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International Journal of Implant... Feb 2022The aim of this study was to longitudinally evaluate changes in alveolar bone crest (ABC) levels and differences in resorption rates (RR) between the tested grafting... (Randomized Controlled Trial)
Randomized Controlled Trial
A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials.
PURPOSE
The aim of this study was to longitudinally evaluate changes in alveolar bone crest (ABC) levels and differences in resorption rates (RR) between the tested grafting materials following alveolar ridge preservation (ARP) after tooth extraction after 1, 2, and 3 years (T1-T8) of clinical function.
METHODS
Patients were randomly assigned to two different bone allografts (group 1 maxgraft, group 2 Puros) for ARP. Non-restorable teeth were minimal traumatically extracted. Sockets were augmented with the tested materials and covered with a pericardium membrane. After 4 months of healing, 36 implants were placed and sites were clinically and radiographically monitored in the mesial (ABC-M), the distal (ABC-D, T1-T8), the bucco-lingual (ABC-BL), buccal (ABC-B) and oral (ABC-O) aspect (T1-T4).
RESULTS
Changes in (ABC-M), (ABC-D), (ABC-BL), (ABC-B), and (ABC-O) levels showed statistically highly significant differences between T1 and T2 for both bone allografts (p < 0.001). Changes at the ABC-M and ABC-BL levels between T2 and T3 of group 1 showed a statistically significant difference (p < 0.001). Both groups achieved and maintained increased ABC levels without statistically significant differences throughout the monitoring periods of 1-3 years (T6-T8) of clinical function. No failures or adverse events were observed.
CONCLUSIONS
To the best of our knowledge, this study is within its limitations the first study to directly compare ABC-changes and differences in RR of two different allogeneic grafting materials for a period of 3 years after ARP. It was demonstrated to be, despite significant differences in RR, a successful method of preserving increased ABC levels through 1, 2, and 3 years of clinical function. Trial registration DRKS00013010, registered 07/30/2018, http://apps.who.int/trialsearch.
Topics: Alveolar Bone Loss; Alveolar Process; Alveolar Ridge Augmentation; Dental Implants; Hematopoietic Stem Cell Transplantation; Humans; Prospective Studies; Tooth Socket
PubMed: 35102440
DOI: 10.1186/s40729-022-00402-w -
Clinical Interventions in Aging 2017The morphology of the alveolar process determines the retention and stability of prosthetic restorations, thereby determining the result of the therapy. Considering that...
OBJECTIVES
The morphology of the alveolar process determines the retention and stability of prosthetic restorations, thereby determining the result of the therapy. Considering that the edentulous jaws may be affected by the atrophy process, it was hypothesized that the morphology of the alveolar process of the maxilla may be dependent on the anterior facial height and anatomy of the mandible.
SUBJECTS AND METHODS
Twenty-five healthy edentulous Caucasian individuals were randomly chosen. Each subject underwent a lateral cephalogram before and after prosthetic rehabilitation. During exposition, newly made prostheses were placed in the patient's mouth. Teeth remained in maximal intercuspidation. Morphological parameters were evaluated according to the Ricketts, McNamara, and Tallgren's method.
RESULTS
An inversely proportional association was observed between patient age and the distal part of the maxilla. A statistically significant connection was noted between the vertical dimension of alveolar ridge and anterior total and lower facial height conditioned by prosthetic rehabilitation.
CONCLUSION
The height of the lateral part of the alveolar ridge of the maxilla remains in connection with the anterior total and lower facial height obtained in the course of prosthetic rehabilitation. The vertical dimension of the alveolar ridge of the maxilla seems to be in close relationship with the morphology of the lower jaw.
Topics: Adult; Alveolar Process; Atrophy; Cephalometry; Dental Arch; Face; Female; Humans; Male; Mandible; Maxilla; Middle Aged; Mouth, Edentulous; Vertical Dimension
PubMed: 28979109
DOI: 10.2147/CIA.S140791 -
Journal of Periodontal Research Aug 2015Peri-implantitis has a prevalence of 11-47%, involves destruction of peri-implant bone and may lead to implant loss. A detailed understanding of the pathogenesis of... (Comparative Study)
Comparative Study
BACKGROUND AND OBJECTIVE
Peri-implantitis has a prevalence of 11-47%, involves destruction of peri-implant bone and may lead to implant loss. A detailed understanding of the pathogenesis of peri-implantitis is lacking. The objective of this study was to develop a murine model of experimental peri-implantitis.
MATERIAL AND METHODS
Machined, smooth-surface, screw-shaped titanium implants were placed in the healed alveolar bone of the left maxillary molars of C57BL/6J male mice, 8 wk after tooth extraction. Peri-implantitis was induced by securing silk ligatures around the head of the implant fixtures. Implant survival and peri-implant bone levels were analyzed by micro-computed tomography (micro-CT) scans and histology, 12 wk after ligature placement.
RESULTS
Implant survival was 60% (six of 10) for implants with ligatures and 100% (eight of eight) for controls. Micro-CT revealed significantly greater bone loss around the implants that received ligatures and that survived, compared with controls. The radiographic findings were confirmed via histology and toluidine blue staining.
CONCLUSION
This study describes a murine model of experimental peri-implantitis around screw-shaped titanium implants placed in the edentulous alveolar bone. This model should be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate potential treatment interventions.
Topics: Alloys; Alveolar Process; Animals; Coloring Agents; Dental Alloys; Dental Implants; Dental Prosthesis Design; Disease Models, Animal; Male; Maxilla; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Peri-Implantitis; Survival Analysis; Time Factors; Titanium; Tolonium Chloride; Tooth Socket; X-Ray Microtomography
PubMed: 25244403
DOI: 10.1111/jre.12234 -
BMC Oral Health Oct 2021This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation.
MATERIAL AND METHODS
Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distractor activation, patients were randomly divided into two equal groups according to administered drug (placebo and Cissus quadrangularis group). After a consolidation period, distractors were removed and implants were inserted. Clinical evaluation was done to assess wound healing, and distractor and implant stability. Histological evaluation was performed at time of implant insertion. Radiographic evaluation was performed to assess bone volume and density after distraction, as well as, density and bone loss around implant.
RESULTS
Radiographic and histological results showed that bone formation and maturation of study group were faster than that of control group. There was a significant increased bone density in distracted area and around implant in study group than control group. A significant bone loss at end of consolidation period, and around implant at end of the study was reported in control group than study group.
CONCLUSION
Cissus quadrangularis administration during the consolidation period is associated with increased osteogenic potential of distracted bone. The histological and radiographic findings of current study proved that Cissus quadrangularis not only enhances rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time. Trial registration This study was retrospectively registered on www.ClinicalTrial.gov : NCT04669795-17\12\2020.
Topics: Alveolar Ridge Augmentation; Cissus; Dental Implantation, Endosseous; Humans; Mandible; Osteogenesis; Osteogenesis, Distraction; Tooth Socket
PubMed: 34607598
DOI: 10.1186/s12903-021-01847-y -
Medicine Jul 2022The aim of this article is to assess the formation of new vital bone (VB) using histomorphometric analysis in alveolar ridge preservation (ARP), with and without primary... (Randomized Controlled Trial)
Randomized Controlled Trial
Histological and histomorphometric evaluation of alveolar ridge preservation using an allograft and nonresorbable membrane with and without primary closure: A pilot randomized controlled clinical trial.
The aim of this article is to assess the formation of new vital bone (VB) using histomorphometric analysis in alveolar ridge preservation (ARP), with and without primary closure. Eight patients needed bilateral tooth extraction and planned for ARP. All patients had a nonresorbable membrane with freeze-dried bone allograft after the extractions. Biopsies were obtained 6 months after ARP and were evaluated using histomorphometric analysis. The study included 6 males and 2 females, with an average age of 54.2 years (standard deviation, 9.7). The teeth requiring extraction included a bilateral canine (1 case), premolars (5 cases), and molars (2 cases). Histomorphometric values of new VB, residual bone (RB) substitute particles, and marrow tissue formation were 71.1 %, 16.2%, and 9.69% for closed flap and 50.9%, 15.3%, and 8.19 for open flap. P values were 0.066, 0.878, and 0.326, respectively. The present findings indicate that leaving the flap without primary closure did not have any effect on new VB, RB particles, and immature bone marrow compared with closed flap. However, the results favored the closed-flap technique.
Topics: Allografts; Alveolar Process; Alveolar Ridge Augmentation; Female; Humans; Male; Pilot Projects; Tooth Socket
PubMed: 35777057
DOI: 10.1097/MD.0000000000029769 -
Clinical Implant Dentistry and Related... Jun 2021The current evidence regarding the alterations experienced by the alveolar ridge (hard tissue changes) after implant removal due to peri-implantitis is limited.
BACKGROUND
The current evidence regarding the alterations experienced by the alveolar ridge (hard tissue changes) after implant removal due to peri-implantitis is limited.
PURPOSE
To assess the hard tissue dimensional changes following implant removal due to peri-implantitis.
MATERIAL AND METHODS
Clinical records were examined to identify patients with implants that had to be removed due to a hopeless prognosis secondary to peri-implantitis due to expendability of peri-implantitis implants for functional reasons. Patients with preoperative and postoperative cone-beam computed tomography (CBCT) scans were included. Patient-related, implant-related, and surgery-related factors were assessed based on the clinical records. Linear measurements were made to evaluate the influence of bone plate thickness (BPT), ridge width (RW), and ridge height (RH) at various levels upon the outcome of implant removal. A descriptive statistical analysis of the quantitative and qualitative variables was performed. Correlations of the variables with the primary outcome (dimensional changes) were tested using univariate and multivariate analyses (multinomial random intercept mixed model linear regressions).
RESULTS
A total of 26 patients (n = 79) met the eligibility criteria. The mean decrease in RW at 1 and 3 mm below the crest was 11.3% and 4.4%, respectively (P < 0.001). Buccal and lingual RH was significantly reduced by 2.2% and 6.3%, respectively (P < 0.001). Few patient-related, implant-related, and surgery-related factors appeared to have an impact upon the hard tissue dimensional changes. Bone regeneration simultaneous to implant removal minimized the dimensional changes of the ridge both vertically (5% lesser buccal RH reduction) and horizontally (12% lesser RW reduction) when compared with spontaneous healing. The use of a reverse-torque removal kit seemed to be critical in limiting the dimensional changes of the ridge.
CONCLUSIONS
Minimal hard tissue changes can be expected following implant removal due to peri-implantitis. Simultaneous bone regeneration procedures and the use of a removal kit may considerably reduce the impact upon the dimensional changes (NCT04534361).
Topics: Alveolar Bone Loss; Alveolar Process; Bone Regeneration; Dental Implants; Humans; Peri-Implantitis; Retrospective Studies
PubMed: 33949080
DOI: 10.1111/cid.13004 -
Brazilian Dental Journal 2022The aim of this study was to evaluate a Demineralized Human Dentine Matrix (DHDM) as viable biomaterial for alveolar ridge preservation in a rat model. Wistar rats were...
The aim of this study was to evaluate a Demineralized Human Dentine Matrix (DHDM) as viable biomaterial for alveolar ridge preservation in a rat model. Wistar rats were submitted to the extraction of maxillary first molars bilaterally. Sockets were filled with biomaterials and divided into 4 experimental groups (n=5): blood clot, autogenous bone, bovine-derived xenograft (BDX) and DHDM. Animals were sacrificed at 7, 14 e 28 days. Microtomography (uCT) volumetric evaluation and qualitative histological analyses were performed. Results obtained through the uCT showed similar values between the DHDM and the other experimental groups. The histological evaluation demonstrated DHDM with an unspecific inflammatory process and bone neoformation with slow reabsorption of the material. This result indicates that DHDM implanted in rat sockets is biocompatible and reduces the alveolar ridge volume loss after tooth extraction.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Cattle; Dentin; Humans; Rats; Rats, Wistar; Tooth Extraction; Tooth Socket
PubMed: 35766721
DOI: 10.1590/0103-6440202204648 -
Clinical Oral Implants Research Jan 2023The aim of the present study was to evaluate soft and hard tissue alterations around implants with a modified marginal portion placed in a healed, sloped ridge over...
AIM
The aim of the present study was to evaluate soft and hard tissue alterations around implants with a modified marginal portion placed in a healed, sloped ridge over 3 years of follow-up.
MATERIAL AND METHODS
65 patients with a single recipient implant site in an alveolar ridge with a lingual-buccal sloped configuration were recruited. Implants with a modified geometry in the marginal portion were installed in such a way that the sloped part of the device was located at the buccal and most apical position of the osteotomy preparation. Crowns were placed 21 weeks after implant placement. Radiologic examinations were performed at implant installation and at 1 and 3 years of follow-up. Bleeding on probing (BoP), probing pocket depth (PPD), and clinical attachment level (CAL; from the crown margin) were recorded at the insertion of the prosthesis and after 1 and 3 years.
RESULTS
57 patients with 57 implant-supported restorations attended the 3 years follow-up examination. The radiographic analysis revealed a mean marginal bone loss of 0.57 mm during the 3 years period. While the average bone loss between 1 and 3 years amounted to 0.30 mm, approximately 50% of the implants showed no bone loss during this period. The results from the clinical examinations showed a CAL gain of 0.11 ± 0.85 mm between baseline and 3 years of follow-up. About 65% of the implants showed no loss of attachment between 1 and 3 years. BoP and PPD ≥5 mm were identified at <10% of implants at the 3 years examination.
CONCLUSION
Hard and soft tissues formed around dental implants that were designed to match the morphology of an alveolar ridge with a lingual-buccal sloped configuration remained stable over 3 years.
Topics: Humans; Dental Implantation, Endosseous; Dental Implants; Prospective Studies; Alveolar Process; Crowns; Alveolar Bone Loss; Follow-Up Studies; Dental Prosthesis, Implant-Supported; Dental Implants, Single-Tooth
PubMed: 36245313
DOI: 10.1111/clr.14012 -
Dento Maxillo Facial Radiology Mar 2019The measurements were established on 60 MFs of 30 patients (16 males, 14 females) with a mean age of 30.70 ± 9,23 years. The vertical and the horizontal diameters,...
METHODS:
The measurements were established on 60 MFs of 30 patients (16 males, 14 females) with a mean age of 30.70 ± 9,23 years. The vertical and the horizontal diameters, distance to the alveolar crest of the MF was measured by both CBCT and USG. Results obtained with CBCT and USG were statistically compared. And also the blood flow of the MF determined by Doppler USG.
RESULTS:
All of the MFs could be detected by CBCT and USG. The vertical and the horizontal diameter measurements were compatible with each other by CBCT and USG. However, the distance to the alveolar crest was lower in USG than CBCT (p < 0.0001). The blood flow could be detected in all patients by Doppler USG that was weak in 8 MFs and strong in 52 MFs. Also there was no statistically significant association between the blood flow and age or gender. Furthermore, the blood flow was related with the horizontal diameter of the MF; however, it was not related with the vertical diameter and the distance to the alveolar crest.
CONCLUSIONS:
USG is quite effective in showing the shape, size, and the location of the MF easily and rapidly. However, it is not as accurate as CBCT in measuring the distance from the MF to alveolar crest. And also it allows to examine the flow rate of mental artery with its Doppler modes.
Topics: Adult; Alveolar Process; Bicuspid; Cone-Beam Computed Tomography; Female; Humans; Male; Mandible; Ultrasonography; Young Adult
PubMed: 30426757
DOI: 10.1259/dmfr.20180252 -
Medicine Jun 2018The purpose of this study was to evaluate the clinical and radiological outcomes of 2 piezosurgical split techniques performed in conjunction with the sinus lift.The... (Comparative Study)
Comparative Study Observational Study
The purpose of this study was to evaluate the clinical and radiological outcomes of 2 piezosurgical split techniques performed in conjunction with the sinus lift.The present retrospective study included 20 patients with edentulism of the posterior maxilla who had undergone the sinus lift and alveolar ridge split treatment separately or the sinus lift combined with the monoblock alveolar ridge split. Differences between these 2 techniques were analyzed.All the surrounding areas successfully produced an adequate bone volume for the insertion of implants. A clinical evaluation showed a mean vertical augmentation of 3.6 ± 0.4 mm in Group A and 3.2 ± 0.7 mm in Group B. With regards to the lateral augmentation, the clinical evaluation gives a mean gain of 5.2 ± 0.3 mm in Group A and 4.9 ± 0.5 mm in Group B. The mean vertical and horizontal bone augmentation recorded for both types of surgical procedures were comparable.The proposed surgical procedures enabled the tridimensional volume of the alveolar ridge to be recreated. This resulted in the creation of a natural contour of hard and soft tissues which enabled a functional and aesthetic rehabilitation of the edentulous posterior maxilla to be obtained.
Topics: Alveolar Process; Alveolar Ridge Augmentation; Female; Humans; Jaw, Edentulous; Male; Maxillary Sinus; Middle Aged; Retrospective Studies
PubMed: 29901597
DOI: 10.1097/MD.0000000000011029