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Annals of Internal Medicine Nov 2022
Topics: Humans; Double-Blind Method; Treatment Outcome
PubMed: 36162115
DOI: 10.7326/M22-2461 -
BMC Public Health Dec 2023Randomized trials have shown that vitamin C shortens the duration of common colds. Some trials reported greater effects on severe cold symptoms compared with mild... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Randomized trials have shown that vitamin C shortens the duration of common colds. Some trials reported greater effects on severe cold symptoms compared with mild symptoms. This review systematically compares the effects of vitamin C on severe and mild common cold symptoms.
METHODS
We included all placebo-controlled trials of orally administered vitamin C in doses of at least 1 g/day for the common cold for people in good health at baseline. The analysis was restricted to trials which reported both the total duration of the common cold, and the severity of the common cold measured using severity scales, the duration of more severe stages of the cold, or proxies for severe colds such as days indoors. Findings were pooled using the inverse variance, fixed effect options of the metacont function of the R package meta to calculate the ratio of means estimate.
RESULTS
Fifteen comparisons from 10 trials which reported both mild and severe symptoms were identified. All trials were randomized and double-blind. Compared to placebo, vitamin C significantly decreased the severity of the common cold by 15% (95% CI 9-21%). The direct comparison of the effect of vitamin C on mild and severe symptoms was limited to five comparisons which found that vitamin C had a significant benefit on the duration of severe symptoms. In this subset, there was a significant difference in the size of the effect of vitamin C on the overall duration of colds versus the duration of severe colds (P = 0.002), and vitamin C had no significant effect on the duration of mild symptoms.
CONCLUSIONS
The common cold is the leading cause of acute morbidity and a major cause of absenteeism from work and school. However, absenteeism is dependent on the severity of symptoms. The finding that vitamin C may have a greater effect on more severe measures of the common cold is therefore important. Further research on the therapeutic effects of vitamin C on the common cold should measure outcomes of differing levels of severity.
Topics: Humans; Common Cold; Ascorbic Acid; Vitamins; Double-Blind Method; Absenteeism; Randomized Controlled Trials as Topic
PubMed: 38082300
DOI: 10.1186/s12889-023-17229-8 -
European Review For Medical and... Jun 2022The present study aimed to investigate the effects of a 4-week repeated oral intake of a quercetin-containing supplement on allergen-induced reactions and relative... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
The present study aimed to investigate the effects of a 4-week repeated oral intake of a quercetin-containing supplement on allergen-induced reactions and relative subjective symptoms in Japanese adults who complained of discomfort in the eyes and nose.
SUBJECTS AND METHODS
A randomized, placebo-controlled, double-blind parallel-group study was conducted on 66 subjects (22-78 years old) with allergic symptoms of pollinosis. The subjects were given the test product (200 mg quercetin) or the control product (vehicle) daily for 4 weeks. The Japanese Rhino-conjunctivitis Quality of Life Questionnaire (JRQLQ) scores and other tests were examined in each subject before and after starting the product intake. A new food-grade bioavailable formulation of quercetin, Quercetin phytosome®, was used.
RESULTS
At 1:4 weeks after the start of the supplement intake, several scores of JRQLQ, including allergic symptoms, such as eye itching, sneezing, nasal discharge, and sleep disorder, were significantly improved in the quercetin-containing supplement group compared with the placebo group. Furthermore, the quality of life of these subjects significantly improved based on the original questionnaire and visual analog scale. Minor notable adverse effects were noted throughout the study.
CONCLUSIONS
The results indicated that oral intake of quercetin-containing supplements might effectively reduce some allergy symptoms derived from pollinosis.
Topics: Adult; Aged; Allergens; Double-Blind Method; Humans; Middle Aged; Quality of Life; Quercetin; Rhinitis, Allergic, Seasonal; Young Adult
PubMed: 35776034
DOI: 10.26355/eurrev_202206_29072 -
Journal of the American Society of... Nov 2020
Topics: Anemia; Darbepoetin alfa; Double-Blind Method; Glycine; Humans; Isoquinolines; Japan; Renal Dialysis; Renal Insufficiency, Chronic
PubMed: 32915765
DOI: 10.1681/ASN.2020071096 -
Archivos de Bronconeumologia Apr 2018
Topics: Adult; Asthma; Azithromycin; Double-Blind Method; Humans; Neutrophils; Quality of Life; Sputum
PubMed: 29357995
DOI: 10.1016/j.arbres.2017.11.018 -
Anaesthesia Feb 2018
Topics: Control Groups; Double-Blind Method; Equipment Design; Needles; Single-Blind Method
PubMed: 29333711
DOI: 10.1111/anae.14208 -
Clinics (Sao Paulo, Brazil) 2021
Topics: Antibodies, Monoclonal, Humanized; Double-Blind Method; Humans; Psoriasis; Severity of Illness Index
PubMed: 33978074
DOI: 10.6061/clinics/2021/e2629 -
La Tunisie Medicale Mar 2023The placement of central venous catheters (CVC) is a frequent procedure in intensive care. It is not devoid of complications, the diagnosis of which relied for a long... (Comparative Study)
Comparative Study
INTRODUCTION
The placement of central venous catheters (CVC) is a frequent procedure in intensive care. It is not devoid of complications, the diagnosis of which relied for a long time on the chest X-ray. Currently, ultrasound appears to be an interesting alternative.
AIM
To report the impact of the use of ultrasound on the time to exclusion of mechanical complications after CVC placement.
METHODS
This is a prospective, multicenter, comparative, double-blind study. Were included the patients in whom the placement of a CVC was decided. After placement, a chest X-ray was ordered and an ultrasound was performed to look for signs of misplacement and pneumothorax. The two examinations were interpreted by two different doctors. The primary endpoint between the ultrasound group and the RTX group was the time "T1" represented by the time required to exclude complications.
RESULTS
30 patients were included in our study. The mean ultrasound T1time was significantly lower than the mean radiological T1time (p=0.000). Only one case of pneumothorax was observed. It was first detected by ultrasound. For the 29 other patients, exclusion of pneumothorax was confirmed by ultrasound and chest X-ray. No misplacement type complications detected. This was confirmed by ultrasound and radiological exclusions.
CONCLUSION
Ultrasound is a faster tool than RTX in excluding mechanical complications after CVC placement. It guarantees a non-irradiating examination as efficient as chest X-ray for intensive care patients.
Topics: Humans; Central Venous Catheters; Pneumothorax; Prospective Studies; Radiography; X-Rays; Double-Blind Method
PubMed: 38263923
DOI: No ID Found -
Kidney International Apr 2020
Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Double-Blind Method; Glucosides; Humans; Metformin; Sodium-Glucose Transporter 2; Vasoconstriction; Vasodilation
PubMed: 32200865
DOI: 10.1016/j.kint.2020.01.008 -
Kidney International Apr 2019
Topics: Cyclosporine; Double-Blind Method; Humans; Lupus Nephritis
PubMed: 30904071
DOI: 10.1016/j.kint.2018.12.010