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Journal of the American Association For... Sep 2021The Syrian hamster () is a solitary and naturally territorial animal, with female hamsters being more aggressive than males. This behavior makes handling difficult...
The Syrian hamster () is a solitary and naturally territorial animal, with female hamsters being more aggressive than males. This behavior makes handling difficult because they are usually housed in groups, which can lead to aggressive behavior. The objective of this study was to refine the management of Syrian hamsters in order to minimize aggressiveness, reduce the animal injuries, and lessen the risk of accidents among laboratory animal technicians due to the hamster aggression during handling. The experiment was conducted at the Center for Animals Experimentation, Oswaldo Cruz Institute. Four groups of hamsters were observed by video recording: group 1 (group-housed males, 6 to 8 wk of age), group 2 (group-housed females 6 to 8 wk of age), group 3 (group-housed female, 3 to 4 wk of age), and group 4 (individually housed females, 6 to 8 wk of age). Group 1 animals were less aggressive and agitated both during housing and during handling by the animal technician as compared with groups 2 and 3. Groups 2 and 3 showed greater agitation and aggression. Marked reduction in the level of aggressiveness and agitation was observed in group 4 as compared with all other groups evaluated during handling by the animal technician. Male hamsters housed in groups of 4 and females housed individually have reduced risks of accident during handling, thereby averting distress and consequent physiologic alterations. Avoiding these risks is essential to obtaining reliable experimental results.
Topics: Aggression; Animals; Cricetinae; Female; Housing; Male; Mesocricetus; Territoriality
PubMed: 34301345
DOI: 10.30802/AALAS-JAALAS-21-000020 -
International Journal of Molecular... Aug 2022Being different multifactorial forms of psychopathology, aggression, depression and suicidal behavior, which is considered to be violent aggression directed against the... (Review)
Review
Being different multifactorial forms of psychopathology, aggression, depression and suicidal behavior, which is considered to be violent aggression directed against the self, have principal neurobiological links: preclinical and clinical evidence associates depression, aggression and suicidal behavior with dysregulation in central serotonergic (5-HT) neurotransmission. The implication of different types of 5-HT receptors in the genetic and epigenetic mechanisms of aggression, depression and suicidality has been well recognized. In this review, we consider and compare the orchestra of 5-HT receptors involved in these severe psychopathologies. Specifically, it concentrates on the role of 5-HT, 5-HT, 5-HT, 5-HT, 5-HT, 5-HT and 5-HT receptors in the mechanisms underlying the predisposition to aggression, depression and suicidal behavior. The review provides converging lines of evidence that: (1) depression-related 5-HT receptors include those receptors with pro-depressive properties (5-HT, 5-HT and 5-HT) as well as those providing an antidepressant effect (5-HT, 5-HT, 5-HT subtypes). (2) Aggression-related 5-HT receptors are identical to depression-related 5-HT receptors with the exception of 5-HT receptors. Activation of 5-HT, 5-HT 5-HT, 5-HT receptors attenuate aggressiveness, whereas agonists of 5-HT intensify aggressive behavior.
Topics: Aggression; Depression; Humans; Receptors, Serotonin; Serotonin; Suicide
PubMed: 35955946
DOI: 10.3390/ijms23158814 -
Journal of Fish Biology May 2021Fishes show remarkably diverse aggressive behaviour. Aggression is expressed to secure resources; adjusting aggression levels according to context is key to avoid... (Review)
Review
Fishes show remarkably diverse aggressive behaviour. Aggression is expressed to secure resources; adjusting aggression levels according to context is key to avoid negative consequences for fitness and survival. Nonetheless, despite its importance, the physiological basis of aggression in fishes is still poorly understood. Several reports suggest hormonal modulation of aggression, particularly by androgens, but contradictory studies have been published. Studies exploring the role of chemical communication in aggressive behaviour are also scant, and the pheromones involved remain to be unequivocally characterized. This is surprising as chemical communication is the most ancient form of information exchange and plays a variety of other roles in fishes. Furthermore, the study of chemical communication and aggression is relevant at the evolutionary, ecological and economic levels. A few pioneering studies support the hypothesis that aggressive behaviour, at least in some teleosts, is modulated by "dominance pheromones" that reflect the social status of the sender, but there is little information on the identity of the compounds involved. This review aims to provide a global view of aggressive behaviour in fishes and its underlying physiological mechanisms including the involvement of chemical communication, and discusses the potential use of dominance pheromones to improve fish welfare. Methodological considerations and future research directions are also outlined.
Topics: Aggression; Androgens; Animal Communication; Animals; Behavior, Animal; Biological Evolution; Fishes; Hormones; Pheromones
PubMed: 33410154
DOI: 10.1111/jfb.14667 -
Medicine Sep 2023Anger and aggression are common sources of distress and impairment. There is, however, no available data on anger and aggression based on bibliometric analysis. This...
Anger and aggression are common sources of distress and impairment. There is, however, no available data on anger and aggression based on bibliometric analysis. This study uses bibliometric analysis to analyze research hotspots and trends in anger and aggression. Publications on anger and aggression within the last ten years were collected from the Web of Science Core Collection. Using descriptive bibliometrics, journals, countries, institutions, authors, references, and keywords in anger and aggression research were visually analyzed via CiteSpace. A total of 3114 articles were included, and studies on anger and aggression increased yearly. The publications are mainly from 106 countries led by the USA and 381 institutions led by Univ Penn. We identified 505 authors, where Emil F. Coccaro had the highest number of articles, while Buss A.H. was the most frequently co-cited author. AGGRESSIVE BEHAVIOR is the journal that bore most of the studies, while PLOS ONE was the most cited journal. Our analysis demonstrated that research on anger and aggression is flourishing. Behaviors of anger and aggression, risk factors, neural mechanisms, personality, and adolescence have been researched hotspots in the past ten years. Besides, victimization, drosophila melanogaster, psychopathic traits, and perpetration are emerging anger and aggression research trends.
Topics: Animals; Drosophila melanogaster; Aggression; Anger; Bullying; Bibliometrics
PubMed: 37682125
DOI: 10.1097/MD.0000000000035132 -
CNS Spectrums Jun 2015Elevations of impulsive behavior have been observed in a number of serious mental illnesses. These phenomena can lead to harmful behaviors, including violence, and thus... (Review)
Review
Elevations of impulsive behavior have been observed in a number of serious mental illnesses. These phenomena can lead to harmful behaviors, including violence, and thus represent a serious public health concern. Such violence is often a reason for psychiatric hospitalization, and it often leads to prolonged hospital stays, suffering by patients and their victims, and increased stigmatization. Despite the attention paid to violence, little is understood about its neural basis in schizophrenia. On a psychological level, aggression in schizophrenia has been primarily attributed to psychotic symptoms, desires for instrumental gain, or impulsive responses to perceived personal slights. Often, multiple attributions can coexist during a single aggressive incident. In this review, I discuss the neural circuitry associated with impulsivity and aggression in schizophrenia, with an emphasis on implications for treatment. Impulsivity appears to account for a great deal of aggression in schizophrenia, especially in inpatient settings. Urgency, defined as impulsivity in the context of strong emotion, is the primary focus of this article. It is elevated in several psychiatric disorders, and in schizophrenia, it has been related to aggression. Many studies have implicated dysfunctional frontotemporal circuitry in impulsivity and aggression in schizophrenia, and pharmacological treatments may act via that circuitry to reduce urgency and aggressive behaviors; however, more mechanistic studies are critically needed. Recent studies point toward manipulable neurobehavioral targets and suggest that cognitive, pharmacological, neuromodulatory, and neurofeedback treatment approaches can be developed to ameliorate urgency and aggression in schizophrenia. It is hoped that these approaches will improve treatment efficacy.
Topics: Aggression; Humans; Impulsive Behavior; Nerve Net; Neurobiology; Schizophrenic Psychology
PubMed: 25900066
DOI: 10.1017/S1092852915000206 -
International Journal of Environmental... Feb 2022Harsh parenting and its effect on children's aggressive behavior has received attention from researchers, however few studies have considered the role of the emotional...
Harsh parenting and its effect on children's aggressive behavior has received attention from researchers, however few studies have considered the role of the emotional process. This study aims to examine the relationship between harsh parenting, children's aggressive behavior, normative beliefs about aggression, and regulatory emotional self-efficacy, alongside their mechanism of interplay. A sample of 235 senior primary school students in Beijing were recruited as participants by using the Harsh Parenting Scale, the Normative Beliefs about Aggression Scale, the Buss-Warren Aggression Questionnaire, and the Regulatory Emotional Self-Efficacy Scale. Results indicated that: (1) Harsh parenting had a significant positive predictive effect on children's aggressive behavior after controlling gender; (2) normative beliefs about the aggression of children mediated the relationship between harsh parenting and children's aggressive behavior; and (3) regulatory emotional self-efficacy had moderating effects both the mediation model of normative beliefs about the aggression of children and in the direct predictive model of harsh parenting on children's aggressive behavior. The results are not only helpful to understand the relationship between harsh parenting and children's aggressive behavior from the perspective of an integrated model of emotion processes and cognition, but also provide a new practical way to prevent and intervene in children's aggressive behavior in the future.
Topics: Aggression; Beijing; Child; Emotions; Humans; Parenting; Students
PubMed: 35206591
DOI: 10.3390/ijerph19042403 -
Evolutionary Psychology : An... 2018Research shows that interpersonal rejection increases aggression and decreases helping toward the rejecter. Based on the assumptions of the evolutionary approach, it was...
Research shows that interpersonal rejection increases aggression and decreases helping toward the rejecter. Based on the assumptions of the evolutionary approach, it was hypothesized that aggression would be higher and helping would be lower after rejection by a same-sex rather than an opposite-sex other. Moreover, it was predicted that the effect for aggression would be stronger in men, and the effect for helping would be stronger in women. Participants ( N = 100) were rejected or accepted by a same- or opposite-sex person, and later aggression and helping were measured using the tangram Help-Hurt task. The major finding was that same-sex rejection resulted in more aggression and less helping than opposite-sex rejection, but the rejectee's sex did not moderate the effect. Instead, men were more aggressive and less helping independently of condition. Along with the sexual exchange theory, more negative behavior in same-sex rejection could be interpreted as raised in-group sexual competitive tendencies, whereas less negative behavior in opposite-sex rejection could result from the motivation to exchange resources between men and women.
Topics: Adolescent; Adult; Aggression; Female; Helping Behavior; Humans; Interpersonal Relations; Male; Rejection, Psychology; Sex Characteristics; Young Adult
PubMed: 29759017
DOI: 10.1177/1474704918775253 -
Emotion (Washington, D.C.) Apr 2021Aggression is an affect-laden behavior. The within-person variability of affective states that immediately precede, accompany, and follow aggression-and their links to...
Aggression is an affect-laden behavior. The within-person variability of affective states that immediately precede, accompany, and follow aggression-and their links to between-person variability in aggressive behavior and traits-remain incompletely understood. To address this gap in our understanding, we examined 8 studies in which 2,173 participants reported the negative and positive affect they experienced before, during, and after a laboratory or online aggression task. We quantified the within-person variability within and across negative and positive affect intensity, as well as the variability in oscillations between negative and positive affect Internal meta-analyses revealed an association between aggressive behavior and traits and flux in positive affect (against our preregistered predictions). Probing this effect with piecewise growth models showed that less aggressive individuals exhibited a pronounced decrease in positive affect during aggression, as compared to before and after the act. This downward fluctuation in positive affect was attenuated among aggressive individuals, who exhibited relatively stable levels of positive aggression-related affect. Thus, stable positive affect surrounding an aggressive act and higher positive affect during the act may buttress and promote aggressive tendencies. These findings support a reinforcement model of aggressive behavior, contrast with the aggression literature's conventional focus on negative affect and the instability thereof, and point to the utility of dynamic measures of moment-to-moment affect in understanding human social behavior. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Topics: Adolescent; Adult; Affect; Aged; Aged, 80 and over; Aggression; Female; Humans; Male; Middle Aged; Social Behavior; Young Adult
PubMed: 32191100
DOI: 10.1037/emo0000730 -
Translational Psychiatry Oct 2023The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), published in 2013, includes an alternative model of personality disorders (AMPD)...
The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), published in 2013, includes an alternative model of personality disorders (AMPD) focusing on a maladaptive trait model utilized to diagnose several personality disorders. Borderline personality disorder (BPD) and antisocial personality disorder (ASPD) are two conditions categorized by AMPD that exhibit high rates of violence and aggression. Several of the traits outlined in the AMPD, including hostility, impulsivity, risk-taking, and callousness, have been previously linked to aggression in BPD and ASPD. However, to the best of our knowledge, there has never been a synthesis of neuroimaging studies that have investigated links between these traits and aggression in BPD and ASPD. To overcome this gap, we conducted a systematic review under the PRISMA framework to locate neuroimaging articles published since the release of AMPD linking trait anger/hostility, impulsivity, risk-taking, and callousness to aggression in BPD and ASPD. Key findings included the following: i) anger/hostility, associated with alterations in the interplay between prefrontal and subcortical regions (primarily the amygdala), may be a common factor explaining aggressive reactions to response to interpersonal threat or provocation; ii) alterations of fronto-temporal-limbic regions and serotonergic and endocannabinoid signaling systems may link impulsivity to aggression in BPD and ASPD; iii) weaker cortico-striatal connectivity could relate to greater risk taking and greater proclivity for violence. Insufficient evidence from neuroimaging articles was discerned to describe a relationship between callousness and aggression. Overall, results of this review reveal a relative paucity of neuroimaging studies examining AMPD traits relevant to aggression in BPD and ASPD. In addition to encouraging further investigation of neuroimaging markers of AMPD traits linked to aggression, we recommend multi-methodological designs, including the incorporation of other biomarkers, such as hormones and indices of physiological arousal, to fully expand our understanding of aggression in BPD and ASPD.
Topics: Humans; Aggression; Anger; Antisocial Personality Disorder; Borderline Personality Disorder; Diagnostic and Statistical Manual of Mental Disorders
PubMed: 37884552
DOI: 10.1038/s41398-023-02612-1 -
European Neuropsychopharmacology : the... Jan 2020The RBFOX1 gene (or A2BP1) encodes a splicing factor important for neuronal development that has been related to autism spectrum disorder and other neurodevelopmental... (Review)
Review
The RBFOX1 gene (or A2BP1) encodes a splicing factor important for neuronal development that has been related to autism spectrum disorder and other neurodevelopmental phenotypes. Evidence from complementary sources suggests that this gene contributes to aggressive behavior. Suggestive associations with RBFOX1 have been identified in genome-wide association studies (GWAS) of anger, conduct disorder, and aggressive behavior. Nominal association signals in RBFOX1 were also found in an epigenome-wide association study (EWAS) of aggressive behavior. Also, variants in this gene affect temporal lobe volume, a brain area that is altered in several aggression-related phenotypes. In animals, this gene has been shown to modulate aggressive behavior in Drosophila. RBFOX1 has also been associated with canine aggression and is upregulated in mice that show increased aggression after frustration of an expected reward. Associated common genetic variants as well as rare duplications and deletions affecting RBFOX1 have been identified in several psychiatric and neurodevelopmental disorders that are often comorbid with aggressive behaviors. In this paper, we comprehensively review the cumulative evidence linking RBFOX1 to aggression behavior and provide new results implicating RBFOX1 in this phenotype. Most of these studies (genetic and epigenetic analyses in humans, neuroimaging genetics, gene expression and animal models) are hypothesis-free, which strengthens the validity of the findings, although all the evidence is nominal and should therefore be taken with caution. Further studies are required to clarify in detail the role of this gene in this complex phenotype.
Topics: Aggression; Animals; Epigenesis, Genetic; Genetic Association Studies; Genetic Variation; Genome-Wide Association Study; Humans; RNA Splicing Factors
PubMed: 29174947
DOI: 10.1016/j.euroneuro.2017.11.012