-
Frontiers in Bioscience (Elite Edition) Apr 2023Dermal wound infections are a rising source of morbidity and mortality in patients worldwide as new and worsening complications reduce the efficacy of traditional... (Review)
Review
Dermal wound infections are a rising source of morbidity and mortality in patients worldwide as new and worsening complications reduce the efficacy of traditional treatments. These challenges in wound care are increasingly caused by comorbidities such as obesity and diabetes as well as surging rates of antibiotic resistance. As a result, there is an urgent need for alternative treatment options. Gaseous ozone has shown great promise as a potential new treatment for infected dermal wounds. In this brief review of current wound therapy techniques found in the literature, an in-depth discussion of the mechanisms, benefits, and results of topical ozone gas as a therapy for infected dermal wounds is presented. This includes studies of ozone applied to wounds performed , , and clinical settings, as well as the use of ozone as an adjunct therapy for increasing the efficacy of traditional treatments. The overwhelming evidence suggests that ozone exhibits significant antimicrobial properties and has been shown to promote wound healing factors, especially when applied between 5-60 ppm. As such, this promising alternative therapy warrants a significant investment of time and resources to fully utilize ozone as an effective treatment against antibiotic resistant bacteria and other rising challenges in wound treatment.
Topics: Humans; Ozone; Anti-Infective Agents; Wound Infection; Anti-Bacterial Agents; Administration, Topical
PubMed: 37369568
DOI: 10.31083/j.fbe1502009 -
International Journal of Molecular... Jun 2024Currently, treatment with medical ozone (MO) is considered one of the most interesting and safe integrative options that can effectively complement many conventional...
Currently, treatment with medical ozone (MO) is considered one of the most interesting and safe integrative options that can effectively complement many conventional medical therapies, mainly, but not exclusively, involving aging and pain [...].
Topics: Ozone; Humans; Animals
PubMed: 38892336
DOI: 10.3390/ijms25116148 -
American Journal of Respiratory and... Oct 2019
Topics: Air Pollutants; Air Pollution; Cause of Death; Ozone; United States
PubMed: 31185178
DOI: 10.1164/rccm.201906-1105ED -
Journal of Korean Medical Science Dec 2019The effects on particulate matter (PM) and ozone on health are being reported by a number of studies. The effects of these air pollutants are likely to be stronger in...
BACKGROUND
The effects on particulate matter (PM) and ozone on health are being reported by a number of studies. The effects of these air pollutants are likely to be stronger in the elderly population, but studies in this regard are scarce. The purpose of this study was to study the effects of PM ≤ 2.5 μ and ozone on chronic health effects of the elderly population.
METHODS
In order to analyze the health status of the elderly population, National Statistical Office Mortality records were used. In this study, we calculated the number of deaths in Seoul of people who were 60 years or older between 2002 and 2012. The current study analyzed each disorder separately and the lag effect. PM and ozone were analyzed using the single exposure model, as well as the adjusted multi exposure model.
RESULTS
In the single exposure analysis with PM2.5 as the exposure variable, with the increase of 10 μ/m³, the number of deaths increased by 1.0039 fold, and vascular disease 1.0053 fold. In the multi exposure model adjusting for ozone, the number of deaths increased by 1.0037 fold, and vascular disease 1.0049 fold. In the single exposure analysis with ozone as the exposure variable, with the increase of 10 ppb, the number of deaths increased by 1.0038 fold, and in the multi exposure model adjusting for PM2.5, the number of deaths increased by 1.0027 fold. These results differed depending on the period or season. There was a 5-day lag effect between PM2.5 and deaths in the multi exposure model, and 1.0028 fold when adjusted for ozone. There was a 1-day lag effect in single exposure models with ozone as the main variable, and 1.0027 fold increase in deaths.
CONCLUSION
In our study, an increase in the number of deaths in the elderly population in accordance with the increase in the PM2.5 and ozone was found. The association found in our study could also influence socioeconomic burden. Future studies need to be performed in regards to younger population, as well as other air pollutants.
Topics: Aged; Air Pollutants; Databases, Factual; Environmental Exposure; Heart Diseases; Humans; Lung Diseases; Middle Aged; Ozone; Particulate Matter
PubMed: 31833266
DOI: 10.3346/jkms.2019.34.e311 -
Pediatric Pulmonology May 2023Ground level ozone is a potent respiratory toxicant with decades of accumulated data demonstrating respiratory harms to children. Despite the ubiquity of ozone in the... (Review)
Review
Ground level ozone is a potent respiratory toxicant with decades of accumulated data demonstrating respiratory harms to children. Despite the ubiquity of ozone in the United States, impacting both urban and rural communities, the associated harms of exposure to this important air pollutant are often infrequently or inadequately covered during medical training including pulmonary specialization. Thus, many providers caring for children's respiratory health may have limited knowledge of the harms which may result in reduced discussion of ozone pollution during clinical encounters. Further, the current US air quality standard for ozone does not adequately protect children. In this nonsystematic review, we present basic background information for healthcare providers caring for children's respiratory health, review the US process for setting air quality standards, discuss the respiratory harms of ozone for healthy children and those with underlying respiratory disease, highlight the urgent need for a more protective ozone standard to adequately protect children's respiratory health, review impacts of climate change on ozone levels, and provide information for discussion in clinical encounters.
Topics: Child; Humans; United States; Ozone; Air Pollution; Air Pollutants; Lung; Respiratory Tract Diseases
PubMed: 36815617
DOI: 10.1002/ppul.26368 -
PloS One 2021In order to develop a fast combined method for onychomycosis treatment using an in vitro and an ex vivo models, a combination of two dual-diode lasers at 405 nm and 639...
In order to develop a fast combined method for onychomycosis treatment using an in vitro and an ex vivo models, a combination of two dual-diode lasers at 405 nm and 639 nm wavelengths, in a continuous manner, together with different ozone concentrations (until 80 ppm), was used for performing the experiments on fungal strains growing on PDA agar medium or on pig's hooves samples. In the in vitro model experiments, with 30 min combined treatment, all species are inhibited at 40 ppm ozone concentration, except S. brevicaulis, which didn't show an inhibition in comparison with only ozone treatment. In the ex vivo model experiments, with the same duration and ozone concentration, A. chrysogenum and E. floccosum showed total inhibition; T. mentagrophytes and T. rubrum showed a 75% growth inhibition; M. canis showed a delay in sporulation; and S. brevicaulis and A. terreus did not show growth inhibition. This combined laser and ozone treatment may be developed as a fast therapy for human onychomycosis, as a potential alternative to the use of antifungal drugs with potential side effects and long duration treatments.
Topics: Animals; Fungi; Humans; Lasers; Microbial Viability; Models, Biological; Onychomycosis; Ozone; Swine
PubMed: 34191858
DOI: 10.1371/journal.pone.0253979 -
PloS One 2022The current COVID-19 pandemic is causing profound health, economic, and social problems worldwide. The global shortage of medical and personal protective equipment (PPE)...
The current COVID-19 pandemic is causing profound health, economic, and social problems worldwide. The global shortage of medical and personal protective equipment (PPE) in specialized centers during the outbreak demonstrated the need for efficient methods to disinfect and recycle them in times of emergency. We have previously described that high ozone concentrations destroyed viral RNA in an inactivated SARS-CoV-2 strain within a few minutes. However, the efficient ozone dosages for active SARS-CoV-2 are still unknown. The present study aimed to evaluate the systematic effects of ozone exposure on face masks from hospitalized patients infected with SARS-CoV-2. Face masks from COVID-19 patients were collected and treated with a clinical ozone generator at high ozone concentrations in small volumes for short periods. The study focused on SARS-CoV-2 gene detection (assessed by real-time quantitative polymerase chain reaction (RT-qPCR)) and on the virus inactivation by in vitro studies. We assessed the effects of different high ozone concentrations and exposure times on decontamination efficiency. We showed that high ozone concentrations (10,000, 2,000, and 4,000 ppm) and short exposure times (10, 10, and 2 minutes, respectively), inactivated both the original strain and the B.1.1.7 strain of SARS-CoV-2 from 24 contaminated face masks from COVID-19 patients. The validation results showed that the best condition for SARS-CoV-2 inactivation was a treatment of 4,000 ppm of ozone for 2 minutes. Further studies are in progress to advance the potential applications of these findings.
Topics: COVID-19; Humans; Masks; Ozone; Pandemics; SARS-CoV-2
PubMed: 35867641
DOI: 10.1371/journal.pone.0271826 -
Environment International Dec 2021There is increasing interest in the health effects of air pollution. However, the relationships between ozone exposure and mortality attributable to neurological...
BACKGROUND
There is increasing interest in the health effects of air pollution. However, the relationships between ozone exposure and mortality attributable to neurological diseases remain unclear.
OBJECTIVES
To assess associations of long-term exposure to ozone with death from Parkinson's disease, dementia, stroke, and multiple sclerosis.
METHODS
Our analyses were based on the 2001 Canadian Census Health and Environment Cohort. Census participants were linked with vital statistics records through 2016, resulting in a cohort of 3.5 million adults/51,045,700 person-years, with 8,500/51,300/43,300/1,300 deaths from Parkinson's/dementia/stroke/multiple sclerosis, respectively. Ten-year average ozone concentrations estimated by chemical transport models and adjusted by ground measurements were assigned to subjects based on postal codes. Cox proportional hazards models were used to calculate hazard ratios (HRs) for deaths from the four neurological diseases, adjusting for eight common demographic and socioeconomic factors, seven environmental indexes, and six contextual covariates.
RESULTS
The fully adjusted HRs for Parkinson's, dementia, stroke, and multiple sclerosis mortalities related to one interquartile range increase in ozone (10.1 ppb), were 1.09 (95% confidence interval 1.04-1.14), 1.08 (1.06-1.10), 1.06 (1.04-1.09), and 1.35 (1.20-1.51), respectively. The covariates did not influence significance of the ozone-mortality associations, except airshed (i.e., broad region of Canada). During the period of 2001-2016, 5.66%/5.01%/ 3.77%/19.11% of deaths from Parkinson's/dementia/stroke/multiple sclerosis, respectively, were attributable to ozone exposure.
CONCLUSIONS
We found positive associations between ozone exposure and mortality due to Parkinson's, dementia, stroke, and multiple sclerosis.
Topics: Adult; Air Pollutants; Air Pollution; Canada; Environmental Exposure; Humans; Mortality; Ozone; Particulate Matter
PubMed: 34385046
DOI: 10.1016/j.envint.2021.106817 -
Medical Gas Research 2023Ozone can be medically useful concerning healing wounds and relieving pain in various conditions, such as disc disease. The aspects of human blood ozonation have been... (Review)
Review
Ozone can be medically useful concerning healing wounds and relieving pain in various conditions, such as disc disease. The aspects of human blood ozonation have been reviewed, as well as potential complications that may arise. The mechanisms of ozone therapy are discussed in detail. It is imperative to recognize ozone as a useful proxy in oxidative-stress related diseases, consolidating other medical gases recognized for their therapeutic importance. The utility of hyperbaric oxygen therapy is also discussed. Disc herniation is very common, as more than 3 million cases are treated per year. Herein we review the medical, surgical, and gene-based therapies that ozone therapy can provide regarding disc disease.
Topics: Humans; Hyperbaric Oxygenation; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; Oxygen; Ozone
PubMed: 35946215
DOI: 10.4103/2045-9912.351890 -
Environmental Science & Technology Nov 2023Ozone is a commonly applied disinfectant and oxidant in drinking water and has more recently been implemented for enhanced municipal wastewater treatment for potable... (Review)
Review
Ozone is a commonly applied disinfectant and oxidant in drinking water and has more recently been implemented for enhanced municipal wastewater treatment for potable reuse and ecosystem protection. One drawback is the potential formation of bromate, a possible human carcinogen with a strict drinking water standard of 10 μg/L. The formation of bromate from bromide during ozonation is complex and involves reactions with both ozone and secondary oxidants formed from ozone decomposition, i.e., hydroxyl radical. The underlying mechanism has been elucidated over the past several decades, and the extent of many parallel reactions occurring with either ozone or hydroxyl radicals depends strongly on the concentration, type of dissolved organic matter (DOM), and carbonate. On the basis of mechanistic considerations, several approaches minimizing bromate formation during ozonation can be applied. Removal of bromate after ozonation is less feasible. We recommend that bromate control strategies be prioritized in the following order: (1) control bromide discharge at the source and ensure optimal ozone mass-transfer design to minimize bromate formation, (2) minimize bromate formation during ozonation by chemical control strategies, such as ammonium with or without chlorine addition or hydrogen peroxide addition, which interfere with specific bromate formation steps and/or mask bromide, (3) implement a pretreatment strategy to reduce bromide and/or DOM prior to ozonation, and (4) assess the suitability of ozonation altogether or utilize a downstream treatment process that may already be in place, such as reverse osmosis, for post-ozone bromate abatement. A one-size-fits-all approach to bromate control does not exist, and treatment objectives, such as disinfection and micropollutant abatement, must also be considered.
Topics: Humans; Bromates; Drinking Water; Bromides; Ecosystem; Ozone; Water Purification; Hydroxyl Radical; Oxidants; Water Pollutants, Chemical
PubMed: 37363871
DOI: 10.1021/acs.est.3c00538