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Applied Radiation and Isotopes :... Aug 2023Magnetic nanoparticle-based hyperthermia as a new cancer treatment technology has been applied for some kinds of tumors. To review the different applications and...
Magnetic nanoparticle-based hyperthermia as a new cancer treatment technology has been applied for some kinds of tumors. To review the different applications and effectiveness of this new cancer treatment technique, PubMed, Science Direct, Web of Science, and Google Scholar databases were explored up to November 2022, using the following keywords combined in different ways: "Magnetic Nanoparticles Based Hyperthermia", "Magnetic Nanoparticles" AND "Hyperthermia" AND "Cancer". The obtained results were screened for the title and abstract and the relevant papers were reviewed for further details. Finally, 24 papers were included in the study. These papers have evaluated the application of magnetic nanoparticle-based hyperthermia for treating different cancers including breast, liver, prostate, pancreas, colon, brain, lung, and stem cell. Various nanoparticles including Iron Oxide (FeO, FeO), Dextran Spermine, Iron Chloride, Magnetic nanoparticles conjugated with Liposomes (MCLs), and Variable Molecular Weight Nanoparticles (VMWNPs) were used in different reviewed studies. The results of reviewed studies revealed that the nanoparticle-based hyperthermia technique as a new progressive modality can significantly improve treatment outcomes for some special cancers. Increasing life expectancy by up to 30% using Iron Oxide magnetic nanoparticle-based hyperthermia for pancreatic cancer and increasing tumor ablation by about 33% for other cancers were reported in reviewed articles. However, further studies are required to extend this new treatment technique to other cancers and for providing more accurate information on nanoparticle-based hyperthermia's effectiveness as a complementary technique in cancer treatment.
Topics: Male; Humans; Adult; Magnetite Nanoparticles; Hyperthermia, Induced; Neoplasms; Lung
PubMed: 37257266
DOI: 10.1016/j.apradiso.2023.110873 -
Cureus Feb 2024Pancreatic ductal adenocarcinoma (PDAC) is a formidable global health concern with a dire prognosis, highlighting the critical need for early detection strategies. This... (Review)
Review
Pancreatic ductal adenocarcinoma (PDAC) is a formidable global health concern with a dire prognosis, highlighting the critical need for early detection strategies. This systematic review delves into the potential of salivary biomarkers as a non-invasive means for identifying PDAC at its incipient stages. Saliva's proximity to the circulatory system enables the detection of tumor-derived biomolecules, making it an ideal candidate for mass screening. The analysis of three selected studies reveals promising candidates such as Neisseria mucosa, Fusobacterium periodonticum, polyamines, and specific long non-coding RNAs (lncRNAs). Notably, polyamines like spermine show potential in distinguishing PDAC, while lncRNAs HOX transcript antisense RNA (HOTAIR) and plasmacytoma variant translocation 1 (PVT1) exhibit superior sensitivity and specificity compared to traditional serum markers. However, challenges, including small sample sizes and a lack of validation, underscore the need for standardized diagnostic panels and large-scale collaborative studies. Advancements in nanotechnology, machine learning, and ethical considerations are crucial for harnessing the diagnostic potential of saliva. The review emphasizes the imperative for extensive clinical trials to validate salivary biomarkers, ensuring not only diagnostic accuracy but also cost-effectiveness, patient compliance, and long-term benefits in the realm of PDAC screening. Longitudinal studies are recommended to unravel temporal changes in salivary biomarkers, shedding light on disease progression and treatment response.
PubMed: 38550499
DOI: 10.7759/cureus.55003