-
International Journal of Surgical... Jan 2024Currently, there is no robust evidence demonstrating a clear association between Lynch syndrome and non-malignant breast pathology such as adenomyoepithelioma. We report...
Currently, there is no robust evidence demonstrating a clear association between Lynch syndrome and non-malignant breast pathology such as adenomyoepithelioma. We report a case of benign breast adenomyoepithelioma, which after recurrence was associated with ductal carcinoma in-situ (DCIS) in a 41-year-old woman with Lynch syndrome, who lacked significant family history of breast or ovarian cancer. Both, the adenomyoepithelioma and DCIS were found to have nuclear loss of MSH2/MSH6 by immunohistochemistry, while germline testing confirmed gene mutation. Concordant loss of MSH2 in both lesions in the context of a pathogenic variant in this patient with Lynch syndrome illustrates that the benign adenomyoepithelioma behaved as a likely precursor of DCIS. Our report provides a novel perspective that in some patients with Lynch syndrome adenomyoepithelioma may represent a pre-malignant precursor lesion of DCIS.
PubMed: 38297508
DOI: 10.1177/10668969241226704 -
Zhongguo Yi Xue Ke Xue Yuan Xue Bao.... Apr 2024Malignant adenomyoepithelioma(MAME)of the breast is a rare tumor with an incidence less than 1% of primary breast cancer.The low incidence and diverse histomorphology... (Review)
Review
Malignant adenomyoepithelioma(MAME)of the breast is a rare tumor with an incidence less than 1% of primary breast cancer.The low incidence and diverse histomorphology pose challenges to the accurate diagnosis and clinical management of MAME.This paper reports a case of MAME of the breast with an intraductal papillary growth pattern and summarizes the clinical features,pathological features,diagnosis,treatment,and prognosis of MAME of the breast in the last 5 years.
Topics: Humans; Adenomyoepithelioma; Female; Breast Neoplasms; Middle Aged
PubMed: 38686730
DOI: 10.3881/j.issn.1000-503X.15759 -
ANZ Journal of Surgery Dec 2023
Topics: Humans; Female; Adenomyoepithelioma; Breast; Neoplasms; Breast Neoplasms
PubMed: 37641233
DOI: 10.1111/ans.18676 -
Journal of Surgical Case Reports Feb 2024Adenomyoepithelioma represents a rare tumor of the breast characterized by biphasic proliferation of epithelial and myoepithelial cells. Owing to its nonspecific...
Adenomyoepithelioma represents a rare tumor of the breast characterized by biphasic proliferation of epithelial and myoepithelial cells. Owing to its nonspecific clinical presentation, the rarity, and the morphological pitfalls in differential diagnosis, the diagnosis may be extremely difficult especially on limited samples such as core needle biopsy; thus, the diagnosis is histological, which is confirmed by the specificities of the immunohistochemical analyses. Here we report a case of a 64-year-old female who presented a benign adenomyoepithelioma diagnosed on core needle biopsy, review the clinicopathological features of breast adenomyoepithelioma diagnosed on core needle biopsy, and discuss the useful clues to prompt accurate diagnosis.
PubMed: 38426182
DOI: 10.1093/jscr/rjae090 -
International Journal of Surgery Case... Aug 2023Adenomyoepithelial tumors of the breast are very rare tumors comprising of - fibroepithelial and myoepithelial components PRESENTATION OF THE CASE: We present the case...
Adenomyoepithelial tumors of the breast are very rare tumors comprising of - fibroepithelial and myoepithelial components PRESENTATION OF THE CASE: We present the case of a 66 years old lady who presented with a right breast lump 5 cm in size, diagnosed as an atypical adenomyoepithelioma who underwent successful excision and returned two and half years later with a recurrence DISCUSSION: These tumors present a diagnostic dilemma needing histopathology for definitive diagnosis. Recurrence is not uncommon CONCLUSION: Adenomyoepitheliomas demand regular surveillance for early detection of any recurrence.
PubMed: 37557038
DOI: 10.1016/j.ijscr.2023.108632 -
International Journal of Surgical... Aug 2023
Topics: Humans; Female; Adenomyoepithelioma; Colorectal Neoplasms, Hereditary Nonpolyposis; Breast; Breast Neoplasms
PubMed: 35707990
DOI: 10.1177/10668969221105623 -
Pathology, Research and Practice Aug 2023We describe an unusual case of multifocal breast adenoid cystic carcinoma (AdCC) with adenomyoepitheliomatous morphology. Most breast AdCCs are unifocal and only four...
We describe an unusual case of multifocal breast adenoid cystic carcinoma (AdCC) with adenomyoepitheliomatous morphology. Most breast AdCCs are unifocal and only four cases of multifocal AdCC have been reported previously, however, to our best knowledge, multifocality in AdCC confirmed by molecular analysis has not been reported, so this report adds to the literature on this unique presentation. An 80-year-old woman presented with a left breast mass at 1 o'clock and non-mass enhancement lesion at 5 o'clock on imaging. Incisional biopsy at 1 o'clock showed AdCC based on histopathological features and MYB rearrangement by fluorescent in situ hybridization (FISH). As AdCC involved the margins and the non-mass enhancing lesion remained, mastectomy was performed. Microscopically, the lesion at 5 o'clock demonstrated multinodularity and a biphasic epithelial-basaloid/myoepithelial pattern. Although histological features resembled adenomyoepithelioma, MYB rearrangement was identified on FISH, so the 5 o'clock lesion was also diagnosed as AdCC showing an adenomyoepitheliomatous pattern. This unusual presentation is a potential diagnostic pitfall, so pathologists should consider AdCC as a possible differential diagnosis of multifocal basaloid breast tumors with adenomyoepitheliomatous features.
PubMed: 37392549
DOI: 10.1016/j.prp.2023.154650 -
Cureus May 2024Adenomyoepitheliomas of the breast are rare tumors that are characterized histologically as having both epithelial and myoepithelial components. While...
Adenomyoepitheliomas of the breast are rare tumors that are characterized histologically as having both epithelial and myoepithelial components. While adenomyoepitheliomas are considered benign lesions, existing literature supports their potential for malignant transformation. These tumors also exhibit nonspecific and variable findings on noninvasive imaging, posing additional challenges in management. We present a rare case of an adenomyoepithelioma diagnosed in a 65-year-old female who was treated with surgical resection of her tumor, with histopathology negative for malignant transformation. By describing this patient's management course, we aim to contribute to existing literature analyzing adenomyoepitheliomas and help guide future treatment.
PubMed: 38903269
DOI: 10.7759/cureus.60801