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GMS Journal For Medical Education 2021
Topics: COVID-19; Humans; Medicine
PubMed: 33763532
DOI: 10.3205/zma001444 -
Acta Medica Iranica Mar 2017Personalized medicine as a novel field of medicine refers to the prescription of specific therapeutics procedure for an individual. This approach has established based... (Review)
Review
Personalized medicine as a novel field of medicine refers to the prescription of specific therapeutics procedure for an individual. This approach has established based on pharmacogenetic and pharmacogenomic information and data. The terms precision and personalized medicines are sometimes applied interchangeably. However, there has been a shift from "personalized medicine" towards "precision medicine". Although personalized medicine emerged from pharmacogenetics, nowadays it covers many fields of healthcare. Accordingly, regenerative medicine and cellular therapy as the new fields of medicine use cell-based products in order to develop personalized treatments. Different sources of stem cells including mesenchymal stem cells, embryonic stem cells and induced pluripotent stem cells (iPSCs) have been considered in targeted therapies which could give many advantages. iPSCs as the novel and individual pluripotent stem cells have been introduced as the appropriate candidates for personalized cell therapies. Cellular therapies can provide a personalized approach. Because of person-to-person and population differences in the result of stem cell therapy, individualized cellular therapy must be adjusted according to the patient specific profile, in order to achieve best therapeutic results and outcomes. Several factors should be considered to achieve personalized stem cells therapy such as, recipient factors, donor factors, and the overall body environment in which the stem cells could be active and functional. In addition to these factors, the source of stem cells must be carefully chosen based on functional and physical criteria that lead to optimal outcomes.
Topics: Cell- and Tissue-Based Therapy; Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Mesenchymal Stem Cells; Precision Medicine; Regenerative Medicine; Stem Cell Transplantation
PubMed: 28282715
DOI: No ID Found -
International Journal of Molecular... Jul 2022In recent decades, tremendous progress has been made in the medicinal field in understanding the molecular mechanisms underlying human pathologies, due to the...
In recent decades, tremendous progress has been made in the medicinal field in understanding the molecular mechanisms underlying human pathologies, due to the significant development of advanced laboratory techniques and technologies [...].
Topics: Gastroenterology; Gastrointestinal Tract; Humans; Precision Medicine; Protein Processing, Post-Translational; Proteomics
PubMed: 35897777
DOI: 10.3390/ijms23158201 -
International Journal of Molecular... Aug 2023Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one patient to... (Review)
Review
Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one patient to another is now widely recognized. Consequently, one-size-fits-all approaches to the treatment of cancer have been superseded by precision medicines that target specific disease characteristics, promising maximum clinical efficacy, minimal safety concerns, and reduced economic burden. While precision oncology has been very successful in the treatment of some tumors with specific characteristics, a large number of patients do not yet have access to precision medicines for their disease. The success of next-generation precision oncology depends on the discovery of new actionable disease characteristics, rapid, accurate, and comprehensive diagnosis of complex phenotypes within each patient, novel clinical trial designs with improved response rates, and worldwide access to novel targeted anticancer therapies for all patients. This review outlines some of the current technological trends, and highlights some of the complex multidisciplinary efforts that are underway to ensure that many more patients with cancer will be able to benefit from precision oncology in the near future.
Topics: Humans; Neoplasms; Precision Medicine; Medical Oncology; Interdisciplinary Studies; Phenotype
PubMed: 37628794
DOI: 10.3390/ijms241612613 -
Lakartidningen Sep 2022Healthcare professionals play a central role in health promotion and supporting patients to healthy lifestyles. The handbook FYSS (Physical Activity in the Prevention...
Healthcare professionals play a central role in health promotion and supporting patients to healthy lifestyles. The handbook FYSS (Physical Activity in the Prevention and Treatment of Disease), produced by Swedish Professional Associations for Physical Activity (YFA), can facilitate this work by providing evidence-based recommendations on how to prevent and treat common diseases and conditions using physical activity in a systematic way. This thematic issue presents a sample of the chapters included in the new FYSS 2021.
Topics: Exercise; Health Personnel; Health Promotion; Healthy Lifestyle; Humans; Precision Medicine
PubMed: 36106735
DOI: No ID Found -
Ugeskrift For Laeger Apr 2023Paediatric urology is a subspeciality of urology, with close links to paediatric surgery. This review concludes that a holistic life-long approach to management in... (Review)
Review
Paediatric urology is a subspeciality of urology, with close links to paediatric surgery. This review concludes that a holistic life-long approach to management in highly specialised treatment centres is essential for many of the rare congenital conditions - in Denmark, paediatric urology is centralised to two institutions: Rigshospitalet in Copenhagen and Aarhus University Hospital in Aarhus. Other than performing basic urology in paediatric patients, both centres specialise in complex and rare urological conditions and thus have been accredited by the European Reference Network on rare diseases through the eUrogen collaboration. Patient populations have covered span from prenatal to childhood, transition and for some anomalies, even into adulthood.
Topics: Child; Humans; Urology; Specialization; Pediatrics
PubMed: 37057699
DOI: No ID Found -
Ugeskrift For Laeger Apr 2023This review summarises the current reconstructive urological procedures seeking to optimise urinary tract function. This includes nephrectomy to avoid complications in... (Review)
Review
This review summarises the current reconstructive urological procedures seeking to optimise urinary tract function. This includes nephrectomy to avoid complications in non-functioning kidneys and reconstruction of uretero-pelvic junction stenosis. Re-implantation of the ureters is indicated in case of reflux or stenosis. The technique depends on the defect and ranges from re-implantation to transplantation of the kidney into the pelvis. Intestine is used for bladder augmentation or to create a new reservoir. Urethral reconstruction is used for complicated strictures, while penile reconstruction includes insertion of implants and straightening procedures.
Topics: Humans; Urology; Constriction, Pathologic; Ureter; Kidney; Plastic Surgery Procedures
PubMed: 37057698
DOI: No ID Found -
Lakartidningen Feb 2018Substantial differences in valuation of lifestyle-related knowledge at Swedish medical schools Lifestyle factors are crucial for prevention and management of many...
Substantial differences in valuation of lifestyle-related knowledge at Swedish medical schools Lifestyle factors are crucial for prevention and management of many non-communicable diseases such as hypertension, stroke, diabetes, coronary heart disease and chronic obstructive pulmonary disease. Lifestyle medicine is included in national learning outcomes for undergraduate medical education in Sweden. Since assessment drives learning, we reviewed questions from 124 written examinations from all 7 medical schools in Sweden, conducted between 2012 and 2015. There is up to a 5-fold difference between different universities in the weight attached to lifestyle-related knowledge compared to knowledge related to pharmacological treatments.
Topics: Academic Performance; Education, Medical, Undergraduate; Educational Measurement; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Life Style; Pharmacology; Preventive Medicine; Sweden
PubMed: 29437200
DOI: No ID Found -
Ugeskrift For Laeger Mar 2023
Topics: Humans; Anabolic Androgenic Steroids; Public Health
PubMed: 36896609
DOI: No ID Found -
Nature Reviews. Rheumatology Mar 2023The human genome project led to the advancement of genetic technologies and genomic medicine for a variety of human diseases, including monogenic autoimmune and... (Review)
Review
The human genome project led to the advancement of genetic technologies and genomic medicine for a variety of human diseases, including monogenic autoimmune and autoinflammatory diseases. As a result, the genome of an individual can now be rapidly sequenced at a low cost, and this technology is beginning to change the practice of rheumatology. In this Perspective, we describe how new sequencing technologies combined with careful clinical phenotyping have led to the discovery of rare rheumatic diseases and their corresponding disease-causing mutations. Additionally, we explore ways in which single-gene mutations, including somatic mutations, are creating opportunities to develop personalized medicines. To illustrate this idea, we focus on diseases affecting the TREX1-cGAS-STING pathway, which is associated with monogenic autoinflammatory diseases and vasculopathies. For many of the affected patients and families, there is an urgent, unmet need for the development of personalized therapies. New innovations related to small molecular inhibitors and gene therapies have the potential to benefit these families, and might help drive further innovations that could prove useful for patients with more common forms of autoimmunity and autoinflammation.
Topics: Humans; Inflammation; Precision Medicine; Autoimmunity; Hereditary Autoinflammatory Diseases; Autoimmune Diseases
PubMed: 36750685
DOI: 10.1038/s41584-022-00904-2