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Anesthesiology May 2018
Topics: Acute Disease; Cardiac Tamponade; Echocardiography, Transesophageal; Humans; Pericardial Effusion
PubMed: 29210710
DOI: 10.1097/ALN.0000000000001999 -
Annals of the American Thoracic Society Jun 2021
Topics: Acute Disease; COVID-19; Humans; SARS-CoV-2
PubMed: 34076561
DOI: 10.1513/AnnalsATS.202103-255ED -
Nature Communications Jul 2021Acute pancreatitis is a disease associated with suffering and high lethality. Although the disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic...
Acute pancreatitis is a disease associated with suffering and high lethality. Although the disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar cells is a known pathogenic trigger. Here, we show macrophage membrane-coated nanoparticles with a built-in 'lure and kill' mechanism (denoted 'MΦ-NP(L&K)') for the treatment of acute pancreatitis. MΦ-NP(L&K) are made with polymeric cores wrapped with natural macrophage membrane doped with melittin and MJ-33. The membrane incorporated melittin and MJ-33 function as a PLA2 attractant and a PLA2 inhibitor, respectively. These molecules, together with membrane lipids, work synergistically to lure and kill PLA2 enzymes. These nanoparticles can neutralize PLA2 activity in the sera of mice and human patients with acute pancreatitis in a dose-dependent manner and suppress PLA2-induced inflammatory response accordingly. In mouse models of both mild and severe acute pancreatitis, MΦ-NP(L&K) confer effective protection against disease-associated inflammation, tissue damage and lethality. Overall, this biomimetic nanotherapeutic strategy offers an anti-PLA2 treatment option that might be applicable to a wide range of PLA2-mediated inflammatory disorders.
Topics: Acute Disease; Animals; Cytokines; Disease Models, Animal; Female; Humans; Inflammation; Macrophages; Melitten; Mice; Nanoparticles; Pancreatitis; Phospholipases A2; THP-1 Cells
PubMed: 34230486
DOI: 10.1038/s41467-021-24447-4 -
Annals of Hepatology 2022
Topics: Acute Disease; COVID-19; Child; Hepatitis; Humans; Pandemics
PubMed: 35786447
DOI: 10.1016/j.aohep.2022.100731 -
Nature Communications Feb 2023Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly...
Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, we show our method can reverse life-threatening acute allergic reactions in a female mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine, which is the current gold standard 'self-injectable epinephrine' strategy. This innovative method may provide a promising means to manage acute disease for personalized medicine.
Topics: Animals; Mice; Female; Acute Disease; Drug Delivery Systems; Administration, Cutaneous; Skin; Acoustics
PubMed: 36797284
DOI: 10.1038/s41467-023-36581-2 -
Saudi Journal of Gastroenterology :... 2022
Topics: Humans; Pancreatitis; Acute Disease; Cholecystectomy; Cholelithiasis; Recurrence
PubMed: 36254931
DOI: 10.4103/sjg.sjg_396_22 -
CMAJ : Canadian Medical Association... Sep 2022
Topics: Humans; Diverticulitis; Acute Disease
PubMed: 36265064
DOI: 10.1503/cmaj.220139 -
BMC Emergency Medicine Jul 2019The demand on Emergency Departments and acute medical services is increasing internationally, creating pressure on health systems and negatively influencing the quality... (Comparative Study)
Comparative Study
BACKGROUND
The demand on Emergency Departments and acute medical services is increasing internationally, creating pressure on health systems and negatively influencing the quality of delivered care. Visible consequences of the increased demand on acute services is crowding and queuing. This manifests as delays in the Emergency Departments, adverse clinical outcomes and poor patient experience.
OVERVIEW
Despite the similarities in the UK's and Dutch health care systems, such as universal health coverage, there are differences in the number of patients presenting at the Emergency Departments and the burden of crowding between these countries. Given the similarities in funding, this paper explores the similarities and differences in the organisational structure of acute care in the UK and the Netherlands. In the Netherlands, less patients are seen at the ED than in England and the admission rate is higher. GPs and so-called GP-posts serve 24/7 as gatekeepers in acute care, but EDs are heterogeneously organised. In the UK, the acute care system has a number of different access points and the accessibility of GPs seems to be suboptimal. Acute ambulatory care may relieve the pressure from EDs and Acute Medical Units. In both countries the ageing population leads to a changing case mix at the ED with an increased amount of multimorbid patients with polypharmacy, requiring generalistic and multidisciplinary care.
CONCLUSION
The acute and emergency care in the Netherlands and the UK face similar challenges. We believe that each system has strengths that the other can learn from. The Netherlands may benefit from an acute ambulatory care system and the UK by optimizing the accessibility of GPs 24/7 and improving signposting for urgent care services. In both countries the changing case mix at the ED needs doctors who are superspecialists instead of subspecialists. Finally, to improve the organisation of health care, doctors need to be visible medical leaders and participate in the organisation of care.
Topics: Acute Disease; Crowding; Emergency Medicine; Emergency Service, Hospital; General Practitioners; Humans; Netherlands; Physicians; Referral and Consultation; United Kingdom
PubMed: 31349797
DOI: 10.1186/s12873-019-0257-y -
Hematology. American Society of... Dec 2020Treatment of acute leukemia has been delivered predominantly in academic and larger leukemia treatment centers with the infrastructure and staff needed to manage... (Review)
Review
Treatment of acute leukemia has been delivered predominantly in academic and larger leukemia treatment centers with the infrastructure and staff needed to manage patients receiving complex therapeutic regimens and supportive care. However, in recent years, several oral agents and less-myelosuppressive regimens were approved, making it possible for these patients to receive therapy in smaller community hospitals and oncology office practices. In this review, we discuss the optimum community setting, type of patient who can be treated, agents that can be applied, and an appropriate clinical circumstance in which a referral to a tertiary center should be made.
Topics: Acute Disease; Community Mental Health Centers; Humans; Leukemia; Referral and Consultation
PubMed: 33275676
DOI: 10.1182/hematology.2020000096 -
Deutsches Arzteblatt International Jun 2017
Topics: Acute Disease; Aged, 80 and over; Humans; Male; Pulmonary Embolism; Radionuclide Imaging
PubMed: 28655375
DOI: 10.3238/arztebl.2017.0398