-
Der Anaesthesist May 2020
Topics: COVID-19; Humans; Ventilators, Mechanical
PubMed: 32328694
DOI: 10.1007/s00101-020-00782-x -
Neuroscience and Biobehavioral Reviews Dec 2023Déjà vu can be defined as conflict between a subjective evaluation of familiarity and a concurrent evaluation of novelty. Accounts of the déjà vu experience have not... (Review)
Review
Déjà vu can be defined as conflict between a subjective evaluation of familiarity and a concurrent evaluation of novelty. Accounts of the déjà vu experience have not explicitly referred to a "conflict account of déjà vu" despite the acceptance of conflict-based definitions of déjà vu and relatively recent neuroimaging work that has implicated brain areas associated with conflict as underpinning the experience. Conflict monitoring functioning follows a similar age-related trajectory to déjà vu with a peak in young adulthood and a subsequent age-related decline. In this narrative review of the literature to date, we consider how déjà vu is defined and how this has influenced the understanding of déjà vu. We also review how déjà vu can be understood within theories of recognition memory and cognitive control. Finally, we summarise the conflict account of déjà vu and propose that this account of the experience may provide a coherent explanation as to why déjà vu experiences tend to decrease with age in the non-clinical population.
Topics: Humans; Young Adult; Adult; Motivation; Recognition, Psychology; Brain; Neuroimaging
PubMed: 37979736
DOI: 10.1016/j.neubiorev.2023.105467 -
The EMBO Journal Dec 2016Twenty‐five years ago, in August 1991, I spent a couple of afternoons at Los Alamos National Laboratory writing some simple software that enabled a small group of...
Twenty‐five years ago, in August 1991, I spent a couple of afternoons at Los Alamos National Laboratory writing some simple software that enabled a small group of physicists to share drafts of their articles via automated email transactions with a central repository. Within a few years, the site migrated to the nascent WorldWideWeb as arXiv.org, and experienced both expansion in coverage and heavy growth in usage that continues to this day. In 1998, I gave a talk to a group of biologists—including David Lipman, Pat Brown, and Michael Eisen—at a meeting at Cold Spring Harbor Laboratory (CSHL) to describe the sharing of articles “pre‐publication” by physicists. The talk was met with some enthusiasm and prompted the “e‐biomed” proposal in the following spring by then NIH director Harold Varmus. He encouraged the creation of an NIH‐run electronic archive for all biomedical research articles, including both a preprint server and an archive of published peer‐reviewed articles, which generated significant discussion.
PubMed: 27760783
DOI: 10.15252/embj.201695531 -
Journal of Urban Health : Bulletin of... Aug 2022
Topics: Humans; Mpox (monkeypox)
PubMed: 35916973
DOI: 10.1007/s11524-022-00671-1 -
Drug Discovery Today May 2020In the past decade we have seen two major Ebola virus outbreaks in Africa, the Zika virus in Brazil and the Americas and the current pandemic of coronavirus disease... (Review)
Review
In the past decade we have seen two major Ebola virus outbreaks in Africa, the Zika virus in Brazil and the Americas and the current pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is a strong sense of déjà vu because there are still no effective treatments. In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. Promising SARS-CoV-2 viral targets and computational approaches are described and discussed. Here, we propose, based on open antiviral drug discovery approaches for previous outbreaks, that there could still be gaps in our approach to drug discovery.
Topics: Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Betacoronavirus; COVID-19; Chlorocebus aethiops; Computer Simulation; Coronavirus Infections; Drug Discovery; Drug Repositioning; Hemorrhagic Fever, Ebola; Humans; In Vitro Techniques; Middle East Respiratory Syndrome Coronavirus; Molecular Docking Simulation; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Severe acute respiratory syndrome-related coronavirus; SARS-CoV-2; Severe Acute Respiratory Syndrome; Spike Glycoprotein, Coronavirus; Vero Cells; Zika Virus Infection; COVID-19 Drug Treatment
PubMed: 32320852
DOI: 10.1016/j.drudis.2020.03.019 -
New Ideas in Psychology Apr 2023The experiences associated with remembering, including metamemory feelings about the act of remembering and attempts at remembering, are not often integrated into...
The experiences associated with remembering, including metamemory feelings about the act of remembering and attempts at remembering, are not often integrated into general accounts of memory. For example, David Rubin (2022) proposes a unified, three-dimensional conceptual space for mapping memory states, a map that does not systematically specify metamemory feelings. Drawing on Rubin's model, we define a distinct role for metamemory in relation to first-order memory content. We propose a fourth dimension for the model and support the proposal with conceptual, neurocognitive, and clinical lines of reasoning. We use the modified model to illustrate several cases, and show how it helps to conceptualize a new category of memory state: , exemplified by . We also caution not to assume that memory experience is directly correlated with or caused by memory content, an assumption Tulving (1989) labeled the .
PubMed: 38223256
DOI: 10.1016/j.newideapsych.2022.100995 -
Journal of Intelligence Jun 2023Curiosity during learning increases information-seeking behaviors and subsequent memory retrieval success, yet the mechanisms that drive curiosity and its accompanying...
Curiosity during learning increases information-seeking behaviors and subsequent memory retrieval success, yet the mechanisms that drive curiosity and its accompanying information-seeking behaviors remain elusive. Hints throughout the literature suggest that curiosity may result from a metacognitive signal-possibly of closeness to a not yet accessible piece of information-that in turn leads the experiencer to seek out additional information that will resolve a perceptibly small knowledge gap. We examined whether metacognition sensations thought to signal the likely presence of an as yet unretrieved relevant memory (such as familiarity or déjà vu) might be involved. Across two experiments, when cued recall failed, participants gave higher curiosity ratings during reported déjà vu (Experiment 1) or déjà entendu (Experiment 2), and these states were associated with increased expenditure of limited experimental resources to discover the answer. Participants also spent more time attempting to retrieve information and generated more incorrect information when experiencing these déjà vu-like states than when not. We propose that metacognition signaling of the possible presence of an as yet unretrieved but relevant memory may drive curiosity and prompt information-seeking that includes further search efforts.
PubMed: 37367514
DOI: 10.3390/jintelligence11060112 -
Dialogues in Clinical Neuroscience Sep 2018A crisis of confidence was triggered by the disappointment that diagnostic validity, an important goal, was not achieved with the publication of . The Research Domain... (Review)
Review
A crisis of confidence was triggered by the disappointment that diagnostic validity, an important goal, was not achieved with the publication of . The Research Domain Criteria (RDoC) project, which provides a framework for neuroscientific research, was initially conceptualized as an alternative to . However, RDoC and are complementary rather than mutually exclusive. From a historical perspective, this article argues that the debate opposing psychology and brain in psychiatric classification is not new and has an air of déjà vu. We go back to the first classifications based on a scientific taxonomy in the late 18th century with Boissier de Sauvages, which were supposed to describe diseases as they really existed in nature. Emil Kraepelin successfully associated psychopathology and brain research, prefiguring the interaction between and RDoC. DSM symptoms remain valuable because they are the only data that are immediately and directly observable. Computational science is a promising instrument to interconnect psychopathological and neuroscientific data in the future.
Topics: Diagnostic and Statistical Manual of Mental Disorders; History, 18th Century; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Mental Disorders; Neurosciences; Psychiatry; Psychopathology
PubMed: 30581284
DOI: 10.31887/DCNS.2018.20.3/macrocq -
Hypertension (Dallas, Tex. : 1979) Jun 2017
Topics: Humans; Renin-Angiotensin System
PubMed: 28396531
DOI: 10.1161/HYPERTENSIONAHA.117.09167 -
Annals of Neurology Nov 2023Familial mesial temporal lobe epilepsy (FMTLE) is an important focal epilepsy syndrome; its molecular genetic basis is unknown. Clinical descriptions of FMTLE vary...
OBJECTIVE
Familial mesial temporal lobe epilepsy (FMTLE) is an important focal epilepsy syndrome; its molecular genetic basis is unknown. Clinical descriptions of FMTLE vary between a mild syndrome with prominent déjà vu to a more severe phenotype with febrile seizures and hippocampal sclerosis. We aimed to refine the phenotype of FMTLE by analyzing a large cohort of patients and asked whether common risk variants for focal epilepsy and/or febrile seizures, measured by polygenic risk scores (PRS), are enriched in individuals with FMTLE.
METHODS
We studied 134 families with ≥ 2 first or second-degree relatives with temporal lobe epilepsy, with clear mesial ictal semiology required in at least one individual. PRS were calculated for 227 FMTLE cases, 124 unaffected relatives, and 16,077 population controls.
RESULTS
The age of patients with FMTLE onset ranged from 2.5 to 70 years (median = 18, interquartile range = 13-28 years). The most common focal seizure symptom was déjà vu (62% of cases), followed by epigastric rising sensation (34%), and fear or anxiety (22%). The clinical spectrum included rare cases with drug-resistance and/or hippocampal sclerosis. FMTLE cases had a higher mean focal epilepsy PRS than population controls (odds ratio = 1.24, 95% confidence interval = 1.06, 1.46, p = 0.007); in contrast, no enrichment for the febrile seizure PRS was observed.
INTERPRETATION
FMTLE is a generally mild drug-responsive syndrome with déjà vu being the commonest symptom. In contrast to dominant monogenic focal epilepsy syndromes, our molecular data support a polygenic basis for FMTLE. Furthermore, the PRS data suggest that sub-genome-wide significant focal epilepsy genome-wide association study single nucleotide polymorphisms are important risk variants for FMTLE. ANN NEUROL 2023;94:825-835.
Topics: Humans; Child, Preschool; Child; Adolescent; Young Adult; Adult; Middle Aged; Aged; Epilepsy, Temporal Lobe; Genome-Wide Association Study; Seizures, Febrile; Magnetic Resonance Imaging; Electroencephalography; Syndrome; Hippocampus
PubMed: 37597255
DOI: 10.1002/ana.26765