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Foods (Basel, Switzerland) Oct 2023Food safety has emerged as a significant concern for global public health and sustainable development. The development of analytical tools capable of rapidly,... (Review)
Review
Food safety has emerged as a significant concern for global public health and sustainable development. The development of analytical tools capable of rapidly, conveniently, and sensitively detecting food safety hazards is imperative. Over the past few decades, personal glucose meters (PGMs), characterized by their rapid response, low cost, and high degree of commercialization, have served as portable signal output devices extensively utilized in the construction of biosensors. This paper provides a comprehensive overview of the mechanism underlying the construction of PGM-based biosensors, which consists of three fundamental components: recognition, signal transduction, and signal output. It also detailedly enumerates available recognition and signal transduction elements, and their modes of integration. Then, a multitude of instances is examined to present the latest advancements in the application of PGMs in food safety detection, including targets such as pathogenic bacteria, mycotoxins, agricultural and veterinary drug residues, heavy metal ions, and illegal additives. Finally, the challenges and prospects of PGM-based biosensors are highlighted, aiming to offer valuable references for the iterative refinement of detection techniques and provide a comprehensive framework and inspiration for further investigations.
PubMed: 37959066
DOI: 10.3390/foods12213947 -
Journal of Dairy Science Feb 2023The primary objective of this observational study was to investigate whether incremental milk flow rates (in the 0-15 s, 15-30 s, 30-60 s, and 60-120 s intervals) from... (Observational Study)
Observational Study
The primary objective of this observational study was to investigate whether incremental milk flow rates (in the 0-15 s, 15-30 s, 30-60 s, and 60-120 s intervals) from electronic on-farm milk flow meters can be used to detect bimodal milk flow curves in dairy cows compared with the use of a portable milk flow meter. Our second objective was to study the concordance between an electronic on-farm milk flow meter and a portable milk flow meter for assessing the 2-min milk yield and total milk yield. In this cross-sectional study, data from 92 milking observations from individual cows were analyzed. We collected data on incremental milk flow rates, the 2-min milk yield, and the total milk yield simultaneously with an on-farm milk flow meter and a portable milk flow meter. Bimodality detected by the on-farm milk flow meter was defined as lower milk flow rates during any of the 15-30 s, 30-60 s, and 60-120 s intervals compared with the previous intervals (0-15 s, 15-30 s, and 30-60 s). Bimodality according to the portable milk flow meter (BIM) was observed through automatic detection. κ statistics indicated good agreement between bimodality detected by the on-farm milk flow meter and BIM [κ (95% confidence interval): 0.69 (0.49-0.90)]. Using BIM as the gold standard, diagnostic test statistics for bimodality detected by the on-farm milk flow meter indicated moderate performance for sensitivity [0.73 (0.54-0.86)] as well as high performance for positive predictive value [0.83 (0.63-0.93)], specificity [0.94 (0.85-0.98)], and negative predictive value [0.90 (0.81-0.95)]. Receiver operating characteristic curve analyses revealed that the 30-60 s milk flow rate was the variable that best predicted BIM yielding an area under the curve of 0.89. Pearson correlation coefficients (r) revealed a very strong correlation between the 2 devices for both the 2-min milk yield [0.97 (0.96-0.98)] and total milk yield [r (95% confidence interval), 0.97 (0.96-0.98)]. Additionally, intraclass correlation coefficients (ICC) and concordance correlation coefficients (CCC) indicated excellent agreement between the 2 devices for the 2-min milk yield [ICC, 0.97 (0.96-0.98); CCC, 0.94 (0.92-0.96)] and total milk yield [ICC, 0.97 (0.96-0.98); CCC, 0.97 (0.95-0.98)]. Therefore, we concluded that electronic on-farm milk flow meters that measure incremental milk flow rates can be used to detect bimodality in dairy cows and that on-farm milk flow meters facilitate precise measurements of the 2-min milk yield and total milk yield.
Topics: Female; Cattle; Animals; Milk; Lactation; Cross-Sectional Studies; Dairying; ROC Curve
PubMed: 36494231
DOI: 10.3168/jds.2022-22437 -
Sensors (Basel, Switzerland) Feb 2023This paper provides a comprehensive review of the applications of smart meters in the control and optimisation of power grids to support a smooth energy transition... (Review)
Review
This paper provides a comprehensive review of the applications of smart meters in the control and optimisation of power grids to support a smooth energy transition towards the renewable energy future. The smart grids become more complicated due to the presence of small-scale low inertia generators and the implementation of electric vehicles (EVs), which are mainly based on intermittent and variable renewable energy resources. Optimal and reliable operation of this environment using conventional model-based approaches is very difficult. Advancements in measurement and communication technologies have brought the opportunity of collecting temporal or real-time data from prosumers through Advanced Metering Infrastructure (AMI). Smart metering brings the potential of applying data-driven algorithms for different power system operations and planning services, such as infrastructure sizing and upgrade and generation forecasting. It can also be used for demand-side management, especially in the presence of new technologies such as EVs, 5G/6G networks and cloud computing. These algorithms face privacy-preserving and cybersecurity challenges that need to be well addressed. This article surveys the state-of-the-art of each of these topics, reviewing applications, challenges and opportunities of using smart meters to address them. It also stipulates the challenges that smart grids present to smart meters and the benefits that smart meters can bring to smart grids. Furthermore, the paper is concluded with some expected future directions and potential research questions for smart meters, smart grids and their interplay.
PubMed: 36850711
DOI: 10.3390/s23042118 -
Pulmonary Medicine 2017Portable inhalers are divisible into those that deliver medication by patient triggering (pMDIs: a gentle slow inhalation) and those that use the patient's inspiratory... (Review)
Review
Portable inhalers are divisible into those that deliver medication by patient triggering (pMDIs: a gentle slow inhalation) and those that use the patient's inspiratory effort as the force for deaggregation and delivery (DPIs: a stronger deeper inspiratory effort). Patient confusion and poor technique are commonplace. The use of training tools has become standard practice, and unique amongst these is an inspiratory flow meter (In-Check) which is able to simulate the resistance characteristics of different inhalers and, thereby, guide the patient to the correct effort. In-Check's origins lie in the 1960s peak flow meters, the development of the Mini-Wright peak flow meter, and inspiratory flow assessment via the nose during the 1970s-1980s. The current device (In-Check DIAL G16) is the third iteration of the original 1998 training tool, with detailed and ongoing assessments of all common inhaler resistances (including combination and breath-actuated inhaler types) summarised into resistance ranges that are preset within the device. The device works by interpolating one of six ranges with the inspiratory effort. Use of the tool has been shown to be contributory to significant improvements in asthma care and control, and it is being advocated for assessment and training in irreversible lung disease.
Topics: Administration, Inhalation; Dry Powder Inhalers; Equipment Design; Humans; Inhalation; Metered Dose Inhalers; Patient Education as Topic; Respiratory Therapy
PubMed: 29348936
DOI: 10.1155/2017/1495867 -
Sensors (Basel, Switzerland) Jan 2021To meet password selection criteria of a server, a user occasionally needs to provide multiple choices of password candidates to an on-line password meter, but such...
To meet password selection criteria of a server, a user occasionally needs to provide multiple choices of password candidates to an on-line password meter, but such user-chosen candidates tend to be derived from the user's previous passwords-the meter may have a high chance to acquire information about a user's passwords employed for various purposes. A third party password metering service may worsen this threat. In this paper, we first explore a new on-line password meter concept that does not necessitate the exposure of user's passwords for evaluating user-chosen password candidates in the server side. Our basic idea is straightforward; to adapt fully homomorphic encryption (FHE) schemes to build such a system but its performance achievement is greatly challenging. Optimization techniques are necessary for performance achievement in practice. We employ various performance enhancement techniques and implement the NIST (National Institute of Standards and Technology) metering method as seminal work in this field. Our experiment results demonstrate that the running time of the proposed meter is around 60 s in a conventional desktop server, expecting better performance in high-end hardware, with an FHE scheme in HElib library where parameters support at least 80-bit security. We believe the proposed method can be further explored and used for a password metering in case that password secrecy is very important-the user's password candidates should not be exposed to the meter and also an internal mechanism of password metering should not be disclosed to users and any other third parties.
PubMed: 33419094
DOI: 10.3390/s21020345 -
Sensors (Basel, Switzerland) Mar 2023Chlorophyll meters are portable devices used to assess and improve plants' nitrogen management and to help farmers in the determination of the health condition of plants...
Chlorophyll meters are portable devices used to assess and improve plants' nitrogen management and to help farmers in the determination of the health condition of plants through leaf greenness measurements. These optical electronic instruments can provide an assessment of chlorophyll content by measuring the light passing through a leaf or by measuring the light radiation reflected from its surface. However, independently of the main principle of operation and use (e.g., absorbance vs. reflectance measurements), commercial chlorophyll meters usually cost hundreds or even thousands of euros, making them inaccessible to growers and ordinary citizens who are interested in self-cultivation, farmers, crop researchers, and communities lacking resources in general. A low-cost chlorophyll meter based on light-to-voltage measurements of the remaining light after two LED light emissions through a leaf is designed, constructed, evaluated, and compared against two well-known commercial chlorophyll meters, the SPAD-502 and the atLeaf CHL Plus. Initial tests of the proposed device on lemon tree leaves and on young Brussels sprouts plant leaves revealed promising results compared to the commercial instruments. The coefficient of determination, R2, was estimated to be 0.9767 for the SPAD-502 and 0.9898 for the atLeaf-meter in lemon tree leaves samples compared to the proposed device, while for the Brussels sprouts plant, R2 was estimated to be 0.9506 and 0.9624, respectively. Further tests conducted as a preliminary evaluation of the proposed device are also presented.
Topics: Chlorophyll; Plant Leaves; Nitrogen
PubMed: 36904902
DOI: 10.3390/s23052699 -
Diabetes Spectrum : a Publication of... Feb 2022To demonstrate the clinical value of OneTouch (OT) Verio Flex glucose meter used in combination with a Spanish-language version of the OT Reveal mobile application (app)...
Use of a Meter With Color-Range Indicators and a Mobile Diabetes Management App Improved Glycemic Control and Patient Satisfaction in an Underserved Hispanic Population: "Tu Salud"-A Randomized Controlled Partial Cross-Over Clinical Study.
OBJECTIVE
To demonstrate the clinical value of OneTouch (OT) Verio Flex glucose meter used in combination with a Spanish-language version of the OT Reveal mobile application (app) to support diabetes care and improve glycemic control in an underserved Hispanic population with type 2 diabetes.
RESEARCH DESIGN AND METHODS
Test subjects ( = 81) used the meter and app for 12 weeks, while a randomized control group ( = 39) used their own glucose meters without connection to an app. Thereafter, test subjects continued the same regimen for an additional 12 weeks to determine the durability of effect, and control subjects crossed over to use the new meter and app.
RESULTS
Test subjects experienced a mean reduction in A1C of 1.0% after 12 weeks ( <0.001), a statistically significant greater reduction than in control subjects ( = 0.045). The improvement in A1C in test subjects was sustained over the next 12 weeks. Crossed-over subjects also demonstrated significant improvements in A1C ( <0.001). Mean blood glucose was reduced significantly without an increase in hypoglycemia, and results in range increased over 12 weeks of meter and mobile app use. Results were independent of subjects' numeracy skills. Subjects using the new meter and app reacted favorably to the tools and expressed improvements in their diabetes treatment satisfaction based on Diabetes Treatment Satisfaction Questionnaire-Change scores.
CONCLUSION
Use of the OT meter and a Spanish-language version of its diabetes management app in an underserved population helped participants achieve a sustained improvement in glycemic control. The tools were well received by the subjects and may have important utility in other low-numeracy, low-literacy populations.
PubMed: 35308153
DOI: 10.2337/ds20-0101 -
Archivos Espanoles de Urologia Sep 2021Portable pH meters are robust and reliable tools for measuring urinary pH bypatients at home. This study evaluated the usability of a prototype smart Lit-Control® pH...
OBJECTIVES
Portable pH meters are robust and reliable tools for measuring urinary pH bypatients at home. This study evaluated the usability of a prototype smart Lit-Control® pH Meter and an associated mobile medical app, with the aim of identifying possible design and functionality issues along with usability problems among non-expert voluntary users.
MATHERIALS AND METHODS
Twenty-one individuals of both genders, between 26 and 61 years old, tested the dyad pH meter/app for 14 days (three readings per day). The participants were asked to carry out a sequence of use of the system equivalent to what an intended user would do for urinary pH self-monitoring. At the end of the trial period, each participant filled out study questionnaires regarding the learning times, i.e. the time used by a new user to perform a task with the technology, usability, errors detected, and suggestions for improvement. RESULTS: The mean age of participants was 35.4 (range, 26 to 61) years. The readings from the pH meter yielded average values of 5.72 (SD = 0.26), 6.13 (SD= 0.43), and 5.47 (SD = 1.27) for the morning, evening, and night micturitions, respectively. The time of the day with greater adherence was the morning (49.7% of all readings). The learning times were in general short as reported by the participants: 73.7% were able to register in the App, rated as the least easy task, in less than two and a half minutes. The task of uploading the pH readings, both manually and automatically, was mostly performed in less than 35 seconds.
CONCLUSION
This pilot study of real-world usage pattern shows that the dyad smart Lit-Control pH meter/Appwas perceived as fit for purpose by non-expert volunteers and had no relevant functionality or usability issues that would pose a significant barrier to the intended users. New studies are ongoing in order to test the usability by patients with lithiasis history.
Topics: Adult; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Mobile Applications; Pilot Projects; Surveys and Questionnaires
PubMed: 34472438
DOI: No ID Found -
Nature Communications Feb 2023Electron beam quality is paramount for X-ray pulse production in free-electron-lasers (FELs). State-of-the-art linear accelerators (linacs) can deliver multi-GeV...
Electron beam quality is paramount for X-ray pulse production in free-electron-lasers (FELs). State-of-the-art linear accelerators (linacs) can deliver multi-GeV electron beams with sufficient quality for hard X-ray-FELs, albeit requiring km-scale setups, whereas plasma-based accelerators can produce multi-GeV electron beams on metre-scale distances, and begin to reach beam qualities sufficient for EUV FELs. Here we show, that electron beams from plasma photocathodes many orders of magnitude brighter than state-of-the-art can be generated in plasma wakefield accelerators (PWFAs), and then extracted, captured, transported and injected into undulators without significant quality loss. These ultrabright, sub-femtosecond electron beams can drive hard X-FELs near the cold beam limit to generate coherent X-ray pulses of attosecond-Angstrom class, reaching saturation after only 10 metres of undulator. This plasma-X-FEL opens pathways for advanced photon science capabilities, such as unperturbed observation of electronic motion inside atoms at their natural time and length scale, and towards higher photon energies.
Topics: Electrons; Particle Accelerators; X-Rays; Lasers; Photons
PubMed: 36828817
DOI: 10.1038/s41467-023-36592-z -
PloS One 2021Dietary acrylamide is found in certain foods, such as deep frying, baking and roasting, and is associated with higher inflammatory and oxidative stress parameters. The...
BACKGROUND
Dietary acrylamide is found in certain foods, such as deep frying, baking and roasting, and is associated with higher inflammatory and oxidative stress parameters. The association between dietary acrylamide and physical performance has not yet been explored. The aim of the study was to investigate the relationship between dietary acrylamide intake and physical performance tests in a large cohort of North American individuals affected by knee osteoarthritis or at high risk for this condition.
METHODS
Dietary acrylamide intake was obtained through a food frequency questionnaire and reported in quartiles and as an increase in deciles. Physical performance was explored using the 20-meter usual pace test, the 400-meter walking distance, and the chair stands time. The association between dietary acrylamide and physical performance tests was explored using linear regression analysis, adjusted for potential confounders.
RESULTS
4,436 participants (2,578 women, mean age: 61.3) were enrolled. People in the highest quartile of dietary acrylamide reported significantly longer 20-meter walking (15.53±3.32 vs. 15.15±2.91 s), 400-meter walking (312±54 vs. 305±58 s) and chair stands (11.36±4.08 vs. 10.67±3.50 s) times than their counterparts in Q1. In adjusted linear regression analyses, each increase in one decile in dietary acrylamide was associated with a longer time in walking for 20 meters (beta = 0.032; 95%CI: 0.016-0.048; p = 0.04), 400 meters (beta = 0.048; 95%CI: 0.033-0.063; p = 0.002) and chair stands (beta = 0.016; 95%CI: 0.005-0.037; p = 0.04) times.
CONCLUSION
Higher dietary acrylamide intake was significantly associated with poor physical performance, also after accounting for potential confounders, suggesting a role for this food contaminant as a possible risk factor for sarcopenia.
Topics: Acrylamide; Adult; Aged; Cross-Sectional Studies; Humans; Middle Aged
PubMed: 34727127
DOI: 10.1371/journal.pone.0259320