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Supportive Care in Cancer : Official... Apr 2023In ovarian cancer (OC), suboptimal muscle morphology (i.e., low muscle mass and density) is associated with poor clinical outcomes, yet little is known about the effect...
OBJECTIVES
In ovarian cancer (OC), suboptimal muscle morphology (i.e., low muscle mass and density) is associated with poor clinical outcomes, yet little is known about the effect of interventions aimed at improving these measures. We investigated the effect of resistance exercise after first-line treatment on muscle mass and density, muscle strength and physical function, health-related quality of life (QoL), and pelvic-floor function in advanced-stage OC survivors.
METHODS
Fifteen OC survivors participated in supervised resistance exercise twice weekly for 12 weeks (in-clinic or by telehealth). Assessments included muscle mass and density (dual-energy X-ray absorptiometry, peripheral quantitative computed tomography), muscle strength (1-repetition maximum [1RM] chest press, 5RM leg press, handgrip strength), physical function (400-m walk, timed up-and-go [TUG]), QoL (QLQ-C30 questionnaire), and self-reported pelvic floor function (Australian Pelvic Floor Questionnaire).
RESULTS
The median age was 64 (range 33-72) years, 10 women underwent neoadjuvant chemotherapy and five underwent adjuvant chemotherapy. All participants completed the intervention (median attendance = 92%; range 79-100%). Post-intervention improvements were observed for whole-body lean mass (1.0 ± 1.4 kg, p = 0.015), appendicular lean mass (0.6 ± 0.9 kg, p = 0.013), muscle density (p = 0.011), upper and lower body strength (p ≤ 0.001), 400-m walk (p = 0.001), TUG (p = 0.005), and social and cognitive QoL domains (p = 0.002 and 0.007), with no change to pelvic floor symptoms (p > 0.05).
CONCLUSION
In this study, supervised resistance exercise effectively improved muscle mass and density, muscle strength, and physical functioning without deleterious effects on the pelvic floor. Considering the prognostic value of these outcomes, larger studies are needed to confirm the benefits of resistance exercise in OC supportive care.
Topics: Adult; Aged; Female; Humans; Middle Aged; Australia; Carcinoma, Ovarian Epithelial; Hand Strength; Muscle Strength; Ovarian Neoplasms; Quality of Life; Resistance Training
PubMed: 37101013
DOI: 10.1007/s00520-023-07754-y -
The Journal of Manual & Manipulative... Aug 2022Thoracic hyperkyphosis is one of the most common postural deformities in the geriatric population. This study investigated whether trunk proprioception, muscle strength,...
BACKGROUND AND OBJECTIVES
Thoracic hyperkyphosis is one of the most common postural deformities in the geriatric population. This study investigated whether trunk proprioception, muscle strength, and endurance differ between older adults with hyperkyphosis and the age-matched control group. This study also aimed to explore the association of kyphotic posture with muscle performance, position sense, and force sense.
METHODS
Ninety-seven elderly volunteers (61 with hyperkyphosis and 36 normal controls) participated in this cross-sectional study. The kyphosis degree, trunk position sense, force sense, back muscle strength, and endurance were assessed in all participants.
RESULTS
The results showed lower back extensor strength and endurance, also higher force and position sense error in the hyperkyphotic group than the control group. In addition, the findings revealed that back extensor strength and endurance, as well as trunk position sense, were associated with kyphotic posture in older adults.
DISCUSSION AND IMPLICATIONS
This study suggests that back extensor strength and endurance and trunk position sense and force sense are potentially modifiable impairments associated with thoracic kyphosis in older adults with hyperkyphosis. It seems monitoring these potentially contributing factors would be helpful in the assessment and treatment of hyperkyphotic older individuals.
Topics: Aged; Back Muscles; Cross-Sectional Studies; Humans; Kyphosis; Muscle Strength; Proprioception
PubMed: 35133255
DOI: 10.1080/10669817.2022.2034403 -
Nutrients Jun 2022There is conflicting evidence of the roles vitamin D and iron have in isolation and combined in relation to muscle health. The purpose of this narrative review was to... (Review)
Review
There is conflicting evidence of the roles vitamin D and iron have in isolation and combined in relation to muscle health. The purpose of this narrative review was to examine the current literature on the roles that vitamin D and iron have on skeletal muscle mass, strength, and function and how these nutrients are associated with skeletal muscle health in specific populations. Secondary purposes include exploring if low vitamin D and iron status are interrelated with skeletal muscle health and chronic inflammation and reviewing the influence of animal-source foods rich in these nutrients on health and performance. PubMed, Scopus, SPORT Discus, EMBAE, MEDLINE, and Google Scholar databases were searched to determine eligible studies. There was a positive effect of vitamin D on muscle mass, particularly in older adults. There was a positive effect of iron on aerobic and anaerobic performance. Studies reported mixed results for both vitamin D and iron on muscle strength and function. While vitamin D and iron deficiency commonly occur in combination, few studies examined effects on skeletal muscle health and inflammation. Isolated nutrients such as iron and vitamin D may have positive outcomes; however, nutrients within food sources may be most effective in improving skeletal muscle health.
Topics: Animals; Dietary Supplements; Inflammation; Iron; Muscle Strength; Muscle, Skeletal; Vitamin D; Vitamin D Deficiency; Vitamins
PubMed: 35807896
DOI: 10.3390/nu14132717 -
Medicina (Kaunas, Lithuania) May 2023: Idiopathic anterior knee pain is a common condition in adolescents and is mostly of unknown cause. The aim of this study was to examine the influence of the Q-angle...
: Idiopathic anterior knee pain is a common condition in adolescents and is mostly of unknown cause. The aim of this study was to examine the influence of the Q-angle and muscle strength on idiopathic anterior knee pain. : Seventy-one adolescents (41 females and 30 males) diagnosed with anterior knee pain were included in this prospective study. The extensor strength in the knee joint and the Q-angle were monitored. The healthy extremity was used as a control. The Student's paired sample -test was applied for testing the difference. Statistical significance was set at 0.05. : There was no statistically significant difference in the Q-angle value between the idiopathic AKP and the healthy extremity ( > 0.05) within the entire sample. A statistically significant higher Q-angle of the idiopathic AKP knee ( < 0.05) was obtained in the female subgroup. No statistically significant difference ( > 0.05) was found in the male subgroup. Within the male subgroup, the strength of the extensors within the knee joint of the healthy extremity had statistically significant higher values than the strength of these muscles in the affected extremity ( < 0.05). : A greater Q-angle is a risk factor linked to anterior knee pain within the female population. Decreased muscle strength of knee joint extensors is a risk factor linked to anterior knee pain in both sex subgroups.
Topics: Humans; Male; Female; Adolescent; Prospective Studies; Knee Joint; Lower Extremity; Muscle Strength; Pain; Muscle, Skeletal
PubMed: 37374224
DOI: 10.3390/medicina59061016 -
Experimental Gerontology Jul 2024Muscular strength and muscle mass are considered key factors for healthy ageing. Modification of body composition and redistribution of adipose tissue has been described...
BACKGROUND
Muscular strength and muscle mass are considered key factors for healthy ageing. Modification of body composition and redistribution of adipose tissue has been described in advanced age. Muscle strength has an important predictive role for health outcomes. However, little is known regarding the relationship between muscle strength and epicardial fat.
METHODS AND MATERIALS
In a cohort of healthy adults following physical capacity evaluations, anthropometric measurements, handgrip strength (HGS), echocardiography and bioimpedance analysis (BIA) were performed. Kruskal-Wallis test, Spearman's correlation and regression analysis adjusted for confounders were applied.
RESULTS
A total population of 226 adults, age range 18-83 years, were included. Epicardial fat thickness resulted significantly associated with age p < 0.001, HGS (p < 0.001). Regression analysis adjusted for confounders revealed an independent relationship between handgrip strength and epicardial fat thickness: regression coefficient: -1.34; R2 = 0.27 and p = 0.044.
CONCLUSIONS
The relationship between epicardial fat and muscle strength is inverse and independent. Implementation of HGS measurement may be useful for the identification of subjects with excessive epicardial fat and cardiovascular risk. Measurement of epicardial fat could be helpful in the early detection of physical decline associated to ageing.
Topics: Humans; Adult; Aged; Middle Aged; Male; Female; Aged, 80 and over; Young Adult; Pericardium; Adolescent; Hand Strength; Adipose Tissue; Electric Impedance; Echocardiography; Body Composition; Aging; Muscle Strength; Epicardial Adipose Tissue
PubMed: 38692441
DOI: 10.1016/j.exger.2024.112447 -
Journal of Cachexia, Sarcopenia and... Apr 2023We aimed to quantify declines from baseline in lower limb skeletal muscle size and strength of uninjured adults following single-leg disuse. We searched EMBASE, Medline,... (Meta-Analysis)
Meta-Analysis Review
We aimed to quantify declines from baseline in lower limb skeletal muscle size and strength of uninjured adults following single-leg disuse. We searched EMBASE, Medline, CINAHL, and CCRCT up to 30 January 2022. Studies were included in the systematic review if they (1) recruited uninjured participants; (2) were an original experimental study; (3) employed a single-leg disuse model; and (4) reported muscle strength, size, or power data following a period of single-leg disuse for at least one group without a countermeasure. Studies were excluded if they (1) did not meet all inclusion criteria; (2) were not in English; (3) reported previously published muscle strength, size, or power data; or (4) could not be sourced from two different libraries, repeated online searches, and the authors. We used the Cochrane Risk of Bias Assessment Tool to assess risk of bias. We then performed random-effects meta-analyses on studies reporting measures of leg extension strength and extensor size. Our search revealed 6548 studies, and 86 were included in our systematic review. Data from 35 and 20 studies were then included in the meta-analyses for measures of leg extensor strength and size, respectively (40 different studies). No meta-analysis for muscle power was performed due to insufficient homogenous data. Effect sizes (Hedges' g ) with 95% confidence intervals for leg extensor strength were all durations = -0.80 [-0.92, -0.68] (n = 429 participants; n = 68 aged 40 years or older; n ≥ 78 females); ≤7 days of disuse = -0.57 [-0.75, -0.40] (n = 151); >7 days and ≤14 days = -0.93 [-1.12, -0.74] (n = 206); and >14 days = -0.95 [-1.20, -0.70] (n = 72). Effect sizes for measures of leg extensor size were all durations = -0.41 [-0.51, -0.31] (n = 233; n = 32 aged 40 years or older; n ≥ 42 females); ≤7 days = -0.26 [-0.36, -0.16] (n = 84); >7 days and ≤14 days = -0.49 [-0.67, -0.30] (n = 102); and >14 days = -0.52 [-0.74, -0.30] (n = 47). Decreases in leg extensor strength (cast: -0.94 [-1.30, -0.59] (n = 73); brace: -0.90 [-1.18, -0.63] (n = 106)) and size (cast: -0.61[-0.87, -0.35] (n = 41); brace: (-0.48 [-1.04, 0.07] (n = 41)) following 14 days of disuse did not differ for cast and brace disuse models. Single-leg disuse in adults resulted in a decline in leg extensor strength and size that reached a nadir beyond 14 days. Bracing and casting led to similar declines in leg extensor strength and size following 14 days of disuse. Studies including females and males and adults over 40 years of age are lacking.
Topics: Male; Female; Humans; Adult; Middle Aged; Leg; Muscle, Skeletal; Muscle Strength
PubMed: 36883219
DOI: 10.1002/jcsm.13201 -
Scientific Reports Jan 2023The purpose of this study was to compare the therapeutic effects of low-level laser therapy (LLLT) with 808 and 660 nm wavelength on muscle strength and functional... (Randomized Controlled Trial)
Randomized Controlled Trial
The purpose of this study was to compare the therapeutic effects of low-level laser therapy (LLLT) with 808 and 660 nm wavelength on muscle strength and functional outcomes in individuals with knee osteoarthritis (OA). A total of 47 participants were randomly assigned to the 808 nm, 660 nm, and sham control groups. Two LLLT groups received continuous LLLT with a mean power of 300 mW in different wavelengths at the knee joint 15 min a session three days per week for eight weeks, while the control group received the sham LED treatment. The knee strength and functional performance involving 30-s sit-to-stand, 40 m fast-paced walk, stair climbing, and the TUG test were measured at the baseline and one week after the interventions were completed. The results showed that knee extensor strength was more improved in the 808 nm group as compared to the 660 nm group (p < 0.001, d = 0.57) and the sham control (p < 0.001, d = 0.40), while increased flexor strength was demonstrated in the 808 nm (p = 0.009, d = 0.67) and sham control groups (p < 0.001, d = 0.97). The number of 30-s sit-to-stand was increased only in the 660 nm group (p = 0.006, d = 0.49). All three groups exhibited improvements in the other three functional performance-based tests after the interventions with no statistically significant differences among the groups. In conclusion, both intervention groups improved muscle strength and functional performance as compared to the control group. The 808 nm wavelength group showed better results in knee extensor strength. Therefore, laser therapy is suggested to be integrated into rehabilitation programs to improve muscle strength and functional performance in the population with knee OA.
Topics: Humans; Knee Joint; Low-Level Light Therapy; Muscle Strength; Osteoarthritis, Knee
PubMed: 36599881
DOI: 10.1038/s41598-022-26553-9 -
The Journal of Medical Investigation :... 2021Age-related changes in muscle strength and physical functions, and the association between vitamin D status and skeletal muscle functions were investigated in 36 men...
Age-related changes in muscle strength and physical functions, and the association between vitamin D status and skeletal muscle functions were investigated in 36 men (21-90 years old) and 52 women (21-104 years old). Significant ageing-related decreases in several skeletal muscle functions and serum 25-hydroxyvitamin D [25(OH)D] levels were observed in both men and women. Cut-off values for the Timed up and go (TUG) test, walking speed, handgrip strength and Barthel Index (BI) detecting walking difficulties in the receiver operating characteristic (ROC) analysis were 11.1 sec, 0.60 m / sec, 17.0 kg, and 90.0 in males, and 28.6 sec, 0.43 m / sec, 13.9 kg, and 67.5 in females, respectively. By comparing personal present data of muscle strength with these cut-off values, people can easily understand their process to walking difficulty. Therefore, these results are important and useful to avoid or to delay a handicapped and dependent status by improving the vitamin D level, rehabilitation and nursing care. J. Med. Invest. 68 : 48-52, February, 2021.
Topics: Adult; Aged; Female; Hand Strength; Humans; Japan; Male; Muscle Strength; Muscle, Skeletal; Walking
PubMed: 33994479
DOI: 10.2152/jmi.68.48 -
Epidemiology and Health 2020Muscle strength in older adults is associated with greater physical ability. Identifying interventions to maintain muscle strength can therefore improve quality of life....
OBJECTIVES
Muscle strength in older adults is associated with greater physical ability. Identifying interventions to maintain muscle strength can therefore improve quality of life. The purpose of this study was to evaluate whether current or former smoking status is associated with a decrease in muscle strength in older adults.
METHODS
Data from the Health and Retirement Study from 2012-2014 were analyzed with regard to maximum dominant hand grip strength, maximum overall hand grip strength, and smoking status (current, former, or never). Unadjusted linear regression was conducted. Other factors known to be related to strength were included in the adjusted linear regression analyses.
RESULTS
For maximum grip strength, the regression coefficient was 4.91 for current smoking (standard error [SE], 0.58; p<0.001), 3.58 for former smoking (SE, 0.43; p<0.001), and 28.12 for never smoking (SE, 0.34). Fully adjusted linear regression on the relationship between dominant hand grip strength and smoking did not yield a significant result. The factors significantly associated with dominant hand grip strength were male sex, younger age, a race/ethnicity of non-Hispanic White or non-Hispanic Black, higher income, morbidity of ≤1 condition, no pain, and moderate or vigorous exercise more than once a week.
CONCLUSIONS
Muscle strength in older adults was not associated with smoking status in the adjusted analysis.
Topics: Aged; Aged, 80 and over; Female; Hand Strength; Humans; Male; Middle Aged; Muscle Strength; Smoking; United States
PubMed: 32777884
DOI: 10.4178/epih.e2020055 -
Journal of Neurophysiology Oct 2022It is important to understand the effects of rapid changes in weight on neuromuscular functions of combat athletes. The purpose of this case study was to investigate...
It is important to understand the effects of rapid changes in weight on neuromuscular functions of combat athletes. The purpose of this case study was to investigate time-course changes in muscle strength, muscle size, and neural input during rapid weight loss in a professional boxer. One professional male boxer (26 yr) participated in two matches during measurements: welterweight (66.6 kg; weight loss: WL) and super welterweight (69.85 kg; control: CON). His muscle contraction properties and body composition were measured from 6 wk (baseline) before the matches to 1 wk after them. Maximal voluntary isometric knee extension torque, muscle cross-sectional area (mCSA) of the vastus lateralis using ultrasound, and high-density surface electromyography of the vastus lateralis during submaximal ramp-up contraction were measured. Individual motor units were identified, and modified discharge rates were calculated from a regression line between the recruitment threshold and discharge rates at 60%-70% of maximum torque according to the baseline value. His body weights for WL and CON decreased from 70.80 and 71.42 kg at the baseline to 68.75 and 71.36 kg immediately before the matches, respectively. Muscle strength changed little for either match. For WL, skeletal muscle mass and mCSA decreased, but there was no decrease for CON. The modified motor unit discharge rate for WL increased immediately before the match compared with other periods but did not change for CON. After rapid weight loss, neural input increased to compensate for lost muscle mass, and muscle strength was maintained. This case study found that neural input to muscle, which was evaluated by high-density surface electrocardiography, increased to compensate for the decline of body weight and muscle mass and to maintain muscle strength during rapid weight loss, while neuromuscular characteristics were not markedly changed during no significant weight loss.
Topics: Electromyography; Humans; Isometric Contraction; Male; Muscle Contraction; Muscle Strength; Muscle, Skeletal; Quadriceps Muscle; Weight Loss
PubMed: 36129200
DOI: 10.1152/jn.00307.2022