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Frontiers in Endocrinology 2023Epicardial adipose tissue (EAT) is related to atrial fibrillation. The association between EAT volume and premature ventricular complexes (PVCs) remains unclear. Our... (Observational Study)
Observational Study
BACKGROUND
Epicardial adipose tissue (EAT) is related to atrial fibrillation. The association between EAT volume and premature ventricular complexes (PVCs) remains unclear. Our study aimed to investigate the effect of EAT volume on the risk of frequent PVCs and burden levels of PVCs.
METHODS
This observational study retrospectively recruited consecutive patients who had consultation between 2019 and 2021 at the First Affiliated Hospital of Zhengzhou University. Frequent PVC patients ( = 402) and control patients ( = 402) undergoing non-contrast computed tomography (CT) were enrolled. We selected evaluation criteria for the conduct of a 1:1 propensity score matching (PSM) analysis. Multivariable logistic analysis was used to investigate factors related to frequent PVCs. Furthermore, the determinants of EAT volume and the burden levels of PVCs were evaluated.
RESULTS
Patients with PVCs had a significantly larger EAT volume than control patients. EAT volume was significantly larger in male PVC patients with BMI ≥24 kg/m, diabetes mellitus, and E/A ratio <1. EAT volume was independently associated with PVCs. Moreover, the larger EAT volume was an independent predictor for the high burden level of PVCs. We revealed that the risk of high PVC burden level was increased with the rising of EAT volume by restricted cubic splines.
CONCLUSIONS
EAT volume was larger in frequent PVC patients than in control patients, regardless of other confounding factors. A large EAT volume was independently associated with high burden levels of PVCs. EAT volume may be a new mechanism to explain the pathogenesis of PVCs.
Topics: Humans; Male; Retrospective Studies; Ventricular Premature Complexes; Atrial Fibrillation; Pericardium
PubMed: 37822598
DOI: 10.3389/fendo.2023.1219890 -
The Journal of Thoracic and... Jan 2017
Topics: Fontan Procedure; Pericardium; Prostheses and Implants
PubMed: 27751578
DOI: 10.1016/j.jtcvs.2016.09.043 -
Frontiers in Immunology 2023Epicardial adipose tissue (EAT) acts as an active immune organ and plays a critical role in the pathogenesis of heart failure (HF). However, the characteristics of...
BACKGROUND
Epicardial adipose tissue (EAT) acts as an active immune organ and plays a critical role in the pathogenesis of heart failure (HF). However, the characteristics of immune cells in EAT of HF patients have rarely been elucidated.
METHODS
To identify key immune cells in EAT, an integrated bioinformatics analysis was performed on public datasets. EAT samples with paired subcutaneous adipose tissue (SAT), heart, and peripheral blood samples from HF patients were collected in validation experiments. T cell receptor (TCR) repertoire was assessed by high-throughput sequencing. The phenotypic characteristics and key effector molecules of T lymphocytes in EAT were assessed by flow cytometry and histological staining.
RESULTS
Compared with SAT, EAT was enriched for immune activation-related genes and T lymphocytes. Compared with EAT from the controls, activation of T lymphocytes was more pronounced in EAT from HF patients. T lymphocytes in EAT of HF patients were enriched by highly expanded clonotypes and had greater TCR clonotype sharing with cardiac tissue relative to SAT. Experiments confirmed the abundance of IFN-γ effector memory T lymphocytes (T) in EAT of HF patients. CCL5 and GZMK were confirmed to be associated with T lymphocytes in EAT of HF patients.
CONCLUSION
EAT of HF patients was characterized by pronounced immune activation of clonally expanded IFN-γ T and a generally higher degree of TCR clonotypes sharing with paired cardiac tissue.
Topics: Humans; Adipose Tissue; Heart Failure; Subcutaneous Fat; Pericardium; Receptors, Antigen, T-Cell
PubMed: 36960061
DOI: 10.3389/fimmu.2023.1126997 -
JACC. Cardiovascular Imaging Jun 2023
Topics: Humans; Computed Tomography Angiography; Artificial Intelligence; Predictive Value of Tests; Coronary Angiography; Adipose Tissue; Coronary Artery Disease; Pericardium
PubMed: 36881422
DOI: 10.1016/j.jcmg.2022.12.004 -
BMC Cardiovascular Disorders Jun 2021The primitive neuroectodermal tumors (PNETs) are a family of highly malignant tumors with a multidirectional differential potential. The tumors are characterized by... (Review)
Review
BACKGROUND
The primitive neuroectodermal tumors (PNETs) are a family of highly malignant tumors with a multidirectional differential potential. The tumors are characterized by aggressive small round tumor cells that originate from the spinal cord of the central and sympathetic nervous systems. Cases involving the pericardium are extremely rare. Herein, we present a case of peripheral primitive neuroectodermal tumor (pPNET) that originated in the pericardium.
CASE PRESENTATION
A 23-year-old woman presented with cough and progressive dyspnea for 1 month, followed by eyelid and facial edema for 10 days, without any apparent cause. Significantly elevated tumor markers were detected in her blood. A cardiac ultrasound revealed a 74 mm × 61 mm spherical mass that was attached to the left pericardium, as well as massive pericardial effusion. Positron emission tomography-CT (PET-CT) showed focal hypermetabolism in the left pericardium. Via histopathology and immunohistochemistry, the spherical mass was identified as PNETS. The patient was successfully treated with a combination of surgical resection via thoracotomy and postoperative chemotherapy, and she was disease-free for 7 years at follow-up. Unfortunately, at 7 years after the treatment, the patient's pPNET recurred. Positron emission tomography-MRI (PET-MRI) and 64-slice coronary CTA revealed that the aorta and multiple coronary arteries were involved. Subsequently, the patient refused a heart transplant and voluntarily left the hospital.
CONCLUSIONS
This paper reports on a rare and recurrent case of PNET in the parietal pericardium. With respect to the different biologic characteristics and prognoses of pPNETs (compared to other known pericardium tumors), it is essential to consider this entity as a differential diagnosis in pericardium tumors.
Topics: Cardiac Surgical Procedures; Chemotherapy, Adjuvant; Female; Heart Neoplasms; Humans; Neoplasm Recurrence, Local; Neuroectodermal Tumors, Primitive, Peripheral; Pericardium; Time Factors; Treatment Outcome; Young Adult
PubMed: 34134636
DOI: 10.1186/s12872-021-02113-3 -
Nutrients Jul 2022The observation of correlations between obesity and chronic metabolic and cardiovascular diseases has led to the emergence of strong interests in "adipocyte biology", in... (Review)
Review
The observation of correlations between obesity and chronic metabolic and cardiovascular diseases has led to the emergence of strong interests in "adipocyte biology", in particular in relation to a specific visceral adipose tissue that is the epicardial adipose tissue (EAT) and its pro-inflammatory role. In recent years, different imaging techniques frequently used in daily clinical practice have tried to obtain an EAT quantification. We provide a useful update on comorbidities related to chronic inflammation typical of cardiac adiposity, analyzing how the EAT assessment could impact and provide data on the patient prognosis. We assessed for eligibility 50 papers, with a total of 10,458 patients focusing the review on the evaluation of EAT in two main contexts: cardiovascular and metabolic diseases. Given its peculiar properties and rapid responsiveness, EAT could act as a marker to investigate the basal risk factor and follow-up conditions. In the future, EAT could represent a therapeutic target for new medications. The assessment of EAT should become part of clinical practice to help clinicians to identify patients at greater risk of developing cardiovascular and/or metabolic diseases and to provide information on their clinical and therapeutic outcomes.
Topics: Adipose Tissue; Adiposity; Biomarkers; Coronary Artery Disease; Humans; Inflammation; Intra-Abdominal Fat; Obesity; Pericardium; Risk Factors
PubMed: 35889883
DOI: 10.3390/nu14142926 -
JACC. Clinical Electrophysiology Jun 2023Despite extensive conventional endoepicardial ablation, significant intramural arrhythmogenic substrate may remain out of reach of unipolar radiofrequency ablation... (Review)
Review
Despite extensive conventional endoepicardial ablation, significant intramural arrhythmogenic substrate may remain out of reach of unipolar radiofrequency ablation (RFA). The authors present clinical findings and procedural workflow for bipolar radiofrequency ablation (B-RFA) with 1 catheter placed against the endocardium and the other in the pericardial sac to ablate refractory ventricular arrhythmias. No serious adverse events occurred during B-RFA procedures, and the short-term and midterm clinical results were satisfactory. Optimal catheter choice and ablation parameters settings for B-RFA remain to be determined.
Topics: Humans; Tachycardia, Ventricular; Treatment Outcome; Catheter Ablation; Arrhythmias, Cardiac; Pericardium
PubMed: 37227350
DOI: 10.1016/j.jacep.2023.02.026 -
Cell Reports Jun 2020Epicardial cells are cardiac progenitors that give rise to the majority of cardiac fibroblasts, coronary smooth muscle cells, and pericytes during development. An...
Epicardial cells are cardiac progenitors that give rise to the majority of cardiac fibroblasts, coronary smooth muscle cells, and pericytes during development. An integral phase of epicardial fate transition is epithelial-to-mesenchymal transition (EMT) that confers motility. We uncover an essential role for the protein arginine methyltransferase 1 (PRMT1) in epicardial invasion and differentiation. Using scRNA-seq, we show that epicardial-specific deletion of Prmt1 reduced matrix and ribosomal gene expression in epicardial-derived cell lineages. PRMT1 regulates splicing of Mdm4, which is a key controller of p53 stability. Loss of PRMT1 leads to accumulation of p53 that enhances Slug degradation and blocks EMT. During heart development, the PRMT1-p53 pathway is required for epicardial invasion and formation of epicardial-derived lineages: cardiac fibroblasts, coronary smooth muscle cells, and pericytes. Consequently, this pathway modulates ventricular morphogenesis and coronary vessel formation. Altogether, our study reveals molecular mechanisms involving the PRMT1-p53 pathway and establish its roles in heart development.
Topics: Animals; Cell Differentiation; Epithelial-Mesenchymal Transition; Female; Heart; Mice; Myocardium; Pericardium; Pregnancy; Protein-Arginine N-Methyltransferases; Signal Transduction; Tumor Suppressor Protein p53
PubMed: 32521264
DOI: 10.1016/j.celrep.2020.107739 -
Methodist DeBakey Cardiovascular Journal 2023Constrictive pericarditis (CP) is a type of diastolic heart failure caused by an inelastic pericardium that impairs cardiac filling. Diagnosing CP can be challenging,...
Constrictive pericarditis (CP) is a type of diastolic heart failure caused by an inelastic pericardium that impairs cardiac filling. Diagnosing CP can be challenging, and a variety of imaging techniques may be necessary. We present a unique case of severely calcified pericardium leading to CP.
Topics: Humans; Pericarditis, Constrictive; Tomography, X-Ray Computed; Pericardium; Echocardiography
PubMed: 36698864
DOI: 10.14797/mdcvj.1183 -
The Journal of Thoracic and... Mar 2017
Topics: Hemodynamics; Internet; Pericardium
PubMed: 27964976
DOI: 10.1016/j.jtcvs.2016.09.090