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Urology Journal Sep 2015Polyomavirus hominis 1, better known as BK virus (BKV) infection might be a predisposing factor for prostate cancer (PCa). The aim of this study was to compare the...
PURPOSE
Polyomavirus hominis 1, better known as BK virus (BKV) infection might be a predisposing factor for prostate cancer (PCa). The aim of this study was to compare the frequency of BK virus infection in pathological specimens of patients with PCa compared to patients with benign prostatic hyperplasia.
MATERIALS AND METHODS
From July 2011 to June 2012, paraffin-embedded tissue blocks of patients with PCa (60 specimens) and also with benign prostatic hyperplasia (60 specimens) were investigated. After DNA purification, existence of virus nucleic acid was assessed by polymerase chain reaction.
RESULTS
Viral DNA was identified in 9 patients (15%) with benign prostatic hyperplasia (BPH) and 17 patients (28%) with PCa (P = .076). In patients with PCa, viral DNA was observed more often in those with lower total Gleason scores (P = .045).
CONCLUSION
The frequency of BK virus infection in PCa patients was higher than BPH patients. BK virus was more often observed in patients with lower Gleason scores. Less detection of BK virus DNA in overt cancer may prove the activity of the virus which paves the way for tumorigenic transformation at early stages of PCa.
Topics: Aged; Aged, 80 and over; BK Virus; DNA, Viral; Follow-Up Studies; Humans; Incidence; Iran; Male; Middle Aged; Neoplasm Grading; Polymerase Chain Reaction; Polyomavirus Infections; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Retrospective Studies; Risk Factors; Tumor Virus Infections
PubMed: 26341765
DOI: No ID Found -
Annals of Agricultural and... 2015Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell...
INTRODUCTION
Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell carcinoma (SCC). There are many risk factors causing this type of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Other important risk factor include infectious factors.
OBJECTIVE
The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC).
MATERIALS AND METHOD
The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcohol abuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, was analyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC), 75 males, and 17 females, aged between 40 - 87 (average 56.8). All the patients underwent surgery and were not subjected to chemotherapy or radiotherapy prior to treatment. The analyzed samples were collected from paraffin sections.
RESULTS
BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKV DNA was statistically more frequently detected among patients with squamous carcinoma, compared to the control group (p<0.05).
CONCLUSIONS
The obtained results suggest that the BKV virus may play an important role in the development of oral squamous cell carcinoma.
Topics: Adult; Aged, 80 and over; BK Virus; Carcinoma, Squamous Cell; Female; Humans; JC Virus; Male; Middle Aged; Mouth Neoplasms; Poland; Polyomavirus Infections; Prevalence; Risk Factors; Tumor Virus Infections
PubMed: 25780838
DOI: 10.5604/12321966.1141378