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Anais Brasileiros de Dermatologia 2020A 58-year-old female patient presented with a single-digit clubbing on the second finger of her right hand two years previously. After investigation with imaging and...
A 58-year-old female patient presented with a single-digit clubbing on the second finger of her right hand two years previously. After investigation with imaging and incisional biopsy, superficial acral fibromyxoma was diagnosed. A brief review on single-digit clubbing and its causes is presented, focusing on superficial acral fibromyxoma.
Topics: Female; Fibroma; Fingers; Ganglion Cysts; Humans; Hypertrophy; Middle Aged; Soft Tissue Neoplasms
PubMed: 32448714
DOI: 10.1016/j.abd.2020.01.006 -
In Vivo (Athens, Greece) 2020Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive... (Review)
Review
BACKGROUND
Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive review of the literature.
PATIENTS AND METHODS
We report a case of a 23-year-old female with a mass located in the posterior neck and the upper back and a case of a 50-year-old male with a mass located in the posterior neck, which were proved to be nuchal-type fibromas in the histopathological examination. We also searched the PubMed/Medline database for published cases of nuchal-type fibromas.
RESULTS AND DISCUSSION
Nuchal-type fibroma is a rare benign tumor arising from the connective tissue, usually in the posterior neck, which affects different ages, with most patients being male. It is a poorly circumscribed tumor consisting of hypocellular, thick, dense and haphazardly arranged collagen bundles with entrapped adipocytes, nerve fibers and muscle fascicles and a few scattered spindle cells, which are CD34 positive. Its excision is curative, and the recurrence risk is generally low. However, patients with Gardner's syndrome may experience recurrence more frequently.
CONCLUSION
Nuchal-type fibroma should be included in the differential diagnosis of subcutaneous, soft-tissue masses, especially when these involve the posterior neck.
Topics: Adult; Diagnosis, Differential; Female; Fibroma; Gardner Syndrome; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neck; Neoplasm Recurrence, Local; Young Adult
PubMed: 32871744
DOI: 10.21873/invivo.12032 -
Clinical Cancer Research : An Official... Jul 2017Children and adolescents who present with neuroendocrine tumors are at extremely high likelihood of having an underlying germline predisposition for the multiple... (Review)
Review
Children and adolescents who present with neuroendocrine tumors are at extremely high likelihood of having an underlying germline predisposition for the multiple endocrine neoplasia (MEN) syndromes, including MEN1, MEN2A and MEN2B, MEN4, and hyperparathyroid-jaw tumor (HPT-JT) syndromes. Each of these autosomal dominant syndromes results from a specific germline mutation in unique genes: MEN1 is due to pathogenic variants (11q13), MEN2A and MEN2B are due to pathogenic variants (10q11.21), MEN4 is due to pathogenic variants (12p13.1), and the HPT-JT syndrome is due to pathogenic variants (1q25). Although each of these genetic syndromes share the presence of neuroendocrine tumors, each syndrome has a slightly different tumor spectrum with specific surveillance recommendations based upon tumor penetrance, including the age and location for which specific tumor types most commonly present. Although the recommended surveillance strategies for each syndrome contain similar approaches, important differences do exist among them. Therefore, it is important for caregivers of children and adolescents with these syndromes to become familiar with the unique diagnostic criteria for each syndrome, and also to be aware of the specific tumor screening and prophylactic surgery recommendations for each syndrome. .
Topics: Adenoma; Adolescent; Child; Fibroma; Genetic Predisposition to Disease; Germ-Line Mutation; Humans; Hyperparathyroidism; Jaw Neoplasms; Multiple Endocrine Neoplasia; Multiple Endocrine Neoplasia Type 2b; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Risk Factors; Tumor Suppressor Proteins
PubMed: 28674121
DOI: 10.1158/1078-0432.CCR-17-0548 -
The Canadian Veterinary Journal = La... Oct 2021A 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass...
A 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.
Topics: Animals; Diagnosis, Differential; Dog Diseases; Dogs; Eyelids; Fibroma; Lacrimal Apparatus; Male; Neoplasm Recurrence, Local
PubMed: 34602632
DOI: No ID Found -
Radiologia 2023Palpable tumors in children are a common reason for consulting a radiologist. The origin of these lesions varies widely, and although they are common, classic radiology...
Palpable tumors in children are a common reason for consulting a radiologist. The origin of these lesions varies widely, and although they are common, classic radiology books do not cover some of them. This series of two articles aims to review the clinical and radiological characteristics of a selection of palpable tumors in children that radiologists need to be familiar with.
Topics: Humans; Child; Fibroma; Soft Tissue Neoplasms; Diagnostic Imaging
PubMed: 36842785
DOI: 10.1016/j.rxeng.2023.01.001 -
Head and Neck Pathology Mar 2019Excluding human papillomavirus (HPV)-driven conditions, oral papillary lesions consist of a variety of reactive and neoplastic conditions and, on occasion, can herald... (Review)
Review
Excluding human papillomavirus (HPV)-driven conditions, oral papillary lesions consist of a variety of reactive and neoplastic conditions and, on occasion, can herald internal malignancy or be part of a syndrome. The objectives of this paper are to review the clinical and histopathological features of the most commonly encountered non-HPV papillary conditions of the oral mucosa. These include normal anatomic structures (retrocuspid papillae, lingual tonsils), reactive lesions (hairy tongue, inflammatory papillary hyperplasia), neoplastic lesions (giant cell fibroma), lesions of unknown pathogenesis (verruciform xanthoma, spongiotic gingival hyperplasia) and others associated with syndromes (for instance Cowden syndrome) or representing paraneoplastic conditions (malignant acanthosis nigricans). Common questions regarding differential diagnosis, management, and diagnostic pitfalls are addressed, stressing the importance of clinico-pathologic correlation and collaboration.
Topics: Acanthosis Nigricans; Fibroma; Hamartoma Syndrome, Multiple; Humans; Mouth Diseases; Mouth Mucosa; Mouth Neoplasms; Tongue, Hairy; Xanthomatosis
PubMed: 30693457
DOI: 10.1007/s12105-019-01001-9 -
In Vivo (Athens, Greece) 2023Foxp3 is a transcription factor responsible for the formation of T regulatory lymphocytes. Foxp3 expression can be associated with either neoplastic progression or...
BACKGROUND/AIM
Foxp3 is a transcription factor responsible for the formation of T regulatory lymphocytes. Foxp3 expression can be associated with either neoplastic progression or regression. The aim of the study was to evaluate Foxp3 expression in soft tissue tumours (fibromas and fibrosarcomas) of skin and subcutaneous tissue in dogs and to describe its relationship with tumour malignancy grade.
MATERIALS AND METHODS
The study was conducted on 71 skin and subcutaneous tumours including 31 fibromas and 40 fibrosarcomas. The samples underwent histological and immunohistochemical evaluation using anti-Foxp3, anti-Ki, and vimentin antibodies.
RESULTS
Cytoplasmic expression of Foxp3 protein in the cutaneous and subcutaneous fibrosarcomas in dogs was confirmed. Moreover, a positive relationship between the expression of Foxp3 and tumour malignancy grade and between Foxp3 and Ki-67 expression was noted.
CONCLUSION
A positive correlation between the Foxp3 expression intensity and malignancy grade suggests a significant role of Foxp3 in the carcinogenesis of skin and subcutaneous fibrosarcomas in dogs. Increased expression of Foxp3 may have a positive effect on the progression of cancer.
Topics: Animals; Dogs; Fibroma; Fibrosarcoma; Skin; Subcutaneous Tissue; Forkhead Transcription Factors
PubMed: 36881099
DOI: 10.21873/invivo.13120 -
BMJ Case Reports Aug 2019Ossifying fibromyxoid tumour (OFMT) is a rarely occurring soft tissue neoplasm of mesenchymal origin. It is a rarely found tumour with intermediate behaviour and...
Ossifying fibromyxoid tumour (OFMT) is a rarely occurring soft tissue neoplasm of mesenchymal origin. It is a rarely found tumour with intermediate behaviour and differentiation. Although it is mostly benign, malignant variants also exist. We are presenting a case of 32-year-old man presented in clinic with complaints of painless swelling in left distal thigh. After reviewing his X-ray, a diagnostic biopsy was planned which came out to be suspicious of solitary fibrous tumour. Other radiological workup was done and the patient was planned to undergo wide margin excision. The final histopathology showed a diagnosis of OFMT of soft tissue, atypical variant. The patient is under follow-up and is disease free. This type of tumour possesses potential of local recurrence and metastases; therefore, it is important to keep a long-term follow-up of patient.
Topics: Adult; Biopsy; Diagnosis, Differential; Fibroma, Ossifying; Humans; Inflammation; Magnetic Resonance Imaging; Male; Radiography; Soft Tissue Neoplasms; Thigh; Treatment Outcome
PubMed: 31466971
DOI: 10.1136/bcr-2019-229371 -
Journal of the American College of... Jun 2015
Topics: Female; Fibroma; Heart Neoplasms; Humans; Male
PubMed: 26046737
DOI: 10.1016/j.jacc.2015.04.021 -
Actas Dermo-sifiliograficas Nov 2020
Topics: Fibroma; Humans; Skin Neoplasms
PubMed: 32531243
DOI: 10.1016/j.ad.2020.05.005