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Revista Portuguesa de Cardiologia Jan 2018
Topics: Female; Fibroma; Heart Neoplasms; Humans; Infant
PubMed: 29287998
DOI: 10.1016/j.repc.2017.02.019 -
Mathematical Biosciences and... Jan 2022In this study we review the current state of the art for Dupuytren's disease (DD), while emphasising the need for a better integration of clinical, experimental and... (Review)
Review
In this study we review the current state of the art for Dupuytren's disease (DD), while emphasising the need for a better integration of clinical, experimental and quantitative predictive approaches to understand the evolution of the disease and improve current treatments. We start with a brief review of the biology of this disease and current treatment approaches. Then, since certain aspects in the pathogenesis of this disorder have been compared to various biological aspects of wound healing and malignant processes, next we review some (mathematical modelling and simulations) predictive approaches for complex multi-scale biological interactions occurring in wound healing and cancer. We also review the very few approaches for DD, and emphasise the applicability of these approaches to address more biological questions related to this disease. We conclude by proposing new mathematical modelling and computational approaches for DD, which could be used in the absence of animal models to make qualitative and quantitative predictions about the evolution of this disease that could be further tested .
Topics: Animals; Dupuytren Contracture; Research Design; Wound Healing
PubMed: 35240811
DOI: 10.3934/mbe.2022132 -
In Vivo (Athens, Greece) 2021Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous... (Review)
Review
Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous tissue of upper extremity. Magnetic resonance imaging reveals a well-defined mass in intimate association with dense connective tissue and prominent low signal intensity on all pulse sequences. Peripheral and septal enhancement is usually seen after intravenous contrast. Histologically, the lesion is paucicellular and consists of spindle to stellate-shaped cells embedded in a collagenous or myxocollagenous stroma with low vascularity. Diffuse and strong nuclear immunoreactivity for FOS-like antigen 1 seems to be characteristic of desmoplastic fibroblastoma. Cytogenetic studies have demonstrated the presence of 11q12 rearrangements and an identical t(2;11)(q31;q12) translocation. This review provides an updated overview of the clinical, radiological, histological, cytogenetic and molecular genetic features of desmoplastic fibroblastoma and discusses the relationship to fibroma of tendon sheath.
Topics: Fibroma; Fibroma, Desmoplastic; Humans; Magnetic Resonance Imaging; Soft Tissue Neoplasms; Translocation, Genetic
PubMed: 33402451
DOI: 10.21873/invivo.12233 -
Kardiologia Polska 2022
Topics: Aortic Valve; Cardiac Papillary Fibroelastoma; Fibroma; Heart Neoplasms; Humans
PubMed: 35442510
DOI: 10.33963/KP.a2022.0102 -
Nature Communications Jul 2018Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an infiltrative growth pattern and a high local recurrence rate. Here we report the genetic...
Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an infiltrative growth pattern and a high local recurrence rate. Here we report the genetic and epigenetic landscape of MFS based on the results of whole-exome sequencing (N = 41), RNA sequencing (N = 29), and methylation analysis (N = 41), using 41 MFSs as a discovery set, and subsequent targeted sequencing of 140 genes in the entire cohort of 99 MFSs and 17 MFSs' data from TCGA. Fourteen driver genes are identified, including potentially actionable therapeutic targets seen in 37% of cases. There are frequent alterations in p53 signaling (51%) and cell cycle checkpoint genes (43%). Other conceivably actionable driver genes including ATRX, JAK1, NF1, NTRK1, and novel oncogenic BRAF fusion gene are identified. Methylation patterns cluster into three subtypes associated with unique combinations of driver mutations, clinical outcomes, and immune cell compositions. Our results provide a valuable genomic resource to enable the design of precision medicine for MFS.
Topics: Animals; Cohort Studies; Epigenesis, Genetic; Fibroma; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Genes, cdc; Heterografts; Humans; Janus Kinase 1; Mice; Mice, Nude; Monosaccharide Transport Proteins; Mutation; Neurofibromin 1; Oncogene Proteins, Fusion; Proto-Oncogene Proteins B-raf; Receptor, trkA; Survival Analysis; Tumor Suppressor Protein p53; Exome Sequencing; X-linked Nuclear Protein
PubMed: 30018380
DOI: 10.1038/s41467-018-03891-9 -
American Family Physician Sep 2021
Topics: Female; Fibroma; Humans; Middle Aged; Nail Diseases
PubMed: 34523898
DOI: No ID Found -
Revista Espanola de Enfermedades... Mar 2021Plexiform fibromyxoma (PF) is an uncommon primary tumor of the gastrointestinal tract, with a mesenchymal origin and a benign behavior. Herein, we report a case and... (Review)
Review
Plexiform fibromyxoma (PF) is an uncommon primary tumor of the gastrointestinal tract, with a mesenchymal origin and a benign behavior. Herein, we report a case and provide a literature review. A 41-year-old male patient underwent surgery in our unit for a PF at the gastric antrum, after being admitted due to vomiting and weight loss. As illustrated by our case, the mean age at presentation is around 40 years, the antrum is the most common location and abdominal pain the most widely reported manifestation. None of the reviewed cases involved regional or distant spread.
Topics: Adult; Digestive System Neoplasms; Fibroma; Gastrointestinal Stromal Tumors; Humans; Male; Pyloric Antrum; Stomach Neoplasms
PubMed: 33213171
DOI: 10.17235/reed.2020.7048/2020 -
Stomatologija 2021Peripheral ossifying fibroma (POF) is a reactive lesion that originates in the gingiva. Morphological similarity to other epulides and similar nomenclature to neoplastic...
Peripheral ossifying fibroma (POF) is a reactive lesion that originates in the gingiva. Morphological similarity to other epulides and similar nomenclature to neoplastic tumors give rise to obvious problems both at the stage of diagnosis and treatment of POF. Although POF is one of the less common gingival lesions, it accounts for up to 2% of all oral lesions, which means that most general dentists will encounter POF in their practice. This paper aims to present the case of a 56-year-old woman diagnosed with POF. In the described case, POF most likely resulted from chronic periodontal irritation due to the presence of prosthetic crowns. The applied treatment in the form of total excision of POF, removal of irritants and gingivoplasty brought the expected therapeutic effect, i.e. no recurrence in the period of the hitherto follow-up. Terminological difficulties, the basics of differentiating typical gingival tumors, therapeutic options with suggested management of POF, and recurrence rate with the follow-up scheme were discussed. Despite the reactive nature of POF, this lesion recurs up to 20% and can transform to giant POF. For this reason, POF should not be underestimated, and proper diagnosis, treatment, and follow-up are critical to the success of therapy.
Topics: Female; Fibroma, Ossifying; Gingiva; Gingival Neoplasms; Humans; Middle Aged
PubMed: 34528910
DOI: No ID Found -
Journal of Clinical Research in... Nov 2023Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23).... (Review)
Review
Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23). Maxillofacial tumors are rarely involved in TIO, especially maxillary TIO in children. We present a 14-year-old boy with osteomalacia and high serum levels of FGF23, a hormone associated with decreased phosphate resorption, due to a maxillary tumor. The patient was treated with oral phosphorus and calcitriol, and surgical removal of the tumor was performed. After 21 months follow-up, he was pain free and had returned to full activity. We review the reported pediatric cases of TIO in the maxillofacial and oral region and discuss the management of these patients considering the published evidence.
Topics: Male; Humans; Child; Adolescent; Osteomalacia; Fibroma, Ossifying; Paraneoplastic Syndromes; Neoplasms
PubMed: 35135186
DOI: 10.4274/jcrpe.galenos.2022.2021-8-14 -
The Pan African Medical Journal 2018Papillary fibroelastoma is a rare primary benign cardiac tumor which can cause severe embolic complications. We report the case of a 69-year old man presenting with...
Papillary fibroelastoma is a rare primary benign cardiac tumor which can cause severe embolic complications. We report the case of a 69-year old man presenting with dyspnea. The patient underwent transthoracic echocardiography that showed sessile mass on the mitral valve. Surgically excision of the mass was performed followed by histological examination. The diagnosis of papillary fibroelastoma was then confirmed.
Topics: Aged; Dyspnea; Echocardiography; Fibroma; Heart Neoplasms; Heart Valve Diseases; Humans; Male; Mitral Valve
PubMed: 30167043
DOI: 10.11604/pamj.2018.30.15.13649