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PloS One 2022Having a good awareness of ovarian cancer (OC) risk and protective factors could facilitate early diagnosis. This study aimed to assess Palestinian women's awareness...
INTRODUCTION
Having a good awareness of ovarian cancer (OC) risk and protective factors could facilitate early diagnosis. This study aimed to assess Palestinian women's awareness about OC risk and protective factors and to identify the factors associated with having good awareness.
METHODS
A cross-sectional study was conducted from July 2019 to March 2020 in the two main areas of Palestine: the West Bank and Jerusalem (WBJ) and the Gaza Strip. A translated-into-Arabic version of the validated OC awareness measure was utilized. Adult women attending hospitals, primary healthcare centers, and public spaces at 11 governorates were invited to participate. The awareness level was categorized based on the number of factors recognized: poor (0 to 5), fair (6 to 10) and good (11 to 15).
RESULTS
Of the 6095 women approached, 5618 agreed and completed the questionnaire (response rate = 92.1%). The final analysis included 5411 questionnaires. The most identified modifiable OC risk factor was 'being a smoker' (n = 4024, 74.4%), whereas the least identified was 'having in vitro fertilization treatment' (n = 1652, 30.5%). The most identified non-modifiable OC risk factor was 'having ovarian cysts' (n = 3136, 58.0%), whereas the least identified was 'having endometriosis' (n = 1880, 34.7%). The most identified OC protective factor was 'breastfeeding' (n = 4770, 88.2%), whereas the least identified was 'using the pill for a long time' (n = 930, 17.2%). Only 820 women (15.2%) displayed good awareness of OC risk and protective factors. Women from the Gaza Strip were slightly more likely than women from the WBJ to have good awareness (16.4% vs. 14.2%). In contrast, post-secondary education, higher monthly income, being married, and knowing someone with cancer were associated with an increase in the likelihood of displaying good awareness.
CONCLUSION
The overall awareness of OC risk and protective factors in this study was low. Educational interventions are needed to improve Palestinian women's awareness.
Topics: Adult; Arabs; Carcinoma, Ovarian Epithelial; Cross-Sectional Studies; Female; Health Knowledge, Attitudes, Practice; Humans; Ovarian Neoplasms; Protective Factors; Risk Factors; Surveys and Questionnaires
PubMed: 35312720
DOI: 10.1371/journal.pone.0265452 -
Journal of Psychiatric Research Apr 2022This is a multicenter prospective observational study, aimed to evaluate the relations between Fear of COVID-19 and postpartum depression (PPD) symptom, that included a... (Observational Study)
Observational Study
This is a multicenter prospective observational study, aimed to evaluate the relations between Fear of COVID-19 and postpartum depression (PPD) symptom, that included a cohort of women who delivered during COVID-19 lockdown between 03 and 05/2020. Participants were approached after delivery and asked to complete an online questionnaire. Data was verified with each center's perinatal database. The validated Fear of COVID-19 Scale was in use. PPD was evaluated using the EPDS questionnaire as a categorical (≥13) and as a continuous scale. Pre-existing maternal disability was defined as any prior physiological/psychological chronic health condition. Continuous medical supervision or stress contributing complications at birth included pregnancy and labor related complications. Regression analysis and ROC statistics were utilized to evaluate associations and control for confounders. Overall, 421 women completed the questionnaires. Of them, 53(12.6%) had a high EPDS score. Fear of COVID-19 was positively correlated with PPD symptoms (r = 0.35,p = 0.000), ROC-AUC 0.73, 95% CI 0.65-0.81, p = 0.000. Following adjustment to confounders (maternal age, nulliparity, ethnicity, marital status, financial difficulties, maternal disability, accessibility to medical services, and continuous medical supervision (, the most important factor that correlated with depression symptoms was maternal disability (aOR 4.61,95% CI 1.96-10.82) followed by Fear of COVID-19 (aOR 1.11,95% CI 1.05-1.17). High accessibility to medical services during pregnancy (aOR 0.62, 95%CI 0.45-0.84) was protective for PPD symptoms. To conclude, during the COVID-19 pandemic, maternal disability and Fear of COVID-19 are positively associated with a high EPDS score. High medical accessibility during pregnancy was found as a protective factor for PPD.
Topics: COVID-19; Communicable Disease Control; Depression, Postpartum; Fear; Female; Humans; Infant, Newborn; Pandemics; Pregnancy; Prevalence; Protective Factors; Risk Factors
PubMed: 35134728
DOI: 10.1016/j.jpsychires.2022.01.015 -
Frontiers in Public Health 2022Many causes of cancer related morbidity and mortality can be traced back to childhood behaviors. The culmination of cancer related risk and protective factors impacting...
INTRODUCTION
Many causes of cancer related morbidity and mortality can be traced back to childhood behaviors. The culmination of cancer related risk and protective factors impacting the health and wellbeing of American Indian youth is unknown. The aim of this Mixed Studies Review was to identify cancer related risk and protective factors among American Indian youth. Results will be shared with Tribal communities to inform surveillance efforts.
METHODS
A Mixed Studies Review process was deemed most appropriate for the search process and data collection. Seven databases were included in the search along with 3 databases that were hand searched. Google Scholar and Google power searching were also conducted. Covidence was utilized for abstract and full-text review. Out of 1,512 articles, 75 articles were included for review and data from each article was sorted out into the levels of the social ecological model.
RESULTS
After extracting significant cancer related risk and protective factors from the 75 relevant articles, cancer related themes were identified at the individual, relationship (family and non-family), community, institutional, and cultural levels of the social ecological model. It was observed that the risk and protective factor profile for substance use spanned all levels of the social ecological model, whereas physical health-diet indicators and sexual health indicators did not. Most articles ( = 58, 77%) focused on substance use-related risk and protective factors.
DISCUSSION
The method that was used for this study can be utilized by other professionals researching risk and protective factors impacting the health and wellbeing of American Indian youth for a multitude of health outcomes. Tribal communities will be able to use the results from our literature review to inform the creation of a community specific data collection tool focused on cancer related risk and protective factors. Upon completion of the overarching research, results will be shared with the community and can be used to inform ongoing surveillance efforts, influence priorities for intervention and education work, and inform the management of resources. The continuation of community informed and driven research with Tribal communities is essential to the health and wellbeing of Tribal Nations as community grounded research is limited.
Topics: Adolescent; Child; Educational Status; Humans; Neoplasms; Protective Factors; Substance-Related Disorders; American Indian or Alaska Native
PubMed: 35548066
DOI: 10.3389/fpubh.2022.828776 -
International Journal of Environmental... Mar 2022In recent decades, there has been a growing body of research showing the relationship between teaching work and several health problems, both physical and psychological....
In recent decades, there has been a growing body of research showing the relationship between teaching work and several health problems, both physical and psychological. Some of these studies relate personal competencies and resources to teachers' occupational health. Based on the construct of Effective Personality, proposed by Martin del Buey, Martín Palacio, and Di Giusto, the aim was to analyse the relationship between the dimensions of the construct and Teachers' Occupational Health. A descriptive cross-sectional design was used. It was based on the application of the Teacher Health Questionnaire (CSD) and the Efficacy Personality Questionnaire-Adults (CPE-A). The sample consisted of 700 non-university teachers aged between 26 and 66 years, = 47.65 = 8.68. Descriptive, correlational, linear regression, and structural equation analyses were carried out. The results confirmed the relationship between the Efficacy Personality construct and Teachers' Occupational Health ( = 0.45 **). In addition, the regression analysis indicated the relevance of each factor of Efficacy Personality in the factors of Teachers' Occupational Health. The variance of Self-efficacy is the most explained by the dimensions of Efficacy Personality (40.2%), with positive relationships. The structural equation analysis confirmed the influence between Efficacy Personality and the factors of Self-Efficacy and Satisfaction, explaining 55.0% of the variance. It is concluded, therefore, that Efficacy Personality has a protective function on Teacher Occupational Health; the higher the Efficacy Personality scores are, the better the results in health gain-Self-efficacy and satisfaction-and the lower the result in health loss-burnout, cognitive affections, musculoskeletal affections, and voice alterations. These results facilitate the design of prevention and intervention programmes for teachers' occupational health, which strengthen and improve personal and socio-affective competencies.
Topics: Adult; Aged; Cross-Sectional Studies; Educational Personnel; Humans; Middle Aged; Occupational Health; Personality; Protective Factors; School Teachers
PubMed: 35270602
DOI: 10.3390/ijerph19052907 -
Hereditas Apr 2020The study aimed to identify the targeting genes and miRNAs using the microarray expression profile dataset for Osteoarthritis (OA) patients. Differentially expressed...
BACKGROUND
The study aimed to identify the targeting genes and miRNAs using the microarray expression profile dataset for Osteoarthritis (OA) patients. Differentially expressed genes (DEGs) between OA and control samples were identified using Bayes method of limma package. Subsequently, a protein-protein interaction (PPI) network was constructed. miRNAs and transcription factor (TFs) based on DEGs in PPI network were identified using Webgestalt and ENCODE, respectively. Finally, MCODE, Gene Ontology (GO) function, and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed. The expressions of several DEGs and predicted miRNAs in OA rats were detected by RT-PCR.
RESULTS
A total of 594 DEGs were identified. In PPI network, there were 313 upregulated DEGs and 22 downregulated DEGs. Besides, the regulatory relationships included 467 upregulated interactions and 85 downregulated interactions (miR-124A → QKI and MAP 1B) between miRNA and DEGs in PPI network. The module from downregulated DEGs-TFs-miRNA networks was mainly enriched to low-density lipoprotein particle clearance, response to linoleic acid, and small molecule metabolic process BP terms. Moreover, QKI, MAP 1B mRNA and miR-9 expressions were significantly reduced in OA rats.
CONCLUSION
miR-9 might be a protective factor for OA patients via inhibiting proliferation and differentiation of cartilage progenitor cells. miR-124A might play an important role in progression of OA through targeting QKI and MAP 1B.
Topics: Animals; Bayes Theorem; Computational Biology; Datasets as Topic; Gene Ontology; Humans; Male; MicroRNAs; Osteoarthritis; Protective Factors; Protein Interaction Maps; Rats; Rats, Sprague-Dawley; Transcription Factors
PubMed: 32321579
DOI: 10.1186/s41065-020-00128-y -
Problemy Endokrinologii May 2023Searching for aging key points is one of the main problems in geriatrics. More and more research in recent years has been devoted to the study of geroprotective... (Review)
Review
Searching for aging key points is one of the main problems in geriatrics. More and more research in recent years has been devoted to the study of geroprotective mechanisms, the impact of various conditions and diseases on aging in general. Of particular importance is the determination of age-related involutive processes in the human body, whether they are part of normal aging or a condition that needs to be corrected to improve the functioning of organs and systems. An important mechanism of aging starts is a change in hormonal activity of endocrine glands, in particular in hormonal activity of thyroid. Frequency of hypothyroidism in advanced age explains relevance of the chosen topic. The aim of the review was to find out the role hypothyroidism in aging. The main task was to define, whether thyroid hormones decrease in older age was a protective factor or pathological process. A review of the literature over the past 10 years on subclinical treatment was carried out and we identified the most pressing issues associated with hypothyroidism and aging. We studied data on the relationship between hypothyroidism and major geriatric syndromes, with special attention paid to cognitive diseases and emotional disorders.
Topics: Humans; Aged; Protective Factors; Hypothyroidism; Aging; Thyroid Hormones
PubMed: 37448266
DOI: 10.14341/probl13156 -
Revista Da Escola de Enfermagem Da U S P 2022To analyze the risk and protective factors to the development of children under three years of age during the COVID-19 pandemic.
OBJECTIVE
To analyze the risk and protective factors to the development of children under three years of age during the COVID-19 pandemic.
METHOD
Cross-sectional, quantitative study carried out in three early childhood education centers in the city of São Paulo, Brazil, in October 2020. The data were collected with an online questionnaire. Risk and protection factors were measured with the Primeira Infância Para Adultos Saudáveis (Early Childhood For Healthy Adults) instrument and the children's development status was measured using the Caregiver Reported Early Development Instruments - CREDI.
RESULTS
The study included 108 parents and guardians of children up to three years of age. Living with grandparents and participating in cash transfer programs were protective factors for child development. The family being headed by a woman posed a significant risk factor for child development.
CONCLUSION
Intersectoral actions to support families headed by women and access to cash transfer programs are essential for promoting equity opportunities for the development in early childhood.
Topics: Adult; Brazil; COVID-19; Child; Child Development; Child, Preschool; Cross-Sectional Studies; Female; Humans; Pandemics; Protective Factors
PubMed: 36197030
DOI: 10.1590/1980-220X-REEUSP-2022-0196en -
The Journals of Gerontology. Series B,... May 2023Treatments that target the biological causes of dementia remain limited, making prevention critically important. Well-being-defined broadly as living in accordance with... (Review)
Review
OBJECTIVES
Treatments that target the biological causes of dementia remain limited, making prevention critically important. Well-being-defined broadly as living in accordance with one's potential and experiencing one's life as enjoyable and satisfying-is a promising avenue for prevention. It can be targeted by large-scale, noninvasive interventions and has been linked with better cognitive health and lower dementia risk. In the current review, we begin by summarizing empirical evidence linking well-being to cognitive functioning, cognitive decline, dementia diagnosis, and dementia-related neuropathology. Then, we highlight 3 key areas for future research.
METHODS
We searched the literature on wellbeing, cognitive decline, and dementia, focusing on prospective and longitidinal evidence.
RESULTS
The research reviewed here provides consistent evidence for associations of well-being with cognitive decline, dementia risk, and cognitive resilience to neuropathology. However, several open questions remain regarding (1) causality and mechanism(s), (2) specificity versus generalizability of associations, and (3) timing.
DISCUSSION
To inform potential intervention efforts, the field must address complex open questions about whether, how, when, and for whom well-being influences dementia risk. The majority of existing research on well-being and cognitive health is correlational, and few studies have tested potential mechanisms that may explain those associations. Further, relatively little is known about the generalizability of associations across different aspects of well-being and for different sociocultural groups. Finally, we do not yet understand when in the life span and on what timescale well-being might influence cognitive health. We discuss challenges and opportunities for addressing each of these open questions, including concrete recommendations for research designs and use of open science practices.
Topics: Humans; Dementia; Prospective Studies; Protective Factors; Cognitive Dysfunction; Cognition
PubMed: 36734357
DOI: 10.1093/geronb/gbad020 -
Cellular and Molecular Gastroenterology... 2020
Topics: Apoptosis; Epithelium; Intestines; Proline; Protective Factors
PubMed: 32871157
DOI: 10.1016/j.jcmgh.2020.08.001 -
Scientific Reports Oct 2023The purpose of the analysis was to identify the risk and protective factors for health behaviour in European adolescents from population health status and expenditure,...
The purpose of the analysis was to identify the risk and protective factors for health behaviour in European adolescents from population health status and expenditure, mental health status, sexual life, social life and education indices and the existence of national strategies, programmes. National and international databases providing information on the presumed health behaviour predictors were used in the analysis. The existence of national health strategies, the level of health expenditure, the socioeconomic conditions, the level of education and literacy had significant influence on the health-risk behaviour of adolescents in the European societies. Six clusters of European countries were extracted by considering the health behaviour risks and health protection strategies. National health strategies combined with governmental support for health prevention and action plans have the most effective impact on the health-risk behaviour of adolescents.
Topics: Humans; Adolescent; Protective Factors; Europe; Health Behavior; Health Status; Educational Status; Risk Factors
PubMed: 37903868
DOI: 10.1038/s41598-023-45800-1