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Scientific Reports Mar 2022HIV and psychoactive substances can impact the integrity of the basal ganglia (BG), a neural substrate of cognition, motor control, and reward-seeking behaviors. This...
HIV and psychoactive substances can impact the integrity of the basal ganglia (BG), a neural substrate of cognition, motor control, and reward-seeking behaviors. This study assessed BG gray matter (GM) volume as a function of polysubstance (stimulant and opioid) use and HIV status. We hypothesized that comorbid polysubstance use and HIV seropositivity would alter BG GM volume differently than would polysubstance use or HIV status alone. We collected structural MRI scans, substance use history, and HIV diagnoses. Participants who had HIV (HIV +), a history of polysubstance dependence (POLY +), both, or neither completed assessments for cognition, motor function, and risk-taking behaviors (N = 93). All three clinical groups showed a left-lateralized pattern of GM reduction in the BG relative to controls. However, in the HIV + /POLY + group, stimulant use was associated with increased GM volume within the globus pallidus and putamen. This surpassed the effects from opioid use, as indicated by decreased GM volume throughout the BG in the HIV-/POLY + group. Motor learning was impaired in all three clinical groups, and in the HIV + /POLY + group, motor learning was associated with increased caudate and putamen GM volume. We also observed associations between BG GM volume and risk-taking behaviors in the HIV + /POLY- and HIV-/POLY + groups. The effects of substance use on the BG differed as a function of substance type used, HIV seropositivity, and BG subregion. Although BG volume decreased in association with HIV and opioid use, stimulants can, inversely, lead to BG volume increases within the context of HIV.
Topics: Analgesics, Opioid; Basal Ganglia; HIV Seropositivity; Humans; Magnetic Resonance Imaging; Putamen; Substance-Related Disorders
PubMed: 35288604
DOI: 10.1038/s41598-022-08364-0 -
Neurological Sciences : Official... Oct 2020The first years of relapsing-remitting multiple sclerosis (RRMS) constitute the most vulnerable phase for the progression of cognitive impairment (CImp), due to a...
BACKGROUND
The first years of relapsing-remitting multiple sclerosis (RRMS) constitute the most vulnerable phase for the progression of cognitive impairment (CImp), due to a gradual decrease of compensatory mechanisms. In the first 10 years of RRMS, the temporal volumetric changes of deep gray matter structures must be clarified, since they could constitute reliable cognitive biomarkers for diagnostic, prognostic, and therapeutic purposes.
METHODS
Forty-five cognitively asymptomatic patients with RRMS lasting ≤ 10 years, and with a brain MRI performed in a year from the neuropsychological evaluation (Te-MRI), were included. They performed the Brief International Cognitive Assessment battery for MS. Thirty-one brain MRIs performed in the year of diagnosis (Td-MRI) and 13 brain MRIs of age- and sex-matched healthy controls (HCs) were also included in the study. The relationships between clinical features, cognitive performances, and Te- and Td-MRI volumes were statistically analyzed.
RESULTS
Cognitively preserved (CP) patients had significantly increased Td-L-putamen (P = 0.035) and Td-R-putamen volume (P = 0.027) with respect to cognitively impaired (CI) ones. CI patients had significantly reduced Te-L-hippocampus (P = 0.019) and Te-R-hippocampus volume (P = 0.042) compared, respectively, with Td-L-hippocampus and Td-R-hippocampus volume. Td-L-putamen volume (P = 0.011) and Te-L-hippocampus volume (P = 0.023) were independent predictors of the Symbol Digit Modalities Test score in all patients (r2 = 0.31, F = 6.175, P = 0.001).
CONCLUSION
In the first years of RRMS, putamen hypertrophy and hippocampus atrophy could represent promising indices of cognitive performance and reserve, and become potentially useful tools for diagnostic, prognostic, and therapeutic purposes.
Topics: Atrophy; Cognition; Cognition Disorders; Hippocampus; Humans; Hypertrophy; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Neuropsychological Tests; Putamen
PubMed: 32333180
DOI: 10.1007/s10072-020-04395-5 -
Cerebral Cortex (New York, N.Y. : 1991) Jan 2019Fronto-striatal circuitry involving the orbitofrontal cortex has been identified as mediating successful reversal of stimulus-outcome contingencies. The region of the...
Fronto-striatal circuitry involving the orbitofrontal cortex has been identified as mediating successful reversal of stimulus-outcome contingencies. The region of the striatum that most contributes to reversal learning remains unclear, with studies in primates implicating both caudate nucleus and putamen. We trained four marmosets on a touchscreen-based serial reversal task and implanted each with cannulae targeting both putamen and caudate bilaterally. This allowed reversible inactivation of the two areas within the same monkeys, but across separate sessions, to directly investigate their respective contributions to reversal performance. Behavioral sensitivity to the GABAA agonist muscimol varied across subjects and between brain regions, so each marmoset received a range of doses. Intermediate doses of intra-putamen muscimol selectively impaired reversal performance, leaving the baseline discrimination phase unchanged. There was no effect of low doses and high doses were generally disruptive. By contrast, low doses of intra-caudate muscimol improved reversal performance, while high doses impaired both reversal and baseline discrimination performance. These data provide evidence for a specific role of the putamen in serial reversal learning, which may reflect the more habitual nature of repeated reversals using the same stimulus pair.
Topics: Animals; Callithrix; Discrimination Learning; Male; Photic Stimulation; Putamen; Reversal Learning
PubMed: 30395188
DOI: 10.1093/cercor/bhy276 -
NeuroImage Sep 2021The ability to perceive the numerosity of items in the environment is critical for behavior of species across the evolutionary tree. Though the focus of studies of...
The ability to perceive the numerosity of items in the environment is critical for behavior of species across the evolutionary tree. Though the focus of studies of numerosity perception lays on the parietal and frontal cortices, the ability to perceive numerosity by a range of species suggests that subcortical nuclei may be implicated in the process. Recently, we have uncovered tuned neural responses to haptic numerosity in the human cortex. Here, we questioned whether subcortical nuclei are also engaged in perception of haptic numerosity. To that end, we utilized a task of haptic numerosity exploration, together with population receptive field model of numerosity selective responses measured at ultra-high field MRI (7T). We found tuned neural responses to haptic numerosity in the bilateral putamen. Similar to the cortex, the population receptive fields tuning width increased with numerosity. The tuned responses to numerosity in the putamen extend its role in cognition and propose that the motor-sensory loops of the putamen and basal ganglia might take an active part in numerosity perception and preparation for future action.
Topics: Adult; Female; Humans; Judgment; Magnetic Resonance Imaging; Male; Middle Aged; Putamen; Size Perception; Touch Perception
PubMed: 34020014
DOI: 10.1016/j.neuroimage.2021.118178 -
Brain and Behavior May 2015Stenography, or shorthand, is a unique set of skills that involves intensive training which is nearly life-long and orchestrating various brain functional modules,...
INTRODUCTION
Stenography, or shorthand, is a unique set of skills that involves intensive training which is nearly life-long and orchestrating various brain functional modules, including auditory, linguistic, cognitive, mnemonic, and motor. Stenography provides cognitive neuroscientists with a unique opportunity to investigate the neural mechanisms underlying the neural plasticity that enables such a high degree of expertise. However, shorthand is quickly being replaced with voice recognition technology. We took this nearly final opportunity to scan the brains of the last alive shorthand experts of the Japanese language.
METHODS
Thirteen right-handed stenographers and fourteen right-handed controls participated in the functional magnetic resonance imaging (fMRI) study.
RESULTS
The fMRI data revealed plastic reorganization of the neural circuits around the putamen. The acquisition of expert skills was accompanied by structural and functional changes in the area. The posterior putamen is known as the execution center of acquired sensorimotor skills. Compared to nonexperts, the posterior putamen in stenographers had high covariation with the cerebellum and midbrain.The stenographers' brain developed different neural circuits from those of the nonexpert brain.
CONCLUSIONS
The current data illustrate the vigorous plasticity in the putamen and in its connectivity to other relevant areas in the expert brain. This is a case of vigorous neural plastic reorganization in response to massive overtraining, which is rare especially considering that it occurred in adulthood.
Topics: Adult; Brain Mapping; Case-Control Studies; Female; Humans; Japan; Language; Magnetic Resonance Imaging; Male; Neural Pathways; Neuronal Plasticity; Putamen; Shorthand; Young Adult
PubMed: 25874166
DOI: 10.1002/brb3.333 -
Journal of Cerebral Blood Flow and... Mar 2023Hemodialysis (HD) is the most regularly applied replacement therapy for end-stage renal disease, but it may result in brain injuries. The correlation between cerebral...
Hemodialysis (HD) is the most regularly applied replacement therapy for end-stage renal disease, but it may result in brain injuries. The correlation between cerebral blood flow (CBF) alteration and iron deposition has not been investigated in patients undergoing HD. Ferritin level may be a dominant factor in CBF and iron deposition change. We hypothesize that ferritin level might be the key mediator between iron deposition and CBF alteration. The correlation in the putamen was estimated between the susceptibility values and CBF in patients undergoing HD. Compared with healthy controls, patients showed more altered global susceptibility values and CBF. The susceptibility value was negatively correlated with CBF in the putamen in patients. Moreover, the susceptibility value was negatively correlated with ferritin level and positively correlated with serum iron level in the putamen of patients. CBF was positively correlated with ferritin level and negatively correlated with serum iron level in the putamen of patients. These findings indicate that iron dyshomeostasis and vascular damage might exist in the putamen in patients. The results revealed that iron dyshomeostasis and vascular damage in the putamen may be potential neural mechanisms for neurodegenerative processes in patients undergoing HD.
Topics: Humans; Putamen; Renal Dialysis; Iron; Cerebrovascular Circulation; Ferritins; Magnetic Resonance Imaging
PubMed: 36284493
DOI: 10.1177/0271678X221134384 -
Deep learning segmentation results in precise delineation of the putamen in multiple system atrophy.European Radiology Oct 2023The precise segmentation of atrophic structures remains challenging in neurodegenerative diseases. We determined the performance of a Deep Neural Patchwork (DNP) in...
OBJECTIVES
The precise segmentation of atrophic structures remains challenging in neurodegenerative diseases. We determined the performance of a Deep Neural Patchwork (DNP) in comparison to established segmentation algorithms regarding the ability to delineate the putamen in multiple system atrophy (MSA), Parkinson's disease (PD), and healthy controls.
METHODS
We retrospectively included patients with MSA and PD as well as healthy controls. A DNP was trained on manual segmentations of the putamen as ground truth. For this, the cohort was randomly split into a training (N = 131) and test set (N = 120). The DNP's performance was compared with putaminal segmentations as derived by Automatic Anatomic Labelling, Freesurfer and Fastsurfer. For validation, we assessed the diagnostic accuracy of the resulting segmentations in the delineation of MSA vs. PD and healthy controls.
RESULTS
A total of 251 subjects (61 patients with MSA, 158 patients with PD, and 32 healthy controls; mean age of 61.5 ± 8.8 years) were included. Compared to the dice-coefficient of the DNP (0.96), we noted significantly weaker performance for AAL3 (0.72; p < .001), Freesurfer (0.82; p < .001), and Fastsurfer (0.84, p < .001). This was corroborated by the superior diagnostic performance of MSA vs. PD and HC of the DNP (AUC 0.93) versus the AUC of 0.88 for AAL3 (p = 0.02), 0.86 for Freesurfer (p = 0.048), and 0.85 for Fastsurfer (p = 0.04).
CONCLUSION
By utilization of a DNP, accurate segmentations of the putamen can be obtained even if substantial atrophy is present. This allows for more precise extraction of imaging parameters or shape features from the putamen in relevant patient cohorts.
CLINICAL RELEVANCE STATEMENT
Deep learning-based segmentation of the putamen was superior to currently available algorithms and is beneficial for the diagnosis of multiple system atrophy.
KEY POINTS
• A Deep Neural Patchwork precisely delineates the putamen and performs equal to human labeling in multiple system atrophy, even when pronounced putaminal volume loss is present. • The Deep Neural Patchwork-based segmentation was more capable to differentiate between multiple system atrophy and Parkinson's disease than the AAL3 atlas, Freesurfer, or Fastsurfer.
Topics: Humans; Middle Aged; Aged; Multiple System Atrophy; Parkinson Disease; Putamen; Deep Learning; Retrospective Studies; Magnetic Resonance Imaging
PubMed: 37121929
DOI: 10.1007/s00330-023-09665-2 -
Cortex; a Journal Devoted To the Study... Nov 2022Functional magnetic resonance imaging (fMRI) studies on the dynamic representation of task content focus preferentially on the cerebral cortex. However,...
Functional magnetic resonance imaging (fMRI) studies on the dynamic representation of task content focus preferentially on the cerebral cortex. However, neurophysiological studies report coding of task-relevant features also by neurons in the striatum, suggesting basal ganglia involvement in cognitive decision-making. Here we use fMRI data to show that also in humans the striatum is an integrated part of the cognitive brain network. Twelve participants performed 3 cognitive tasks in the scanner, i.e., the Eriksen flanker task, a 2-back matching spatial working memory task, and a response scheme switching task. First, we use region of interest-based multivariate pattern classification to demonstrate that each task reliably induces a unique activity pattern in the striatum and in the lateral prefrontal cortex. We show that the three tasks can also be distinguished in putamen, caudate nucleus and ventral striatum alone. We additionally establish that the contribution of striatum to cognition is not sensitive to habituation or learning. Secondly, we use voxel-to-voxel functional connectivity to establish that voxels in the lateral prefrontal cortex and in the striatum that prefer the same task show significantly stronger functional coupling than voxel pairs in these remote structures that prefer different tasks. These results suggest that striatal neurons form subnetworks with cognition-related regions of the prefrontal cortex. These remote neuron populations are interconnected via functional couplings that exceed the time of execution of the specific tasks.
Topics: Humans; Neural Pathways; Prefrontal Cortex; Corpus Striatum; Caudate Nucleus; Putamen; Ventral Striatum; Magnetic Resonance Imaging
PubMed: 36240722
DOI: 10.1016/j.cortex.2022.06.015 -
Proceedings of the National Academy of... Jun 2016
Topics: Brain Tissue Transplantation; Dopaminergic Neurons; Fetal Tissue Transplantation; Humans; Parkinson Disease; Putamen; Transplants
PubMed: 27247420
DOI: 10.1073/pnas.1606342113 -
Journal of Neurophysiology Dec 2020The common marmoset () is a small-bodied New World primate that is becoming an important model to study brain functions. Despite several studies exploring the...
The common marmoset () is a small-bodied New World primate that is becoming an important model to study brain functions. Despite several studies exploring the somatosensory system of marmosets, all results have come from anesthetized animals using invasive techniques and postmortem analyses. Here, we demonstrate the feasibility for getting high-quality and reproducible somatosensory mapping in awake marmosets with functional magnetic resonance imaging (fMRI). We acquired fMRI sequences in four animals, while they received tactile stimulation (via air-puffs), delivered to the face, arm, or leg. We found a topographic body representation with the leg representation in the most medial part, the face representation in the most lateral part, and the arm representation between leg and face representation within areas 3a, 3b, and 1/2. A similar sequence from leg to face from caudal to rostral sites was identified in areas S2 and PV. By generating functional connectivity maps of seeds defined in the primary and second somatosensory regions, we identified two clusters of tactile representation within the posterior and midcingulate cortex. However, unlike humans and macaques, no clear somatotopic maps were observed. At the subcortical level, we found a somatotopic body representation in the thalamus and, for the first time in marmosets, in the putamen. These maps have similar organizations, as those previously found in Old World macaque monkeys and humans, suggesting that these subcortical somatotopic organizations were already established before Old and New World primates diverged. Our results show the first whole brain mapping of somatosensory responses acquired in a noninvasive way in awake marmosets. We used somatosensory stimulation combined with functional MRI (fMRI) in awake marmosets to reveal the topographic body representation in areas S1, S2, thalamus, and putamen. We showed the existence of a body representation organization within the thalamus and the cingulate cortex by computing functional connectivity maps from seeds defined in S1/S2, using resting-state fMRI data. This noninvasive approach will be essential for chronic studies by guiding invasive recording and manipulation techniques.
Topics: Animals; Arm; Behavior, Animal; Brain Mapping; Callithrix; Connectome; Face; Female; Gyrus Cinguli; Leg; Magnetic Resonance Imaging; Male; Physical Stimulation; Putamen; Somatosensory Cortex; Thalamus; Touch Perception
PubMed: 33112698
DOI: 10.1152/jn.00480.2020