubMed: 36918950
DOI: 10.1186/s12964-023-01077-5 -
Journal of the International Society of... 2018Lipids as a fuel source for energy supply during submaximal exercise originate from subcutaneous adipose tissue derived fatty acids (FA), intramuscular triacylglycerides... (Review)
Review
Lipids as a fuel source for energy supply during submaximal exercise originate from subcutaneous adipose tissue derived fatty acids (FA), intramuscular triacylglycerides (IMTG), cholesterol and dietary fat. These sources of fat contribute to fatty acid oxidation (FAox) in various ways. The regulation and utilization of FAs in a maximal capacity occur primarily at exercise intensities between 45 and 65% VO, is known as maximal fat oxidation (MFO), and is measured in g/min. Fatty acid oxidation occurs during submaximal exercise intensities, but is also complimentary to carbohydrate oxidation (CHOox). Due to limitations within FA transport across the cell and mitochondrial membranes, FAox is limited at higher exercise intensities. The point at which FAox reaches maximum and begins to decline is referred to as the crossover point. Exercise intensities that exceed the crossover point (~65% VO) utilize CHO as the predominant fuel source for energy supply. Training status, exercise intensity, exercise duration, sex differences, and nutrition have all been shown to affect cellular expression responsible for FAox rate. Each stimulus affects the process of FAox differently, resulting in specific adaptions that influence endurance exercise performance. Endurance training, specifically long duration (>2 h) facilitate adaptations that alter both the origin of FAs and FAox rate. Additionally, the influence of sex and nutrition on FAox are discussed. Finally, the role of FAox in the improvement of performance during endurance training is discussed.
Topics: Dietary Carbohydrates; Dietary Fats; Exercise; Fatty Acids; Humans; Oxidation-Reduction; Oxygen Consumption
PubMed: 29344008
DOI: 10.1186/s12970-018-0207-1 -
Topics in Cognitive Science Jul 2018To explain how abstract concepts are grounded in sensory-motor experiences, several theories have been proposed. I will discuss two of these proposals, Conceptual... (Review)
Review
To explain how abstract concepts are grounded in sensory-motor experiences, several theories have been proposed. I will discuss two of these proposals, Conceptual Metaphor Theory and Situated Cognition, and argue why they do not fully explain grounding. A central idea in Conceptual Metaphor Theory is that image schemas ground abstract concepts in concrete experiences. Image schemas might themselves be abstractions, however, and therefore do not solve the grounding problem. Moreover, image schemas are too simple to explain the full richness of abstract concepts. Situated cognition might provide such richness. Research in our laboratory, however, has shown that even for concrete concepts, sensory-motor grounding is task dependent. Therefore, it is questionable whether abstract concepts can be significantly grounded in sensory-motor processing.
Topics: Concept Formation; Humans; Metaphor; Psychological Theory
PubMed: 29214726
DOI: 10.1111/tops.12311 -
Frontiers in Psychology 2022Accepting the idea that the mental representations of concepts, diagrams, relations, plans, etc., are thought-shapers, I suggest going a bit further. Any kind of...
Accepting the idea that the mental representations of concepts, diagrams, relations, plans, etc., are thought-shapers, I suggest going a bit further. Any kind of representation, be it mental or public, i.e., accessible to others, bears thought-shaping potential, albeit not in the same manner. Just as the idea of embodied cognition takes into consideration environmental facilities and obstacles, I suggest investigating thought processes in a broader context, i.e., placing thought-shapers in the context of their formation. I propose that the elements of the above mentioned definition of thought-shapers are built upon a structure that consists of representational skills, means, and institutions. In accordance with the idea of embeddedness and enactment, the need for communication and the given cognitive and physical aptitudes result in different kinds of expression, i.e., different kinds of representations available to others. When an expressional mode solidifies, it opens up new possibilities and limitations. I propose that mundane, almost unnoticeable affordances and their accompanying limits do shape our thoughts thoroughly. In my argument for the thought-shaper potential of the generative technique of public representations, I will delineate a historical overview of representational means in tandem with the main characteristics of different eras' crucial ideals and patterns of reasoning. I will close the historical overview with a terminological excursion exploring how publicly available representation and mental representation relate to each other and the kinds of ambiguities that accompany the latter term's use. Accordingly, embedding thought-shapers, I will outline the evolution of different representational techniques and skills. Then, because language is a decisive representational means, I will investigate its orientating and distortive potential. I will rely on some of Bergson's lesser-known remarks. I will illuminate how ocular-centrism was able to be a decisive metaphor in science and philosophy for long centuries, until recently even. In conclusion, as a case study, I will illuminate how the term "mental representation" as a highly abstract term facilitates and at the same time hinders philosophical and scientific inquiry.
PubMed: 35928426
DOI: 10.3389/fpsyg.2022.918820 -
Tijdschrift Voor Psychiatrie 2023Clear and unambiguous description of psychiatric symptoms is a prerequisite for a personalized and reliable mental state examination.
BACKGROUND
Clear and unambiguous description of psychiatric symptoms is a prerequisite for a personalized and reliable mental state examination.
AIM
To draw attention to the correct use of psychiatric language.
METHOD
Description of persistent linguistic errors and relevant but too little used terms, and a new Dutch translation for some psychopathological terms.
RESULTS
The following linguistic errors are presented: ‘concentration’ as if it means the sustaining of attention; ‘compulsive behaviour’ that is not really compulsive; ‘no diagnosis’ while no disorder is diagnosed; ‘no psychopathology’ as if the patient has no science of psychopathology; ‘to impress as’ for characteristic that are not impressive; ‘mild’ while psychiatric disorders are never mild; ‘inhibition’ as if we can observe that subjective phenomenon; ‘signs’ for symptoms that do not appear to us at all; ‘weather and climate’ for affect and mood, while the mood generally changes somewhat faster than he climate. Attention is drawn for the terms chronognosia, overvalued idea, sensory hyporeactivity and disorders of self-awareness. New Dutch translations for dysmorphic disorder, délire de négation, and paranoic are explained.
CONCLUSION
Psychiatrists, watch your language!
Topics: Male; Humans; Mental Disorders; Language; Psychiatry
PubMed: 36951767
DOI: No ID Found -
Philosophical Transactions of the Royal... Aug 2018Grounded theories of cognition claim that concept representation relies on the systems for perception and action. The sensory-motor grounding of abstract concepts... (Review)
Review
Grounded theories of cognition claim that concept representation relies on the systems for perception and action. The sensory-motor grounding of abstract concepts presents a challenge for these theories. Some accounts propose that abstract concepts are indirectly grounded via image schemas or situations. Recent research, however, indicates that the role of sensory-motor processing for concrete concepts may be limited, providing evidence against the idea that abstract concepts are grounded via concrete concepts. Hybrid models that combine language and sensory-motor experience may provide a more viable account of abstract and concrete representations. We propose that sensory-motor grounding is important during acquisition and provides structure to concepts. Later activation of concepts relies on this structure but does not necessarily involve sensory-motor processing. Language is needed to create coherent concepts from diverse sensory-motor experiences.This article is part of the theme issue 'Varieties of abstract concepts: development, use and representation in the brain'.
Topics: Cognition; Concept Formation; Feedback, Sensory; Humans; Language; Learning; Models, Psychological
PubMed: 29915000
DOI: 10.1098/rstb.2017.0132 -
PloS One 2016We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the...
We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the framework, we undertook a Delphi survey; ran an open meeting at a trial methodology conference; conducted a review of definitions outside the health research context; consulted experts at an international consensus meeting; and reviewed 27 empirical pilot or feasibility studies. We initially adopted mutually exclusive definitions of pilot and feasibility studies. However, some Delphi survey respondents and the majority of open meeting attendees disagreed with the idea of mutually exclusive definitions. Their viewpoint was supported by definitions outside the health research context, the use of the terms 'pilot' and 'feasibility' in the literature, and participants at the international consensus meeting. In our framework, pilot studies are a subset of feasibility studies, rather than the two being mutually exclusive. A feasibility study asks whether something can be done, should we proceed with it, and if so, how. A pilot study asks the same questions but also has a specific design feature: in a pilot study a future study, or part of a future study, is conducted on a smaller scale. We suggest that to facilitate their identification, these studies should be clearly identified using the terms 'feasibility' or 'pilot' as appropriate. This should include feasibility studies that are largely qualitative; we found these difficult to identify in electronic searches because researchers rarely used the term 'feasibility' in the title or abstract of such studies. Investigators should also report appropriate objectives and methods related to feasibility; and give clear confirmation that their study is in preparation for a future randomised controlled trial designed to assess the effect of an intervention.
Topics: Delphi Technique; Feasibility Studies; Pilot Projects; Randomized Controlled Trials as Topic; Validation Studies as Topic
PubMed: 26978655
DOI: 10.1371/journal.pone.0150205 -
La Tunisie Medicale Dec 2023Access to medication is a major public health issue worldwide and can be considered as an indicator of the quality of public health services in a country.
INTRODUCTION
Access to medication is a major public health issue worldwide and can be considered as an indicator of the quality of public health services in a country.
AIM
To evaluate patient satisfaction with the services provided by the external pharmacy in the drug distribution circuit in public healthcare facilities in Tunisia.
METHODS
To achieve this goal, a satisfaction survey was conducted on a sample of 200 patients at the external pharmacies of two university hospitals in Tunis, namely the La Rabta University Hospital and the Charles Nicolle University Hospital.
RESULTS
This survey revealed that despite the efforts made by the state and the importance of the drug market in Tunisia, 80% of patients reported difficulties in finding their medication in the healthcare facilities where they consult, and more than 60% are forced to obtain them from private pharmacies. The survey also highlighted a contrast between the quality of services provided by the external hospital pharmacy and those of private pharmacies. Indeed, only 25% of the surveyed patients were satisfied with the services provided by the external pharmacy. Although this satisfaction was conditioned by several factors, the main concern of the patients remained the availability of medication. In fact, with little difference in terms of care, 80.5% of the participants favored the idea of transferring the services provided by the external pharmacy to private pharmacies.
CONCLUSION
In summary, this study has highlighted the need to rethink the drug supply and distribution system and to explore alternative approaches to significantly improve access to medication and the quality of services provided by external pharmacies in Tunisian public hospitals.
Topics: Humans; Pharmacies; Tunisia; Pharmacy; Delivery of Health Care; Surveys and Questionnaires
PubMed: 38477198
DOI: No ID Found -
Clinical Pharmacology and Therapeutics Apr 2020In the last few years, machine learning (ML) and artificial intelligence have seen a new wave of publicity fueled by the huge and ever-increasing amount of data and... (Review)
Review
In the last few years, machine learning (ML) and artificial intelligence have seen a new wave of publicity fueled by the huge and ever-increasing amount of data and computational power as well as the discovery of improved learning algorithms. However, the idea of a computer learning some abstract concept from data and applying them to yet unseen situations is not new and has been around at least since the 1950s. Many of these basic principles are very familiar to the pharmacometrics and clinical pharmacology community. In this paper, we want to introduce the foundational ideas of ML to this community such that readers obtain the essential tools they need to understand publications on the topic. Although we will not go into the very details and theoretical background, we aim to point readers to relevant literature and put applications of ML in molecular biology as well as the fields of pharmacometrics and clinical pharmacology into perspective.
Topics: Cluster Analysis; Humans; Machine Learning; Models, Theoretical; Pharmacology, Clinical
PubMed: 32128792
DOI: 10.1002/cpt.1796 -
Ugeskrift For Laeger Apr 2024This review delves into the possible role of artificial intelligence (AI) in medical research, from planning to publication. AI can aid in idea generation, data... (Review)
Review
This review delves into the possible role of artificial intelligence (AI) in medical research, from planning to publication. AI can aid in idea generation, data analysis, and writing, with tools like chatbots and transcription systems enhancing efficiency. However, AI's limitations, including the "hallucination" problem in which it generates false information, require careful use and verification. Ensuring anonymity compliance with sensitive data is also vital. AI's transformative potential in research brings opportunities for innovation, necessitating mindful application to manage biases and data accuracy.
Topics: Artificial Intelligence; Biomedical Research; Humans; Data Accuracy
PubMed: 38704722
DOI: 10.61409/V08230532