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Infection and Drug Resistance 2018
PubMed: 29608189
DOI: 10.2147/IDR.S163186 -
Antimicrobial Agents and Chemotherapy Aug 2015We solved the crystal structure of the class C β-lactamase MOX-1 complexed with the inhibitor aztreonam at 1.9Å resolution. The main-chain oxygen of Ser315 interacts...
We solved the crystal structure of the class C β-lactamase MOX-1 complexed with the inhibitor aztreonam at 1.9Å resolution. The main-chain oxygen of Ser315 interacts with the amide nitrogen of aztreonam. Surprisingly, compared to that in the structure of free MOX-1, this main-chain carboxyl changes its position significantly upon binding to aztreonam. This result indicates that the interaction between MOX-1 and β-lactams can be accompanied by conformational changes in the B3 β-strand main chain.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Aztreonam; Bacterial Proteins; Binding Sites; Carbon Dioxide; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Klebsiella pneumoniae; Microbial Sensitivity Tests; Models, Molecular; Moxalactam; Protein Conformation; Substrate Specificity; beta-Lactamases
PubMed: 26055361
DOI: 10.1128/AAC.04428-14 -
Archivos Argentinos de Pediatria Feb 2019The Allergic Reactions to Betalactam Antibiotics are adverse events that cannot be explained by their pharmacological action, but mediated by an immunological mechanism....
The Allergic Reactions to Betalactam Antibiotics are adverse events that cannot be explained by their pharmacological action, but mediated by an immunological mechanism. They are the most frequent cause of drug allergy in the world. Betalactam antibiotics include penicillins, cephalosporins, carbapenems, monobactams, cefems (moxalactam, cefoxitin), and clavulanic acid. They can produce immediate, accelerated or delayed allergic reactions. Its diagnostic methodology is complex and it is carried out by well-defined stages. Its timely diagnosis is very important due to the risk involved and the associated costs that demand the alternative use of other antibiotics that supplant them.
Topics: Anti-Bacterial Agents; Drug Hypersensitivity; Humans; beta-Lactams
PubMed: 31833344
DOI: 10.5546/aap.2019.S24