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Nature Biotechnology Apr 2019Wearable biosensors are garnering substantial interest due to their potential to provide continuous, real-time physiological information via dynamic, noninvasive... (Review)
Review
Wearable biosensors are garnering substantial interest due to their potential to provide continuous, real-time physiological information via dynamic, noninvasive measurements of biochemical markers in biofluids, such as sweat, tears, saliva and interstitial fluid. Recent developments have focused on electrochemical and optical biosensors, together with advances in the noninvasive monitoring of biomarkers including metabolites, bacteria and hormones. A combination of multiplexed biosensing, microfluidic sampling and transport systems have been integrated, miniaturized and combined with flexible materials for improved wearability and ease of operation. Although wearable biosensors hold promise, a better understanding of the correlations between analyte concentrations in the blood and noninvasive biofluids is needed to improve reliability. An expanded set of on-body bioaffinity assays and more sensing strategies are needed to make more biomarkers accessible to monitoring. Large-cohort validation studies of wearable biosensor performance will be needed to underpin clinical acceptance. Accurate and reliable real-time sensing of physiological information using wearable biosensor technologies would have a broad impact on our daily lives.
Topics: Biosensing Techniques; Biotechnology; Body Fluids; Computer Systems; Humans; Iontophoresis; Lab-On-A-Chip Devices; Monitoring, Physiologic; Saliva; Sweat; Tears; Wearable Electronic Devices
PubMed: 30804534
DOI: 10.1038/s41587-019-0045-y -
Frontiers in Public Health 2022Mental disorders (e.g., depression) and sedentary behavior are increasing, also among emerging adults. One particular target group of emerging adults with high sitting... (Review)
Review
Mental disorders (e.g., depression) and sedentary behavior are increasing, also among emerging adults. One particular target group of emerging adults with high sitting times and vulnerability to mental disorders are university students. In particular, anxiety and depressive symptoms as well as stress symptoms are very common among university students. The present manuscript discusses whether physical activity and exercise interventions can help to promote the mental health of emerging adults such as university students. The manuscript will summarize current scientific evidence and based on this evidence, introduce an university-based scientific research project that investigates if physical activity, exercise interventions and acute bouts of exercise of low- to moderate intensity can buffer perceived stress, alleviate mental health symptoms and strengthen well-being (psychologically and physiologically) among university students by positively influencing depressive and anxiety symptoms, perceived stress and emotion perception, body awareness and subjective well-being including overall quality of life. The research project, its concept, multimethod approach, and first results from available studies are discussed in relation to current scientific evidence, health care needs and future developments. The results from the studies conducted within the research project so far and that are briefly summarized in this manuscript suggest that physical activity, mental health and well-being are positively related, also in university students as an important group of emerging adults. The results further suggest that exercise interventions comprising aerobic exercises of low- to moderate intensity may work best to improve mental health (alleviate depressive symptoms and perceived stress) among university students after a few weeks of intervention. In addition, acute bouts of certain types of exercises (yoga in particular) seem to be particularly effective in changing perception of bodily signals, cardiac activity and emotion processing immediately after the exercise. The results underscore the importance of systematic investigations of the combined examination of psychological and physiological factors that promote an active lifestyle and that strengthen mental health and well-being (psychologically and physiologically) among emerging adults such as university students.
Topics: Adult; Exercise; Humans; Mental Health; Quality of Life; Sedentary Behavior; Students; Universities
PubMed: 35548074
DOI: 10.3389/fpubh.2022.849093 -
Best Practice & Research. Clinical... Sep 2020In primary polydipsia pathologically high levels of water intake physiologically lower arginine vasopressin (AVP) secretion, and in this way mirror the secondary... (Review)
Review
In primary polydipsia pathologically high levels of water intake physiologically lower arginine vasopressin (AVP) secretion, and in this way mirror the secondary polydipsia in diabetes insipidus in which pathologically low levels of AVP (or renal responsiveness to AVP) physiologically increase water intake. Primary polydipsia covers several disorders whose clinical features and significance, risk factors, pathophysiology and treatment are reviewed here. While groupings may appear somewhat arbitrary, they are associated with distinct alterations in physiologic parameters of water balance. The polydipsia is typically unrelated to homeostatic regulation of water intake, but instead reflects non-homeostatic influences. Recent technological advances, summarized here, have disentangled functional neurocircuits underlying both homeostatic and non-homeostatic physiologic influences, which provides an opportunity to better define the mechanisms of the disorders. We summarize this recent literature, highlighting hypothalamic circuitry that appears most clearly positioned to contribute to primary polydipsia. The life-threatening water imbalance in psychotic disorders is caused by an anterior hippocampal induced stress-diathesis that can be reproduced in animal models, and involves phylogenetically preserved pathways that appear likely to include one or more of these circuits. Ongoing translational neuroscience studies in these animal models may potentially localize reversible pathological changes which contribute to both the water imbalance and psychotic disorder.
Topics: Animals; Diabetes Insipidus; Drinking; Homeostasis; Humans; Hyponatremia; Polydipsia; Polydipsia, Psychogenic; Risk Factors; Water-Electrolyte Balance; Water-Electrolyte Imbalance
PubMed: 33222764
DOI: 10.1016/j.beem.2020.101469 -
The Western Journal of Emergency... Dec 2015Airway management in critically ill patients involves the identification and management of the potentially difficult airway in order to avoid untoward complications.... (Review)
Review
Airway management in critically ill patients involves the identification and management of the potentially difficult airway in order to avoid untoward complications. This focus on difficult airway management has traditionally referred to identifying anatomic characteristics of the patient that make either visualizing the glottic opening or placement of the tracheal tube through the vocal cords difficult. This paper will describe the physiologically difficult airway, in which physiologic derangements of the patient increase the risk of cardiovascular collapse from airway management. The four physiologically difficult airways described include hypoxemia, hypotension, severe metabolic acidosis, and right ventricular failure. The emergency physician should account for these physiologic derangements with airway management in critically ill patients regardless of the predicted anatomic difficulty of the intubation.
Topics: Acidosis; Airway Management; Critical Illness; Glottis; Heart Failure; Humans; Hypotension; Hypoxia; Intubation, Intratracheal; Risk Factors
PubMed: 26759664
DOI: 10.5811/westjem.2015.8.27467 -
Nature Jan 2016Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human...
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.
Topics: Adult; Bicycling; Body Water; Calibration; Electrolytes; Female; Glucose; Healthy Volunteers; Humans; Lactic Acid; Male; Monitoring, Physiologic; Precision Medicine; Reproducibility of Results; Running; Skin; Skin Temperature; Sweat; Young Adult
PubMed: 26819044
DOI: 10.1038/nature16521 -
International Journal of Molecular... Jan 2023The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester bond at the sn-2 position of the phospholipids, generating a free fatty acid and a... (Review)
Review
The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester bond at the sn-2 position of the phospholipids, generating a free fatty acid and a lysophospholipid. The PLA2s are amphiphilic in nature and work only at the water/lipid interface, acting on phospholipid assemblies rather than on isolated single phospholipids. The superfamily of PLA2 comprises at least six big families of isoenzymes, based on their structure, location, substrate specificity and physiologic roles. We are reviewing the secreted PLA2 (sPLA2), cytosolic PLA2 (cPLA2), Ca-independent PLA2 (iPLA2), lipoprotein-associated PLA2 (LpPLA2), lysosomal PLA2 (LPLA2) and adipose-tissue-specific PLA2 (AdPLA2), focusing on the differences in their structure, mechanism of action, substrate specificity, interfacial kinetics and tissue distribution. The PLA2s play important roles both physiologically and pathologically, with their expression increasing significantly in diseases such as sepsis, inflammation, different cancers, glaucoma, obesity and Alzheimer's disease, which are also detailed in this review.
Topics: Humans; Isoenzymes; Phospholipases A2, Secretory; Neoplasms; Catalysis
PubMed: 36674864
DOI: 10.3390/ijms24021353 -
International Journal of Sports... Apr 2017The increase in competition demands in elite team sports over recent years has prompted much attention from researchers and practitioners to the monitoring of adaptation... (Review)
Review
The increase in competition demands in elite team sports over recent years has prompted much attention from researchers and practitioners to the monitoring of adaptation and fatigue in athletes. Monitoring fatigue and gaining an understanding of athlete status may also provide insights and beneficial information pertaining to player availability, injury, and illness risk. Traditional methods used to quantify recovery and fatigue in team sports, such as maximal physical-performance assessments, may not be feasible to detect variations in fatigue status throughout competitive periods. Faster, simpler, and nonexhaustive tests such as athlete self-report measures, autonomic nervous system response via heart-rate-derived indices, and to a lesser extent, jump protocols may serve as promising tools to quantify and establish fatigue status in elite team-sport athletes. The robust rationalization and precise detection of a meaningful fluctuation in these measures are of paramount importance for practitioners working alongside athletes and coaches on a daily basis. There are various methods for arriving at a minimal clinically important difference, but these have been rarely adopted by sport scientists and practitioners. The implementation of appropriate, reliable, and sensitive measures of fatigue can provide important information to key stakeholders in team-sport environments. Future research is required to investigate the sensitivity of these tools to fundamental indicators such as performance, injury, and illness.
Topics: Adaptation, Physiological; Athletes; Athletic Performance; Fatigue; Humans; Monitoring, Physiologic; Self Report; Sports
PubMed: 28095065
DOI: 10.1123/ijspp.2016-0434 -
International Journal of Molecular... Sep 2022Angiogenesis is a multi-step process by which new blood capillaries are formed starting from preexisting functional vessels [...].
Angiogenesis is a multi-step process by which new blood capillaries are formed starting from preexisting functional vessels [...].
Topics: Capillaries; Cardiovascular Physiological Phenomena; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic
PubMed: 36142885
DOI: 10.3390/ijms231810962 -
Journal of Applied Physiology... Feb 2018
Topics: Decision Support Techniques; Humans; Monitoring, Physiologic; Wearable Electronic Devices
PubMed: 29097633
DOI: 10.1152/japplphysiol.00964.2017