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Sensors (Basel, Switzerland) Aug 2022Industry 4.0, smart homes, and the Internet of Things are boosting the employment of autonomous aerial vehicles in indoor environments, where localization is still...
Industry 4.0, smart homes, and the Internet of Things are boosting the employment of autonomous aerial vehicles in indoor environments, where localization is still challenging, especially in the case of close and cluttered areas. In this paper, we propose a Visual Inertial Odometry localization method based on fiducial markers. Our approach enables multi-rotor aerial vehicle navigation in indoor environments and tackles the most challenging aspects of image-based indoor localization. In particular, we focus on a proper and continuous pose estimation, working from take-off to landing, at several different flying altitudes. With this aim, we designed a map of fiducial markers that produces results that are both dense and heterogeneous. Narrowly placed tags lead to minimal information loss during rapid aerial movements while four different classes of marker size provide consistency when the camera zooms in or out according to the vehicle distance from the ground. We have validated our approach by comparing the output of the localization algorithm with the ground-truth information collected through an optoelectronic motion capture system, using two different platforms in different flying conditions. The results show that error mean and standard deviation can remain constantly lower than 0.11 m, so not degrading when the aerial vehicle increases its altitude and, therefore, strongly improving similar state-of-the-art solutions.
Topics: Algorithms; Altitude; Internet; Motion; Movement
PubMed: 35957353
DOI: 10.3390/s22155798 -
Journal of Molecular Medicine (Berlin,... Dec 2017About 1.2 to 33% of high-altitude populations suffer from Monge's disease or chronic mountain sickness (CMS). Number of factors such as age, sex, and population of... (Review)
Review
About 1.2 to 33% of high-altitude populations suffer from Monge's disease or chronic mountain sickness (CMS). Number of factors such as age, sex, and population of origin (older, male, Andean) contribute to the percentage reported from a variety of samples. It is estimated that there are around 83 million people who live at altitudes > 2500 m worldwide and are at risk for CMS. In this review, we focus on a human "experiment in nature" in various high-altitude locations in the world-namely, Andean, Tibetan, and Ethiopian populations that have lived under chronic hypoxia conditions for thousands of years. We discuss the adaptive as well as mal-adaptive changes at the genomic and physiological levels. Although different genes seem to be involved in adaptation in the three populations, we can observe convergence at genetic and signaling, as well as physiological levels. What is important is that we and others have shown that lessons learned from the genes mined at high altitude can be helpful in better understanding and treating diseases that occur at sea level. We discuss two such examples: EDNRB and SENP1 and their role in cardiac tolerance and in the polycythemic response, respectively.
Topics: Adaptation, Physiological; Altitude; Founder Effect; Genetics, Population; Genomics; Humans; Hypoxia
PubMed: 28951950
DOI: 10.1007/s00109-017-1584-7 -
Sensors (Basel, Switzerland) Nov 2022This paper introduces a technique to transform between geometric and barometric estimates of altitude and vice-versa. Leveraging forecast numerical weather models, the...
This paper introduces a technique to transform between geometric and barometric estimates of altitude and vice-versa. Leveraging forecast numerical weather models, the method is unbiased and has a vertical error with a standard deviation of around 30 m (100 ft), regardless of aircraft altitude, which makes it significantly more precise than established comparable conversion functions. This result may find application in various domains of civil aviation, including vertical RNP, systemized airspace, and automatic landing systems.
Topics: Aircraft; Altitude; Aviation; Weather
PubMed: 36501962
DOI: 10.3390/s22239263 -
Journal of Applied Gerontology : the... Jun 2022To assess the association between municipality altitude and quality of life (QOL) of older people in Colombia.
OBJECTIVE
To assess the association between municipality altitude and quality of life (QOL) of older people in Colombia.
METHODS
Cross-sectional study with data from the Colombian Demographic and Health Survey Older Adult Questionnaire 2015 ( = 13,970). QOL was measured in six domains: physical health, psychological health, functional status, social relations, medical history and economic status. Regression analyses were carried out adjusting by individual and contextual level variables.
RESULTS
Low altitude was associated with better QOL: physical health (OR = 1.92, 95%CI 1.47-2.52), psychological health (OR = 1.59, 95%CI 1.26-2.00), functional status (OR=1.80, 95%CI 1.45-2.23), social relations (OR = 2.16 95%CI 1.73-2.70), and medical history (OR = 1.57, 95%CI 1.37-1.81). Economic status was not associated with altitude.
DISCUSSION
Living at high altitude was associated with lower QOL for Colombian older adults. This finding encourages further study of high altitude and health outcomes among older adults in Colombia and other countries with populations living at high altitudes.
Topics: Aged; Altitude; Colombia; Cross-Sectional Studies; Humans; Quality of Life; Socioeconomic Factors
PubMed: 35426334
DOI: 10.1177/07334648221078577 -
Brazilian Journal of Microbiology :... Dec 2020There are many kinds of microorganisms in the gastrointestinal tract of mammals, some of which are closely related to the host. Rumen microorganisms are essential for...
There are many kinds of microorganisms in the gastrointestinal tract of mammals, some of which are closely related to the host. Rumen microorganisms are essential for normal physiological activities of their host by decomposing plant crude lignin and providing essential nutrients. The composition and diversity of this microbial population are influenced by the host, environment, and diet. Despite its importance, little is known about the effects of factors such as altitude variation on rumen microbial population abundance and diversity in different ruminants. Here, we described the changes in overall rumen bacteria in four groups of cattle, including the Zhongdian yellow cattle and Zhongdian yaks, grazing at high altitudes (3600 m); the Jiangcheng yellow cattle and Jiangcheng buffalo were kept at an altitude of 1100 m. We found that there was a significant difference in rumen bacterial abundance of the Zhongdian yellow cattle and Zhongdian yaks at high altitude and there was obvious homogeneity in rumen bacterial abundance and diversity in the Jiangcheng yellow cattle and Jiangcheng buffalo at low altitude. Therefore, our research concluded that under the same dietary environment, there were differences in the abundance and diversity of certain bacteria in the rumen of different breeds of cattle, indicating that host genetic factors and intestinal microorganisms related to altitudinal variation had a greater influence on rumen bacterial abundance in the cattle.
Topics: Altitude; Animal Feed; Animals; Bacteria; Cattle; Gastrointestinal Microbiome; Phylogeny; Rumen
PubMed: 32949385
DOI: 10.1007/s42770-020-00380-4 -
Bone Jan 2022Mountaineers at high altitude are at increased risk of acute mountain sickness as well as high altitude pulmonary and cerebral edema. A densitometric study in...
Mountaineers at high altitude are at increased risk of acute mountain sickness as well as high altitude pulmonary and cerebral edema. A densitometric study in mountaineers has suggested that expeditions at high altitude decrease bone mineral density. Surprisingly, the in vivo skeletal effects of hypobaric hypoxia are largely unknown, and have not been studied using advanced contemporary methods to assess bone microstructure. Eighty-four 22-week-old female mice were divided into seven groups with 12 mice in each group: 1. Baseline; 2. Normobaric, 4 weeks; 3. Hypobaric hypoxia, 4 weeks; 4. Normobaric, 8 weeks; 5. Hypobaric hypoxia, 8 weeks; 6. Normobaric, 12 weeks; and 7. Hypobaric hypoxia, 12 weeks. Hypobaric hypoxia mice were housed in hypobaric chambers at an ambient pressure of 500 mbar (5500 m altitude), while normobaric mice were housed at sea level atmospheric pressure for 4, 8, or 12 weeks, respectively. Hypobaric hypoxia had a profound impact on femoral cortical bone and L4 trabecular bone, while the effect on femoral trabecular bone was less pronounced. Hypobaric hypoxia reduced the bone strength of the femoral mid-diaphysis and L4 at all time-points. At femoral cortical bone, hypobaric hypoxia reduced bone formation through fewer mineralizing surfaces and lower bone formation rate after 2 weeks. In addition, bone strength decreased, and C-terminal telopeptide of type I collagen (CTX-I) increased independently of the duration of exposure to simulated high altitude. At L4, hypobaric hypoxia resulted in a substantial reduction in bone volume fraction, trabecular thickness, and trabecular number after 4 weeks of exposure. Hypobaric hypoxia reduced bone strength and femoral bone mass, while femoral trabecular bone was much less affected, indicating the skeletal response to hypobaric hypoxia differ between cortical and trabecular bone. These findings provide initial preclinical support for future clinical studies in mountaineers to assess bone status and bone strength after exposure to prolonged high altitude exposure.
Topics: Acute Disease; Altitude; Altitude Sickness; Animals; Bone Density; Female; Hypoxia; Mice
PubMed: 34536630
DOI: 10.1016/j.bone.2021.116203 -
Scientific Reports Sep 2023High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on...
High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better methods of acclimatization/training at high altitude. The aspect of altitude de-induction/de-acclimatization has remained clouded despite the fact that it was documented since the first decade of twentieth century. A few recent studies, particularly in China, have stated unanimously that high altitude de-acclimatization involved multiple observable clinical symptoms ranging from headache to abdominal distention. These symptoms have been collectively referred to as "high altitude de-acclimatization syndrome" (HADAS). However, computational omics and network biology centric investigations concerning HADAS are nascent. In this study, we focus on the quantitative proteo-informatics, especially network biology, of human plasma proteome in individuals who successfully descended from high altitude areas after a stay of 120 days. In brief, the protein list was uploaded into STRING and IPA to compute z-score based cut-offs which were used to analyze the directionality and significance of various identified protein networks as well as the proteins within them. Relevant upstream regulators extracted using computational strategies were also validated. Time-points till the 180th day of de-induction have been investigated to comparatively assess the changes in the plasma proteome and protein pathways of such individuals since the 7th day of arrival at altitude. Our investigation revealed extensive effects of de-induction on lipid metabolism, inflammation and innate immune system as well as coagulation system. This novel study provides a conceptual framework for formulating therapeutic strategies to ease the symptoms of HADAS during de-acclimatization. Such strategies should focus on normalization of lipid metabolism, inflammatory signaling and coagulation systems.
Topics: Humans; Altitude; Proteome; Acclimatization; Blood Coagulation; China
PubMed: 37679378
DOI: 10.1038/s41598-023-40576-w -
BMC Public Health Nov 2021The SARS-CoV-2/COVID-19 pandemic has claimed nearly 900,000 lives worldwide and infected more than 27 million people. Researchers worldwide are studying ways to decrease...
BACKGROUND
The SARS-CoV-2/COVID-19 pandemic has claimed nearly 900,000 lives worldwide and infected more than 27 million people. Researchers worldwide are studying ways to decrease SARS-CoV-2 transmission and COVID-19 related deaths. Several studies found altitude having a negative association with both COVID-19 incidence and deaths. Ecuadorian data was used to explore the relationship between altitude and COVID-19.
METHODS
This is an ecological study examining province-level data. To explore a relationship between altitude and COVID-19, this study utilized publicly available COVID-19 data and population statistics. ANOVA, correlation statistics, and a multivariate linear model explored the relationship between different Ecuadorian altitudes against incidence, mortality, and case-fatality rates. Population statistics attributed to COVID-19 were included in the linear model to control for confounding factors.
RESULTS
Statistically significant differences were observed in the regions of Amazónica, Sierra, Costa of Ecuador for incidence, mortality, and case fatality rates, suggesting an association between altitude and SARS-CoV-2 transmission and COVID-19 disease severity (p-value ≤0.05). In univariate analysis, altitude had a negative association to mortality rate with a 1-unit change in altitude resulting in the decrease of 0.006 units in mortality rate (p-value = 0.03). The multiple linear models adjusted for population statistics showed a statistically significant negative association of altitude with mortality rate (p-value = 0.01) with a 1-unit change in altitude resulting in the decrease in mortality rate by 0.015 units. Overall, the model helped in explaining 50% (R = 0.4962) of the variance in mortality rate.
CONCLUSION
Altitude may have an effect on COVID-19 mortality rates. However, based on our model and R value, the relationship between our variables of interest and COVID-19 mortality may be nonlinear. More research is needed to understand why altitude may have a protective effect against COVID-19 mortality and how this may be applicable in a clinical setting.
Topics: Altitude; COVID-19; Ecuador; Humans; Pandemics; SARS-CoV-2
PubMed: 34772396
DOI: 10.1186/s12889-021-12162-0 -
Italian Journal of Pediatrics Mar 2024Asthma is one of the most common non-communicable diseases, and its prevalence and morbidity are influenced by a wide array of factors that are only partially... (Review)
Review
Asthma is one of the most common non-communicable diseases, and its prevalence and morbidity are influenced by a wide array of factors that are only partially understood. In addition to individual predisposition linked to genetic background and early life infections, environmental factors are crucial in determining the impact of asthma both on an individual patient and on a population level.Several studies have examined the role of the environment where asthmatic subjects live in the pathogenesis of asthma. This review aims to investigate the differences in the prevalence and characteristics of asthma between the pediatric population residing at higher altitudes and children living at lower altitudes, trying to define factors that potentially determine such differences. For this purpose, we reviewed articles from the literature concerning observational studies assessing the prevalence of pediatric asthma in these populations and its characteristics, such as spirometric and laboratory parameters and associated sensitization to aeroallergens.Despite the heterogeneity of the environments examined, the hypothesis of a beneficial effect of residing at a higher altitude on the prevalence of pediatric asthma could be confirmed, as well as a good profile on airway inflammation in asthmatic children. However, the possibility of a higher hospitalization risk for asthma in children living at higher altitudes was demonstrated. Moreover, a positive association between residing at a higher altitude and sensitization to pollens and between lower altitude and sensitization to house dust mites could be confirmed in some pediatric patients, even if the results are not homogeneous, probably due to the different geographical and climatic regions considered. Nonetheless, further studies, e.g., extensive and international works, need to be conducted to better understand the complex interplay between different environmental factors, such as altitude, and the pathogenesis of asthma and how its prevalence and characteristics could vary due to climate change.
Topics: Humans; Child; Altitude; Asthma; Genotype; Geography; Hospitalization
PubMed: 38448980
DOI: 10.1186/s13052-023-01492-x -
Clinical Autonomic Research : Official... Feb 2021
Topics: Altitude; Autonomic Nervous System; Exercise; Heart Rate; Humans; Hypoxia
PubMed: 33399958
DOI: 10.1007/s10286-020-00754-6